{
    "resourceType": "ServiceRequest",
    "id": "ServiceRequest-NonWGSTestOrder-VariantReinterpretation-Example",
    "basedOn":  [
        {
            "reference": "ServiceReques/ServiceRequest-NonWGSTestOrderForm-SyndromicEpilepsy-Example"
        }
    ],
    "extension":  [
        {
            "url": "https://fhir.hl7.org.uk/StructureDefinition/Extension-UKCore-Coverage",
            "valueCodeableConcept": {
                "coding":  [
                    {
                        "system": "https://fhir.hl7.org.uk/CodeSystem/UKCore-FundingCategory",
                        "code": "nhs-england",
                        "display": "NHS England"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "category":  [
        {
            "coding":  [
                {
                    "system": "https://fhir.hl7.org.uk/CodeSystem/UKCore-GenomeSequencingCategory",
                    "code": "rare-disease-non-wgs"
                }
            ]
        }
    ],
    "priority": "routine",
    "code": {
        "coding":  [
            {
                "system": "https://fhir.nhs.uk/CodeSystem/England-GenomicTestDirectory",
                "code": "R442",
                "display": "Variant Re-interpretation",
                "version": "7"
            }
        ]
    },
    "orderDetail":  [
        {
            "coding":  [
                {
                    "system": "https://fhir.nhs.uk/CodeSystem/England-GenomicTestDirectory",
                    "code": "R59",
                    "display": "Early onset or syndromic epilepsy",
                    "version": "7"
                }
            ]
        },
        {
            "coding":  [
                {
                    "system": "https://fhir.nhs.uk/CodeSystem/types-of-reanalysistest-genomics",
                    "code": "original-gene-panels",
                    "display": "Original Gene Panels"
                }
            ]
        }
    ],
    "subject": {
        "reference": "Patient/Patient-SalimaPomfrets-Example",
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "8449303444"
        }
    },
    "authoredOn": "2023-10-01T10:08:00Z",
    "requester": {
        "reference": "PractitionerRole/PractitionerRole-GeneSmith-Example"
    },
    "reasonCode":  [
        {
            "coding":  [
                {
                    "system": "https://fhir.nhs.uk/CodeSystem/reasonfortesting-genomics",
                    "code": "diagnostic",
                    "display": "Diagnostic"
                }
            ]
        }
    ],
    "supportingInfo":  [
        {
            "reference": "Observation/Observation-GenomicEthnicity-Example"
        },
        {
            "reference": "Observation/Observation-DiseaseStatus-Example"
        },
        {
            "reference": "Observation/Observation-NoPregnancy-Example"
        },
        {
            "reference": "Observation/Observation-NonConsanguinousUnion-Example"
        },
        {
            "reference": "Observation/Observation-NoBoneMarrowTransplant-Example"
        },
        {
            "reference": "Observation/Observation-NoTransfusion-Example"
        }
    ],
    "note":  [
        {
            "text": "No sample required."
        },
        {
            "text": "No family history of genomic testing"
        },
        {
            "text": "Free text for diagnosis/reason for referral, relevant information including family history, phenotypic details/ HPO Terms/ For example: new evidence available that will likely change the classification of the variant- identification of additional patient(s) with the same genetic variant"
        }
    ]
}

<ServiceRequest xmlns="http://hl7.org/fhir">
    <id value="ServiceRequest-NonWGSTestOrder-VariantReinterpretation-Example" />
    <extension url="https://fhir.hl7.org.uk/StructureDefinition/Extension-UKCore-Coverage">
        <valueCodeableConcept>
            <coding>
                <system value="https://fhir.hl7.org.uk/CodeSystem/UKCore-FundingCategory" />
                <code value="nhs-england" />
                <display value="NHS England" />
            </coding>
        </valueCodeableConcept>
    </extension>
    <basedOn>
        <reference value="ServiceReques/ServiceRequest-NonWGSTestOrderForm-SyndromicEpilepsy-Example" />
    </basedOn>
    <status value="active" />
    <intent value="order" />
    <category>
        <coding>
            <system value="https://fhir.hl7.org.uk/CodeSystem/UKCore-GenomeSequencingCategory" />
            <code value="rare-disease-non-wgs" />
        </coding>
    </category>
    <priority value="routine" />
    <code>
        <coding>
            <system value="https://fhir.nhs.uk/CodeSystem/England-GenomicTestDirectory" />
            <version value="7" />
            <code value="R442" />
            <display value="Variant Re-interpretation" />
        </coding>
    </code>
    <orderDetail>
        <coding>
            <system value="https://fhir.nhs.uk/CodeSystem/England-GenomicTestDirectory" />
            <version value="7" />
            <code value="R59" />
            <display value="Early onset or syndromic epilepsy" />
        </coding>
    </orderDetail>
    <orderDetail>
        <coding>
            <system value="https://fhir.nhs.uk/CodeSystem/types-of-reanalysistest-genomics" />
            <code value="original-gene-panels" />
            <display value="Original Gene Panels" />
        </coding>
    </orderDetail>
    <subject>
        <reference value="Patient/Patient-SalimaPomfrets-Example" />
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="8449303444" />
        </identifier>
    </subject>
    <authoredOn value="2023-10-01T10:08:00Z" />
    <requester>
        <reference value="PractitionerRole/PractitionerRole-GeneSmith-Example" />
    </requester>
    <reasonCode>
        <coding>
            <system value="https://fhir.nhs.uk/CodeSystem/reasonfortesting-genomics" />
            <code value="diagnostic" />
            <display value="Diagnostic" />
        </coding>
    </reasonCode>
    <supportingInfo>
        <reference value="Observation/Observation-GenomicEthnicity-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-DiseaseStatus-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NoPregnancy-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NonConsanguinousUnion-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NoBoneMarrowTransplant-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NoTransfusion-Example" />
    </supportingInfo>
    <note>
        <text value="No sample required." />
    </note>
    <note>
        <text value="No family history of genomic testing" />
    </note>
    <note>
        <text value="Free text for diagnosis/reason for referral, relevant information including family history, phenotypic details/ HPO Terms/ For example: new evidence available that will likely change the classification of the variant- identification of additional patient(s) with the same genetic variant" />
    </note>
</ServiceRequest>

Propose a change to ServiceRequest-NonWGSTestOrder-VariantReinterpretation-Example

{
    "resourceType": "ServiceRequest",
    "id": "ServiceRequest-NonWGSTestOrderForm-Cancellation-Example",
    "extension":  [
        {
            "url": "https://fhir.hl7.org.uk/StructureDefinition/Extension-UKCore-Coverage",
            "valueCodeableConcept": {
                "coding":  [
                    {
                        "system": "https://fhir.hl7.org.uk/CodeSystem/UKCore-FundingCategory",
                        "code": "nhs-england",
                        "display": "NHS England"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "category":  [
        {
            "coding":  [
                {
                    "system": "https://fhir.hl7.org.uk/CodeSystem/UKCore-GenomeSequencingCategory",
                    "code": "rare-disease-non-wgs",
                    "display": "Rare Disease - Non-WGS"
                }
            ]
        }
    ],
    "priority": "routine",
    "code": {
        "coding":  [
            {
                "system": "https://fhir.nhs.uk/CodeSystem/England-GenomicTestDirectory",
                "code": "R67.1",
                "display": "Monogenic hearing loss",
                "version": "7"
            }
        ]
    },
    "subject": {
        "reference": "Patient/Patient-MeirLieberman-Example",
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9449307873"
        }
    },
    "authoredOn": "2023-08-05T10:08:00Z",
    "requester": {
        "reference": "PractitionerRole/PractitionerRole-GeneSmithENT-Example"
    },
    "reasonCode":  [
        {
            "coding":  [
                {
                    "system": "https://fhir.nhs.uk/CodeSystem/reasonfortesting-genomics",
                    "code": "diagnostic",
                    "display": "Diagnostic"
                }
            ]
        }
    ],
    "supportingInfo":  [
        {
            "reference": "Observation/Observation-GenomicEthnicity-Example"
        },
        {
            "reference": "Observation/Observation-NoPregnancy-Example"
        },
        {
            "reference": "Observation/Observation-DiseaseStatus-Example"
        },
        {
            "reference": "Observation/Observation-NonConsanguinousUnion-Example"
        },
        {
            "reference": "Observation/Observation-NoBoneMarrowTransplant-Example"
        },
        {
            "reference": "Observation/Observation-NoTransfusion-Example"
        },
        {
            "reference": "Observation/Observation-RiskOfInfection-Example"
        },
        {
            "reference": "Observation/Observation-NatureAndAgeOfHearingLoss-Example"
        }
    ],
    "specimen":  [
        {
            "display": "Specimen/Specimen-BloodEDTA-Example"
        }
    ],
    "note":  [
        {
            "text": "Free text for diagnosis/reason for referral, relevant information including family history, phenotypic details/ HPO Terms Patient in need of test...example"
        }
    ]
}

<ServiceRequest xmlns="http://hl7.org/fhir">
    <id value="ServiceRequest-NonWGSTestOrderForm-Cancellation-Example" />
    <extension url="https://fhir.hl7.org.uk/StructureDefinition/Extension-UKCore-Coverage">
        <valueCodeableConcept>
            <coding>
                <system value="https://fhir.hl7.org.uk/CodeSystem/UKCore-FundingCategory" />
                <code value="nhs-england" />
                <display value="NHS England" />
            </coding>
        </valueCodeableConcept>
    </extension>
    <status value="active" />
    <intent value="order" />
    <category>
        <coding>
            <system value="https://fhir.hl7.org.uk/CodeSystem/UKCore-GenomeSequencingCategory" />
            <code value="rare-disease-non-wgs" />
            <display value="Rare Disease - Non-WGS" />
        </coding>
    </category>
    <priority value="routine" />
    <code>
        <coding>
            <system value="https://fhir.nhs.uk/CodeSystem/England-GenomicTestDirectory" />
            <version value="7" />
            <code value="R67.1" />
            <display value="Monogenic hearing loss" />
        </coding>
    </code>
    <subject>
        <reference value="Patient/Patient-MeirLieberman-Example" />
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9449307873" />
        </identifier>
    </subject>
    <authoredOn value="2023-08-05T10:08:00Z" />
    <requester>
        <reference value="PractitionerRole/PractitionerRole-GeneSmithENT-Example" />
    </requester>
    <reasonCode>
        <coding>
            <system value="https://fhir.nhs.uk/CodeSystem/reasonfortesting-genomics" />
            <code value="diagnostic" />
            <display value="Diagnostic" />
        </coding>
    </reasonCode>
    <supportingInfo>
        <reference value="Observation/Observation-GenomicEthnicity-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NoPregnancy-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-DiseaseStatus-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NonConsanguinousUnion-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NoBoneMarrowTransplant-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NoTransfusion-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-RiskOfInfection-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NatureAndAgeOfHearingLoss-Example" />
    </supportingInfo>
    <specimen>
        <display value="Specimen/Specimen-BloodEDTA-Example" />
    </specimen>
    <note>
        <text value="Free text for diagnosis/reason for referral, relevant information including family history, phenotypic details/ HPO Terms Patient in need of test...example" />
    </note>
</ServiceRequest>

Propose a change to ServiceRequest-NonWGSTestOrderForm-Cancellation-Example

{
    "resourceType": "ServiceRequest",
    "id": "ServiceRequest-NonWGSTestOrderForm-CancerSolidTumor-Example",
    "extension":  [
        {
            "url": "https://fhir.hl7.org.uk/StructureDefinition/Extension-UKCore-Coverage",
            "valueCodeableConcept": {
                "coding":  [
                    {
                        "system": "https://fhir.hl7.org.uk/CodeSystem/UKCore-FundingCategory",
                        "code": "nhs-england",
                        "display": "NHS England"
                    }
                ]
            }
        },
        {
            "url": "https://fhir.hl7.org.uk/StructureDefinition/Extension-UKCore-AdditionalContact",
            "valueReference": {
                "reference": "PractitionerRole/PractitionerRole-AnnaLaneKingstonPathology-Example"
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "category":  [
        {
            "coding":  [
                {
                    "system": "https://fhir.hl7.org.uk/CodeSystem/UKCore-GenomeSequencingCategory",
                    "code": "cancer-non-wgs",
                    "display": "Cancer - Non-WGS"
                }
            ]
        }
    ],
    "priority": "routine",
    "code": {
        "coding":  [
            {
                "system": "https://fhir.nhs.uk/CodeSystem/England-GenomicTestDirectory",
                "code": "M119.5",
                "display": "Multi Target NGS Panel Small",
                "version": "9"
            }
        ]
    },
    "subject": {
        "reference": "Patient/Patient-PatrickSammy-Example",
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9449307555"
        }
    },
    "authoredOn": "2023-09-08",
    "requester": {
        "reference": "PractitionerRole/PractitionerRole-HazelSmithKingstonPathology-Example"
    },
    "reasonCode":  [
        {
            "coding":  [
                {
                    "system": "https://fhir.nhs.uk/CodeSystem/reasonfortesting-genomics",
                    "code": "relapse",
                    "display": "Relapse"
                }
            ]
        }
    ],
    "performer":  [
        {
            "identifier": {
                "system": "https://fhir.nhs.uk/Id/ods-organization-code",
                "value": "RJZ"
            },
            "display": "KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST"
        }
    ],
    "supportingInfo":  [
        {
            "reference": "Observation/Observation-Cellularity-Example"
        },
        {
            "reference": "Observation/Observation-TumorType-Example"
        },
        {
            "reference": "Observation/Observation-Necrosis-Example"
        },
        {
            "reference": "Observation/Observation-NeoplasticCell-Example"
        },
        {
            "reference": "Condition/Condition-LungTumor-Example"
        }
    ],
    "specimen":  [
        {
            "reference": "Specimen/Specimen-SolidTumor-Example"
        }
    ],
    "note":  [
        {
            "text": "Free text for diagnosis/reason for referral, transplant, life status at time of request details/ e.g. malignant tumour - molecular assessment will aid management"
        }
    ]
}

<ServiceRequest xmlns="http://hl7.org/fhir">
    <id value="ServiceRequest-NonWGSTestOrderForm-CancerSolidTumor-Example" />
    <extension url="https://fhir.hl7.org.uk/StructureDefinition/Extension-UKCore-Coverage">
        <valueCodeableConcept>
            <coding>
                <system value="https://fhir.hl7.org.uk/CodeSystem/UKCore-FundingCategory" />
                <code value="nhs-england" />
                <display value="NHS England" />
            </coding>
        </valueCodeableConcept>
    </extension>
    <extension url="https://fhir.hl7.org.uk/StructureDefinition/Extension-UKCore-AdditionalContact">
        <valueReference>
            <reference value="PractitionerRole/PractitionerRole-AnnaLaneKingstonPathology-Example" />
        </valueReference>
    </extension>
    <status value="active" />
    <intent value="order" />
    <category>
        <coding>
            <system value="https://fhir.hl7.org.uk/CodeSystem/UKCore-GenomeSequencingCategory" />
            <code value="cancer-non-wgs" />
            <display value="Cancer - Non-WGS" />
        </coding>
    </category>
    <priority value="routine" />
    <code>
        <coding>
            <system value="https://fhir.nhs.uk/CodeSystem/England-GenomicTestDirectory" />
            <version value="9" />
            <code value="M119.5" />
            <display value="Multi Target NGS Panel Small" />
        </coding>
    </code>
    <subject>
        <reference value="Patient/Patient-PatrickSammy-Example" />
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9449307555" />
        </identifier>
    </subject>
    <authoredOn value="2023-09-08" />
    <requester>
        <reference value="PractitionerRole/PractitionerRole-HazelSmithKingstonPathology-Example" />
    </requester>
    <performer>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/ods-organization-code" />
            <value value="RJZ" />
        </identifier>
        <display value="KING&#39;S COLLEGE HOSPITAL NHS FOUNDATION TRUST" />
    </performer>
    <reasonCode>
        <coding>
            <system value="https://fhir.nhs.uk/CodeSystem/reasonfortesting-genomics" />
            <code value="relapse" />
            <display value="Relapse" />
        </coding>
    </reasonCode>
    <supportingInfo>
        <reference value="Observation/Observation-Cellularity-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-TumorType-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-Necrosis-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NeoplasticCell-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Condition/Condition-LungTumor-Example" />
    </supportingInfo>
    <specimen>
        <reference value="Specimen/Specimen-SolidTumor-Example" />
    </specimen>
    <note>
        <text value="Free text for diagnosis/reason for referral, transplant, life status at time of request details/ e.g. malignant tumour - molecular assessment will aid management" />
    </note>
</ServiceRequest>

Propose a change to ServiceRequest-NonWGSTestOrderForm-CancerSolidTumor-Example

{
    "resourceType": "ServiceRequest",
    "id": "ServiceRequest-NonWGSTestOrderForm-CascadeTesting-Example",
    "basedOn":  [
        {
            "reference": "ServiceRequest-NonWGSTestOrderForm-FatherOfFayMutlow-Example"
        }
    ],
    "extension":  [
        {
            "url": "https://fhir.hl7.org.uk/StructureDefinition/Extension-UKCore-Coverage",
            "valueCodeableConcept": {
                "coding":  [
                    {
                        "system": "https://fhir.hl7.org.uk/CodeSystem/UKCore-FundingCategory",
                        "code": "nhs-england",
                        "display": "NHS England"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "category":  [
        {
            "coding":  [
                {
                    "system": "https://fhir.hl7.org.uk/CodeSystem/UKCore-GenomeSequencingCategory",
                    "code": "rare-disease-non-wgs",
                    "display": "Rare Disease - Non-WGS"
                }
            ]
        }
    ],
    "priority": "routine",
    "code": {
        "coding":  [
            {
                "system": "https://fhir.nhs.uk/CodeSystem/England-GenomicTestDirectory",
                "code": "R134",
                "display": "Familial Hypercholesterolaemia",
                "version": "7"
            }
        ]
    },
    "subject": {
        "reference": "Patient/Patient-FayMutlow-Example",
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9449307806"
        }
    },
    "authoredOn": "2023-10-04T11:00:00Z",
    "requester": {
        "reference": "PractitionerRole/PractitionerRole-MarySmith-Example"
    },
    "reasonCode":  [
        {
            "coding":  [
                {
                    "system": "https://fhir.nhs.uk/CodeSystem/reasonfortesting-genomics",
                    "code": "predictive",
                    "display": "Predictive"
                }
            ]
        }
    ],
    "supportingInfo":  [
        {
            "reference": "Observation/Observation-GenomicEthnicity-Example"
        },
        {
            "reference": "Observation/Observation-NoPregnancy-Example"
        },
        {
            "reference": "Observation/Observation-DiseaseStatus-Example"
        },
        {
            "reference": "Observation/Observation-NonConsanguinousUnion-Example"
        },
        {
            "reference": "Observation/Observation-NoTransplant-Example"
        },
        {
            "reference": "Observation/Observation-NoTransfusion-Example"
        },
        {
            "reference": "Observation/Observation-DutchLipidScore-Example"
        },
        {
            "reference": "Observation/Observation-QueryXanthoma-Example"
        },
        {
            "reference": "Observation/Observation-SimonBroomeCriteria-Example"
        }
    ],
    "specimen":  [
        {
            "reference": "Specimen/Specimen-BloodEDTA-WithCollectionDetails-Example"
        }
    ],
    "note":  [
        {
            "text": "Free text for diagnosis/reason for referral, relevant information including family history, phenotypic details/ HPO Terms"
        },
        {
            "text": "Father tested positive for FH. Confirmation required if daughter is positive for FH"
        }
    ]
}

<ServiceRequest xmlns="http://hl7.org/fhir">
    <id value="ServiceRequest-NonWGSTestOrderForm-CascadeTesting-Example" />
    <extension url="https://fhir.hl7.org.uk/StructureDefinition/Extension-UKCore-Coverage">
        <valueCodeableConcept>
            <coding>
                <system value="https://fhir.hl7.org.uk/CodeSystem/UKCore-FundingCategory" />
                <code value="nhs-england" />
                <display value="NHS England" />
            </coding>
        </valueCodeableConcept>
    </extension>
    <basedOn>
        <reference value="ServiceRequest-NonWGSTestOrderForm-FatherOfFayMutlow-Example" />
    </basedOn>
    <status value="active" />
    <intent value="order" />
    <category>
        <coding>
            <system value="https://fhir.hl7.org.uk/CodeSystem/UKCore-GenomeSequencingCategory" />
            <code value="rare-disease-non-wgs" />
            <display value="Rare Disease - Non-WGS" />
        </coding>
    </category>
    <priority value="routine" />
    <code>
        <coding>
            <system value="https://fhir.nhs.uk/CodeSystem/England-GenomicTestDirectory" />
            <version value="7" />
            <code value="R134" />
            <display value="Familial Hypercholesterolaemia" />
        </coding>
    </code>
    <subject>
        <reference value="Patient/Patient-FayMutlow-Example" />
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9449307806" />
        </identifier>
    </subject>
    <authoredOn value="2023-10-04T11:00:00Z" />
    <requester>
        <reference value="PractitionerRole/PractitionerRole-MarySmith-Example" />
    </requester>
    <reasonCode>
        <coding>
            <system value="https://fhir.nhs.uk/CodeSystem/reasonfortesting-genomics" />
            <code value="predictive" />
            <display value="Predictive" />
        </coding>
    </reasonCode>
    <supportingInfo>
        <reference value="Observation/Observation-GenomicEthnicity-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NoPregnancy-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-DiseaseStatus-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NonConsanguinousUnion-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NoTransplant-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NoTransfusion-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-DutchLipidScore-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-QueryXanthoma-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-SimonBroomeCriteria-Example" />
    </supportingInfo>
    <specimen>
        <reference value="Specimen/Specimen-BloodEDTA-WithCollectionDetails-Example" />
    </specimen>
    <note>
        <text value="Free text for diagnosis/reason for referral, relevant information including family history, phenotypic details/ HPO Terms" />
    </note>
    <note>
        <text value="Father tested positive for FH. Confirmation required if daughter is positive for FH" />
    </note>
</ServiceRequest>

Propose a change to ServiceRequest-NonWGSTestOrderForm-CascadeTesting-Example

{
    "resourceType": "ServiceRequest",
    "id": "ServiceRequest-NonWGSTestOrderForm-DeceasedPatient-Example",
    "extension":  [
        {
            "url": "https://fhir.hl7.org.uk/StructureDefinition/Extension-UKCore-Coverage",
            "valueCodeableConcept": {
                "coding":  [
                    {
                        "system": "https://fhir.hl7.org.uk/CodeSystem/UKCore-FundingCategory",
                        "code": "nhs-england",
                        "display": "NHS England"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "category":  [
        {
            "coding":  [
                {
                    "system": "https://fhir.hl7.org.uk/CodeSystem/UKCore-GenomeSequencingCategory",
                    "code": "rare-disease-non-wgs",
                    "display": "Rare Disease - Non-WGS"
                }
            ]
        }
    ],
    "priority": "routine",
    "code": {
        "coding":  [
            {
                "system": "https://fhir.nhs.uk/CodeSystem/England-GenomicTestDirectory",
                "code": "R138",
                "display": "Sudden Cardiac Death",
                "version": "7"
            }
        ]
    },
    "subject": {
        "reference": "Patient/Patient-AnitaLambertsDeceasedPatient-Example",
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "8449303649"
        }
    },
    "authoredOn": "2023-11-01T10:00:00Z",
    "requester": {
        "reference": "PractitionerRole/PractitionerRole-GeneSmith-Example"
    },
    "reasonCode":  [
        {
            "coding":  [
                {
                    "system": "https://fhir.nhs.uk/CodeSystem/reasonfortesting-genomics",
                    "code": "diagnostic",
                    "display": "Diagnostic"
                }
            ]
        }
    ],
    "supportingInfo":  [
        {
            "reference": "Observation/Observation-GenomicEthnicity-Example"
        },
        {
            "reference": "Observation/Observation-NoPregnancy-Example"
        },
        {
            "reference": "Observation/Observation-DiseaseStatus-Example"
        },
        {
            "reference": "Observation/Observation-NonConsanguinousUnion-Example"
        },
        {
            "reference": "Observation/Observation-NoBoneMarrowTransplant-Example"
        },
        {
            "reference": "Observation/Observation-NoTransfusion-Example"
        },
        {
            "reference": "Observation/Observation-RiskOfInfection-Example"
        }
    ],
    "specimen":  [
        {
            "display": "Blood EDTA Specimen to be provided later"
        }
    ],
    "note":  [
        {
            "text": "No family history of genomic testing"
        },
        {
            "text": "Free text for diagnosis/reason for referral, relevant information including family history, phenotypic details/ HPO Terms."
        }
    ]
}

<ServiceRequest xmlns="http://hl7.org/fhir">
    <id value="ServiceRequest-NonWGSTestOrderForm-DeceasedPatient-Example" />
    <extension url="https://fhir.hl7.org.uk/StructureDefinition/Extension-UKCore-Coverage">
        <valueCodeableConcept>
            <coding>
                <system value="https://fhir.hl7.org.uk/CodeSystem/UKCore-FundingCategory" />
                <code value="nhs-england" />
                <display value="NHS England" />
            </coding>
        </valueCodeableConcept>
    </extension>
    <status value="active" />
    <intent value="order" />
    <category>
        <coding>
            <system value="https://fhir.hl7.org.uk/CodeSystem/UKCore-GenomeSequencingCategory" />
            <code value="rare-disease-non-wgs" />
            <display value="Rare Disease - Non-WGS" />
        </coding>
    </category>
    <priority value="routine" />
    <code>
        <coding>
            <system value="https://fhir.nhs.uk/CodeSystem/England-GenomicTestDirectory" />
            <version value="7" />
            <code value="R138" />
            <display value="Sudden Cardiac Death" />
        </coding>
    </code>
    <subject>
        <reference value="Patient/Patient-AnitaLambertsDeceasedPatient-Example" />
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="8449303649" />
        </identifier>
    </subject>
    <authoredOn value="2023-11-01T10:00:00Z" />
    <requester>
        <reference value="PractitionerRole/PractitionerRole-GeneSmith-Example" />
    </requester>
    <reasonCode>
        <coding>
            <system value="https://fhir.nhs.uk/CodeSystem/reasonfortesting-genomics" />
            <code value="diagnostic" />
            <display value="Diagnostic" />
        </coding>
    </reasonCode>
    <supportingInfo>
        <reference value="Observation/Observation-GenomicEthnicity-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NoPregnancy-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-DiseaseStatus-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NonConsanguinousUnion-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NoBoneMarrowTransplant-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NoTransfusion-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-RiskOfInfection-Example" />
    </supportingInfo>
    <specimen>
        <display value="Blood EDTA Specimen to be provided later" />
    </specimen>
    <note>
        <text value="No family history of genomic testing" />
    </note>
    <note>
        <text value="Free text for diagnosis/reason for referral, relevant information including family history, phenotypic details/ HPO Terms." />
    </note>
</ServiceRequest>

Propose a change to ServiceRequest-NonWGSTestOrderForm-DeceasedPatient-Example

{
    "resourceType": "ServiceRequest",
    "id": "ServiceRequest-NonWGSTestOrderForm-Example",
    "extension":  [
        {
            "url": "https://fhir.hl7.org.uk/StructureDefinition/Extension-UKCore-Coverage",
            "valueCodeableConcept": {
                "coding":  [
                    {
                        "system": "https://fhir.hl7.org.uk/CodeSystem/UKCore-FundingCategory",
                        "code": "nhs-england",
                        "display": "NHS England"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "category":  [
        {
            "coding":  [
                {
                    "system": "https://fhir.hl7.org.uk/CodeSystem/UKCore-GenomeSequencingCategory",
                    "code": "rare-disease-non-wgs",
                    "display": "Rare Disease - Non-WGS"
                }
            ]
        }
    ],
    "priority": "routine",
    "code": {
        "coding":  [
            {
                "system": "https://fhir.nhs.uk/CodeSystem/England-GenomicTestDirectory",
                "code": "R67.2",
                "display": "Monogenic hearing loss",
                "version": "7"
            }
        ]
    },
    "subject": {
        "reference": "Patient/Patient-MeirLieberman-Example",
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9449307873"
        }
    },
    "authoredOn": "2023-08-05",
    "requester": {
        "reference": "PractitionerRole/PractitionerRole-GeneSmithENT-Example"
    },
    "reasonCode":  [
        {
            "coding":  [
                {
                    "system": "https://fhir.nhs.uk/CodeSystem/reasonfortesting-genomics",
                    "code": "diagnostic",
                    "display": "Diagnostic"
                }
            ]
        }
    ],
    "supportingInfo":  [
        {
            "reference": "Observation/Observation-DiseaseStatus-Example"
        },
        {
            "reference": "Observation/Observation-GenomicEthnicity-Example"
        },
        {
            "reference": "Observation/Observation-NoPregnancy-Example"
        },
        {
            "reference": "Observation/Observation-NoTransplant-Example"
        },
        {
            "reference": "Observation/Observation-NoTransfusion-Example"
        },
        {
            "reference": "Condition/Condition-HearingLoss-Example"
        }
    ],
    "note":  [
        {
            "text": "No family history of genomic testing"
        },
        {
            "text": "Free text for diagnosis/reason for referral, relevant information including family history, phenotypic details/ HPO Terms/Patient in need of test...example"
        }
    ]
}

<ServiceRequest xmlns="http://hl7.org/fhir">
    <id value="ServiceRequest-NonWGSTestOrderForm-Example" />
    <extension url="https://fhir.hl7.org.uk/StructureDefinition/Extension-UKCore-Coverage">
        <valueCodeableConcept>
            <coding>
                <system value="https://fhir.hl7.org.uk/CodeSystem/UKCore-FundingCategory" />
                <code value="nhs-england" />
                <display value="NHS England" />
            </coding>
        </valueCodeableConcept>
    </extension>
    <status value="active" />
    <intent value="order" />
    <category>
        <coding>
            <system value="https://fhir.hl7.org.uk/CodeSystem/UKCore-GenomeSequencingCategory" />
            <code value="rare-disease-non-wgs" />
            <display value="Rare Disease - Non-WGS" />
        </coding>
    </category>
    <priority value="routine" />
    <code>
        <coding>
            <system value="https://fhir.nhs.uk/CodeSystem/England-GenomicTestDirectory" />
            <version value="7" />
            <code value="R67.2" />
            <display value="Monogenic hearing loss" />
        </coding>
    </code>
    <subject>
        <reference value="Patient/Patient-MeirLieberman-Example" />
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9449307873" />
        </identifier>
    </subject>
    <authoredOn value="2023-08-05" />
    <requester>
        <reference value="PractitionerRole/PractitionerRole-GeneSmithENT-Example" />
    </requester>
    <reasonCode>
        <coding>
            <system value="https://fhir.nhs.uk/CodeSystem/reasonfortesting-genomics" />
            <code value="diagnostic" />
            <display value="Diagnostic" />
        </coding>
    </reasonCode>
    <supportingInfo>
        <reference value="Observation/Observation-DiseaseStatus-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-GenomicEthnicity-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NoPregnancy-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NoTransplant-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Observation/Observation-NoTransfusion-Example" />
    </supportingInfo>
    <supportingInfo>
        <reference value="Condition/Condition-HearingLoss-Example" />
    </supportingInfo>
    <note>
        <text value="No family history of genomic testing" />
    </note>
    <note>
        <text value="Free text for diagnosis/reason for referral, relevant information including family history, phenotypic details/ HPO Terms/Patient in need of test...example" />
    </note>
</ServiceRequest>

Propose a change to ServiceRequest-NonWGSTestOrderForm-Example

{
    "resourceType": "ServiceRequest",
    "id": "ServiceRequest-NonWGSTestOrderForm-FetalScenario-Example",
    "extension":  [
        {
            "url": "https://fhir.hl7.org.uk/StructureDefinition/Extension-UKCore-Coverage",
            "valueCodeableConcept": {
                "coding":  [
                    {
                        "system": "https://fhir.hl7.org.uk/CodeSystem/UKCore-FundingCategory",
                        "code": "nhs-england",
                        "display": "NHS England"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "category":  [
        {
            "coding":  [
                {
                    "system": "https://fhir.hl7.org.uk/CodeSystem/UKCore-GenomeSequencingCategory",
                    "code": "rare-disease-non-wgs",
                    "display": "Rare Disease - Non-WGS"
                }
            ]
        }
    ],
    "priority": "urgent",
    "code": {
        "coding":  [
            {
                "system": "https://fhir.nhs.uk/CodeSystem/England-GenomicTestDirectory",
                "code": "R21",
                "display": "Fetal anomalies with a likely genetic cause",
                "version": "7"
            }
        ]
    },
    "subject": {
        "reference": "Patient/Patient-FoetusOfRyanneBoulder-Example",
        "identifier":  [
            {
                "system": "urn:oid:2.16.840.1.113883.2.1.3.2.4.18.24",
                "value": "FT-RWT13521",
                "assigner": {
                    "identifier": {
                        "system": "https://fhir.nhs.uk/Id/ods-organization-code",
                        "value": "RAX"
                    }
                }
            }
        ]
    },
    "authoredOn": "2023-09-25",
    "requester": {
        "reference": "PractitionerRole/PractitionerRole-LoisLaneKingstonClinicalGenetics-Example"
    },
    "reasonCode":  [
        {
            "coding":  [
                {
                    "system": "https://fhir.nhs.uk/CodeSystem/reasonfortesting-genomics",
                    "code": "staging-or-prognosis",
                    "display": "Staging or Prognosis"
                }
            ]
        }
    ],
    "supportingInfo":  [
        {
            "reference": "Observation/Observation-HistoryOfFetalLoss-Example"
        },
        {
            "reference": "Observation/Observation-NonConsanguinousUnion-Example"
        },
        {
            "reference": "Observation/Observation-GenomicEthnicity-Example"
        },
        {
            "reference": "Observation/Observation-PregnancyConfirmation-Example"
        },
        {
            "reference": "Observation/Observation-NoTransplant-Example"
        },
        {
            "reference": "Observation/Observation-NoFirstTrimesterFetalAnomalies-Example"
        },
        {
            "reference": "Observation/Observation-NoSecondTrimesterFetalAnomalies-Example"
        },
        {
            "reference": "Procedure/Procedure-InVitroFertilisation-Example"
        },
        {
            "reference": "RelatedPerson/RelatedPerson-RyanneBoulder-Example"
        },
        {
            "reference": "Patient/Patient-RyanneBoulder-Example"
        },
        {
            "reference": "RelatedPerson/RelatedPerson-RyanneBoulderPartner-Example"
        },
        {
            "reference": "Patient/Patient-RyanneBoulderPartner-Example"
        },
        {
            "reference": "Specimen/Specimen-BloodEDTA-Example"
        },
        {
            "reference": "Specimen/Specimen-RyanneBoulderSaliva-Example"
        }
    ],
    "note":  [
        {
            "text": "Samples are to be provided at a later date"
        },
        {
            "text": "No family history of relevant testing"
        },
        {
            "text": "Free text for diagnosis/reason for referral, relevant information including family history, phenotypic details/ HPO Terms/ E.g. large echogenic kidneys with normal bladder"
        }
    ]
}