EvidenceVariable

Description

We adapted the EvidenceVariable resource and created two profiles to collect information about the intervention or exposure in a study.

Title	Canonical
NFDI4Health_PR_MDS_Evidence_Variable_Exposure	https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-evidence-variable-exposure
NFDI4Health_PR_MDS_Evidence_Variable_Intervention	https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-evidence-variable-intervention

References

Reference direction	Title	Path
referenced by	NFDI4Health PR MDS Study	ResearchStudy.extension[comparisonGroup].extension[intendedExposure]

Intervention

EvidenceVariable	I		EvidenceVariable	Element id EvidenceVariable Short description Interventions of the [RESOURCE] Definition Group of items providing information about the interventions of the [RESOURCE]. Comments Additional information: Specification of the intervention(s) associated with each arm. Data type EvidenceVariable Constraints dom-2: If the resource is contained in another resource, it SHALL NOT contain nested Resources `contained.contained.empty()` dom-4: If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated `contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()` dom-3: If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource `contained.where((('#'+id in (%resource.descendants().reference \| %resource.descendants().as(canonical) \| %resource.descendants().as(uri) \| %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()` dom-6: A resource should have narrative for robust management text.`div`.exists() dom-5: If a resource is contained in another resource, it SHALL NOT have a security label `contained.meta.security.empty()` evv-0: Name should be usable as an identifier for the module by machine processing applications such as code generation `name.matches('[A-Z]([A-Za-z0-9_]){0,254}')` Mappings rim: Entity. Role, or Act workflow: Definition NFDI4Health: Design.interventions
id	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.id Short description Logical id of this artifact Definition The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes. Comments The only time that a resource does not have an id is when it is being submitted to the server using a create operation. Data type string
meta	Σ	0..1	Meta	There are no (further) constraints on this element Element id EvidenceVariable.meta Short description Metadata about the resource Definition The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource. Data type Meta Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: N/A
implicitRules	Σ ?!	0..1	uri	There are no (further) constraints on this element Element id EvidenceVariable.implicitRules Short description A set of rules under which this content was created Definition A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc. Comments Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of it's narrative along with other profiles, value sets, etc. Data type uri Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
language		0..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.language Short description Language of the resource content Definition The base language in which the resource is written. Comments Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource. Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute). Data type code Binding A human language. CommonLanguages (preferred) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
text		0..1	Narrative	There are no (further) constraints on this element Element id EvidenceVariable.text Short description Text summary of the resource, for human interpretation Alternate names narrative, html, xhtml, display Definition A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it "clinically safe" for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety. Comments Contained resources do not have narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied). This may be necessary for data from legacy systems where information is captured as a "text blob" or where text is additionally entered raw or narrated and encoded information is added later. Data type Narrative Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: N/A rim: Act.text?
contained		0..*	Resource	There are no (further) constraints on this element Element id EvidenceVariable.contained Short description Contained, inline Resources Alternate names inline resources, anonymous resources, contained resources Definition These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, and nor can they have their own independent transaction scope. Comments This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags In their meta elements, but SHALL NOT have security labels. Data type Resource Mappings rim: Entity. Role, or Act rim: N/A
extension	I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the resource. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Sliced: Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
modifierExtension	?! I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.modifierExtension Short description Extensions that cannot be ignored Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Sliced: Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
url	Σ	0..1	uri	There are no (further) constraints on this element Element id EvidenceVariable.url Short description Canonical identifier for this evidence variable, represented as a URI (globally unique) Definition An absolute URI that is used to identify this evidence variable when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which at which an authoritative instance of this evidence variable is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the evidence variable is stored on different servers. Requirements Allows the evidence variable to be referenced by a single globally unique identifier. Comments Can be a urn:uuid: or a urn:oid: but real http: addresses are preferred. Multiple instances may share the same URL if they have a distinct version. The determination of when to create a new version of a resource (same url, new version) vs. defining a new artifact is up to the author. Considerations for making this decision are found in Technical and Business Versions. In some cases, the resource can no longer be found at the stated url, but the url itself cannot change. Implementations can use the meta.source element to indicate where the current master source of the resource can be found. Data type uri Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.url w5: FiveWs.identifier
identifier	Σ	0..*	Identifier	There are no (further) constraints on this element Element id EvidenceVariable.identifier Short description Additional identifier for the evidence variable Definition A formal identifier that is used to identify this evidence variable when it is represented in other formats, or referenced in a specification, model, design or an instance. Requirements Allows externally provided and/or usable business identifiers to be easily associated with the module. Comments Typically, this is used for identifiers that can go in an HL7 V3 II (instance identifier) data type, and can then identify this evidence variable outside of FHIR, where it is not possible to use the logical URI. Data type Identifier Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: CX / EI (occasionally, more often EI maps to a resource id or a URL) rim: II - The Identifier class is a little looser than the v3 type II because it allows URIs as well as registered OIDs or GUIDs. Also maps to Role[classCode=IDENT] servd: Identifier workflow: Definition.identifier w5: FiveWs.identifier objimpl: no-gen-base
version	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.version Short description Business version of the evidence variable Definition The identifier that is used to identify this version of the evidence variable when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the evidence variable author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence. To provide a version consistent with the Decision Support Service specification, use the format Major.Minor.Revision (e.g. 1.0.0). For more information on versioning knowledge assets, refer to the Decision Support Service specification. Note that a version is required for non-experimental active artifacts. Comments There may be different evidence variable instances that have the same identifier but different versions. The version can be appended to the url in a reference to allow a reference to a particular business version of the evidence variable with the format [url]\|[version]. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.version w5: FiveWs.version
name	Σ I	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.name Short description Name for this evidence variable (computer friendly) Definition A natural language name identifying the evidence variable. This name should be usable as an identifier for the module by machine processing applications such as code generation. Requirements Support human navigation and code generation. Comments The name is not expected to be globally unique. The name should be a simple alphanumeric type name to ensure that it is machine-processing friendly. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
title	Σ	1..1	string	Element id EvidenceVariable.title Short description Name of the intervention Definition A short descriptive name of the intervention. Comments If the same intervention is associated with more than one arm, please provide the information once and use the field 'Name(s) of the arm(s) associated with the given intervention' to associate it with more than one arm. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.title NFDI4Health: Design.interventions.name
shortTitle	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.shortTitle Short description Title for use in informal contexts Definition The short title provides an alternate title for use in informal descriptive contexts where the full, formal title is not necessary. Requirements Need to be able to reference the content by a short description, but still provide a longer, more formal title for the content. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
subtitle		0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.subtitle Short description Subordinate title of the EvidenceVariable Definition An explanatory or alternate title for the EvidenceVariable giving additional information about its content. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
status	Σ ?!	1..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.status Short description draft \| active \| retired \| unknown Definition The status of this evidence variable. Enables tracking the life-cycle of the content. Comments Allows filtering of evidence variables that are appropriate for use versus not. Data type code Binding The lifecycle status of an artifact. PublicationStatus (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.status w5: FiveWs.status
date	Σ	0..1	dateTime	There are no (further) constraints on this element Element id EvidenceVariable.date Short description Date last changed Alternate names Revision Date Definition The date (and optionally time) when the evidence variable was published. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the evidence variable changes. Comments Note that this is not the same as the resource last-modified-date, since the resource may be a secondary representation of the evidence variable. Additional specific dates may be added as extensions or be found by consulting Provenances associated with past versions of the resource. Data type dateTime Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.date w5: FiveWs.recorded
publisher	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.publisher Short description Name of the publisher (organization or individual) Definition The name of the organization or individual that published the evidence variable. Requirements Helps establish the "authority/credibility" of the evidence variable. May also allow for contact. Comments Usually an organization but may be an individual. The publisher (or steward) of the evidence variable is the organization or individual primarily responsible for the maintenance and upkeep of the evidence variable. This is not necessarily the same individual or organization that developed and initially authored the content. The publisher is the primary point of contact for questions or issues with the evidence variable. This item SHOULD be populated unless the information is available from context. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.publisher w5: FiveWs.witness
contact	Σ	0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.contact Short description Contact details for the publisher Definition Contact details to assist a user in finding and communicating with the publisher. Comments May be a web site, an email address, a telephone number, etc. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.contact
description	Σ	0..1	markdown	Element id EvidenceVariable.description Short description Additional information about the intervention Definition If needed, additional descriptive information about the given intervention. Comments This description can be used to capture details such as why the evidence variable was built, comments about misuse, instructions for clinical use and interpretation, literature references, examples from the paper world, etc. It is not a rendering of the evidence variable as conveyed in the 'text' field of the resource itself. This item SHOULD be populated unless the information is available from context (e.g. the language of the evidence variable is presumed to be the predominant language in the place the evidence variable was created). Data type markdown Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.description NFDI4Health: Design.interventions.description
note		0..*	Annotation	There are no (further) constraints on this element Element id EvidenceVariable.note Short description Used for footnotes or explanatory notes Definition A human-readable string to clarify or explain concepts about the resource. Comments For systems that do not have structured annotations, they can simply communicate a single annotation with no author or time. This element may need to be included in narrative because of the potential for modifying information. Annotations SHOULD NOT be used to communicate "modifying" information that could be computable. (This is a SHOULD because enforcing user behavior is nearly impossible). Data type Annotation Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: N/A rim: Act
useContext	Σ	0..*	UsageContext	There are no (further) constraints on this element Element id EvidenceVariable.useContext Short description The context that the content is intended to support Definition The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate evidence variable instances. Requirements Assist in searching for appropriate content. Comments When multiple useContexts are specified, there is no expectation that all or any of the contexts apply. Data type UsageContext Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.useContext
jurisdiction	Σ	0..*	CodeableConceptBinding	There are no (further) constraints on this element Element id EvidenceVariable.jurisdiction Short description Intended jurisdiction for evidence variable (if applicable) Definition A legal or geographic region in which the evidence variable is intended to be used. Comments It may be possible for the evidence variable to be used in jurisdictions other than those for which it was originally designed or intended. Data type CodeableConcept Binding Countries and regions within which this artifact is targeted for use. Jurisdiction ValueSet (extensible) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: CE/CNE/CWE rim: CD orim: fhir:CodeableConcept rdfs:subClassOf dt:CD workflow: Definition.jurisdiction
copyright		0..1	markdown	There are no (further) constraints on this element Element id EvidenceVariable.copyright Short description Use and/or publishing restrictions Alternate names License, Restrictions Definition A copyright statement relating to the evidence variable and/or its contents. Copyright statements are generally legal restrictions on the use and publishing of the evidence variable. Requirements Consumers must be able to determine any legal restrictions on the use of the evidence variable and/or its content. Comments Systems are not required to have markdown support, so the text should be readable without markdown processing. The markdown syntax is GFM - see https://github.github.com/gfm/ Data type markdown Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.copyright objimpl: no-gen-base
approvalDate		0..1	date	There are no (further) constraints on this element Element id EvidenceVariable.approvalDate Short description When the evidence variable was approved by publisher Definition The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage. Comments The 'date' element may be more recent than the approval date because of minor changes or editorial corrections. Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.approvalDate objimpl: no-gen-base
lastReviewDate		0..1	date	There are no (further) constraints on this element Element id EvidenceVariable.lastReviewDate Short description When the evidence variable was last reviewed Definition The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date. Requirements Gives a sense of how "current" the content is. Resources that have not been reviewed in a long time may have a risk of being less appropriate/relevant. Comments If specified, this date follows the original approval date. Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.lastReviewDate objimpl: no-gen-base
effectivePeriod	Σ I	0..1	Period	There are no (further) constraints on this element Element id EvidenceVariable.effectivePeriod Short description When the evidence variable is expected to be used Definition The period during which the evidence variable content was or is planned to be in active use. Requirements Allows establishing a transition before a resource comes into effect and also allows for a sunsetting process when new versions of the evidence variable are or are expected to be used instead. Comments The effective period for a evidence variable determines when the content is applicable for usage and is independent of publication and review dates. For example, a measure intended to be used for the year 2016 might be published in 2015. Data type Period Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` per-1: If present, start SHALL have a lower value than end `start.hasValue().not() or end.hasValue().not() or (start <= end)` Mappings rim: n/a v2: DR rim: IVL<TS>[lowClosed="true" and highClosed="true"] or URG<TS>[lowClosed="true" and highClosed="true"] workflow: Definition.effectivePeriod objimpl: no-gen-base
topic		0..*	CodeableConcept	There are no (further) constraints on this element Element id EvidenceVariable.topic Short description The category of the EvidenceVariable, such as Education, Treatment, Assessment, etc. Definition Descriptive topics related to the content of the EvidenceVariable. Topics provide a high-level categorization grouping types of EvidenceVariables that can be useful for filtering and searching. Requirements Repositories must be able to determine how to categorize the EvidenceVariable so that it can be found by topical searches. Comments Not all terminology uses fit this general pattern. In some cases, models should not use CodeableConcept and use Coding directly and provide their own structure for managing text, codings, translations and the relationship between elements and pre- and post-coordination. Data type CodeableConcept Binding High-level categorization of the definition, used for searching, sorting, and filtering. DefinitionTopic (example) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: CE/CNE/CWE rim: CD orim: fhir:CodeableConcept rdfs:subClassOf dt:CD
author		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.author Short description Who authored the content Definition An individiual or organization primarily involved in the creation and maintenance of the content. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: .participation[typeCode=AUT]
editor		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.editor Short description Who edited the content Definition An individual or organization primarily responsible for internal coherence of the content. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
reviewer		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.reviewer Short description Who reviewed the content Definition An individual or organization primarily responsible for review of some aspect of the content. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: .participation[typeCode=VRF] {not clear whether VRF best corresponds to reviewer or endorser}
endorser		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.endorser Short description Who endorsed the content Definition An individual or organization responsible for officially endorsing the content for use in some setting. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: .participation[typeCode=VRF] {not clear whether VRF best corresponds to reviewer or endorser}
relatedArtifact		0..*	RelatedArtifact	There are no (further) constraints on this element Element id EvidenceVariable.relatedArtifact Short description Additional documentation, citations, etc. Definition Related artifacts such as additional documentation, justification, or bibliographic references. Requirements EvidenceVariables must be able to provide enough information for consumers of the content (and/or interventions or results produced by the content) to be able to determine and understand the justification for and evidence in support of the content. Comments Each related artifact is either an attachment, or a reference to another resource, but not both. Data type RelatedArtifact Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
type	Σ	0..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.type Short description dichotomous \| continuous \| descriptive Definition The type of evidence element, a population, an exposure, or an outcome. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type code Binding The possible types of variables for exposures or outcomes (E.g. Dichotomous, Continuous, Descriptive). EvidenceVariableType (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
characteristic	Σ	1..*	BackboneElement	There are no (further) constraints on this element Element id EvidenceVariable.characteristic Short description What defines the members of the evidence element Definition A characteristic that defines the members of the evidence element. Multiple characteristics are applied with "and" semantics. Comments Characteristics can be defined flexibly to accommodate different use cases for membership criteria, ranging from simple codes, all the way to using an expression language to express the criteria. Data type BackboneElement Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Sliced: Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
modifierExtension	Σ ?! I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
description		0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.description Short description Natural language description of the characteristic Definition A short, natural language description of the characteristic that could be used to communicate the criteria to an end-user. Requirements Need to be able to describe characteristics in natural language so that end users can understand the criteria. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
definition[x]	Σ	1..1		Element id EvidenceVariable.characteristic.definition[x] Short description What code or expression defines members? Definition Define members of the evidence element using Codes (such as condition, medication, or observation), Expressions ( using an expression language such as FHIRPath or CQL) or DataRequirements (such as Diabetes diagnosis onset in the last year). Requirements Need to be able to define members in simple codes when the membership aligns well with terminology, with common criteria such as observations in a value set or lab tests within a year, or with expression language to support criteria that do not fit in the above. Sliced: Unordered, Open, by $this(Type) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
definitionCanonical			canonical(ActivityDefinition)	There are no (further) constraints on this element Data type canonical(ActivityDefinition)
definitionExpression			Expression	There are no (further) constraints on this element Data type Expression
definitionDataRequirement			DataRequirement	There are no (further) constraints on this element Data type DataRequirement
definitionTriggerDefinition			TriggerDefinition	There are no (further) constraints on this element Data type TriggerDefinition
definitionReference			Reference(Group)	There are no (further) constraints on this element Data type Reference(Group)
definitionCodeableConcept	Σ	1..1	CodeableConceptBinding	Element id EvidenceVariable.characteristic.definition[x]:definitionCodeableConcept Short description Type of the intervention Definition General type of the given intervention. Requirements Need to be able to define members in simple codes when the membership aligns well with terminology, with common criteria such as observations in a value set or lab tests within a year, or with expression language to support criteria that do not fit in the above. Data type CodeableConcept Binding Value set defining codes to specify the general type of the given intervention in the study. NFDI4Health_VS_MDS_Study_Intervention_Type_NCI (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a NFDI4Health: Design.interventions.type
usageContext		0..*	UsageContext	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.usageContext Short description What code/value pairs define members? Definition Use UsageContext to define the members of the population, such as Age Ranges, Genders, Settings. Requirements Need to be able to define members more structurally when more information can be communicated such as age range. Data type UsageContext Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
exclude		0..1	boolean	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.exclude Short description Whether the characteristic includes or excludes members Definition When true, members with this characteristic are excluded from the element. Meaning when missing False Data type boolean Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
participantEffective[x]		0..1		There are no (further) constraints on this element Element id EvidenceVariable.characteristic.participantEffective[x] Short description What time period do participants cover Definition Indicates what effective period the study covers. Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
participantEffectiveDateTime			dateTime	There are no (further) constraints on this element Data type dateTime
participantEffectivePeriod			Period	There are no (further) constraints on this element Data type Period
participantEffectiveDuration			Duration	There are no (further) constraints on this element Data type Duration
participantEffectiveTiming			Timing	There are no (further) constraints on this element Data type Timing
timeFromStart	I	0..1	Duration	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.timeFromStart Short description Observation time from study start Definition Indicates duration from the participant's study entry. Comments The context of use may frequently define what kind of quantity this is and therefore what kind of units can be used. The context of use may also restrict the values for the comparator. Data type Duration Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` qty-3: If a code for the unit is present, the system SHALL also be present `code.empty() or system.exists()` drt-1: There SHALL be a code if there is a value and it SHALL be an expression of time. If system is present, it SHALL be UCUM. `code.exists() implies ((system = %ucum) and value.exists())` Mappings rim: n/a v2: SN (see also Range) or CQ rim: PQ, IVL<PQ>, MO, CO, depending on the values rim: PQ, IVL<PQ> depending on the values
groupMeasure		0..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.groupMeasure Short description mean \| median \| mean-of-mean \| mean-of-median \| median-of-mean \| median-of-median Definition Indicates how elements are aggregated within the study effective period. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type code Binding Possible group measure aggregates (E.g. Mean, Median). GroupMeasure (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a

EvidenceVariable	I		EvidenceVariable	Element id EvidenceVariable Short description Interventions of the [RESOURCE] Definition Group of items providing information about the interventions of the [RESOURCE]. Comments Additional information: Specification of the intervention(s) associated with each arm. Data type EvidenceVariable Constraints dom-2: If the resource is contained in another resource, it SHALL NOT contain nested Resources `contained.contained.empty()` dom-4: If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated `contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()` dom-3: If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource `contained.where((('#'+id in (%resource.descendants().reference \| %resource.descendants().as(canonical) \| %resource.descendants().as(uri) \| %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()` dom-6: A resource should have narrative for robust management text.`div`.exists() dom-5: If a resource is contained in another resource, it SHALL NOT have a security label `contained.meta.security.empty()` evv-0: Name should be usable as an identifier for the module by machine processing applications such as code generation `name.matches('[A-Z]([A-Za-z0-9_]){0,254}')` Mappings rim: Entity. Role, or Act workflow: Definition NFDI4Health: Design.interventions
id	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.id Short description Logical id of this artifact Definition The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes. Comments The only time that a resource does not have an id is when it is being submitted to the server using a create operation. Data type string
meta	Σ	0..1	Meta	There are no (further) constraints on this element Element id EvidenceVariable.meta Short description Metadata about the resource Definition The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource. Data type Meta Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: N/A
implicitRules	Σ ?!	0..1	uri	There are no (further) constraints on this element Element id EvidenceVariable.implicitRules Short description A set of rules under which this content was created Definition A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc. Comments Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of it's narrative along with other profiles, value sets, etc. Data type uri Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
language		0..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.language Short description Language of the resource content Definition The base language in which the resource is written. Comments Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource. Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute). Data type code Binding A human language. CommonLanguages (preferred) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
text		0..1	Narrative	There are no (further) constraints on this element Element id EvidenceVariable.text Short description Text summary of the resource, for human interpretation Alternate names narrative, html, xhtml, display Definition A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it "clinically safe" for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety. Comments Contained resources do not have narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied). This may be necessary for data from legacy systems where information is captured as a "text blob" or where text is additionally entered raw or narrated and encoded information is added later. Data type Narrative Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: N/A rim: Act.text?
contained		0..*	Resource	There are no (further) constraints on this element Element id EvidenceVariable.contained Short description Contained, inline Resources Alternate names inline resources, anonymous resources, contained resources Definition These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, and nor can they have their own independent transaction scope. Comments This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags In their meta elements, but SHALL NOT have security labels. Data type Resource Mappings rim: Entity. Role, or Act rim: N/A
extension	I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the resource. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Sliced: Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
modifierExtension	?! I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.modifierExtension Short description Extensions that cannot be ignored Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Sliced: Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
url	Σ	0..1	uri	There are no (further) constraints on this element Element id EvidenceVariable.url Short description Canonical identifier for this evidence variable, represented as a URI (globally unique) Definition An absolute URI that is used to identify this evidence variable when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which at which an authoritative instance of this evidence variable is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the evidence variable is stored on different servers. Requirements Allows the evidence variable to be referenced by a single globally unique identifier. Comments Can be a urn:uuid: or a urn:oid: but real http: addresses are preferred. Multiple instances may share the same URL if they have a distinct version. The determination of when to create a new version of a resource (same url, new version) vs. defining a new artifact is up to the author. Considerations for making this decision are found in Technical and Business Versions. In some cases, the resource can no longer be found at the stated url, but the url itself cannot change. Implementations can use the meta.source element to indicate where the current master source of the resource can be found. Data type uri Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.url w5: FiveWs.identifier
identifier	Σ	0..*	Identifier	There are no (further) constraints on this element Element id EvidenceVariable.identifier Short description Additional identifier for the evidence variable Definition A formal identifier that is used to identify this evidence variable when it is represented in other formats, or referenced in a specification, model, design or an instance. Requirements Allows externally provided and/or usable business identifiers to be easily associated with the module. Comments Typically, this is used for identifiers that can go in an HL7 V3 II (instance identifier) data type, and can then identify this evidence variable outside of FHIR, where it is not possible to use the logical URI. Data type Identifier Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: CX / EI (occasionally, more often EI maps to a resource id or a URL) rim: II - The Identifier class is a little looser than the v3 type II because it allows URIs as well as registered OIDs or GUIDs. Also maps to Role[classCode=IDENT] servd: Identifier workflow: Definition.identifier w5: FiveWs.identifier objimpl: no-gen-base
version	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.version Short description Business version of the evidence variable Definition The identifier that is used to identify this version of the evidence variable when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the evidence variable author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence. To provide a version consistent with the Decision Support Service specification, use the format Major.Minor.Revision (e.g. 1.0.0). For more information on versioning knowledge assets, refer to the Decision Support Service specification. Note that a version is required for non-experimental active artifacts. Comments There may be different evidence variable instances that have the same identifier but different versions. The version can be appended to the url in a reference to allow a reference to a particular business version of the evidence variable with the format [url]\|[version]. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.version w5: FiveWs.version
name	Σ I	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.name Short description Name for this evidence variable (computer friendly) Definition A natural language name identifying the evidence variable. This name should be usable as an identifier for the module by machine processing applications such as code generation. Requirements Support human navigation and code generation. Comments The name is not expected to be globally unique. The name should be a simple alphanumeric type name to ensure that it is machine-processing friendly. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
title	Σ	1..1	string	Element id EvidenceVariable.title Short description Name of the intervention Definition A short descriptive name of the intervention. Comments If the same intervention is associated with more than one arm, please provide the information once and use the field 'Name(s) of the arm(s) associated with the given intervention' to associate it with more than one arm. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.title NFDI4Health: Design.interventions.name
shortTitle	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.shortTitle Short description Title for use in informal contexts Definition The short title provides an alternate title for use in informal descriptive contexts where the full, formal title is not necessary. Requirements Need to be able to reference the content by a short description, but still provide a longer, more formal title for the content. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
subtitle		0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.subtitle Short description Subordinate title of the EvidenceVariable Definition An explanatory or alternate title for the EvidenceVariable giving additional information about its content. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
status	Σ ?!	1..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.status Short description draft \| active \| retired \| unknown Definition The status of this evidence variable. Enables tracking the life-cycle of the content. Comments Allows filtering of evidence variables that are appropriate for use versus not. Data type code Binding The lifecycle status of an artifact. PublicationStatus (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.status w5: FiveWs.status
date	Σ	0..1	dateTime	There are no (further) constraints on this element Element id EvidenceVariable.date Short description Date last changed Alternate names Revision Date Definition The date (and optionally time) when the evidence variable was published. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the evidence variable changes. Comments Note that this is not the same as the resource last-modified-date, since the resource may be a secondary representation of the evidence variable. Additional specific dates may be added as extensions or be found by consulting Provenances associated with past versions of the resource. Data type dateTime Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.date w5: FiveWs.recorded
publisher	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.publisher Short description Name of the publisher (organization or individual) Definition The name of the organization or individual that published the evidence variable. Requirements Helps establish the "authority/credibility" of the evidence variable. May also allow for contact. Comments Usually an organization but may be an individual. The publisher (or steward) of the evidence variable is the organization or individual primarily responsible for the maintenance and upkeep of the evidence variable. This is not necessarily the same individual or organization that developed and initially authored the content. The publisher is the primary point of contact for questions or issues with the evidence variable. This item SHOULD be populated unless the information is available from context. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.publisher w5: FiveWs.witness
contact	Σ	0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.contact Short description Contact details for the publisher Definition Contact details to assist a user in finding and communicating with the publisher. Comments May be a web site, an email address, a telephone number, etc. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.contact
description	Σ	0..1	markdown	Element id EvidenceVariable.description Short description Additional information about the intervention Definition If needed, additional descriptive information about the given intervention. Comments This description can be used to capture details such as why the evidence variable was built, comments about misuse, instructions for clinical use and interpretation, literature references, examples from the paper world, etc. It is not a rendering of the evidence variable as conveyed in the 'text' field of the resource itself. This item SHOULD be populated unless the information is available from context (e.g. the language of the evidence variable is presumed to be the predominant language in the place the evidence variable was created). Data type markdown Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.description NFDI4Health: Design.interventions.description
note		0..*	Annotation	There are no (further) constraints on this element Element id EvidenceVariable.note Short description Used for footnotes or explanatory notes Definition A human-readable string to clarify or explain concepts about the resource. Comments For systems that do not have structured annotations, they can simply communicate a single annotation with no author or time. This element may need to be included in narrative because of the potential for modifying information. Annotations SHOULD NOT be used to communicate "modifying" information that could be computable. (This is a SHOULD because enforcing user behavior is nearly impossible). Data type Annotation Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: N/A rim: Act
useContext	Σ	0..*	UsageContext	There are no (further) constraints on this element Element id EvidenceVariable.useContext Short description The context that the content is intended to support Definition The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate evidence variable instances. Requirements Assist in searching for appropriate content. Comments When multiple useContexts are specified, there is no expectation that all or any of the contexts apply. Data type UsageContext Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.useContext
jurisdiction	Σ	0..*	CodeableConceptBinding	There are no (further) constraints on this element Element id EvidenceVariable.jurisdiction Short description Intended jurisdiction for evidence variable (if applicable) Definition A legal or geographic region in which the evidence variable is intended to be used. Comments It may be possible for the evidence variable to be used in jurisdictions other than those for which it was originally designed or intended. Data type CodeableConcept Binding Countries and regions within which this artifact is targeted for use. Jurisdiction ValueSet (extensible) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: CE/CNE/CWE rim: CD orim: fhir:CodeableConcept rdfs:subClassOf dt:CD workflow: Definition.jurisdiction
copyright		0..1	markdown	There are no (further) constraints on this element Element id EvidenceVariable.copyright Short description Use and/or publishing restrictions Alternate names License, Restrictions Definition A copyright statement relating to the evidence variable and/or its contents. Copyright statements are generally legal restrictions on the use and publishing of the evidence variable. Requirements Consumers must be able to determine any legal restrictions on the use of the evidence variable and/or its content. Comments Systems are not required to have markdown support, so the text should be readable without markdown processing. The markdown syntax is GFM - see https://github.github.com/gfm/ Data type markdown Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.copyright objimpl: no-gen-base
approvalDate		0..1	date	There are no (further) constraints on this element Element id EvidenceVariable.approvalDate Short description When the evidence variable was approved by publisher Definition The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage. Comments The 'date' element may be more recent than the approval date because of minor changes or editorial corrections. Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.approvalDate objimpl: no-gen-base
lastReviewDate		0..1	date	There are no (further) constraints on this element Element id EvidenceVariable.lastReviewDate Short description When the evidence variable was last reviewed Definition The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date. Requirements Gives a sense of how "current" the content is. Resources that have not been reviewed in a long time may have a risk of being less appropriate/relevant. Comments If specified, this date follows the original approval date. Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.lastReviewDate objimpl: no-gen-base
effectivePeriod	Σ I	0..1	Period	There are no (further) constraints on this element Element id EvidenceVariable.effectivePeriod Short description When the evidence variable is expected to be used Definition The period during which the evidence variable content was or is planned to be in active use. Requirements Allows establishing a transition before a resource comes into effect and also allows for a sunsetting process when new versions of the evidence variable are or are expected to be used instead. Comments The effective period for a evidence variable determines when the content is applicable for usage and is independent of publication and review dates. For example, a measure intended to be used for the year 2016 might be published in 2015. Data type Period Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` per-1: If present, start SHALL have a lower value than end `start.hasValue().not() or end.hasValue().not() or (start <= end)` Mappings rim: n/a v2: DR rim: IVL<TS>[lowClosed="true" and highClosed="true"] or URG<TS>[lowClosed="true" and highClosed="true"] workflow: Definition.effectivePeriod objimpl: no-gen-base
topic		0..*	CodeableConcept	There are no (further) constraints on this element Element id EvidenceVariable.topic Short description The category of the EvidenceVariable, such as Education, Treatment, Assessment, etc. Definition Descriptive topics related to the content of the EvidenceVariable. Topics provide a high-level categorization grouping types of EvidenceVariables that can be useful for filtering and searching. Requirements Repositories must be able to determine how to categorize the EvidenceVariable so that it can be found by topical searches. Comments Not all terminology uses fit this general pattern. In some cases, models should not use CodeableConcept and use Coding directly and provide their own structure for managing text, codings, translations and the relationship between elements and pre- and post-coordination. Data type CodeableConcept Binding High-level categorization of the definition, used for searching, sorting, and filtering. DefinitionTopic (example) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: CE/CNE/CWE rim: CD orim: fhir:CodeableConcept rdfs:subClassOf dt:CD
author		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.author Short description Who authored the content Definition An individiual or organization primarily involved in the creation and maintenance of the content. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: .participation[typeCode=AUT]
editor		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.editor Short description Who edited the content Definition An individual or organization primarily responsible for internal coherence of the content. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
reviewer		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.reviewer Short description Who reviewed the content Definition An individual or organization primarily responsible for review of some aspect of the content. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: .participation[typeCode=VRF] {not clear whether VRF best corresponds to reviewer or endorser}
endorser		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.endorser Short description Who endorsed the content Definition An individual or organization responsible for officially endorsing the content for use in some setting. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: .participation[typeCode=VRF] {not clear whether VRF best corresponds to reviewer or endorser}
relatedArtifact		0..*	RelatedArtifact	There are no (further) constraints on this element Element id EvidenceVariable.relatedArtifact Short description Additional documentation, citations, etc. Definition Related artifacts such as additional documentation, justification, or bibliographic references. Requirements EvidenceVariables must be able to provide enough information for consumers of the content (and/or interventions or results produced by the content) to be able to determine and understand the justification for and evidence in support of the content. Comments Each related artifact is either an attachment, or a reference to another resource, but not both. Data type RelatedArtifact Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
type	Σ	0..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.type Short description dichotomous \| continuous \| descriptive Definition The type of evidence element, a population, an exposure, or an outcome. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type code Binding The possible types of variables for exposures or outcomes (E.g. Dichotomous, Continuous, Descriptive). EvidenceVariableType (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
characteristic	Σ	1..*	BackboneElement	There are no (further) constraints on this element Element id EvidenceVariable.characteristic Short description What defines the members of the evidence element Definition A characteristic that defines the members of the evidence element. Multiple characteristics are applied with "and" semantics. Comments Characteristics can be defined flexibly to accommodate different use cases for membership criteria, ranging from simple codes, all the way to using an expression language to express the criteria. Data type BackboneElement Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Sliced: Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
modifierExtension	Σ ?! I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
description		0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.description Short description Natural language description of the characteristic Definition A short, natural language description of the characteristic that could be used to communicate the criteria to an end-user. Requirements Need to be able to describe characteristics in natural language so that end users can understand the criteria. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
definition[x]	Σ	1..1		Element id EvidenceVariable.characteristic.definition[x] Short description What code or expression defines members? Definition Define members of the evidence element using Codes (such as condition, medication, or observation), Expressions ( using an expression language such as FHIRPath or CQL) or DataRequirements (such as Diabetes diagnosis onset in the last year). Requirements Need to be able to define members in simple codes when the membership aligns well with terminology, with common criteria such as observations in a value set or lab tests within a year, or with expression language to support criteria that do not fit in the above. Sliced: Unordered, Open, by $this(Type) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
definitionCanonical			canonical(ActivityDefinition)	There are no (further) constraints on this element Data type canonical(ActivityDefinition)
definitionExpression			Expression	There are no (further) constraints on this element Data type Expression
definitionDataRequirement			DataRequirement	There are no (further) constraints on this element Data type DataRequirement
definitionTriggerDefinition			TriggerDefinition	There are no (further) constraints on this element Data type TriggerDefinition
definitionReference			Reference(Group)	There are no (further) constraints on this element Data type Reference(Group)
definitionCodeableConcept	Σ	1..1	CodeableConceptBinding	Element id EvidenceVariable.characteristic.definition[x]:definitionCodeableConcept Short description Type of the intervention Definition General type of the given intervention. Requirements Need to be able to define members in simple codes when the membership aligns well with terminology, with common criteria such as observations in a value set or lab tests within a year, or with expression language to support criteria that do not fit in the above. Data type CodeableConcept Binding Value set defining codes to specify the general type of the given intervention in the study. NFDI4Health_VS_MDS_Study_Intervention_Type_NCI (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a NFDI4Health: Design.interventions.type
usageContext		0..*	UsageContext	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.usageContext Short description What code/value pairs define members? Definition Use UsageContext to define the members of the population, such as Age Ranges, Genders, Settings. Requirements Need to be able to define members more structurally when more information can be communicated such as age range. Data type UsageContext Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
exclude		0..1	boolean	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.exclude Short description Whether the characteristic includes or excludes members Definition When true, members with this characteristic are excluded from the element. Meaning when missing False Data type boolean Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
participantEffective[x]		0..1		There are no (further) constraints on this element Element id EvidenceVariable.characteristic.participantEffective[x] Short description What time period do participants cover Definition Indicates what effective period the study covers. Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
participantEffectiveDateTime			dateTime	There are no (further) constraints on this element Data type dateTime
participantEffectivePeriod			Period	There are no (further) constraints on this element Data type Period
participantEffectiveDuration			Duration	There are no (further) constraints on this element Data type Duration
participantEffectiveTiming			Timing	There are no (further) constraints on this element Data type Timing
timeFromStart	I	0..1	Duration	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.timeFromStart Short description Observation time from study start Definition Indicates duration from the participant's study entry. Comments The context of use may frequently define what kind of quantity this is and therefore what kind of units can be used. The context of use may also restrict the values for the comparator. Data type Duration Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` qty-3: If a code for the unit is present, the system SHALL also be present `code.empty() or system.exists()` drt-1: There SHALL be a code if there is a value and it SHALL be an expression of time. If system is present, it SHALL be UCUM. `code.exists() implies ((system = %ucum) and value.exists())` Mappings rim: n/a v2: SN (see also Range) or CQ rim: PQ, IVL<PQ>, MO, CO, depending on the values rim: PQ, IVL<PQ> depending on the values
groupMeasure		0..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.groupMeasure Short description mean \| median \| mean-of-mean \| mean-of-median \| median-of-mean \| median-of-median Definition Indicates how elements are aggregated within the study effective period. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type code Binding Possible group measure aggregates (E.g. Mean, Median). GroupMeasure (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a

EvidenceVariable	I		EvidenceVariable	Element id EvidenceVariable Short description Interventions of the [RESOURCE] Definition Group of items providing information about the interventions of the [RESOURCE]. Comments Additional information: Specification of the intervention(s) associated with each arm. Data type EvidenceVariable Constraints dom-2: If the resource is contained in another resource, it SHALL NOT contain nested Resources `contained.contained.empty()` dom-4: If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated `contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()` dom-3: If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource `contained.where((('#'+id in (%resource.descendants().reference \| %resource.descendants().as(canonical) \| %resource.descendants().as(uri) \| %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()` dom-6: A resource should have narrative for robust management text.`div`.exists() dom-5: If a resource is contained in another resource, it SHALL NOT have a security label `contained.meta.security.empty()` evv-0: Name should be usable as an identifier for the module by machine processing applications such as code generation `name.matches('[A-Z]([A-Za-z0-9_]){0,254}')` Mappings rim: Entity. Role, or Act workflow: Definition NFDI4Health: Design.interventions
id	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.id Short description Logical id of this artifact Definition The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes. Comments The only time that a resource does not have an id is when it is being submitted to the server using a create operation. Data type string
meta	Σ	0..1	Meta	There are no (further) constraints on this element Element id EvidenceVariable.meta Short description Metadata about the resource Definition The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource. Data type Meta Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: N/A
implicitRules	Σ ?!	0..1	uri	There are no (further) constraints on this element Element id EvidenceVariable.implicitRules Short description A set of rules under which this content was created Definition A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc. Comments Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of it's narrative along with other profiles, value sets, etc. Data type uri Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
language		0..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.language Short description Language of the resource content Definition The base language in which the resource is written. Comments Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource. Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute). Data type code Binding A human language. CommonLanguages (preferred) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
text		0..1	Narrative	There are no (further) constraints on this element Element id EvidenceVariable.text Short description Text summary of the resource, for human interpretation Alternate names narrative, html, xhtml, display Definition A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it "clinically safe" for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety. Comments Contained resources do not have narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied). This may be necessary for data from legacy systems where information is captured as a "text blob" or where text is additionally entered raw or narrated and encoded information is added later. Data type Narrative Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: N/A rim: Act.text?
contained		0..*	Resource	There are no (further) constraints on this element Element id EvidenceVariable.contained Short description Contained, inline Resources Alternate names inline resources, anonymous resources, contained resources Definition These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, and nor can they have their own independent transaction scope. Comments This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags In their meta elements, but SHALL NOT have security labels. Data type Resource Mappings rim: Entity. Role, or Act rim: N/A
extension	I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the resource. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Sliced: Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
modifierExtension	?! I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.modifierExtension Short description Extensions that cannot be ignored Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Sliced: Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
url	Σ	0..1	uri	There are no (further) constraints on this element Element id EvidenceVariable.url Short description Canonical identifier for this evidence variable, represented as a URI (globally unique) Definition An absolute URI that is used to identify this evidence variable when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which at which an authoritative instance of this evidence variable is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the evidence variable is stored on different servers. Requirements Allows the evidence variable to be referenced by a single globally unique identifier. Comments Can be a urn:uuid: or a urn:oid: but real http: addresses are preferred. Multiple instances may share the same URL if they have a distinct version. The determination of when to create a new version of a resource (same url, new version) vs. defining a new artifact is up to the author. Considerations for making this decision are found in Technical and Business Versions. In some cases, the resource can no longer be found at the stated url, but the url itself cannot change. Implementations can use the meta.source element to indicate where the current master source of the resource can be found. Data type uri Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.url w5: FiveWs.identifier
identifier	Σ	0..*	Identifier	There are no (further) constraints on this element Element id EvidenceVariable.identifier Short description Additional identifier for the evidence variable Definition A formal identifier that is used to identify this evidence variable when it is represented in other formats, or referenced in a specification, model, design or an instance. Requirements Allows externally provided and/or usable business identifiers to be easily associated with the module. Comments Typically, this is used for identifiers that can go in an HL7 V3 II (instance identifier) data type, and can then identify this evidence variable outside of FHIR, where it is not possible to use the logical URI. Data type Identifier Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: CX / EI (occasionally, more often EI maps to a resource id or a URL) rim: II - The Identifier class is a little looser than the v3 type II because it allows URIs as well as registered OIDs or GUIDs. Also maps to Role[classCode=IDENT] servd: Identifier workflow: Definition.identifier w5: FiveWs.identifier objimpl: no-gen-base
version	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.version Short description Business version of the evidence variable Definition The identifier that is used to identify this version of the evidence variable when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the evidence variable author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence. To provide a version consistent with the Decision Support Service specification, use the format Major.Minor.Revision (e.g. 1.0.0). For more information on versioning knowledge assets, refer to the Decision Support Service specification. Note that a version is required for non-experimental active artifacts. Comments There may be different evidence variable instances that have the same identifier but different versions. The version can be appended to the url in a reference to allow a reference to a particular business version of the evidence variable with the format [url]\|[version]. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.version w5: FiveWs.version
name	Σ I	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.name Short description Name for this evidence variable (computer friendly) Definition A natural language name identifying the evidence variable. This name should be usable as an identifier for the module by machine processing applications such as code generation. Requirements Support human navigation and code generation. Comments The name is not expected to be globally unique. The name should be a simple alphanumeric type name to ensure that it is machine-processing friendly. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
title	Σ	1..1	string	Element id EvidenceVariable.title Short description Name of the intervention Definition A short descriptive name of the intervention. Comments If the same intervention is associated with more than one arm, please provide the information once and use the field 'Name(s) of the arm(s) associated with the given intervention' to associate it with more than one arm. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.title NFDI4Health: Design.interventions.name
shortTitle	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.shortTitle Short description Title for use in informal contexts Definition The short title provides an alternate title for use in informal descriptive contexts where the full, formal title is not necessary. Requirements Need to be able to reference the content by a short description, but still provide a longer, more formal title for the content. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
subtitle		0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.subtitle Short description Subordinate title of the EvidenceVariable Definition An explanatory or alternate title for the EvidenceVariable giving additional information about its content. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
status	Σ ?!	1..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.status Short description draft \| active \| retired \| unknown Definition The status of this evidence variable. Enables tracking the life-cycle of the content. Comments Allows filtering of evidence variables that are appropriate for use versus not. Data type code Binding The lifecycle status of an artifact. PublicationStatus (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.status w5: FiveWs.status
date	Σ	0..1	dateTime	There are no (further) constraints on this element Element id EvidenceVariable.date Short description Date last changed Alternate names Revision Date Definition The date (and optionally time) when the evidence variable was published. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the evidence variable changes. Comments Note that this is not the same as the resource last-modified-date, since the resource may be a secondary representation of the evidence variable. Additional specific dates may be added as extensions or be found by consulting Provenances associated with past versions of the resource. Data type dateTime Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.date w5: FiveWs.recorded
publisher	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.publisher Short description Name of the publisher (organization or individual) Definition The name of the organization or individual that published the evidence variable. Requirements Helps establish the "authority/credibility" of the evidence variable. May also allow for contact. Comments Usually an organization but may be an individual. The publisher (or steward) of the evidence variable is the organization or individual primarily responsible for the maintenance and upkeep of the evidence variable. This is not necessarily the same individual or organization that developed and initially authored the content. The publisher is the primary point of contact for questions or issues with the evidence variable. This item SHOULD be populated unless the information is available from context. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.publisher w5: FiveWs.witness
contact	Σ	0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.contact Short description Contact details for the publisher Definition Contact details to assist a user in finding and communicating with the publisher. Comments May be a web site, an email address, a telephone number, etc. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.contact
description	Σ	0..1	markdown	Element id EvidenceVariable.description Short description Additional information about the intervention Definition If needed, additional descriptive information about the given intervention. Comments This description can be used to capture details such as why the evidence variable was built, comments about misuse, instructions for clinical use and interpretation, literature references, examples from the paper world, etc. It is not a rendering of the evidence variable as conveyed in the 'text' field of the resource itself. This item SHOULD be populated unless the information is available from context (e.g. the language of the evidence variable is presumed to be the predominant language in the place the evidence variable was created). Data type markdown Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.description NFDI4Health: Design.interventions.description
note		0..*	Annotation	There are no (further) constraints on this element Element id EvidenceVariable.note Short description Used for footnotes or explanatory notes Definition A human-readable string to clarify or explain concepts about the resource. Comments For systems that do not have structured annotations, they can simply communicate a single annotation with no author or time. This element may need to be included in narrative because of the potential for modifying information. Annotations SHOULD NOT be used to communicate "modifying" information that could be computable. (This is a SHOULD because enforcing user behavior is nearly impossible). Data type Annotation Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: N/A rim: Act
useContext	Σ	0..*	UsageContext	There are no (further) constraints on this element Element id EvidenceVariable.useContext Short description The context that the content is intended to support Definition The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate evidence variable instances. Requirements Assist in searching for appropriate content. Comments When multiple useContexts are specified, there is no expectation that all or any of the contexts apply. Data type UsageContext Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.useContext
jurisdiction	Σ	0..*	CodeableConceptBinding	There are no (further) constraints on this element Element id EvidenceVariable.jurisdiction Short description Intended jurisdiction for evidence variable (if applicable) Definition A legal or geographic region in which the evidence variable is intended to be used. Comments It may be possible for the evidence variable to be used in jurisdictions other than those for which it was originally designed or intended. Data type CodeableConcept Binding Countries and regions within which this artifact is targeted for use. Jurisdiction ValueSet (extensible) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: CE/CNE/CWE rim: CD orim: fhir:CodeableConcept rdfs:subClassOf dt:CD workflow: Definition.jurisdiction
copyright		0..1	markdown	There are no (further) constraints on this element Element id EvidenceVariable.copyright Short description Use and/or publishing restrictions Alternate names License, Restrictions Definition A copyright statement relating to the evidence variable and/or its contents. Copyright statements are generally legal restrictions on the use and publishing of the evidence variable. Requirements Consumers must be able to determine any legal restrictions on the use of the evidence variable and/or its content. Comments Systems are not required to have markdown support, so the text should be readable without markdown processing. The markdown syntax is GFM - see https://github.github.com/gfm/ Data type markdown Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.copyright objimpl: no-gen-base
approvalDate		0..1	date	There are no (further) constraints on this element Element id EvidenceVariable.approvalDate Short description When the evidence variable was approved by publisher Definition The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage. Comments The 'date' element may be more recent than the approval date because of minor changes or editorial corrections. Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.approvalDate objimpl: no-gen-base
lastReviewDate		0..1	date	There are no (further) constraints on this element Element id EvidenceVariable.lastReviewDate Short description When the evidence variable was last reviewed Definition The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date. Requirements Gives a sense of how "current" the content is. Resources that have not been reviewed in a long time may have a risk of being less appropriate/relevant. Comments If specified, this date follows the original approval date. Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.lastReviewDate objimpl: no-gen-base
effectivePeriod	Σ I	0..1	Period	There are no (further) constraints on this element Element id EvidenceVariable.effectivePeriod Short description When the evidence variable is expected to be used Definition The period during which the evidence variable content was or is planned to be in active use. Requirements Allows establishing a transition before a resource comes into effect and also allows for a sunsetting process when new versions of the evidence variable are or are expected to be used instead. Comments The effective period for a evidence variable determines when the content is applicable for usage and is independent of publication and review dates. For example, a measure intended to be used for the year 2016 might be published in 2015. Data type Period Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` per-1: If present, start SHALL have a lower value than end `start.hasValue().not() or end.hasValue().not() or (start <= end)` Mappings rim: n/a v2: DR rim: IVL<TS>[lowClosed="true" and highClosed="true"] or URG<TS>[lowClosed="true" and highClosed="true"] workflow: Definition.effectivePeriod objimpl: no-gen-base
topic		0..*	CodeableConcept	There are no (further) constraints on this element Element id EvidenceVariable.topic Short description The category of the EvidenceVariable, such as Education, Treatment, Assessment, etc. Definition Descriptive topics related to the content of the EvidenceVariable. Topics provide a high-level categorization grouping types of EvidenceVariables that can be useful for filtering and searching. Requirements Repositories must be able to determine how to categorize the EvidenceVariable so that it can be found by topical searches. Comments Not all terminology uses fit this general pattern. In some cases, models should not use CodeableConcept and use Coding directly and provide their own structure for managing text, codings, translations and the relationship between elements and pre- and post-coordination. Data type CodeableConcept Binding High-level categorization of the definition, used for searching, sorting, and filtering. DefinitionTopic (example) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: CE/CNE/CWE rim: CD orim: fhir:CodeableConcept rdfs:subClassOf dt:CD
author		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.author Short description Who authored the content Definition An individiual or organization primarily involved in the creation and maintenance of the content. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: .participation[typeCode=AUT]
editor		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.editor Short description Who edited the content Definition An individual or organization primarily responsible for internal coherence of the content. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
reviewer		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.reviewer Short description Who reviewed the content Definition An individual or organization primarily responsible for review of some aspect of the content. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: .participation[typeCode=VRF] {not clear whether VRF best corresponds to reviewer or endorser}
endorser		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.endorser Short description Who endorsed the content Definition An individual or organization responsible for officially endorsing the content for use in some setting. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: .participation[typeCode=VRF] {not clear whether VRF best corresponds to reviewer or endorser}
relatedArtifact		0..*	RelatedArtifact	There are no (further) constraints on this element Element id EvidenceVariable.relatedArtifact Short description Additional documentation, citations, etc. Definition Related artifacts such as additional documentation, justification, or bibliographic references. Requirements EvidenceVariables must be able to provide enough information for consumers of the content (and/or interventions or results produced by the content) to be able to determine and understand the justification for and evidence in support of the content. Comments Each related artifact is either an attachment, or a reference to another resource, but not both. Data type RelatedArtifact Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
type	Σ	0..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.type Short description dichotomous \| continuous \| descriptive Definition The type of evidence element, a population, an exposure, or an outcome. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type code Binding The possible types of variables for exposures or outcomes (E.g. Dichotomous, Continuous, Descriptive). EvidenceVariableType (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
characteristic	Σ	1..*	BackboneElement	There are no (further) constraints on this element Element id EvidenceVariable.characteristic Short description What defines the members of the evidence element Definition A characteristic that defines the members of the evidence element. Multiple characteristics are applied with "and" semantics. Comments Characteristics can be defined flexibly to accommodate different use cases for membership criteria, ranging from simple codes, all the way to using an expression language to express the criteria. Data type BackboneElement Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Sliced: Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
modifierExtension	Σ ?! I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
description		0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.description Short description Natural language description of the characteristic Definition A short, natural language description of the characteristic that could be used to communicate the criteria to an end-user. Requirements Need to be able to describe characteristics in natural language so that end users can understand the criteria. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
definition[x]	Σ	1..1		Element id EvidenceVariable.characteristic.definition[x] Short description What code or expression defines members? Definition Define members of the evidence element using Codes (such as condition, medication, or observation), Expressions ( using an expression language such as FHIRPath or CQL) or DataRequirements (such as Diabetes diagnosis onset in the last year). Requirements Need to be able to define members in simple codes when the membership aligns well with terminology, with common criteria such as observations in a value set or lab tests within a year, or with expression language to support criteria that do not fit in the above. Sliced: Unordered, Open, by $this(Type) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
definitionCanonical			canonical(ActivityDefinition)	There are no (further) constraints on this element Data type canonical(ActivityDefinition)
definitionExpression			Expression	There are no (further) constraints on this element Data type Expression
definitionDataRequirement			DataRequirement	There are no (further) constraints on this element Data type DataRequirement
definitionTriggerDefinition			TriggerDefinition	There are no (further) constraints on this element Data type TriggerDefinition
definitionReference			Reference(Group)	There are no (further) constraints on this element Data type Reference(Group)
definitionCodeableConcept	Σ	1..1	CodeableConceptBinding	Element id EvidenceVariable.characteristic.definition[x]:definitionCodeableConcept Short description Type of the intervention Definition General type of the given intervention. Requirements Need to be able to define members in simple codes when the membership aligns well with terminology, with common criteria such as observations in a value set or lab tests within a year, or with expression language to support criteria that do not fit in the above. Data type CodeableConcept Binding Value set defining codes to specify the general type of the given intervention in the study. NFDI4Health_VS_MDS_Study_Intervention_Type_NCI (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a NFDI4Health: Design.interventions.type
usageContext		0..*	UsageContext	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.usageContext Short description What code/value pairs define members? Definition Use UsageContext to define the members of the population, such as Age Ranges, Genders, Settings. Requirements Need to be able to define members more structurally when more information can be communicated such as age range. Data type UsageContext Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
exclude		0..1	boolean	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.exclude Short description Whether the characteristic includes or excludes members Definition When true, members with this characteristic are excluded from the element. Meaning when missing False Data type boolean Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
participantEffective[x]		0..1		There are no (further) constraints on this element Element id EvidenceVariable.characteristic.participantEffective[x] Short description What time period do participants cover Definition Indicates what effective period the study covers. Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
participantEffectiveDateTime			dateTime	There are no (further) constraints on this element Data type dateTime
participantEffectivePeriod			Period	There are no (further) constraints on this element Data type Period
participantEffectiveDuration			Duration	There are no (further) constraints on this element Data type Duration
participantEffectiveTiming			Timing	There are no (further) constraints on this element Data type Timing
timeFromStart	I	0..1	Duration	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.timeFromStart Short description Observation time from study start Definition Indicates duration from the participant's study entry. Comments The context of use may frequently define what kind of quantity this is and therefore what kind of units can be used. The context of use may also restrict the values for the comparator. Data type Duration Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` qty-3: If a code for the unit is present, the system SHALL also be present `code.empty() or system.exists()` drt-1: There SHALL be a code if there is a value and it SHALL be an expression of time. If system is present, it SHALL be UCUM. `code.exists() implies ((system = %ucum) and value.exists())` Mappings rim: n/a v2: SN (see also Range) or CQ rim: PQ, IVL<PQ>, MO, CO, depending on the values rim: PQ, IVL<PQ> depending on the values
groupMeasure		0..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.groupMeasure Short description mean \| median \| mean-of-mean \| mean-of-median \| median-of-mean \| median-of-median Definition Indicates how elements are aggregated within the study effective period. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type code Binding Possible group measure aggregates (E.g. Mean, Median). GroupMeasure (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a

{
    "resourceType": "StructureDefinition",
    "id": "nfdi4health-pr-mds-evidence-variable-intervention",
    "url": "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-evidence-variable-intervention",
    "version": "0.9",
    "name": "NFDI4Health_PR_MDS_Evidence_Variable_Intervention",
    "title": "NFDI4Health PR MDS Evidence Variable Intervention",
    "status": "draft",
    "publisher": "NFDI4Health",
    "contact":  [
        {
            "telecom":  [
                {
                    "system": "url",
                    "value": "https://www.nfdi4health.de"
                }
            ]
        }
    ],
    "description": "Information about the intervention or in a study.",
    "fhirVersion": "4.0.1",
    "mapping":  [
        {
            "identity": "workflow",
            "uri": "http://hl7.org/fhir/workflow",
            "name": "Workflow Pattern"
        },
        {
            "identity": "w5",
            "uri": "http://hl7.org/fhir/fivews",
            "name": "FiveWs Pattern Mapping"
        },
        {
            "identity": "objimpl",
            "uri": "http://hl7.org/fhir/object-implementation",
            "name": "Object Implementation Information"
        },
        {
            "identity": "rim",
            "uri": "http://hl7.org/v3",
            "name": "RIM Mapping"
        },
        {
            "identity": "NFDI4Health",
            "name": "NFDI4Health to FHIR Mapping"
        }
    ],
    "kind": "resource",
    "abstract": false,
    "type": "EvidenceVariable",
    "baseDefinition": "http://hl7.org/fhir/StructureDefinition/EvidenceVariable",
    "derivation": "constraint",
    "differential": {
        "element":  [
            {
                "id": "EvidenceVariable",
                "path": "EvidenceVariable",
                "short": "Interventions of the [RESOURCE]",
                "definition": "\nGroup of items providing information about the interventions of the [RESOURCE].",
                "comment": "Additional information: \nSpecification of the intervention(s) associated with each arm.",
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "Design.interventions"
                    }
                ]
            },
            {
                "id": "EvidenceVariable.title",
                "path": "EvidenceVariable.title",
                "short": "Name of the intervention",
                "definition": "A short descriptive name of the intervention.",
                "comment": "If the same intervention is associated with more than one arm, please provide the information once and use the field 'Name(s) of the arm(s) associated with the given intervention' to associate it with more than one arm.",
                "min": 1,
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "Design.interventions.name"
                    }
                ]
            },
            {
                "id": "EvidenceVariable.description",
                "path": "EvidenceVariable.description",
                "short": "Additional information about the intervention",
                "definition": "If needed, additional descriptive information about the given intervention.",
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "Design.interventions.description"
                    }
                ]
            },
            {
                "id": "EvidenceVariable.characteristic.definition[x]",
                "path": "EvidenceVariable.characteristic.definition[x]",
                "slicing": {
                    "discriminator":  [
                        {
                            "type": "type",
                            "path": "$this"
                        }
                    ],
                    "ordered": false,
                    "rules": "open"
                }
            },
            {
                "id": "EvidenceVariable.characteristic.definition[x]:definitionCodeableConcept",
                "path": "EvidenceVariable.characteristic.definition[x]",
                "sliceName": "definitionCodeableConcept",
                "short": "Type of the intervention",
                "definition": "General type of the given intervention.",
                "min": 1,
                "max": "1",
                "type":  [
                    {
                        "code": "CodeableConcept"
                    }
                ],
                "binding": {
                    "strength": "required",
                    "valueSet": "https://www.nfdi4health.de/fhir/metadataschema/ValueSet/nfdi4health-vs-mds-study-intervention-type-nci",
                    "description": "Value set defining codes to specify the general type of the given intervention in the study."
                },
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "Design.interventions.type"
                    }
                ]
            }
        ]
    }
}

Exposure

EvidenceVariable	I		EvidenceVariable	Element id EvidenceVariable Short description Design.exposures: Exposures of the [RESOURCE] Definition Group of items providing information about the exposures of the [RESOURCE]. Comments Specification of the exposure(s) associated with each group. Data type EvidenceVariable Constraints dom-2: If the resource is contained in another resource, it SHALL NOT contain nested Resources `contained.contained.empty()` dom-4: If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated `contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()` dom-3: If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource `contained.where((('#'+id in (%resource.descendants().reference \| %resource.descendants().as(canonical) \| %resource.descendants().as(uri) \| %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()` dom-6: A resource should have narrative for robust management text.`div`.exists() dom-5: If a resource is contained in another resource, it SHALL NOT have a security label `contained.meta.security.empty()` evv-0: Name should be usable as an identifier for the module by machine processing applications such as code generation `name.matches('[A-Z]([A-Za-z0-9_]){0,254}')` Mappings rim: Entity. Role, or Act workflow: Definition NFDI4Health: Design.exposures
id	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.id Short description Logical id of this artifact Definition The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes. Comments The only time that a resource does not have an id is when it is being submitted to the server using a create operation. Data type string
meta	Σ	0..1	Meta	There are no (further) constraints on this element Element id EvidenceVariable.meta Short description Metadata about the resource Definition The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource. Data type Meta Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: N/A
implicitRules	Σ ?!	0..1	uri	There are no (further) constraints on this element Element id EvidenceVariable.implicitRules Short description A set of rules under which this content was created Definition A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc. Comments Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of it's narrative along with other profiles, value sets, etc. Data type uri Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
language		0..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.language Short description Language of the resource content Definition The base language in which the resource is written. Comments Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource. Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute). Data type code Binding A human language. CommonLanguages (preferred) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
text		0..1	Narrative	There are no (further) constraints on this element Element id EvidenceVariable.text Short description Text summary of the resource, for human interpretation Alternate names narrative, html, xhtml, display Definition A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it "clinically safe" for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety. Comments Contained resources do not have narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied). This may be necessary for data from legacy systems where information is captured as a "text blob" or where text is additionally entered raw or narrated and encoded information is added later. Data type Narrative Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: N/A rim: Act.text?
contained		0..*	Resource	There are no (further) constraints on this element Element id EvidenceVariable.contained Short description Contained, inline Resources Alternate names inline resources, anonymous resources, contained resources Definition These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, and nor can they have their own independent transaction scope. Comments This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags In their meta elements, but SHALL NOT have security labels. Data type Resource Mappings rim: Entity. Role, or Act rim: N/A
extension	I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the resource. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Sliced: Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
modifierExtension	?! I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.modifierExtension Short description Extensions that cannot be ignored Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Sliced: Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
url	Σ	0..1	uri	There are no (further) constraints on this element Element id EvidenceVariable.url Short description Canonical identifier for this evidence variable, represented as a URI (globally unique) Definition An absolute URI that is used to identify this evidence variable when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which at which an authoritative instance of this evidence variable is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the evidence variable is stored on different servers. Requirements Allows the evidence variable to be referenced by a single globally unique identifier. Comments Can be a urn:uuid: or a urn:oid: but real http: addresses are preferred. Multiple instances may share the same URL if they have a distinct version. The determination of when to create a new version of a resource (same url, new version) vs. defining a new artifact is up to the author. Considerations for making this decision are found in Technical and Business Versions. In some cases, the resource can no longer be found at the stated url, but the url itself cannot change. Implementations can use the meta.source element to indicate where the current master source of the resource can be found. Data type uri Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.url w5: FiveWs.identifier
identifier	Σ	0..*	Identifier	There are no (further) constraints on this element Element id EvidenceVariable.identifier Short description Additional identifier for the evidence variable Definition A formal identifier that is used to identify this evidence variable when it is represented in other formats, or referenced in a specification, model, design or an instance. Requirements Allows externally provided and/or usable business identifiers to be easily associated with the module. Comments Typically, this is used for identifiers that can go in an HL7 V3 II (instance identifier) data type, and can then identify this evidence variable outside of FHIR, where it is not possible to use the logical URI. Data type Identifier Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: CX / EI (occasionally, more often EI maps to a resource id or a URL) rim: II - The Identifier class is a little looser than the v3 type II because it allows URIs as well as registered OIDs or GUIDs. Also maps to Role[classCode=IDENT] servd: Identifier workflow: Definition.identifier w5: FiveWs.identifier objimpl: no-gen-base
version	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.version Short description Business version of the evidence variable Definition The identifier that is used to identify this version of the evidence variable when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the evidence variable author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence. To provide a version consistent with the Decision Support Service specification, use the format Major.Minor.Revision (e.g. 1.0.0). For more information on versioning knowledge assets, refer to the Decision Support Service specification. Note that a version is required for non-experimental active artifacts. Comments There may be different evidence variable instances that have the same identifier but different versions. The version can be appended to the url in a reference to allow a reference to a particular business version of the evidence variable with the format [url]\|[version]. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.version w5: FiveWs.version
name	Σ I	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.name Short description Name for this evidence variable (computer friendly) Definition A natural language name identifying the evidence variable. This name should be usable as an identifier for the module by machine processing applications such as code generation. Requirements Support human navigation and code generation. Comments The name is not expected to be globally unique. The name should be a simple alphanumeric type name to ensure that it is machine-processing friendly. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
title	Σ	1..1	string	Element id EvidenceVariable.title Short description Name of the exposure Definition A short descriptive name of the exposure. Comments If the same exposure is associated with more than one group, please provide the information once and use the field 'Name(s) of the group(s) associated with the given exposure' to associate it with more than one group. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.title NFDI4Health: Design.exposures.name
shortTitle	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.shortTitle Short description Title for use in informal contexts Definition The short title provides an alternate title for use in informal descriptive contexts where the full, formal title is not necessary. Requirements Need to be able to reference the content by a short description, but still provide a longer, more formal title for the content. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
subtitle		0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.subtitle Short description Subordinate title of the EvidenceVariable Definition An explanatory or alternate title for the EvidenceVariable giving additional information about its content. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
status	Σ ?!	1..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.status Short description draft \| active \| retired \| unknown Definition The status of this evidence variable. Enables tracking the life-cycle of the content. Comments Allows filtering of evidence variables that are appropriate for use versus not. Data type code Binding The lifecycle status of an artifact. PublicationStatus (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.status w5: FiveWs.status
date	Σ	0..1	dateTime	There are no (further) constraints on this element Element id EvidenceVariable.date Short description Date last changed Alternate names Revision Date Definition The date (and optionally time) when the evidence variable was published. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the evidence variable changes. Comments Note that this is not the same as the resource last-modified-date, since the resource may be a secondary representation of the evidence variable. Additional specific dates may be added as extensions or be found by consulting Provenances associated with past versions of the resource. Data type dateTime Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.date w5: FiveWs.recorded
publisher	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.publisher Short description Name of the publisher (organization or individual) Definition The name of the organization or individual that published the evidence variable. Requirements Helps establish the "authority/credibility" of the evidence variable. May also allow for contact. Comments Usually an organization but may be an individual. The publisher (or steward) of the evidence variable is the organization or individual primarily responsible for the maintenance and upkeep of the evidence variable. This is not necessarily the same individual or organization that developed and initially authored the content. The publisher is the primary point of contact for questions or issues with the evidence variable. This item SHOULD be populated unless the information is available from context. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.publisher w5: FiveWs.witness
contact	Σ	0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.contact Short description Contact details for the publisher Definition Contact details to assist a user in finding and communicating with the publisher. Comments May be a web site, an email address, a telephone number, etc. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.contact
description	Σ	0..1	markdown	Element id EvidenceVariable.description Short description Additional information about the exposure Definition If needed, additional descriptive information about the given exposure. Comments This description can be used to capture details such as why the evidence variable was built, comments about misuse, instructions for clinical use and interpretation, literature references, examples from the paper world, etc. It is not a rendering of the evidence variable as conveyed in the 'text' field of the resource itself. This item SHOULD be populated unless the information is available from context (e.g. the language of the evidence variable is presumed to be the predominant language in the place the evidence variable was created). Data type markdown Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.description NFDI4Health: Design.exposures.description
note		0..*	Annotation	There are no (further) constraints on this element Element id EvidenceVariable.note Short description Used for footnotes or explanatory notes Definition A human-readable string to clarify or explain concepts about the resource. Comments For systems that do not have structured annotations, they can simply communicate a single annotation with no author or time. This element may need to be included in narrative because of the potential for modifying information. Annotations SHOULD NOT be used to communicate "modifying" information that could be computable. (This is a SHOULD because enforcing user behavior is nearly impossible). Data type Annotation Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: N/A rim: Act
useContext	Σ	0..*	UsageContext	There are no (further) constraints on this element Element id EvidenceVariable.useContext Short description The context that the content is intended to support Definition The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate evidence variable instances. Requirements Assist in searching for appropriate content. Comments When multiple useContexts are specified, there is no expectation that all or any of the contexts apply. Data type UsageContext Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.useContext
jurisdiction	Σ	0..*	CodeableConceptBinding	There are no (further) constraints on this element Element id EvidenceVariable.jurisdiction Short description Intended jurisdiction for evidence variable (if applicable) Definition A legal or geographic region in which the evidence variable is intended to be used. Comments It may be possible for the evidence variable to be used in jurisdictions other than those for which it was originally designed or intended. Data type CodeableConcept Binding Countries and regions within which this artifact is targeted for use. Jurisdiction ValueSet (extensible) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: CE/CNE/CWE rim: CD orim: fhir:CodeableConcept rdfs:subClassOf dt:CD workflow: Definition.jurisdiction
copyright		0..1	markdown	There are no (further) constraints on this element Element id EvidenceVariable.copyright Short description Use and/or publishing restrictions Alternate names License, Restrictions Definition A copyright statement relating to the evidence variable and/or its contents. Copyright statements are generally legal restrictions on the use and publishing of the evidence variable. Requirements Consumers must be able to determine any legal restrictions on the use of the evidence variable and/or its content. Comments Systems are not required to have markdown support, so the text should be readable without markdown processing. The markdown syntax is GFM - see https://github.github.com/gfm/ Data type markdown Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.copyright objimpl: no-gen-base
approvalDate		0..1	date	There are no (further) constraints on this element Element id EvidenceVariable.approvalDate Short description When the evidence variable was approved by publisher Definition The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage. Comments The 'date' element may be more recent than the approval date because of minor changes or editorial corrections. Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.approvalDate objimpl: no-gen-base
lastReviewDate		0..1	date	There are no (further) constraints on this element Element id EvidenceVariable.lastReviewDate Short description When the evidence variable was last reviewed Definition The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date. Requirements Gives a sense of how "current" the content is. Resources that have not been reviewed in a long time may have a risk of being less appropriate/relevant. Comments If specified, this date follows the original approval date. Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.lastReviewDate objimpl: no-gen-base
effectivePeriod	Σ I	0..1	Period	There are no (further) constraints on this element Element id EvidenceVariable.effectivePeriod Short description When the evidence variable is expected to be used Definition The period during which the evidence variable content was or is planned to be in active use. Requirements Allows establishing a transition before a resource comes into effect and also allows for a sunsetting process when new versions of the evidence variable are or are expected to be used instead. Comments The effective period for a evidence variable determines when the content is applicable for usage and is independent of publication and review dates. For example, a measure intended to be used for the year 2016 might be published in 2015. Data type Period Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` per-1: If present, start SHALL have a lower value than end `start.hasValue().not() or end.hasValue().not() or (start <= end)` Mappings rim: n/a v2: DR rim: IVL<TS>[lowClosed="true" and highClosed="true"] or URG<TS>[lowClosed="true" and highClosed="true"] workflow: Definition.effectivePeriod objimpl: no-gen-base
topic		0..*	CodeableConcept	There are no (further) constraints on this element Element id EvidenceVariable.topic Short description The category of the EvidenceVariable, such as Education, Treatment, Assessment, etc. Definition Descriptive topics related to the content of the EvidenceVariable. Topics provide a high-level categorization grouping types of EvidenceVariables that can be useful for filtering and searching. Requirements Repositories must be able to determine how to categorize the EvidenceVariable so that it can be found by topical searches. Comments Not all terminology uses fit this general pattern. In some cases, models should not use CodeableConcept and use Coding directly and provide their own structure for managing text, codings, translations and the relationship between elements and pre- and post-coordination. Data type CodeableConcept Binding High-level categorization of the definition, used for searching, sorting, and filtering. DefinitionTopic (example) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: CE/CNE/CWE rim: CD orim: fhir:CodeableConcept rdfs:subClassOf dt:CD
author		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.author Short description Who authored the content Definition An individiual or organization primarily involved in the creation and maintenance of the content. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: .participation[typeCode=AUT]
editor		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.editor Short description Who edited the content Definition An individual or organization primarily responsible for internal coherence of the content. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
reviewer		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.reviewer Short description Who reviewed the content Definition An individual or organization primarily responsible for review of some aspect of the content. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: .participation[typeCode=VRF] {not clear whether VRF best corresponds to reviewer or endorser}
endorser		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.endorser Short description Who endorsed the content Definition An individual or organization responsible for officially endorsing the content for use in some setting. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: .participation[typeCode=VRF] {not clear whether VRF best corresponds to reviewer or endorser}
relatedArtifact		0..*	RelatedArtifact	There are no (further) constraints on this element Element id EvidenceVariable.relatedArtifact Short description Additional documentation, citations, etc. Definition Related artifacts such as additional documentation, justification, or bibliographic references. Requirements EvidenceVariables must be able to provide enough information for consumers of the content (and/or interventions or results produced by the content) to be able to determine and understand the justification for and evidence in support of the content. Comments Each related artifact is either an attachment, or a reference to another resource, but not both. Data type RelatedArtifact Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
type	Σ	0..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.type Short description dichotomous \| continuous \| descriptive Definition The type of evidence element, a population, an exposure, or an outcome. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type code Binding The possible types of variables for exposures or outcomes (E.g. Dichotomous, Continuous, Descriptive). EvidenceVariableType (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
characteristic	Σ	1..*	BackboneElement	There are no (further) constraints on this element Element id EvidenceVariable.characteristic Short description What defines the members of the evidence element Definition A characteristic that defines the members of the evidence element. Multiple characteristics are applied with "and" semantics. Comments Characteristics can be defined flexibly to accommodate different use cases for membership criteria, ranging from simple codes, all the way to using an expression language to express the criteria. Data type BackboneElement Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Sliced: Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
modifierExtension	Σ ?! I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
description		0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.description Short description Natural language description of the characteristic Definition A short, natural language description of the characteristic that could be used to communicate the criteria to an end-user. Requirements Need to be able to describe characteristics in natural language so that end users can understand the criteria. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
definition[x]	Σ	1..1		Element id EvidenceVariable.characteristic.definition[x] Short description What code or expression defines members? Definition Define members of the evidence element using Codes (such as condition, medication, or observation), Expressions ( using an expression language such as FHIRPath or CQL) or DataRequirements (such as Diabetes diagnosis onset in the last year). Requirements Need to be able to define members in simple codes when the membership aligns well with terminology, with common criteria such as observations in a value set or lab tests within a year, or with expression language to support criteria that do not fit in the above. Sliced: Unordered, Open, by $this(Type) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
definitionCanonical			canonical(ActivityDefinition)	There are no (further) constraints on this element Data type canonical(ActivityDefinition)
definitionExpression			Expression	There are no (further) constraints on this element Data type Expression
definitionDataRequirement			DataRequirement	There are no (further) constraints on this element Data type DataRequirement
definitionTriggerDefinition			TriggerDefinition	There are no (further) constraints on this element Data type TriggerDefinition
definitionReference			Reference(Group)	There are no (further) constraints on this element Data type Reference(Group)
definitionCodeableConcept	Σ	1..1	CodeableConceptBinding	Element id EvidenceVariable.characteristic.definition[x]:definitionCodeableConcept Short description Design.exposures.type: Type of the exposure Definition Design.exposures.type: General type of the given exposure. Requirements Need to be able to define members in simple codes when the membership aligns well with terminology, with common criteria such as observations in a value set or lab tests within a year, or with expression language to support criteria that do not fit in the above. Data type CodeableConcept Binding Value set defining codes to specify the general type of the given intervention/exposure in the study. NFDI4Health_VS_MDS_Study_Exposure_Type_NCI (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a NFDI4Health: Design.exposures.type
usageContext		0..*	UsageContext	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.usageContext Short description What code/value pairs define members? Definition Use UsageContext to define the members of the population, such as Age Ranges, Genders, Settings. Requirements Need to be able to define members more structurally when more information can be communicated such as age range. Data type UsageContext Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
exclude		0..1	boolean	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.exclude Short description Whether the characteristic includes or excludes members Definition When true, members with this characteristic are excluded from the element. Meaning when missing False Data type boolean Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
participantEffective[x]		0..1		There are no (further) constraints on this element Element id EvidenceVariable.characteristic.participantEffective[x] Short description What time period do participants cover Definition Indicates what effective period the study covers. Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
participantEffectiveDateTime			dateTime	There are no (further) constraints on this element Data type dateTime
participantEffectivePeriod			Period	There are no (further) constraints on this element Data type Period
participantEffectiveDuration			Duration	There are no (further) constraints on this element Data type Duration
participantEffectiveTiming			Timing	There are no (further) constraints on this element Data type Timing
timeFromStart	I	0..1	Duration	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.timeFromStart Short description Observation time from study start Definition Indicates duration from the participant's study entry. Comments The context of use may frequently define what kind of quantity this is and therefore what kind of units can be used. The context of use may also restrict the values for the comparator. Data type Duration Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` qty-3: If a code for the unit is present, the system SHALL also be present `code.empty() or system.exists()` drt-1: There SHALL be a code if there is a value and it SHALL be an expression of time. If system is present, it SHALL be UCUM. `code.exists() implies ((system = %ucum) and value.exists())` Mappings rim: n/a v2: SN (see also Range) or CQ rim: PQ, IVL<PQ>, MO, CO, depending on the values rim: PQ, IVL<PQ> depending on the values
groupMeasure		0..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.groupMeasure Short description mean \| median \| mean-of-mean \| mean-of-median \| median-of-mean \| median-of-median Definition Indicates how elements are aggregated within the study effective period. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type code Binding Possible group measure aggregates (E.g. Mean, Median). GroupMeasure (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a

EvidenceVariable	I		EvidenceVariable	Element id EvidenceVariable Short description Design.exposures: Exposures of the [RESOURCE] Definition Group of items providing information about the exposures of the [RESOURCE]. Comments Specification of the exposure(s) associated with each group. Data type EvidenceVariable Constraints dom-2: If the resource is contained in another resource, it SHALL NOT contain nested Resources `contained.contained.empty()` dom-4: If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated `contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()` dom-3: If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource `contained.where((('#'+id in (%resource.descendants().reference \| %resource.descendants().as(canonical) \| %resource.descendants().as(uri) \| %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()` dom-6: A resource should have narrative for robust management text.`div`.exists() dom-5: If a resource is contained in another resource, it SHALL NOT have a security label `contained.meta.security.empty()` evv-0: Name should be usable as an identifier for the module by machine processing applications such as code generation `name.matches('[A-Z]([A-Za-z0-9_]){0,254}')` Mappings rim: Entity. Role, or Act workflow: Definition NFDI4Health: Design.exposures
id	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.id Short description Logical id of this artifact Definition The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes. Comments The only time that a resource does not have an id is when it is being submitted to the server using a create operation. Data type string
meta	Σ	0..1	Meta	There are no (further) constraints on this element Element id EvidenceVariable.meta Short description Metadata about the resource Definition The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource. Data type Meta Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: N/A
implicitRules	Σ ?!	0..1	uri	There are no (further) constraints on this element Element id EvidenceVariable.implicitRules Short description A set of rules under which this content was created Definition A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc. Comments Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of it's narrative along with other profiles, value sets, etc. Data type uri Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
language		0..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.language Short description Language of the resource content Definition The base language in which the resource is written. Comments Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource. Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute). Data type code Binding A human language. CommonLanguages (preferred) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
text		0..1	Narrative	There are no (further) constraints on this element Element id EvidenceVariable.text Short description Text summary of the resource, for human interpretation Alternate names narrative, html, xhtml, display Definition A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it "clinically safe" for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety. Comments Contained resources do not have narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied). This may be necessary for data from legacy systems where information is captured as a "text blob" or where text is additionally entered raw or narrated and encoded information is added later. Data type Narrative Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: N/A rim: Act.text?
contained		0..*	Resource	There are no (further) constraints on this element Element id EvidenceVariable.contained Short description Contained, inline Resources Alternate names inline resources, anonymous resources, contained resources Definition These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, and nor can they have their own independent transaction scope. Comments This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags In their meta elements, but SHALL NOT have security labels. Data type Resource Mappings rim: Entity. Role, or Act rim: N/A
extension	I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the resource. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Sliced: Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
modifierExtension	?! I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.modifierExtension Short description Extensions that cannot be ignored Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Sliced: Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
url	Σ	0..1	uri	There are no (further) constraints on this element Element id EvidenceVariable.url Short description Canonical identifier for this evidence variable, represented as a URI (globally unique) Definition An absolute URI that is used to identify this evidence variable when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which at which an authoritative instance of this evidence variable is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the evidence variable is stored on different servers. Requirements Allows the evidence variable to be referenced by a single globally unique identifier. Comments Can be a urn:uuid: or a urn:oid: but real http: addresses are preferred. Multiple instances may share the same URL if they have a distinct version. The determination of when to create a new version of a resource (same url, new version) vs. defining a new artifact is up to the author. Considerations for making this decision are found in Technical and Business Versions. In some cases, the resource can no longer be found at the stated url, but the url itself cannot change. Implementations can use the meta.source element to indicate where the current master source of the resource can be found. Data type uri Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.url w5: FiveWs.identifier
identifier	Σ	0..*	Identifier	There are no (further) constraints on this element Element id EvidenceVariable.identifier Short description Additional identifier for the evidence variable Definition A formal identifier that is used to identify this evidence variable when it is represented in other formats, or referenced in a specification, model, design or an instance. Requirements Allows externally provided and/or usable business identifiers to be easily associated with the module. Comments Typically, this is used for identifiers that can go in an HL7 V3 II (instance identifier) data type, and can then identify this evidence variable outside of FHIR, where it is not possible to use the logical URI. Data type Identifier Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: CX / EI (occasionally, more often EI maps to a resource id or a URL) rim: II - The Identifier class is a little looser than the v3 type II because it allows URIs as well as registered OIDs or GUIDs. Also maps to Role[classCode=IDENT] servd: Identifier workflow: Definition.identifier w5: FiveWs.identifier objimpl: no-gen-base
version	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.version Short description Business version of the evidence variable Definition The identifier that is used to identify this version of the evidence variable when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the evidence variable author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence. To provide a version consistent with the Decision Support Service specification, use the format Major.Minor.Revision (e.g. 1.0.0). For more information on versioning knowledge assets, refer to the Decision Support Service specification. Note that a version is required for non-experimental active artifacts. Comments There may be different evidence variable instances that have the same identifier but different versions. The version can be appended to the url in a reference to allow a reference to a particular business version of the evidence variable with the format [url]\|[version]. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.version w5: FiveWs.version
name	Σ I	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.name Short description Name for this evidence variable (computer friendly) Definition A natural language name identifying the evidence variable. This name should be usable as an identifier for the module by machine processing applications such as code generation. Requirements Support human navigation and code generation. Comments The name is not expected to be globally unique. The name should be a simple alphanumeric type name to ensure that it is machine-processing friendly. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
title	Σ	1..1	string	Element id EvidenceVariable.title Short description Name of the exposure Definition A short descriptive name of the exposure. Comments If the same exposure is associated with more than one group, please provide the information once and use the field 'Name(s) of the group(s) associated with the given exposure' to associate it with more than one group. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.title NFDI4Health: Design.exposures.name
shortTitle	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.shortTitle Short description Title for use in informal contexts Definition The short title provides an alternate title for use in informal descriptive contexts where the full, formal title is not necessary. Requirements Need to be able to reference the content by a short description, but still provide a longer, more formal title for the content. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
subtitle		0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.subtitle Short description Subordinate title of the EvidenceVariable Definition An explanatory or alternate title for the EvidenceVariable giving additional information about its content. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
status	Σ ?!	1..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.status Short description draft \| active \| retired \| unknown Definition The status of this evidence variable. Enables tracking the life-cycle of the content. Comments Allows filtering of evidence variables that are appropriate for use versus not. Data type code Binding The lifecycle status of an artifact. PublicationStatus (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.status w5: FiveWs.status
date	Σ	0..1	dateTime	There are no (further) constraints on this element Element id EvidenceVariable.date Short description Date last changed Alternate names Revision Date Definition The date (and optionally time) when the evidence variable was published. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the evidence variable changes. Comments Note that this is not the same as the resource last-modified-date, since the resource may be a secondary representation of the evidence variable. Additional specific dates may be added as extensions or be found by consulting Provenances associated with past versions of the resource. Data type dateTime Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.date w5: FiveWs.recorded
publisher	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.publisher Short description Name of the publisher (organization or individual) Definition The name of the organization or individual that published the evidence variable. Requirements Helps establish the "authority/credibility" of the evidence variable. May also allow for contact. Comments Usually an organization but may be an individual. The publisher (or steward) of the evidence variable is the organization or individual primarily responsible for the maintenance and upkeep of the evidence variable. This is not necessarily the same individual or organization that developed and initially authored the content. The publisher is the primary point of contact for questions or issues with the evidence variable. This item SHOULD be populated unless the information is available from context. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.publisher w5: FiveWs.witness
contact	Σ	0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.contact Short description Contact details for the publisher Definition Contact details to assist a user in finding and communicating with the publisher. Comments May be a web site, an email address, a telephone number, etc. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.contact
description	Σ	0..1	markdown	Element id EvidenceVariable.description Short description Additional information about the exposure Definition If needed, additional descriptive information about the given exposure. Comments This description can be used to capture details such as why the evidence variable was built, comments about misuse, instructions for clinical use and interpretation, literature references, examples from the paper world, etc. It is not a rendering of the evidence variable as conveyed in the 'text' field of the resource itself. This item SHOULD be populated unless the information is available from context (e.g. the language of the evidence variable is presumed to be the predominant language in the place the evidence variable was created). Data type markdown Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.description NFDI4Health: Design.exposures.description
note		0..*	Annotation	There are no (further) constraints on this element Element id EvidenceVariable.note Short description Used for footnotes or explanatory notes Definition A human-readable string to clarify or explain concepts about the resource. Comments For systems that do not have structured annotations, they can simply communicate a single annotation with no author or time. This element may need to be included in narrative because of the potential for modifying information. Annotations SHOULD NOT be used to communicate "modifying" information that could be computable. (This is a SHOULD because enforcing user behavior is nearly impossible). Data type Annotation Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: N/A rim: Act
useContext	Σ	0..*	UsageContext	There are no (further) constraints on this element Element id EvidenceVariable.useContext Short description The context that the content is intended to support Definition The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate evidence variable instances. Requirements Assist in searching for appropriate content. Comments When multiple useContexts are specified, there is no expectation that all or any of the contexts apply. Data type UsageContext Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.useContext
jurisdiction	Σ	0..*	CodeableConceptBinding	There are no (further) constraints on this element Element id EvidenceVariable.jurisdiction Short description Intended jurisdiction for evidence variable (if applicable) Definition A legal or geographic region in which the evidence variable is intended to be used. Comments It may be possible for the evidence variable to be used in jurisdictions other than those for which it was originally designed or intended. Data type CodeableConcept Binding Countries and regions within which this artifact is targeted for use. Jurisdiction ValueSet (extensible) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: CE/CNE/CWE rim: CD orim: fhir:CodeableConcept rdfs:subClassOf dt:CD workflow: Definition.jurisdiction
copyright		0..1	markdown	There are no (further) constraints on this element Element id EvidenceVariable.copyright Short description Use and/or publishing restrictions Alternate names License, Restrictions Definition A copyright statement relating to the evidence variable and/or its contents. Copyright statements are generally legal restrictions on the use and publishing of the evidence variable. Requirements Consumers must be able to determine any legal restrictions on the use of the evidence variable and/or its content. Comments Systems are not required to have markdown support, so the text should be readable without markdown processing. The markdown syntax is GFM - see https://github.github.com/gfm/ Data type markdown Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.copyright objimpl: no-gen-base
approvalDate		0..1	date	There are no (further) constraints on this element Element id EvidenceVariable.approvalDate Short description When the evidence variable was approved by publisher Definition The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage. Comments The 'date' element may be more recent than the approval date because of minor changes or editorial corrections. Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.approvalDate objimpl: no-gen-base
lastReviewDate		0..1	date	There are no (further) constraints on this element Element id EvidenceVariable.lastReviewDate Short description When the evidence variable was last reviewed Definition The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date. Requirements Gives a sense of how "current" the content is. Resources that have not been reviewed in a long time may have a risk of being less appropriate/relevant. Comments If specified, this date follows the original approval date. Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.lastReviewDate objimpl: no-gen-base
effectivePeriod	Σ I	0..1	Period	There are no (further) constraints on this element Element id EvidenceVariable.effectivePeriod Short description When the evidence variable is expected to be used Definition The period during which the evidence variable content was or is planned to be in active use. Requirements Allows establishing a transition before a resource comes into effect and also allows for a sunsetting process when new versions of the evidence variable are or are expected to be used instead. Comments The effective period for a evidence variable determines when the content is applicable for usage and is independent of publication and review dates. For example, a measure intended to be used for the year 2016 might be published in 2015. Data type Period Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` per-1: If present, start SHALL have a lower value than end `start.hasValue().not() or end.hasValue().not() or (start <= end)` Mappings rim: n/a v2: DR rim: IVL<TS>[lowClosed="true" and highClosed="true"] or URG<TS>[lowClosed="true" and highClosed="true"] workflow: Definition.effectivePeriod objimpl: no-gen-base
topic		0..*	CodeableConcept	There are no (further) constraints on this element Element id EvidenceVariable.topic Short description The category of the EvidenceVariable, such as Education, Treatment, Assessment, etc. Definition Descriptive topics related to the content of the EvidenceVariable. Topics provide a high-level categorization grouping types of EvidenceVariables that can be useful for filtering and searching. Requirements Repositories must be able to determine how to categorize the EvidenceVariable so that it can be found by topical searches. Comments Not all terminology uses fit this general pattern. In some cases, models should not use CodeableConcept and use Coding directly and provide their own structure for managing text, codings, translations and the relationship between elements and pre- and post-coordination. Data type CodeableConcept Binding High-level categorization of the definition, used for searching, sorting, and filtering. DefinitionTopic (example) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: CE/CNE/CWE rim: CD orim: fhir:CodeableConcept rdfs:subClassOf dt:CD
author		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.author Short description Who authored the content Definition An individiual or organization primarily involved in the creation and maintenance of the content. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: .participation[typeCode=AUT]
editor		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.editor Short description Who edited the content Definition An individual or organization primarily responsible for internal coherence of the content. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
reviewer		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.reviewer Short description Who reviewed the content Definition An individual or organization primarily responsible for review of some aspect of the content. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: .participation[typeCode=VRF] {not clear whether VRF best corresponds to reviewer or endorser}
endorser		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.endorser Short description Who endorsed the content Definition An individual or organization responsible for officially endorsing the content for use in some setting. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: .participation[typeCode=VRF] {not clear whether VRF best corresponds to reviewer or endorser}
relatedArtifact		0..*	RelatedArtifact	There are no (further) constraints on this element Element id EvidenceVariable.relatedArtifact Short description Additional documentation, citations, etc. Definition Related artifacts such as additional documentation, justification, or bibliographic references. Requirements EvidenceVariables must be able to provide enough information for consumers of the content (and/or interventions or results produced by the content) to be able to determine and understand the justification for and evidence in support of the content. Comments Each related artifact is either an attachment, or a reference to another resource, but not both. Data type RelatedArtifact Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
type	Σ	0..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.type Short description dichotomous \| continuous \| descriptive Definition The type of evidence element, a population, an exposure, or an outcome. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type code Binding The possible types of variables for exposures or outcomes (E.g. Dichotomous, Continuous, Descriptive). EvidenceVariableType (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
characteristic	Σ	1..*	BackboneElement	There are no (further) constraints on this element Element id EvidenceVariable.characteristic Short description What defines the members of the evidence element Definition A characteristic that defines the members of the evidence element. Multiple characteristics are applied with "and" semantics. Comments Characteristics can be defined flexibly to accommodate different use cases for membership criteria, ranging from simple codes, all the way to using an expression language to express the criteria. Data type BackboneElement Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Sliced: Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
modifierExtension	Σ ?! I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
description		0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.description Short description Natural language description of the characteristic Definition A short, natural language description of the characteristic that could be used to communicate the criteria to an end-user. Requirements Need to be able to describe characteristics in natural language so that end users can understand the criteria. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
definition[x]	Σ	1..1		Element id EvidenceVariable.characteristic.definition[x] Short description What code or expression defines members? Definition Define members of the evidence element using Codes (such as condition, medication, or observation), Expressions ( using an expression language such as FHIRPath or CQL) or DataRequirements (such as Diabetes diagnosis onset in the last year). Requirements Need to be able to define members in simple codes when the membership aligns well with terminology, with common criteria such as observations in a value set or lab tests within a year, or with expression language to support criteria that do not fit in the above. Sliced: Unordered, Open, by $this(Type) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
definitionCanonical			canonical(ActivityDefinition)	There are no (further) constraints on this element Data type canonical(ActivityDefinition)
definitionExpression			Expression	There are no (further) constraints on this element Data type Expression
definitionDataRequirement			DataRequirement	There are no (further) constraints on this element Data type DataRequirement
definitionTriggerDefinition			TriggerDefinition	There are no (further) constraints on this element Data type TriggerDefinition
definitionReference			Reference(Group)	There are no (further) constraints on this element Data type Reference(Group)
definitionCodeableConcept	Σ	1..1	CodeableConceptBinding	Element id EvidenceVariable.characteristic.definition[x]:definitionCodeableConcept Short description Design.exposures.type: Type of the exposure Definition Design.exposures.type: General type of the given exposure. Requirements Need to be able to define members in simple codes when the membership aligns well with terminology, with common criteria such as observations in a value set or lab tests within a year, or with expression language to support criteria that do not fit in the above. Data type CodeableConcept Binding Value set defining codes to specify the general type of the given intervention/exposure in the study. NFDI4Health_VS_MDS_Study_Exposure_Type_NCI (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a NFDI4Health: Design.exposures.type
usageContext		0..*	UsageContext	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.usageContext Short description What code/value pairs define members? Definition Use UsageContext to define the members of the population, such as Age Ranges, Genders, Settings. Requirements Need to be able to define members more structurally when more information can be communicated such as age range. Data type UsageContext Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
exclude		0..1	boolean	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.exclude Short description Whether the characteristic includes or excludes members Definition When true, members with this characteristic are excluded from the element. Meaning when missing False Data type boolean Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
participantEffective[x]		0..1		There are no (further) constraints on this element Element id EvidenceVariable.characteristic.participantEffective[x] Short description What time period do participants cover Definition Indicates what effective period the study covers. Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
participantEffectiveDateTime			dateTime	There are no (further) constraints on this element Data type dateTime
participantEffectivePeriod			Period	There are no (further) constraints on this element Data type Period
participantEffectiveDuration			Duration	There are no (further) constraints on this element Data type Duration
participantEffectiveTiming			Timing	There are no (further) constraints on this element Data type Timing
timeFromStart	I	0..1	Duration	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.timeFromStart Short description Observation time from study start Definition Indicates duration from the participant's study entry. Comments The context of use may frequently define what kind of quantity this is and therefore what kind of units can be used. The context of use may also restrict the values for the comparator. Data type Duration Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` qty-3: If a code for the unit is present, the system SHALL also be present `code.empty() or system.exists()` drt-1: There SHALL be a code if there is a value and it SHALL be an expression of time. If system is present, it SHALL be UCUM. `code.exists() implies ((system = %ucum) and value.exists())` Mappings rim: n/a v2: SN (see also Range) or CQ rim: PQ, IVL<PQ>, MO, CO, depending on the values rim: PQ, IVL<PQ> depending on the values
groupMeasure		0..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.groupMeasure Short description mean \| median \| mean-of-mean \| mean-of-median \| median-of-mean \| median-of-median Definition Indicates how elements are aggregated within the study effective period. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type code Binding Possible group measure aggregates (E.g. Mean, Median). GroupMeasure (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a

EvidenceVariable	I		EvidenceVariable	Element id EvidenceVariable Short description Design.exposures: Exposures of the [RESOURCE] Definition Group of items providing information about the exposures of the [RESOURCE]. Comments Specification of the exposure(s) associated with each group. Data type EvidenceVariable Constraints dom-2: If the resource is contained in another resource, it SHALL NOT contain nested Resources `contained.contained.empty()` dom-4: If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated `contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()` dom-3: If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource `contained.where((('#'+id in (%resource.descendants().reference \| %resource.descendants().as(canonical) \| %resource.descendants().as(uri) \| %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()` dom-6: A resource should have narrative for robust management text.`div`.exists() dom-5: If a resource is contained in another resource, it SHALL NOT have a security label `contained.meta.security.empty()` evv-0: Name should be usable as an identifier for the module by machine processing applications such as code generation `name.matches('[A-Z]([A-Za-z0-9_]){0,254}')` Mappings rim: Entity. Role, or Act workflow: Definition NFDI4Health: Design.exposures
id	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.id Short description Logical id of this artifact Definition The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes. Comments The only time that a resource does not have an id is when it is being submitted to the server using a create operation. Data type string
meta	Σ	0..1	Meta	There are no (further) constraints on this element Element id EvidenceVariable.meta Short description Metadata about the resource Definition The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource. Data type Meta Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: N/A
implicitRules	Σ ?!	0..1	uri	There are no (further) constraints on this element Element id EvidenceVariable.implicitRules Short description A set of rules under which this content was created Definition A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc. Comments Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of it's narrative along with other profiles, value sets, etc. Data type uri Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
language		0..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.language Short description Language of the resource content Definition The base language in which the resource is written. Comments Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource. Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute). Data type code Binding A human language. CommonLanguages (preferred) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
text		0..1	Narrative	There are no (further) constraints on this element Element id EvidenceVariable.text Short description Text summary of the resource, for human interpretation Alternate names narrative, html, xhtml, display Definition A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it "clinically safe" for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety. Comments Contained resources do not have narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied). This may be necessary for data from legacy systems where information is captured as a "text blob" or where text is additionally entered raw or narrated and encoded information is added later. Data type Narrative Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: N/A rim: Act.text?
contained		0..*	Resource	There are no (further) constraints on this element Element id EvidenceVariable.contained Short description Contained, inline Resources Alternate names inline resources, anonymous resources, contained resources Definition These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, and nor can they have their own independent transaction scope. Comments This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags In their meta elements, but SHALL NOT have security labels. Data type Resource Mappings rim: Entity. Role, or Act rim: N/A
extension	I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the resource. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Sliced: Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
modifierExtension	?! I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.modifierExtension Short description Extensions that cannot be ignored Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Sliced: Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
url	Σ	0..1	uri	There are no (further) constraints on this element Element id EvidenceVariable.url Short description Canonical identifier for this evidence variable, represented as a URI (globally unique) Definition An absolute URI that is used to identify this evidence variable when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which at which an authoritative instance of this evidence variable is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the evidence variable is stored on different servers. Requirements Allows the evidence variable to be referenced by a single globally unique identifier. Comments Can be a urn:uuid: or a urn:oid: but real http: addresses are preferred. Multiple instances may share the same URL if they have a distinct version. The determination of when to create a new version of a resource (same url, new version) vs. defining a new artifact is up to the author. Considerations for making this decision are found in Technical and Business Versions. In some cases, the resource can no longer be found at the stated url, but the url itself cannot change. Implementations can use the meta.source element to indicate where the current master source of the resource can be found. Data type uri Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.url w5: FiveWs.identifier
identifier	Σ	0..*	Identifier	There are no (further) constraints on this element Element id EvidenceVariable.identifier Short description Additional identifier for the evidence variable Definition A formal identifier that is used to identify this evidence variable when it is represented in other formats, or referenced in a specification, model, design or an instance. Requirements Allows externally provided and/or usable business identifiers to be easily associated with the module. Comments Typically, this is used for identifiers that can go in an HL7 V3 II (instance identifier) data type, and can then identify this evidence variable outside of FHIR, where it is not possible to use the logical URI. Data type Identifier Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: CX / EI (occasionally, more often EI maps to a resource id or a URL) rim: II - The Identifier class is a little looser than the v3 type II because it allows URIs as well as registered OIDs or GUIDs. Also maps to Role[classCode=IDENT] servd: Identifier workflow: Definition.identifier w5: FiveWs.identifier objimpl: no-gen-base
version	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.version Short description Business version of the evidence variable Definition The identifier that is used to identify this version of the evidence variable when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the evidence variable author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence. To provide a version consistent with the Decision Support Service specification, use the format Major.Minor.Revision (e.g. 1.0.0). For more information on versioning knowledge assets, refer to the Decision Support Service specification. Note that a version is required for non-experimental active artifacts. Comments There may be different evidence variable instances that have the same identifier but different versions. The version can be appended to the url in a reference to allow a reference to a particular business version of the evidence variable with the format [url]\|[version]. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.version w5: FiveWs.version
name	Σ I	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.name Short description Name for this evidence variable (computer friendly) Definition A natural language name identifying the evidence variable. This name should be usable as an identifier for the module by machine processing applications such as code generation. Requirements Support human navigation and code generation. Comments The name is not expected to be globally unique. The name should be a simple alphanumeric type name to ensure that it is machine-processing friendly. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
title	Σ	1..1	string	Element id EvidenceVariable.title Short description Name of the exposure Definition A short descriptive name of the exposure. Comments If the same exposure is associated with more than one group, please provide the information once and use the field 'Name(s) of the group(s) associated with the given exposure' to associate it with more than one group. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.title NFDI4Health: Design.exposures.name
shortTitle	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.shortTitle Short description Title for use in informal contexts Definition The short title provides an alternate title for use in informal descriptive contexts where the full, formal title is not necessary. Requirements Need to be able to reference the content by a short description, but still provide a longer, more formal title for the content. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
subtitle		0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.subtitle Short description Subordinate title of the EvidenceVariable Definition An explanatory or alternate title for the EvidenceVariable giving additional information about its content. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
status	Σ ?!	1..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.status Short description draft \| active \| retired \| unknown Definition The status of this evidence variable. Enables tracking the life-cycle of the content. Comments Allows filtering of evidence variables that are appropriate for use versus not. Data type code Binding The lifecycle status of an artifact. PublicationStatus (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.status w5: FiveWs.status
date	Σ	0..1	dateTime	There are no (further) constraints on this element Element id EvidenceVariable.date Short description Date last changed Alternate names Revision Date Definition The date (and optionally time) when the evidence variable was published. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the evidence variable changes. Comments Note that this is not the same as the resource last-modified-date, since the resource may be a secondary representation of the evidence variable. Additional specific dates may be added as extensions or be found by consulting Provenances associated with past versions of the resource. Data type dateTime Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.date w5: FiveWs.recorded
publisher	Σ	0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.publisher Short description Name of the publisher (organization or individual) Definition The name of the organization or individual that published the evidence variable. Requirements Helps establish the "authority/credibility" of the evidence variable. May also allow for contact. Comments Usually an organization but may be an individual. The publisher (or steward) of the evidence variable is the organization or individual primarily responsible for the maintenance and upkeep of the evidence variable. This is not necessarily the same individual or organization that developed and initially authored the content. The publisher is the primary point of contact for questions or issues with the evidence variable. This item SHOULD be populated unless the information is available from context. Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.publisher w5: FiveWs.witness
contact	Σ	0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.contact Short description Contact details for the publisher Definition Contact details to assist a user in finding and communicating with the publisher. Comments May be a web site, an email address, a telephone number, etc. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.contact
description	Σ	0..1	markdown	Element id EvidenceVariable.description Short description Additional information about the exposure Definition If needed, additional descriptive information about the given exposure. Comments This description can be used to capture details such as why the evidence variable was built, comments about misuse, instructions for clinical use and interpretation, literature references, examples from the paper world, etc. It is not a rendering of the evidence variable as conveyed in the 'text' field of the resource itself. This item SHOULD be populated unless the information is available from context (e.g. the language of the evidence variable is presumed to be the predominant language in the place the evidence variable was created). Data type markdown Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.description NFDI4Health: Design.exposures.description
note		0..*	Annotation	There are no (further) constraints on this element Element id EvidenceVariable.note Short description Used for footnotes or explanatory notes Definition A human-readable string to clarify or explain concepts about the resource. Comments For systems that do not have structured annotations, they can simply communicate a single annotation with no author or time. This element may need to be included in narrative because of the potential for modifying information. Annotations SHOULD NOT be used to communicate "modifying" information that could be computable. (This is a SHOULD because enforcing user behavior is nearly impossible). Data type Annotation Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: N/A rim: Act
useContext	Σ	0..*	UsageContext	There are no (further) constraints on this element Element id EvidenceVariable.useContext Short description The context that the content is intended to support Definition The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate evidence variable instances. Requirements Assist in searching for appropriate content. Comments When multiple useContexts are specified, there is no expectation that all or any of the contexts apply. Data type UsageContext Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.useContext
jurisdiction	Σ	0..*	CodeableConceptBinding	There are no (further) constraints on this element Element id EvidenceVariable.jurisdiction Short description Intended jurisdiction for evidence variable (if applicable) Definition A legal or geographic region in which the evidence variable is intended to be used. Comments It may be possible for the evidence variable to be used in jurisdictions other than those for which it was originally designed or intended. Data type CodeableConcept Binding Countries and regions within which this artifact is targeted for use. Jurisdiction ValueSet (extensible) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: CE/CNE/CWE rim: CD orim: fhir:CodeableConcept rdfs:subClassOf dt:CD workflow: Definition.jurisdiction
copyright		0..1	markdown	There are no (further) constraints on this element Element id EvidenceVariable.copyright Short description Use and/or publishing restrictions Alternate names License, Restrictions Definition A copyright statement relating to the evidence variable and/or its contents. Copyright statements are generally legal restrictions on the use and publishing of the evidence variable. Requirements Consumers must be able to determine any legal restrictions on the use of the evidence variable and/or its content. Comments Systems are not required to have markdown support, so the text should be readable without markdown processing. The markdown syntax is GFM - see https://github.github.com/gfm/ Data type markdown Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.copyright objimpl: no-gen-base
approvalDate		0..1	date	There are no (further) constraints on this element Element id EvidenceVariable.approvalDate Short description When the evidence variable was approved by publisher Definition The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage. Comments The 'date' element may be more recent than the approval date because of minor changes or editorial corrections. Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.approvalDate objimpl: no-gen-base
lastReviewDate		0..1	date	There are no (further) constraints on this element Element id EvidenceVariable.lastReviewDate Short description When the evidence variable was last reviewed Definition The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date. Requirements Gives a sense of how "current" the content is. Resources that have not been reviewed in a long time may have a risk of being less appropriate/relevant. Comments If specified, this date follows the original approval date. Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a workflow: Definition.lastReviewDate objimpl: no-gen-base
effectivePeriod	Σ I	0..1	Period	There are no (further) constraints on this element Element id EvidenceVariable.effectivePeriod Short description When the evidence variable is expected to be used Definition The period during which the evidence variable content was or is planned to be in active use. Requirements Allows establishing a transition before a resource comes into effect and also allows for a sunsetting process when new versions of the evidence variable are or are expected to be used instead. Comments The effective period for a evidence variable determines when the content is applicable for usage and is independent of publication and review dates. For example, a measure intended to be used for the year 2016 might be published in 2015. Data type Period Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` per-1: If present, start SHALL have a lower value than end `start.hasValue().not() or end.hasValue().not() or (start <= end)` Mappings rim: n/a v2: DR rim: IVL<TS>[lowClosed="true" and highClosed="true"] or URG<TS>[lowClosed="true" and highClosed="true"] workflow: Definition.effectivePeriod objimpl: no-gen-base
topic		0..*	CodeableConcept	There are no (further) constraints on this element Element id EvidenceVariable.topic Short description The category of the EvidenceVariable, such as Education, Treatment, Assessment, etc. Definition Descriptive topics related to the content of the EvidenceVariable. Topics provide a high-level categorization grouping types of EvidenceVariables that can be useful for filtering and searching. Requirements Repositories must be able to determine how to categorize the EvidenceVariable so that it can be found by topical searches. Comments Not all terminology uses fit this general pattern. In some cases, models should not use CodeableConcept and use Coding directly and provide their own structure for managing text, codings, translations and the relationship between elements and pre- and post-coordination. Data type CodeableConcept Binding High-level categorization of the definition, used for searching, sorting, and filtering. DefinitionTopic (example) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a v2: CE/CNE/CWE rim: CD orim: fhir:CodeableConcept rdfs:subClassOf dt:CD
author		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.author Short description Who authored the content Definition An individiual or organization primarily involved in the creation and maintenance of the content. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: .participation[typeCode=AUT]
editor		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.editor Short description Who edited the content Definition An individual or organization primarily responsible for internal coherence of the content. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
reviewer		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.reviewer Short description Who reviewed the content Definition An individual or organization primarily responsible for review of some aspect of the content. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: .participation[typeCode=VRF] {not clear whether VRF best corresponds to reviewer or endorser}
endorser		0..*	ContactDetail	There are no (further) constraints on this element Element id EvidenceVariable.endorser Short description Who endorsed the content Definition An individual or organization responsible for officially endorsing the content for use in some setting. Data type ContactDetail Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a rim: .participation[typeCode=VRF] {not clear whether VRF best corresponds to reviewer or endorser}
relatedArtifact		0..*	RelatedArtifact	There are no (further) constraints on this element Element id EvidenceVariable.relatedArtifact Short description Additional documentation, citations, etc. Definition Related artifacts such as additional documentation, justification, or bibliographic references. Requirements EvidenceVariables must be able to provide enough information for consumers of the content (and/or interventions or results produced by the content) to be able to determine and understand the justification for and evidence in support of the content. Comments Each related artifact is either an attachment, or a reference to another resource, but not both. Data type RelatedArtifact Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
type	Σ	0..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.type Short description dichotomous \| continuous \| descriptive Definition The type of evidence element, a population, an exposure, or an outcome. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type code Binding The possible types of variables for exposures or outcomes (E.g. Dichotomous, Continuous, Descriptive). EvidenceVariableType (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
characteristic	Σ	1..*	BackboneElement	There are no (further) constraints on this element Element id EvidenceVariable.characteristic Short description What defines the members of the evidence element Definition A characteristic that defines the members of the evidence element. Multiple characteristics are applied with "and" semantics. Comments Characteristics can be defined flexibly to accommodate different use cases for membership criteria, ranging from simple codes, all the way to using an expression language to express the criteria. Data type BackboneElement Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Sliced: Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
modifierExtension	Σ ?! I	0..*	Extension	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a rim: N/A
description		0..1	string	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.description Short description Natural language description of the characteristic Definition A short, natural language description of the characteristic that could be used to communicate the criteria to an end-user. Requirements Need to be able to describe characteristics in natural language so that end users can understand the criteria. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
definition[x]	Σ	1..1		Element id EvidenceVariable.characteristic.definition[x] Short description What code or expression defines members? Definition Define members of the evidence element using Codes (such as condition, medication, or observation), Expressions ( using an expression language such as FHIRPath or CQL) or DataRequirements (such as Diabetes diagnosis onset in the last year). Requirements Need to be able to define members in simple codes when the membership aligns well with terminology, with common criteria such as observations in a value set or lab tests within a year, or with expression language to support criteria that do not fit in the above. Sliced: Unordered, Open, by $this(Type) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
definitionCanonical			canonical(ActivityDefinition)	There are no (further) constraints on this element Data type canonical(ActivityDefinition)
definitionExpression			Expression	There are no (further) constraints on this element Data type Expression
definitionDataRequirement			DataRequirement	There are no (further) constraints on this element Data type DataRequirement
definitionTriggerDefinition			TriggerDefinition	There are no (further) constraints on this element Data type TriggerDefinition
definitionReference			Reference(Group)	There are no (further) constraints on this element Data type Reference(Group)
definitionCodeableConcept	Σ	1..1	CodeableConceptBinding	Element id EvidenceVariable.characteristic.definition[x]:definitionCodeableConcept Short description Design.exposures.type: Type of the exposure Definition Design.exposures.type: General type of the given exposure. Requirements Need to be able to define members in simple codes when the membership aligns well with terminology, with common criteria such as observations in a value set or lab tests within a year, or with expression language to support criteria that do not fit in the above. Data type CodeableConcept Binding Value set defining codes to specify the general type of the given intervention/exposure in the study. NFDI4Health_VS_MDS_Study_Exposure_Type_NCI (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a NFDI4Health: Design.exposures.type
usageContext		0..*	UsageContext	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.usageContext Short description What code/value pairs define members? Definition Use UsageContext to define the members of the population, such as Age Ranges, Genders, Settings. Requirements Need to be able to define members more structurally when more information can be communicated such as age range. Data type UsageContext Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
exclude		0..1	boolean	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.exclude Short description Whether the characteristic includes or excludes members Definition When true, members with this characteristic are excluded from the element. Meaning when missing False Data type boolean Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
participantEffective[x]		0..1		There are no (further) constraints on this element Element id EvidenceVariable.characteristic.participantEffective[x] Short description What time period do participants cover Definition Indicates what effective period the study covers. Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
participantEffectiveDateTime			dateTime	There are no (further) constraints on this element Data type dateTime
participantEffectivePeriod			Period	There are no (further) constraints on this element Data type Period
participantEffectiveDuration			Duration	There are no (further) constraints on this element Data type Duration
participantEffectiveTiming			Timing	There are no (further) constraints on this element Data type Timing
timeFromStart	I	0..1	Duration	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.timeFromStart Short description Observation time from study start Definition Indicates duration from the participant's study entry. Comments The context of use may frequently define what kind of quantity this is and therefore what kind of units can be used. The context of use may also restrict the values for the comparator. Data type Duration Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` qty-3: If a code for the unit is present, the system SHALL also be present `code.empty() or system.exists()` drt-1: There SHALL be a code if there is a value and it SHALL be an expression of time. If system is present, it SHALL be UCUM. `code.exists() implies ((system = %ucum) and value.exists())` Mappings rim: n/a v2: SN (see also Range) or CQ rim: PQ, IVL<PQ>, MO, CO, depending on the values rim: PQ, IVL<PQ> depending on the values
groupMeasure		0..1	codeBinding	There are no (further) constraints on this element Element id EvidenceVariable.characteristic.groupMeasure Short description mean \| median \| mean-of-mean \| mean-of-median \| median-of-mean \| median-of-median Definition Indicates how elements are aggregated within the study effective period. Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type code Binding Possible group measure aggregates (E.g. Mean, Median). GroupMeasure (required) Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a

{
    "resourceType": "StructureDefinition",
    "id": "nfdi4health-pr-mds-evidence-variable-exposure",
    "url": "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-evidence-variable-exposure",
    "version": "0.9",
    "name": "NFDI4Health_PR_MDS_Evidence_Variable_Exposure",
    "title": "NFDI4Health PR MDS Evidence Variable Exposure",
    "status": "draft",
    "publisher": "NFDI4Health",
    "contact":  [
        {
            "telecom":  [
                {
                    "system": "url",
                    "value": "https://www.nfdi4health.de"
                }
            ]
        }
    ],
    "description": "Information about the exposure in a study.",
    "fhirVersion": "4.0.1",
    "mapping":  [
        {
            "identity": "workflow",
            "uri": "http://hl7.org/fhir/workflow",
            "name": "Workflow Pattern"
        },
        {
            "identity": "w5",
            "uri": "http://hl7.org/fhir/fivews",
            "name": "FiveWs Pattern Mapping"
        },
        {
            "identity": "objimpl",
            "uri": "http://hl7.org/fhir/object-implementation",
            "name": "Object Implementation Information"
        },
        {
            "identity": "rim",
            "uri": "http://hl7.org/v3",
            "name": "RIM Mapping"
        },
        {
            "identity": "NFDI4Health",
            "name": "NFDI4Health to FHIR Mapping"
        }
    ],
    "kind": "resource",
    "abstract": false,
    "type": "EvidenceVariable",
    "baseDefinition": "http://hl7.org/fhir/StructureDefinition/EvidenceVariable",
    "derivation": "constraint",
    "differential": {
        "element":  [
            {
                "id": "EvidenceVariable",
                "path": "EvidenceVariable",
                "short": "Design.exposures: Exposures of the [RESOURCE]",
                "definition": "Group of items providing information about the exposures of the [RESOURCE].",
                "comment": "Specification of the exposure(s) associated with each group.",
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "Design.exposures"
                    }
                ]
            },
            {
                "id": "EvidenceVariable.title",
                "path": "EvidenceVariable.title",
                "short": "Name of the exposure",
                "definition": "A short descriptive name of the exposure.",
                "comment": "If the same exposure is associated with more than one group, please provide the information once and use the field 'Name(s) of the group(s) associated with the given exposure' to associate it with more than one group.",
                "min": 1,
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "Design.exposures.name"
                    }
                ]
            },
            {
                "id": "EvidenceVariable.description",
                "path": "EvidenceVariable.description",
                "short": "Additional information about the exposure",
                "definition": "If needed, additional descriptive information about the given exposure.",
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "Design.exposures.description"
                    }
                ]
            },
            {
                "id": "EvidenceVariable.characteristic.definition[x]",
                "path": "EvidenceVariable.characteristic.definition[x]",
                "slicing": {
                    "discriminator":  [
                        {
                            "type": "type",
                            "path": "$this"
                        }
                    ],
                    "ordered": false,
                    "rules": "open"
                }
            },
            {
                "id": "EvidenceVariable.characteristic.definition[x]:definitionCodeableConcept",
                "path": "EvidenceVariable.characteristic.definition[x]",
                "sliceName": "definitionCodeableConcept",
                "short": "Design.exposures.type: Type of the exposure",
                "definition": "Design.exposures.type: General type of the given exposure.",
                "min": 1,
                "max": "1",
                "type":  [
                    {
                        "code": "CodeableConcept"
                    }
                ],
                "binding": {
                    "strength": "required",
                    "valueSet": "https://www.nfdi4health.de/fhir/metadataschema/ValueSet/nfdi4health-vs-mds-study-exposure-type-nci",
                    "description": "Value set defining codes to specify the general type of the given intervention/exposure in the study."
                },
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "Design.exposures.type"
                    }
                ]
            }
        ]
    }
}

Example

Example data for NFDI4Health PR MDS Evidence Variable used to represent an intervention in an interventional study.

Example of NFDI4Health PR MDS Evidence Variable representing the intervention in the interventional study Sport & Long-COVID-Syndrome (SPOVID)
InstanceOfEvidenceVariableSPOVID