A statement higlighting a fact about the patient that requires clinical attention to ensure safety and prevent adverse outcomes. Example 1: intolerance to aspirin due to gastrointestinal bleeding. Example 2: intolerance to captopril because of cough (the patient is not allergic but can't tolerate it because of persistent cough) Example 3: the patient has a rare disease that requires special treatment Example 4: Airway Alert / Difficult Intubation Example 5: Diagnoses such as malignant hyperthermia, porphyria, and bleeding disorders; special treatments like anticoagulants or immunosuppressants; implanted devices. Example 6: transplanted organs illustrate other information that has to be taken into account in a healthcare contact. Example 7: participation in a clinical trial that has to be taken into account in a healthcare contact.