Composition

Description

We adapted the Composition resource to represent the elements from the Core MDS. Depending on what Resource Type is chosen, the Composition Profile references to ResearchStudy, DocumentReference, Questionnaire or Library. Information on the Modules Nutritional Epidemiology and Chronic Diseases are contained within a section of the Composition Profile.

Title Canonical
NFDI4Health PR MDS Composition https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-composition

FHIR Profile according to the NFDI4Health Resource Type

The NFDI4Health value of Resource.classification.type/ Composition.type within the Composition Profile triggers which FHIR resource is referenced. To date, we mainly focus on ResearchStudy, DocumentReference, Questionnaire and Library.

The following table provides an overview of resource types that can be uploaded in the German Central Health Study Hub, definitions (as displayed in the MDS) and the appropriate FHIR resource used to represent these NFDI4Health resources.

Allowed NFDI4Health Values Value Definition and Source Triggered FHIR Resource
Study A detailed examination, analysis, or critical inspection of a subject designed to discover facts about it. NCI [13] ResearchStudy
Substudy A part of a study. NCI [13] ResearchStudy
Dataset Data encoded in a defined structure. DataCite [1] DocumentReference
Registry A registry is a collection of information about individuals, usually focused around a specific diagnosis or condition. NIH [24] Library
Secondary data source Secondary data sources are comprised of data originally collected for purposes other than the registry under consideration (e.g., standard medical care, insurance claims processing). NIH [24] Library
Biobank A biobank is a repository that stores and manages biological samples known as biospecimens for use in research NIH [24] Organization
Study protocol The formal plan of an experiment or research activity, including the objective, rationale, design, materials and methods for the conduct of the study; intervention description, and method of data analysis. NCI [13] DocumentReference - in the future potentially PlanDefinition to represent the concrete activities defined in the Study protocol
Data dictionary A document describing the data, including metadata, and their meaining, usage, and relationship to other data. - NFDI4Health DocumentReference
Informed consent form A template of a document explaining all the relevant information to assist an individual in understanding the expectations and risks in making a decision about a procedure. This document is presented to and signed by the individual or guardian. - NCI [13] DocumentReference
Patient information sheet (1) A document that informs the patient about procedures, potential risks or side effects of a proposed medication or operation.
(2) A document that informs the patient about data being collected. - NFDI4Health
DocumentReference
Manual of operations (SOPs) Detailed, written instructions to achieve uniformity of the performance of a specific function. - EMA [14] DocumentReference
Statistical analysis plan A document that contains a more technical and detailed elaboration of the principal features of the analysis described in the protocol, and includes detailed procedures for executing the statistical analysis of the primary and secondary variables and other data. - NCI [13] DocumentReference - in the future PlanDefinition
Data management plan A document that addresses the overall data management process. - NCI [13], NFDI4Health DocumentReference - in the future PlanDefinition to represent the concrete activities defined in a Data management plan
Case report form A printed, optical, or electronic document designed to record all of the clinical study-required information stipulated in the protocol to be reported to the sponsor on each clinical trial subject. - NCI [13] Questionnaire
Code book Pre-defined categorization scheme used for content coding, a data collection technique to transform qualitative data (textual, video, audio or still-image) originally produced for other purposes into quantitative data. - DDI [9] DocumentReference - in the future PlanDefinition
Questionnaire Set of pre-determined questions presented to study participants - DDI [9] Questionnaire
Interview scheme and themes Themes, topics, and/or questions used in an interview. Can vary between loosely defined themes to more exactly formulated questions. There is more flexibility than in an unstructured questionnaire regarding which questions are asked of each participant and how they are conveyed. - DDI [9] DocumentReference
Observation guide Guidelines (i.e., directions or instructions regarding the methods and procedures to be used for collecting the data) regarding what will be observed. Depending on the study design, an observation guide can be more or less structured, ranging from exact specifications and scales to loosely formulated ideas. - DDI [9] DocumentReference - in the future PlanDefinition
Discussion guide Guidelines (i.e., directions or instructions regarding the methods and procedures to be used for collecting the data) for a group discussion. Depending on the study design, a discussion guide can be more or less structured, ranging from exactly formulated questions to general ideas on what to discuss. For example, a list of topics to be discussed in a focus group, or themes formulated by a researcher to direct a blog discussion, etc. - DDI [9] DocumentReference - in the future PlanDefinition
Participant tasks A description of tasks that participants are asked to carry out as a part of the data collection process. For example, marking places on a map, taking photographs, telling a fairy tale, etc. - DDI [9] DocumentReference - in the future PlanDefinition
Other data collection instrument A data collection instrument that is not covered by any of the othervalues in this list. - NFDI4Health DocumentReference - in the future PlanDefinition
Other study document A study document that is not covered by any of the other values in this list.  - NFDI4Health DocumentReference
Other A resource that is not covered by any of the other values in this list.  - NFDI4Health, DataCite [1] undecided yet

References

Reference direction Title Path
references to NFDI4Health PR MDS Practitioner Role Composition.author
references to NFDI4Health PR MDS Organization Composition.author
references to NFDI4Health PR MDS Document Composition.subject
references to NFDI4Health PR MDS Questionnaire Composition.subject
references to NFDI4Health PR MDS Study Composition.subject
references to NFDI4Health PR MDS Registry Composition.subject
references to NFDI4Health_PR_MDS_Observation_Nutritional_Epidemiology Composition.section[nutritionalData].entry
references to NFDI4Health_PR_MDS_Chronic_Diseases Composition.section[chronicDiseases].entry

idΣ0..1string
metaΣ0..1Meta
implicitRulesΣ ?!0..1uri
language0..1codeBinding
text0..1Narrative
contained0..*Resource
provenanceDataSourceI1..1Extension(Coding)
chronicDiseasesI1..1Extension(boolean)
executionLanguageI0..*Extension
nutritionalDataI1..1Extension(boolean)
modifierExtension?! I0..*Extension
id0..1string
extensionI0..*Extension
useΣ ?!0..1codeBinding
typeΣ0..1CodeableConceptBinding
systemΣ0..1uri
valueΣ1..1string
periodΣ I0..1Period
assignerΣ I0..1Reference(Organization)
statusΣ ?!1..1codeBindingFixed Value
typeΣ1..1CodeableConceptBinding
categoryΣ0..1CodeableConceptBinding
subjectΣ I1..1Reference(NFDI4Health PR MDS Document | NFDI4Health PR MDS Questionnaire | NFDI4Health PR MDS Study | NFDI4Health PR MDS Registry)
encounterΣ I0..1Reference(Encounter)
dateΣ1..1dateTime
id0..1string
nameTypeI1..1Extension(Coding)
referenceΣ I0..1string
typeΣ0..1uriBinding
identifierΣ0..1Identifier
displayΣ0..1string
id0..1string
labelI1..*Extension(Complex)
value0..1System.String
confidentialityΣ0..1codeBinding
id0..1string
extensionI0..*Extension
modifierExtensionΣ ?! I0..*Extension
mode1..1codeBinding
time0..1dateTime
partyI0..1Reference(Patient | RelatedPerson | Practitioner | PractitionerRole | Organization)
custodianΣ I0..1Reference(Organization)
id0..1string
extensionI0..*Extension
modifierExtensionΣ ?! I0..*Extension
code1..1codeBinding
targetIdentifierIdentifier
targetReferenceReference(Composition)
id0..1string
extensionI0..*Extension
modifierExtensionΣ ?! I0..*Extension
codeΣ0..*CodeableConcept
periodΣ I0..1Period
detailΣ I0..*Reference(Resource)
id0..1string
extensionI0..*Extension
modifierExtensionΣ ?! I0..*Extension
title0..1string
code0..1CodeableConcept
authorI0..*Reference(Practitioner | PractitionerRole | Device | Patient | RelatedPerson | Organization)
focusI0..1Reference(Resource)
textI0..1Narrative
mode0..1codeBinding
orderedBy0..1CodeableConceptBinding
entryI0..*Reference(Resource)
emptyReasonI0..1CodeableConceptBinding
sectionI0..*see (section)
id0..1string
extensionI0..*Extension
modifierExtensionΣ ?! I0..*Extension
title0..1string
code1..1CodeableConceptPattern
authorI0..*Reference(Practitioner | PractitionerRole | Device | Patient | RelatedPerson | Organization)
focusI0..1Reference(Resource)
textI0..1Narrative
mode0..1codeBinding
orderedBy0..1CodeableConceptBinding
entryI1..1Reference(NFDI4Health PR MDS Observation Nutritional Epidemiology)
emptyReasonI0..1CodeableConceptBinding
sectionI0..*see (section)
id0..1string
extensionI0..*Extension
modifierExtensionΣ ?! I0..*Extension
title0..1string
code1..1CodeableConceptPattern
authorI0..*Reference(Practitioner | PractitionerRole | Device | Patient | RelatedPerson | Organization)
focusI0..1Reference(Resource)
textI0..1Narrative
mode0..1codeBinding
orderedBy0..1CodeableConceptBinding
entryI1..1Reference(NFDI4Health PR MDS Centers)
emptyReasonI0..1CodeableConceptBinding
sectionI0..*see (section)
idΣ0..1string
metaΣ0..1Meta
implicitRulesΣ ?!0..1uri
language0..1codeBinding
text0..1Narrative
contained0..*Resource
provenanceDataSourceI1..1Extension(Coding)
chronicDiseasesI1..1Extension(boolean)
executionLanguageI0..*Extension
nutritionalDataI1..1Extension(boolean)
modifierExtension?! I0..*Extension
id0..1string
extensionI0..*Extension
useΣ ?!0..1codeBinding
typeΣ0..1CodeableConceptBinding
systemΣ0..1uri
valueΣ1..1string
periodΣ I0..1Period
assignerΣ I0..1Reference(Organization)
statusΣ ?!1..1codeBindingFixed Value
typeΣ1..1CodeableConceptBinding
categoryΣ0..1CodeableConceptBinding
subjectΣ I1..1Reference(NFDI4Health PR MDS Document | NFDI4Health PR MDS Questionnaire | NFDI4Health PR MDS Study | NFDI4Health PR MDS Registry)
encounterΣ I0..1Reference(Encounter)
dateΣ1..1dateTime
id0..1string
nameTypeI1..1Extension(Coding)
referenceΣ I0..1string
typeΣ0..1uriBinding
identifierΣ0..1Identifier
displayΣ0..1string
id0..1string
labelI1..*Extension(Complex)
value0..1System.String
confidentialityΣ0..1codeBinding
id0..1string
extensionI0..*Extension
modifierExtensionΣ ?! I0..*Extension
mode1..1codeBinding
time0..1dateTime
partyI0..1Reference(Patient | RelatedPerson | Practitioner | PractitionerRole | Organization)
custodianΣ I0..1Reference(Organization)
id0..1string
extensionI0..*Extension
modifierExtensionΣ ?! I0..*Extension
code1..1codeBinding
targetIdentifierIdentifier
targetReferenceReference(Composition)
id0..1string
extensionI0..*Extension
modifierExtensionΣ ?! I0..*Extension
codeΣ0..*CodeableConcept
periodΣ I0..1Period
detailΣ I0..*Reference(Resource)
id0..1string
extensionI0..*Extension
modifierExtensionΣ ?! I0..*Extension
title0..1string
code0..1CodeableConcept
authorI0..*Reference(Practitioner | PractitionerRole | Device | Patient | RelatedPerson | Organization)
focusI0..1Reference(Resource)
textI0..1Narrative
mode0..1codeBinding
orderedBy0..1CodeableConceptBinding
entryI0..*Reference(Resource)
emptyReasonI0..1CodeableConceptBinding
sectionI0..*see (section)
id0..1string
extensionI0..*Extension
modifierExtensionΣ ?! I0..*Extension
title0..1string
code1..1CodeableConceptPattern
authorI0..*Reference(Practitioner | PractitionerRole | Device | Patient | RelatedPerson | Organization)
focusI0..1Reference(Resource)
textI0..1Narrative
mode0..1codeBinding
orderedBy0..1CodeableConceptBinding
entryI1..1Reference(NFDI4Health PR MDS Observation Nutritional Epidemiology)
emptyReasonI0..1CodeableConceptBinding
sectionI0..*see (section)
id0..1string
extensionI0..*Extension
modifierExtensionΣ ?! I0..*Extension
title0..1string
code1..1CodeableConceptPattern
authorI0..*Reference(Practitioner | PractitionerRole | Device | Patient | RelatedPerson | Organization)
focusI0..1Reference(Resource)
textI0..1Narrative
mode0..1codeBinding
orderedBy0..1CodeableConceptBinding
entryI1..1Reference(NFDI4Health PR MDS Centers)
emptyReasonI0..1CodeableConceptBinding
sectionI0..*see (section)
idΣ0..1string
metaΣ0..1Meta
implicitRulesΣ ?!0..1uri
language0..1codeBinding
text0..1Narrative
contained0..*Resource
provenanceDataSourceI1..1Extension(Coding)
chronicDiseasesI1..1Extension(boolean)
executionLanguageI0..*Extension
nutritionalDataI1..1Extension(boolean)
modifierExtension?! I0..*Extension
id0..1string
extensionI0..*Extension
useΣ ?!0..1codeBinding
typeΣ0..1CodeableConceptBinding
systemΣ0..1uri
valueΣ1..1string
periodΣ I0..1Period
assignerΣ I0..1Reference(Organization)
statusΣ ?!1..1codeBindingFixed Value
typeΣ1..1CodeableConceptBinding
categoryΣ0..1CodeableConceptBinding
subjectΣ I1..1Reference(NFDI4Health PR MDS Document | NFDI4Health PR MDS Questionnaire | NFDI4Health PR MDS Study | NFDI4Health PR MDS Registry)
encounterΣ I0..1Reference(Encounter)
dateΣ1..1dateTime
id0..1string
nameTypeI1..1Extension(Coding)
referenceΣ I0..1string
typeΣ0..1uriBinding
identifierΣ0..1Identifier
displayΣ0..1string
id0..1string
labelI1..*Extension(Complex)
value0..1System.String
confidentialityΣ0..1codeBinding
id0..1string
extensionI0..*Extension
modifierExtensionΣ ?! I0..*Extension
mode1..1codeBinding
time0..1dateTime
partyI0..1Reference(Patient | RelatedPerson | Practitioner | PractitionerRole | Organization)
custodianΣ I0..1Reference(Organization)
id0..1string
extensionI0..*Extension
modifierExtensionΣ ?! I0..*Extension
code1..1codeBinding
targetIdentifierIdentifier
targetReferenceReference(Composition)
id0..1string
extensionI0..*Extension
modifierExtensionΣ ?! I0..*Extension
codeΣ0..*CodeableConcept
periodΣ I0..1Period
detailΣ I0..*Reference(Resource)
id0..1string
extensionI0..*Extension
modifierExtensionΣ ?! I0..*Extension
title0..1string
code0..1CodeableConcept
authorI0..*Reference(Practitioner | PractitionerRole | Device | Patient | RelatedPerson | Organization)
focusI0..1Reference(Resource)
textI0..1Narrative
mode0..1codeBinding
orderedBy0..1CodeableConceptBinding
entryI0..*Reference(Resource)
emptyReasonI0..1CodeableConceptBinding
sectionI0..*see (section)
id0..1string
extensionI0..*Extension
modifierExtensionΣ ?! I0..*Extension
title0..1string
code1..1CodeableConceptPattern
authorI0..*Reference(Practitioner | PractitionerRole | Device | Patient | RelatedPerson | Organization)
focusI0..1Reference(Resource)
textI0..1Narrative
mode0..1codeBinding
orderedBy0..1CodeableConceptBinding
entryI1..1Reference(NFDI4Health PR MDS Observation Nutritional Epidemiology)
emptyReasonI0..1CodeableConceptBinding
sectionI0..*see (section)
id0..1string
extensionI0..*Extension
modifierExtensionΣ ?! I0..*Extension
title0..1string
code1..1CodeableConceptPattern
authorI0..*Reference(Practitioner | PractitionerRole | Device | Patient | RelatedPerson | Organization)
focusI0..1Reference(Resource)
textI0..1Narrative
mode0..1codeBinding
orderedBy0..1CodeableConceptBinding
entryI1..1Reference(NFDI4Health PR MDS Centers)
emptyReasonI0..1CodeableConceptBinding
sectionI0..*see (section)
{
    "resourceType": "StructureDefinition",
    "id": "nfdi4health-pr-mds-composition",
    "url": "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-composition",
    "version": "0.9",
    "name": "NFDI4Health_PR_MDS_Composition",
    "title": "NFDI4Health PR MDS Composition",
    "status": "draft",
    "publisher": "NFDI4Health",
    "contact":  [
        {
            "telecom":  [
                {
                    "system": "url",
                    "value": "https://www.nfdi4health.de"
                }
            ]
        }
    ],
    "description": "Profile intended to capture information on the core information of resources.",
    "fhirVersion": "4.0.1",
    "mapping":  [
        {
            "identity": "workflow",
            "uri": "http://hl7.org/fhir/workflow",
            "name": "Workflow Pattern"
        },
        {
            "identity": "rim",
            "uri": "http://hl7.org/v3",
            "name": "RIM Mapping"
        },
        {
            "identity": "cda",
            "uri": "http://hl7.org/v3/cda",
            "name": "CDA (R2)"
        },
        {
            "identity": "fhirdocumentreference",
            "uri": "http://hl7.org/fhir/documentreference",
            "name": "FHIR DocumentReference"
        },
        {
            "identity": "w5",
            "uri": "http://hl7.org/fhir/fivews",
            "name": "FiveWs Pattern Mapping"
        },
        {
            "identity": "NFDI4Health",
            "name": "NFDI4Health to FHIR Mapping"
        }
    ],
    "kind": "resource",
    "abstract": false,
    "type": "Composition",
    "baseDefinition": "http://hl7.org/fhir/StructureDefinition/Composition",
    "derivation": "constraint",
    "differential": {
        "element":  [
            {
                "id": "Composition",
                "path": "Composition",
                "constraint":  [
                    {
                        "key": "core-2a",
                        "severity": "error",
                        "human": "When author.extension[nameType] = '125676002' then author only Reference (NFDI4Health_PR_MDS_Practitioner_Role)",
                        "expression": "author.where(extension('https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-name-type').value as Coding).where(code = '125676002').exists() implies $this.reference.contains('PractitionerRole')",
                        "source": "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-composition"
                    },
                    {
                        "key": "core-2b",
                        "severity": "error",
                        "human": "When author.extension[nameType] = '385437003' then author only Reference (NFDI4Health_PR_MDS_Organization)",
                        "expression": "author.where(extension('https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-name-type').value as Coding).where(code = '385437003').exists() implies $this.reference.contains('Organization')",
                        "source": "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-composition"
                    },
                    {
                        "key": "core-1a",
                        "severity": "error",
                        "human": "When Composition.type = 'C63536' OR 'C198230' OR 'C47824' OR 'C61393' OR '178' then Composition.category must be empty.",
                        "expression": "type.coding.where(code = 'C63536' or code = 'C198230' or code = 'C47824' or code = 'C61393' or code = '178').exists() implies category.exists().not()",
                        "source": "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-composition"
                    },
                    {
                        "key": "core-1b",
                        "severity": "error",
                        "human": "When Composition.type != 'C63536' OR 'C198230' OR 'C47824' OR 'C61393' OR '178' then Composition.category must exist.",
                        "expression": "type.coding.where(code = 'C93381' or code = 'C16468' or code = 'C15518' or code = 'C115779' or code = 'C115761' or code = 'C115756' or code = 'C40988' or code = 'C17048' or code = 'C17649' or code = 'C48800' or code = '021' or code = '020' or code = '019' or code = '018' or code = '017' or code = '016' or code = '011' or code = '009').exists() implies category.exists()",
                        "source": "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-composition"
                    },
                    {
                        "key": "core-3a",
                        "severity": "error",
                        "human": "When Composition.type = 'C63536' or 'C198230' or 'C61393' or '178' then subject only Reference (NFDI4Health_PR_MDS_Study)",
                        "expression": "type.coding.where(code = 'C63536'or code = 'C61393' or code = 'C198230' or code = '178').exists() implies subject.reference.contains('ResearchStudy')",
                        "source": "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-composition"
                    },
                    {
                        "key": "core-3b",
                        "severity": "error",
                        "human": "When Composition.type = 009, C16468 , C15518, C115779, C115761, C115756, 011, 016, '017', '018', '021' then subject only Reference (NFDI4Health_PR_MDS_Document)",
                        "expression": "type.coding.where(code = '009' or code = 'C16468' or code = 'C15518' or code = 'C115779' or code = 'C115761' or code = 'C115756' or code = '011' or code = '016' or code = '017' or code = '018' or code = '021').exists() implies subject.reference.contains('Document')",
                        "source": "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-composition"
                    },
                    {
                        "key": "core-3c",
                        "severity": "error",
                        "human": "When Composition.type = 'C17048' or 'C40988' then subject only Reference (Profile: NFDI4Health_PR_MDS_Questionnaire)",
                        "expression": "type.coding.where(code = 'C17048' or code = 'C40988').exists() implies subject.reference.contains('Questionnaire')",
                        "source": "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-composition"
                    },
                    {
                        "key": "core-4a",
                        "severity": "error",
                        "human": "1..*, if Resource.chronicDiseases == 'True' AND Resource.classification.type == ('C93381' OR 'C16468' OR 'C15518' OR 'C115779' OR 'C115761' OR 'C115756' OR 'C40988' OR  '016' OR '017' OR '018' OR '019' OR '021' OR 'C17649'); otherwise 0.. 0",
                        "expression": "extension.where(url ='https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-chronic-diseases').where(value = true).exists() implies section.code.coding.where(code = 'C165593').exists()",
                        "source": "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-composition"
                    },
                    {
                        "key": "core-4b",
                        "severity": "error",
                        "human": "1..*, if Resource.chronicDiseases == 'True' AND Resource.classification.type == ('C93381' OR 'C16468' OR 'C15518' OR 'C115779' OR 'C115761' OR 'C115756' OR 'C40988' OR  '016' OR '017' OR '018' OR '019' OR '021' OR 'C17649'); otherwise 0.. 0",
                        "expression": "type.coding.where(code = 'C93381' or code = 'C16468' or code = 'C15518' or code = 'C115779' or code = 'C115761' or code = 'C115756' or code = 'C40988' or code =  '016' or code = '017' or code = '018' or code = '019' or code = '021' or code = 'C17649').exists()  implies section.code.coding.where(code = 'C165593').exists()",
                        "source": "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-composition"
                    },
                    {
                        "key": "core-5",
                        "severity": "error",
                        "human": "1..*, if Resource.nutritionalData == 'True'; otherwise 0.. 0",
                        "expression": "extension.where(url ='https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-nutritional-data').where(value = true).exists() implies section.code.coding.where(code = 'C16927').exists()",
                        "source": "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-composition"
                    }
                ]
            },
            {
                "id": "Composition.extension",
                "path": "Composition.extension",
                "slicing": {
                    "discriminator":  [
                        {
                            "type": "value",
                            "path": "url"
                        }
                    ],
                    "ordered": false,
                    "rules": "open"
                },
                "min": 1
            },
            {
                "id": "Composition.extension:provenanceDataSource",
                "path": "Composition.extension",
                "sliceName": "provenanceDataSource",
                "min": 1,
                "max": "1",
                "type":  [
                    {
                        "code": "Extension",
                        "profile":  [
                            "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-provenance-data-source"
                        ]
                    }
                ],
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "Resource.provenance.dataSource"
                    }
                ]
            },
            {
                "id": "Composition.extension:chronicDiseases",
                "path": "Composition.extension",
                "sliceName": "chronicDiseases",
                "min": 0,
                "max": "1",
                "type":  [
                    {
                        "code": "Extension",
                        "profile":  [
                            "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-chronic-diseases"
                        ]
                    }
                ],
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "Resource.chronicDiseases"
                    }
                ]
            },
            {
                "id": "Composition.extension:executionLanguage",
                "path": "Composition.extension",
                "sliceName": "executionLanguage",
                "min": 0,
                "max": "*",
                "type":  [
                    {
                        "code": "Extension",
                        "profile":  [
                            "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-execution-language"
                        ]
                    }
                ]
            },
            {
                "id": "Composition.extension:nutritionalData",
                "path": "Composition.extension",
                "sliceName": "nutritionalData",
                "min": 0,
                "max": "1",
                "type":  [
                    {
                        "code": "Extension",
                        "profile":  [
                            "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-nutritional-data"
                        ]
                    }
                ],
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "Resource.nutritionalData"
                    }
                ]
            },
            {
                "id": "Composition.identifier",
                "path": "Composition.identifier",
                "short": "ID of the [RESOURCE]",
                "definition": "Unique identifier of the resource used for identification within the NFDI4Health."
            },
            {
                "id": "Composition.identifier.value",
                "path": "Composition.identifier.value",
                "min": 1,
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "Resource.identifier"
                    }
                ]
            },
            {
                "id": "Composition.status",
                "path": "Composition.status",
                "fixedCode": "final"
            },
            {
                "id": "Composition.type",
                "path": "Composition.type",
                "short": "Resource classification",
                "definition": "Group of items providing information about the classification of the resource within the predefined categories.",
                "binding": {
                    "strength": "required",
                    "valueSet": "https://www.nfdi4health.de/fhir/metadataschema/ValueSet/nfdi4health-vs-mds-resource-type-nci-local"
                },
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "Resource.classification.type"
                    }
                ]
            },
            {
                "id": "Composition.category",
                "path": "Composition.category",
                "short": "In what form is the [RESOURCE] available?",
                "definition": "Specific information about the form in which the [RESOURCE] is available.",
                "comment": "Cardinality: 1..1, if Resource.classification.type != ('Study' OR 'Substudy' OR 'Dataset' OR 'Registry' OR 'Secondary data source'); otherwise 0..0",
                "max": "1",
                "binding": {
                    "strength": "required",
                    "valueSet": "https://www.nfdi4health.de/fhir/metadataschema/ValueSet/nfdi4health-vs-mds-resource-type-general-nci-msh-local"
                },
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "Resource.classificiation.typeGeneral"
                    }
                ]
            },
            {
                "id": "Composition.subject",
                "path": "Composition.subject",
                "comment": "1..1, if Resource.classification.type == ('Study' OR 'Substudy' OR 'Registry' OR 'Secondary data source'); otherwise 0..0",
                "min": 1,
                "type":  [
                    {
                        "code": "Reference",
                        "targetProfile":  [
                            "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-document",
                            "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-questionnaire",
                            "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-study",
                            "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-registry"
                        ]
                    }
                ]
            },
            {
                "id": "Composition.author",
                "path": "Composition.author",
                "short": "Individual or organisation associated with the [RESOURCE]",
                "definition": "Individual or organisation associated with the [RESOURCE] (use practitionerRole to specify their organisation).",
                "type":  [
                    {
                        "code": "Reference",
                        "targetProfile":  [
                            "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-practitioner-role",
                            "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-organization"
                        ]
                    }
                ],
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "Resource.contributors"
                    },
                    {
                        "identity": "NFDI4Health",
                        "map": "Resource.contributors"
                    }
                ]
            },
            {
                "id": "Composition.author.extension",
                "path": "Composition.author.extension",
                "min": 1
            },
            {
                "id": "Composition.author.extension:nameType",
                "path": "Composition.author.extension",
                "sliceName": "nameType",
                "min": 1,
                "max": "1",
                "type":  [
                    {
                        "code": "Extension",
                        "profile":  [
                            "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-name-type"
                        ]
                    }
                ],
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "Resource.contributors.nameType"
                    }
                ]
            },
            {
                "id": "Composition.title",
                "path": "Composition.title",
                "short": "Title/name",
                "definition": "Scientific unabbreviated title or name of the resource.",
                "comment": "Additional Information: If no official title/name has been defined yet, please provide a title/name that is suitable for public display. | Short Input Help: Please provide at least one title/name of the resource. If the original title is not in English, please also provide an English translation of the original title.",
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "Resource.titles"
                    },
                    {
                        "identity": "NFDI4Health",
                        "map": "Resource.acronyms"
                    }
                ]
            },
            {
                "id": "Composition.title.extension",
                "path": "Composition.title.extension",
                "slicing": {
                    "discriminator":  [
                        {
                            "type": "value",
                            "path": "url"
                        }
                    ],
                    "ordered": false,
                    "rules": "open"
                },
                "min": 1
            },
            {
                "id": "Composition.title.extension:label",
                "path": "Composition.title.extension",
                "sliceName": "label",
                "min": 1,
                "max": "*",
                "type":  [
                    {
                        "code": "Extension",
                        "profile":  [
                            "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-label"
                        ]
                    }
                ]
            },
            {
                "id": "Composition.section",
                "path": "Composition.section",
                "slicing": {
                    "discriminator":  [
                        {
                            "type": "value",
                            "path": "code"
                        }
                    ],
                    "rules": "open"
                }
            },
            {
                "id": "Composition.section:nutritionalData",
                "path": "Composition.section",
                "sliceName": "nutritionalData",
                "short": "Group of items providing information on diet assessment.",
                "definition": "Specification of the dietary assessment instrument used in the [RESOURCE].",
                "comment": "1..*, if Resource.nutritionalData == 'Yes'; otherwise 0.. 0",
                "min": 0,
                "max": "*",
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "DietAssessment"
                    }
                ]
            },
            {
                "id": "Composition.section:nutritionalData.code",
                "path": "Composition.section.code",
                "min": 1,
                "patternCodeableConcept": {
                    "coding":  [
                        {
                            "code": "C16927",
                            "system": "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
                            "display": "Nutritional Science"
                        }
                    ]
                }
            },
            {
                "id": "Composition.section:nutritionalData.entry",
                "path": "Composition.section.entry",
                "min": 1,
                "max": "1",
                "type":  [
                    {
                        "code": "Reference",
                        "targetProfile":  [
                            "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-observation-nutritional-epidemiology"
                        ]
                    }
                ]
            },
            {
                "id": "Composition.section:chronicDiseases",
                "path": "Composition.section",
                "sliceName": "chronicDiseases",
                "short": "Includes chronic diseases?",
                "definition": "Indication whether the [RESOURCE] addresses chronic diseases.",
                "comment": "Cardinality: 1..*, if Resource.chronicDiseases == 'Yes' AND Resource.classification.type == ('Study protocol' OR 'Informed consent form' OR 'Patient information sheet' OR 'Manual of operations (SOPs)' OR 'Statistical analysis plan' OR 'Data management plan' OR 'Case report form' OR 'Interview scheme and themes' OR 'Observation guide' OR 'Discussion guide' OR 'Participant tasks' OR 'Other study document' OR 'Other'); otherwise 0..0 / Source of the property and/or allowed values: NFDI4Health UC 5.2 requirements",
                "min": 0,
                "max": "*",
                "mapping":  [
                    {
                        "identity": "NFDI4Health",
                        "map": "ChronicDiseasesEpidemiology"
                    }
                ]
            },
            {
                "id": "Composition.section:chronicDiseases.code",
                "path": "Composition.section.code",
                "min": 1,
                "patternCodeableConcept": {
                    "coding":  [
                        {
                            "code": "C165593",
                            "system": "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
                            "display": "Chronic Disease"
                        }
                    ]
                }
            },
            {
                "id": "Composition.section:chronicDiseases.entry",
                "path": "Composition.section.entry",
                "min": 1,
                "max": "1",
                "type":  [
                    {
                        "code": "Reference",
                        "targetProfile":  [
                            "https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-chronic-diseases"
                        ]
                    }
                ]
            }
        ]
    }
}

Examples

Example data for NFDI4Health PR MDS Composition


WHO Household Transmission:
InstanceOfCompositionWHOHouseholdTransmission

SPOVID:
InstanceOfCompositionSPOVID

SHIP:
InstanceOfCompositionSHIP

Hamburg Cancer Registry:
InstanceOfCompositionRegistryHKR

Household Transmission Investigation Protocol for Coronavirus Disease 2019 (COVID-19):
InstanceOfCompositionHouseholdTransmissionInvestigationForC19