PharmGKB Evidence Level Example Codes
CodeSystem
PharmGKB enthält Beispiele für Konzepte der Evidenzstufe, die nicht mit der klinischen Bedeutung verwechselt werden. Diese können auf PharmGKB https://www.pharmgkb.org/page/clinAnnLevels gefunden werden.
Canonical: http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/pharmgkb-evidence-level-custom-cs
Das CodeSystem PharmGKB Evidence Level Example Codes stammt aus HL7 Genomics Reporting Implementation Guide.
Concepts
This code system http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/pharmgkb-evidence-level-custom-cs defines the following codes:
{
--- We have skipped the narrative for better readability of the resource ---
},
],
{
{
},
{
}
]
}
],
"description": "PharmGKB contains examples of evidence level concepts that are not conflated with clinical significance. These can be found on PharmGKB https://www.pharmgkb.org/page/clinAnnLevels. These examples are informational only, for copyright information contact the relevant source.",
{
]
}
],
{
"definition": "High level of evidence. Supported by a guideline or FDA label with variant specific prescribing guidance. Additionally, supported by at least one publication."
},
{
"definition": "High level of evidence. But, NOT supported by a guideline or FDA label with variant specific prescribing guidance. Additionally, supported by at least one publication."
},
{
"definition": "Moderate level of evidence. Supported by being a KNOWN pharmacogene on https://www.pharmgkb.org/vips. Also, found in multiple studies but may have a minority of studies that did not support the majority opinion. Supported by at least two indpendent publications."
},
{
"definition": "Moderate level of evidence. NOT in the list of very important, KNOWN pharmacogenes. Found in multiple studies but may have a minority of studies that did not support the majority opinion. Supported by at least two indpendent publications."
},
{
"definition": "Low-level of evidence. Where either the assocation is based on a single study, failed to be reproduced, or preliminary evidence."
},
{
"definition": "The evidence does not support an association between the variant and the drug phenotype. (negative)"
}
]
}