MII-Initiative

MII_IG_Medikation_v2

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Medication

Die Medikation, die angesetzt, geplant oder verabreicht wird. Es kann sich um ein Fertigarzneimittel oder eine Rezeptur handeln. Auch die Angabe nur des Wirkstoffes ist möglich. Die Angabe mindestens eines Wirkstoffes wird verlangt.

nameurl
MII_PR_Medikation_Medicationhttps://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/Medication

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id0..1string
WirkstofftypS I0..1Extension(Coding)
WirkstoffrelationS I0..*Extension(Complex)
modifierExtensionΣ ?! I0..*Extension
itemReferenceS0..1Reference(Substance | Medication)
id0..1string
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id0..1string
WirkstofftypS I0..1Extension(Coding)
WirkstoffrelationS I0..*Extension(Complex)
modifierExtensionΣ ?! I0..*Extension
itemReferenceS0..1Reference(Substance | Medication)
id0..1string
extensionI0..*Extension
id0..1string
extensionI0..*Extension
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WirkstofftypS I0..1Extension(Coding)
WirkstoffrelationS I0..*Extension(Complex)
modifierExtensionΣ ?! I0..*Extension
itemReferenceS0..1Reference(Substance | Medication)
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{
    "resourceType": "StructureDefinition",
    "id": "mii-pr-medikation-medication",
    "url": "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/Medication",
    "version": "2.0.0",
    "name": "MII_PR_Medikation_Medication",
    "_name": {
        "extension":  [
            {
                "url": "http://hl7.org/fhir/StructureDefinition/translation",
                "extension":  [
                    {
                        "url": "lang",
                        "valueCode": "en-US"
                    },
                    {
                        "url": "content",
                        "valueString": "MII_PR_Medikation_Medication"
                    }
                ]
            }
        ]
    },
    "title": "MII PR Medikation Medication",
    "_title": {
        "extension":  [
            {
                "url": "http://hl7.org/fhir/StructureDefinition/translation",
                "extension":  [
                    {
                        "url": "lang",
                        "valueCode": "en-US"
                    },
                    {
                        "url": "content",
                        "valueString": "MII PR Medikation Medication"
                    }
                ]
            }
        ]
    },
    "status": "active",
    "date": "2022-05-18",
    "publisher": "Medizininformatik Initiative",
    "contact":  [
        {
            "telecom":  [
                {
                    "system": "url",
                    "value": "https://www.medizininformatik-initiative.de"
                }
            ]
        }
    ],
    "description": "Dieses Profil beschreibt die Medikation, die angesetzt, geplant oder verabreicht wird. Es kann sich um ein Fertigarzneimittel oder eine Rezeptur handeln. Auch die Angabe nur des Wirkstoffes ist möglich. Die Angabe mindestens eines Wirkstoffes wird verlangt.",
    "_description": {
        "extension":  [
            {
                "url": "http://hl7.org/fhir/StructureDefinition/translation",
                "extension":  [
                    {
                        "url": "lang",
                        "valueCode": "en-US"
                    },
                    {
                        "url": "content",
                        "valueString": "The profile describes a prepackaged drug or formulation."
                    }
                ]
            }
        ]
    },
    "fhirVersion": "4.0.1",
    "mapping":  [
        {
            "identity": "script10.6",
            "uri": "http://ncpdp.org/SCRIPT10_6",
            "name": "Mapping to NCPDP SCRIPT 10.6"
        },
        {
            "identity": "rim",
            "uri": "http://hl7.org/v3",
            "name": "RIM Mapping"
        },
        {
            "identity": "w5",
            "uri": "http://hl7.org/fhir/fivews",
            "name": "FiveWs Pattern Mapping"
        },
        {
            "identity": "v2",
            "uri": "http://hl7.org/v2",
            "name": "HL7 v2 Mapping"
        }
    ],
    "kind": "resource",
    "abstract": false,
    "type": "Medication",
    "baseDefinition": "http://hl7.org/fhir/StructureDefinition/Medication",
    "derivation": "constraint",
    "differential": {
        "element":  [
            {
                "id": "Medication",
                "path": "Medication",
                "comment": "MI-I Medikation"
            },
            {
                "id": "Medication.id",
                "path": "Medication.id",
                "mustSupport": true
            },
            {
                "id": "Medication.meta",
                "path": "Medication.meta",
                "mustSupport": true
            },
            {
                "id": "Medication.meta.source",
                "path": "Medication.meta.source",
                "mustSupport": true
            },
            {
                "id": "Medication.meta.profile",
                "path": "Medication.meta.profile",
                "mustSupport": true
            },
            {
                "id": "Medication.code",
                "path": "Medication.code",
                "mustSupport": true
            },
            {
                "id": "Medication.code.coding",
                "path": "Medication.code.coding",
                "slicing": {
                    "discriminator":  [
                        {
                            "type": "pattern",
                            "path": "$this"
                        }
                    ],
                    "rules": "open"
                },
                "mustSupport": true
            },
            {
                "id": "Medication.code.coding:Pharmazentralnummer",
                "path": "Medication.code.coding",
                "sliceName": "Pharmazentralnummer",
                "min": 0,
                "max": "*",
                "patternCoding": {
                    "system": "http://fhir.de/CodeSystem/ifa/pzn"
                },
                "mustSupport": true
            },
            {
                "id": "Medication.code.coding:Pharmazentralnummer.system",
                "path": "Medication.code.coding.system",
                "min": 1,
                "mustSupport": true
            },
            {
                "id": "Medication.code.coding:Pharmazentralnummer.code",
                "path": "Medication.code.coding.code",
                "min": 1,
                "mustSupport": true
            },
            {
                "id": "Medication.code.coding:atcClassDe",
                "path": "Medication.code.coding",
                "sliceName": "atcClassDe",
                "short": "ATC Klassifikation deutsche Version",
                "definition": "ATC-Codes für Fertigarzneimittel bspw. von Kombiprodukten",
                "min": 0,
                "max": "*",
                "patternCoding": {
                    "system": "http://fhir.de/CodeSystem/bfarm/atc"
                },
                "mustSupport": true,
                "binding": {
                    "strength": "required",
                    "valueSet": "http://fhir.de/ValueSet/bfarm/atc"
                }
            },
            {
                "id": "Medication.code.coding:atcClassDe.system",
                "path": "Medication.code.coding.system",
                "min": 1,
                "mustSupport": true
            },
            {
                "id": "Medication.code.coding:atcClassDe.code",
                "path": "Medication.code.coding.code",
                "min": 1,
                "mustSupport": true
            },
            {
                "id": "Medication.code.coding:atcClassEn",
                "path": "Medication.code.coding",
                "sliceName": "atcClassEn",
                "short": "Anatomical Therapeutic Chemical Classification System",
                "definition": "ATC Classification International WHO Version",
                "min": 0,
                "max": "*",
                "patternCoding": {
                    "system": "http://www.whocc.no/atc"
                },
                "mustSupport": true
            },
            {
                "id": "Medication.code.coding:atcClassEn.system",
                "path": "Medication.code.coding.system",
                "min": 1,
                "mustSupport": true
            },
            {
                "id": "Medication.code.coding:atcClassEn.code",
                "path": "Medication.code.coding.code",
                "min": 1,
                "mustSupport": true
            },
            {
                "id": "Medication.code.text",
                "path": "Medication.code.text",
                "mustSupport": true
            },
            {
                "id": "Medication.form",
                "path": "Medication.form",
                "mustSupport": true,
                "binding": {
                    "strength": "preferred",
                    "valueSet": "http://hl7.org/fhir/uv/ips/ValueSet/medicine-doseform"
                }
            },
            {
                "id": "Medication.form.coding",
                "path": "Medication.form.coding",
                "slicing": {
                    "discriminator":  [
                        {
                            "type": "pattern",
                            "path": "$this"
                        }
                    ],
                    "rules": "open"
                },
                "definition": "EDQM pharmaceutical dose forms sind bevorzugt zu verwenden. SNOMED CT und IFA Codes sind Alternativen.",
                "mustSupport": true
            },
            {
                "id": "Medication.form.coding:EDQM",
                "path": "Medication.form.coding",
                "sliceName": "EDQM",
                "min": 0,
                "max": "*",
                "patternCoding": {
                    "system": "http://standardterms.edqm.eu"
                },
                "mustSupport": true
            },
            {
                "id": "Medication.form.coding:EDQM.system",
                "path": "Medication.form.coding.system",
                "min": 1,
                "mustSupport": true
            },
            {
                "id": "Medication.form.coding:EDQM.code",
                "path": "Medication.form.coding.code",
                "min": 1,
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient",
                "path": "Medication.ingredient",
                "min": 1,
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.extension",
                "path": "Medication.ingredient.extension",
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.extension:Wirkstofftyp",
                "path": "Medication.ingredient.extension",
                "sliceName": "Wirkstofftyp",
                "min": 0,
                "max": "1",
                "type":  [
                    {
                        "code": "Extension",
                        "profile":  [
                            "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/wirkstofftyp"
                        ]
                    }
                ],
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.extension:Wirkstoffrelation",
                "path": "Medication.ingredient.extension",
                "sliceName": "Wirkstoffrelation",
                "min": 0,
                "max": "*",
                "type":  [
                    {
                        "code": "Extension",
                        "profile":  [
                            "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/wirkstoffrelation"
                        ]
                    }
                ],
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.item[x]",
                "path": "Medication.ingredient.item[x]",
                "slicing": {
                    "discriminator":  [
                        {
                            "type": "type",
                            "path": "$this"
                        }
                    ],
                    "rules": "open"
                }
            },
            {
                "id": "Medication.ingredient.item[x]:itemReference",
                "path": "Medication.ingredient.item[x]",
                "sliceName": "itemReference",
                "min": 0,
                "max": "1",
                "type":  [
                    {
                        "code": "Reference",
                        "targetProfile":  [
                            "http://hl7.org/fhir/StructureDefinition/Substance",
                            "http://hl7.org/fhir/StructureDefinition/Medication"
                        ]
                    }
                ],
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.item[x]:itemCodeableConcept",
                "path": "Medication.ingredient.item[x]",
                "sliceName": "itemCodeableConcept",
                "min": 0,
                "max": "1",
                "type":  [
                    {
                        "code": "CodeableConcept"
                    }
                ],
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.item[x]:itemCodeableConcept.coding",
                "path": "Medication.ingredient.item[x].coding",
                "slicing": {
                    "discriminator":  [
                        {
                            "type": "pattern",
                            "path": "$this"
                        }
                    ],
                    "rules": "open"
                },
                "min": 1,
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.item[x]:itemCodeableConcept.coding:ASK",
                "path": "Medication.ingredient.item[x].coding",
                "sliceName": "ASK",
                "short": "Arzneistoffkatalog(ASK)-Nummer",
                "min": 0,
                "max": "*",
                "patternCoding": {
                    "system": "http://fhir.de/CodeSystem/ask"
                },
                "mustSupport": true,
                "binding": {
                    "strength": "example",
                    "valueSet": "http://fhir.de/ValueSet/ask"
                }
            },
            {
                "id": "Medication.ingredient.item[x]:itemCodeableConcept.coding:ASK.system",
                "path": "Medication.ingredient.item[x].coding.system",
                "min": 1,
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.item[x]:itemCodeableConcept.coding:ASK.code",
                "path": "Medication.ingredient.item[x].coding.code",
                "min": 1,
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.item[x]:itemCodeableConcept.coding:UNII",
                "path": "Medication.ingredient.item[x].coding",
                "sliceName": "UNII",
                "short": "Unique Ingredient Identifier",
                "min": 0,
                "max": "*",
                "patternCoding": {
                    "system": "http://fdasis.nlm.nih.gov"
                },
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.item[x]:itemCodeableConcept.coding:UNII.system",
                "path": "Medication.ingredient.item[x].coding.system",
                "min": 1,
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.item[x]:itemCodeableConcept.coding:UNII.code",
                "path": "Medication.ingredient.item[x].coding.code",
                "min": 1,
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.item[x]:itemCodeableConcept.coding:CAS",
                "path": "Medication.ingredient.item[x].coding",
                "sliceName": "CAS",
                "short": "Chemical abstract codes",
                "min": 0,
                "max": "*",
                "patternCoding": {
                    "system": "urn:oid:2.16.840.1.113883.6.61"
                },
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.item[x]:itemCodeableConcept.coding:CAS.system",
                "path": "Medication.ingredient.item[x].coding.system",
                "min": 1,
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.item[x]:itemCodeableConcept.coding:CAS.code",
                "path": "Medication.ingredient.item[x].coding.code",
                "min": 1,
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.item[x]:itemCodeableConcept.coding:SNOMED",
                "path": "Medication.ingredient.item[x].coding",
                "sliceName": "SNOMED",
                "min": 0,
                "max": "*",
                "patternCoding": {
                    "system": "http://snomed.info/sct"
                },
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.item[x]:itemCodeableConcept.coding:SNOMED.system",
                "path": "Medication.ingredient.item[x].coding.system",
                "min": 1,
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.item[x]:itemCodeableConcept.coding:SNOMED.code",
                "path": "Medication.ingredient.item[x].coding.code",
                "min": 1,
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.item[x]:itemCodeableConcept.text",
                "path": "Medication.ingredient.item[x].text",
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.strength",
                "path": "Medication.ingredient.strength",
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.strength.numerator",
                "path": "Medication.ingredient.strength.numerator",
                "mustSupport": true
            },
            {
                "id": "Medication.ingredient.strength.denominator",
                "path": "Medication.ingredient.strength.denominator",
                "mustSupport": true
            }
        ]
    }
}

FHIRDatensatzErklaerung
Medication.codeBasismodulMedikation.Medikation.Code

Ein Code (oder eine Reihe von Codes), die dieses Medikament spezifizieren, oder eine Textbeschreibung, wenn kein Code verfügbar ist.

Medication.formBasismodulMedikation.Medikation.Darreichungsform

Darreichungsform nach EDQM

Medication.ingredientBasismodulMedikation.Medikation.Bestandteil

Aktiver oder nicht-aktiver Inhaltsstoff. Identifiziert einen bestimmten Bestandteil der Medikation.

Medication.ingredient.itemCodeableConceptBasismodulMedikation.Medikation.Bestandteil.Code

Ein Code für den Inhaltsstoff oder Wirkstoff, z.B. aus ASK, UNII, CAS oder SNOMED CT.

Medication.ingredient.extension:WirkstofftypBasismodulMedikation.Medikation.Bestandteil.Wirkstofftyp

Differenzierung des Wirkstofftyps in allgemeinen, genauen oder Kombinationswirkstoff.

Medication.ingredient.strengthBasismodulMedikation.Medikation.Bestandteil.MengeStaerke

Wirkstärke, Menge der aktiven Substanz pro Dosiseinheit entsprechend Darreichungsform (1 Tablette, 1 Ampulle, 1 mL etc.)


Suchparameter

Folgende Suchparameter sind für das Modul Medikation relevant, auch in Kombination:

  1. Der Suchparameter _id MUSS unterstützt werden:

    Beispiele:

    GET [base]/Medication?_id=1234

    Anwendungshinweise: Weitere Informationen zur Suche nach "_id" finden sich in der FHIR-Basisspezifikation - Abschnitt "Parameters for all resources".

  2. Der Suchparameter "_profile" MUSS unterstützt werden:

    Beispiele:

    GET [base]/Medication?_profile=https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/Medication

    Anwendungshinweise: Weitere Informationen zur Suche nach "_profile" finden sich in der FHIR-Basisspezifikation - Abschnitt "token".

  3. Der Suchparameter "code" MUSS unterstützt werden:

    Beispiele:

    GET [base]/Medication?code=http://fhir.de/CodeSystem/bfarm/atc|B01AC06

    Anwendungshinweise: Weitere Informationen zur Suche nach "code" finden sich in der FHIR-Basisspezifikation - Abschnitt "token".

  4. Der Suchparameter "form" MUSS unterstützt werden:

    Beispiele:

    GET [base]/Medication?form=http://standardterms.edqm.eu|10219000

    Anwendungshinweise: Weitere Informationen zur Suche nach "code" finden sich in der FHIR-Basisspezifikation - Abschnitt "token".

  5. Der Suchparameter "ingredient" MUSS unterstützt werden:

    Beispiele:

    GET [base]/Medication?ingredient=Medication/mii-exa-medikation-medication-dolomo-tag

    Anwendungshinweise: Weitere Informationen zur Suche nach "based-on" finden sich in der FHIR-Basisspezifikation - Abschnitt "reference".

  6. Der Suchparameter "ingredient-code" MUSS unterstützt werden:

    Beispiele:

    GET [base]/Medication?ingredient-code=http://fhir.de/CodeSystem/ask|00002

    Anwendungshinweise: Weitere Informationen zur Suche nach "code" finden sich in der FHIR-Basisspezifikation - Abschnitt "token".

  7. Der Suchparameter "ingredient-strength-numerator" MUSS unterstützt werden:

    Beispiele:

    GET [base]/Medication?ingredient-strength-numerator=100|http://unitsofmeasure.org|mg

    Anwendungshinweise: Weitere Informationen zur Suche nach "ingredient-strength-numerator" finden sich in der FHIR-Basisspezifikation - Abschnitt "quantity".

  8. Der Suchparameter "ingredient-strength-denominator" MUSS unterstützt werden:

    Beispiele:

    GET [base]/Medication?ingredient-strength-denominator=1|http://standardterms.edqm.eu|10219000

    Anwendungshinweise: Weitere Informationen zur Suche nach "ingredient-strength-denominator" finden sich in der FHIR-Basisspezifikation - Abschnitt "quantity".

  9. Der Suchparameter "ingredient-strength" MUSS unterstützt werden:

    Beispiele:

    GET [base]/Medication?ingredient-strength=100|http://unitsofmeasure.org|mg$1|http://standardterms.edqm.eu|10219000

    Anwendungshinweise: Weitere Informationen zur Suche nach "ingredient-strength" finden sich in der FHIR-Basisspezifikation - Abschnitt "composite".


Beispiele

Beispiel einer Medication-Ressource für ein Fertigarzneimittel mit Angabe einer Pharmazentralnummer, Darreichungsform, Wirkstoff und Wirkstärke:

{
    "resourceType": "Medication",
    "id": "mii-exa-medikation-medication-ass-100",
    "meta": {
        "profile":  [
            "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/Medication"
        ]
    },
    "code": {
        "coding":  [
            {
                "code": "06312077",
                "system": "http://fhir.de/CodeSystem/ifa/pzn",
                "display": "ASS 100 - 1a Pharma TAH Tabletten"
            },
            {
                "code": "B01AC06",
                "system": "http://fhir.de/CodeSystem/bfarm/atc",
                "display": "acetylsalicylic acid"
            }
        ]
    },
    "form": {
        "coding":  [
            {
                "code": "10219000",
                "system": "http://standardterms.edqm.eu",
                "display": "Tablet"
            }
        ]
    },
    "ingredient":  [
        {
            "itemCodeableConcept": {
                "coding":  [
                    {
                        "code": "00002",
                        "system": "http://fhir.de/CodeSystem/ask",
                        "display": "Acetylsalicylsäure"
                    }
                ]
            },
            "strength": {
                "numerator": {
                    "value": 100,
                    "code": "mg",
                    "system": "http://unitsofmeasure.org",
                    "unit": "milligram"
                },
                "denominator": {
                    "value": 1,
                    "code": "10219000",
                    "system": "http://standardterms.edqm.eu",
                    "unit": "Tablet"
                }
            }
        }
    ]
}


Beispiel einer Medication-Ressource für eine Infusionslösung mit Angabe der Darreichungsform, Wirkstoff und Wirkstärke, sowie weitere Bestandteile in Form einer Referenz auf eine eigene Medication-Ressource für die Glucoselösung. Medication.code enthält in diesem Fall nur das text-Element:

{
    "resourceType": "Medication",
    "id": "mii-exa-medikation-medication-rezeptur",
    "meta": {
        "profile":  [
            "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/Medication"
        ]
    },
    "code": {
        "text": "Infusion bestehend aus 85mg Doxorubicin aufgeloest zur Verabreichung in 250ml 5-%iger (50 mg/ml) Glucose-Infusionsloesung"
    },
    "form": {
        "coding":  [
            {
                "code": "11210000",
                "system": "http://standardterms.edqm.eu",
                "display": "Solution for infusion"
            }
        ]
    },
    "ingredient":  [
        {
            "isActive": true,
            "itemCodeableConcept": {
                "coding":  [
                    {
                        "code": "L01DB01",
                        "system": "http://fhir.de/CodeSystem/bfarm/atc",
                        "display": "Doxorubicin"
                    }
                ]
            },
            "strength": {
                "denominator": {
                    "value": 250,
                    "code": "mL",
                    "system": "http://unitsofmeasure.org",
                    "unit": "milliliter"
                },
                "numerator": {
                    "value": 85,
                    "code": "mg",
                    "system": "http://unitsofmeasure.org",
                    "unit": "mg"
                }
            }
        },
        {
            "isActive": true,
            "itemReference": {
                "reference": "Medication/mii-exa-medikation-medication-glucoseloesung"
            }
        }
    ],
    "status": "active"
}


Die im vorrangegangenen Beispiel referenzierte Medication-Ressource:

{
    "resourceType": "Medication",
    "id": "mii-exa-medikation-medication-glucoseloesung",
    "meta": {
        "profile":  [
            "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/Medication"
        ]
    },
    "code": {
        "coding":  [
            {
                "code": "03705422",
                "system": "http://fhir.de/CodeSystem/ifa/pzn",
                "display": "Glucose 5% B.braun Ecoflac Plus"
            },
            {
                "code": "V06DC01",
                "system": "http://fhir.de/CodeSystem/bfarm/atc",
                "display": "Glucose"
            },
            {
                "code": "V06DC01",
                "system": "http://www.whocc.no/atc",
                "display": "glucose"
            }
        ]
    },
    "form": {
        "coding":  [
            {
                "code": "11210000",
                "system": "http://standardterms.edqm.eu",
                "display": "Solution for infusion"
            }
        ]
    },
    "ingredient":  [
        {
            "isActive": true,
            "itemCodeableConcept": {
                "coding":  [
                    {
                        "code": "12829",
                        "system": "http://fhir.de/CodeSystem/ask",
                        "display": "Glucose"
                    },
                    {
                        "code": "50-99-7",
                        "system": "urn:oid:2.16.840.1.113883.6.61",
                        "display": "Glucose"
                    },
                    {
                        "code": "5SL0G7R0OK",
                        "system": "http://fdasis.nlm.nih.gov",
                        "display": "ANHYDROUS DEXTROSE"
                    },
                    {
                        "code": "67079006",
                        "system": "http://snomed.info/sct",
                        "display": "Glucose (substance)"
                    }
                ]
            },
            "strength": {
                "denominator": {
                    "value": 1000,
                    "code": "ml",
                    "system": "http://unitsofmeasure.org",
                    "unit": "ml"
                },
                "numerator": {
                    "value": 50,
                    "code": "g",
                    "system": "http://unitsofmeasure.org",
                    "unit": "g"
                }
            }
        },
        {
            "isActive": false,
            "itemCodeableConcept": {
                "coding":  [
                    {
                        "code": "00343",
                        "system": "http://fhir.de/CodeSystem/ask",
                        "display": "Wasser für Injektionszwecke"
                    },
                    {
                        "code": "7732-18-5",
                        "system": "urn:oid:2.16.840.1.113883.6.61",
                        "display": "WATER"
                    },
                    {
                        "code": "059QF0KO0R",
                        "system": "http://fdasis.nlm.nih.gov",
                        "display": "WATER"
                    },
                    {
                        "code": "11713004",
                        "system": "http://snomed.info/sct",
                        "display": "Water (substance)"
                    }
                ]
            }
        }
    ],
    "status": "active"
}


Die folgenden drei Ressourcen bilden zusammen ein Beispiel für die Darstellung von Kombipackungen. Bei dem Beispiel handelt es sich um eine Arzneimittel dessen Packung zwei unterschiedliche pharmazeutische Produkte enthält. Die erste Instanz der Medication Ressource enthält den PZN Code für das Produkt. In Medication.amount steht die vollständige Anzahl der in der Packung enthaltenen Tabletten. In Medication.ingredient.itemReference wird auf die zwei separate Medication Instanzen referenziert, die jeweils die in der Packung enthaltenen pharmazeutischen Produkte beschreiben mit Anzahl der Tabletten, Wirkstoffen und deren Wirkstärke.

{
    "resourceType": "Medication",
    "id": "mii-exa-medikation-medication-dolomo",
    "meta": {
        "profile":  [
            "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/Medication"
        ]
    },
    "code": {
        "coding":  [
            {
                "system": "http://fhir.de/CodeSystem/ifa/pzn",
                "code": "02758994",
                "display": "dolomo® TN"
            },
            {
                "system": "http://fhir.de/CodeSystem/bfarm/atc",
                "code": "N02BE51",
                "display": "Paracetamol, Kombinationen exkl. Psycholeptika"
            }
        ]
    },
    "form": {
        "coding":  [
            {
                "system": "http://standardterms.edqm.eu",
                "code": "10219000",
                "display": "Tablet"
            }
        ]
    },
    "amount": {
        "numerator": {
            "value": 27,
            "unit": "Tablet",
            "system": "http://standardterms.edqm.eu",
            "code": "10219000"
        },
        "denominator": {
            "value": 1,
            "unit": "Package",
            "system": "http://unitsofmeasure.org",
            "code": "1"
        }
    },
    "ingredient":  [
        {
            "itemReference": {
                "reference": "Medication/mii-exa-medikation-medication-dolomo-tag"
            }
        },
        {
            "itemReference": {
                "reference": "Medication/mii-exa-medikation-medication-dolomo-nacht"
            }
        }
    ]
}

Medication Ressource des ersten referenzierten pharmazeutischen Produktes.

{
    "resourceType": "Medication",
    "id": "mii-exa-medikation-medication-dolomo-tag",
    "meta": {
        "profile":  [
            "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/Medication"
        ]
    },
    "code": {
        "coding":  [
            {
                "system": "http://fhir.de/CodeSystem/bfarm/atc",
                "code": "N02BE51",
                "display": "Paracetamol, Kombinationen exkl. Psycholeptika"
            }
        ]
    },
    "form": {
        "coding":  [
            {
                "system": "http://standardterms.edqm.eu",
                "code": "10219000",
                "display": "Tablet"
            }
        ]
    },
    "amount": {
        "