Covid-19 therapy


Parameter Case Report Form and Response Options

Pharmacological therapy for Covid-19
Antipyretics
Corticosteroids
Atazanavir
Darunavir
Chloroquine phosphate
Hydroxychloroquine
Ivermectin
Lopinavir/ritonavir
Ganciclovir
Oseltamivir
Remdesivir
Ribavirin
Camostat
Favipiravir
Convalescent plasma
Steroids (> 0.5 mg/kg prednisone equivalents)
Steroids (<= 0.5 mg/kg prednisone equivalents)
Tocilizumab
Sarilumab
CNI or mTor inhibitors (e.g. cyclosporin A, tacrolimus, sirolimus, everolimus)
Anti-TNF-alpha inhibitors (e.g. adalimumab, etanercept)
Il1-receptor antangonists
Ruxolitinib
Colchicine
Interferone (any)
25-Hydroxyvitamin D
Zinc
Other

This profile of a FHIR MedicationStatement is derived from the MedicationStatement-profile of the Medical Informatics Initiative (MII).

Use MedicationStatement.medication[x]:medicationCodeableConcept to code the case parameter form response options.


Profile - Pharmacological Therapy

Canonical: https://www.netzwerk-universitaetsmedizin.de/fhir/StructureDefinition/pharmacological-therapy

Snapshot

identifierΣ0..*Identifier
basedOnΣ I0..*Reference(MedicationRequest | CarePlan | ServiceRequest)
partOfS Σ I0..*Reference(MedicationAdministration | MedicationDispense | MedicationStatement | Procedure | Observation)
statusS Σ ?!1..1codeBinding
statusReason0..*CodeableConcept
categoryΣ0..1CodeableConceptBinding
systemΣ1..1uri
versionΣ0..1string
codeΣ1..1code
displayΣ0..1string
userSelectedΣ0..1boolean
systemΣ1..1uri
versionΣ0..1string
codeΣ1..1code
displayΣ0..1string
userSelectedΣ0..1boolean
systemΣ1..1uri
versionΣ0..1string
codeΣ1..1code
displayΣ0..1string
userSelectedΣ0..1boolean
systemΣ1..1uri
versionΣ0..1string
codeΣ1..1code
displayΣ0..1string
userSelectedΣ0..1boolean
textΣ0..1string
subjectS Σ I1..1MII-Reference(Patient | Group)
contextS Σ I0..1Reference(Encounter | EpisodeOfCare)
effectiveDateTimedateTime
effectivePeriodPeriod
dateAssertedΣ0..1dateTime
informationSourceI0..1Reference(Patient | Practitioner | PractitionerRole | RelatedPerson | Organization)
derivedFromI0..*Reference(Resource)
reasonCode0..*CodeableConcept
reasonReferenceS I0..*Reference(Condition | Observation | DiagnosticReport)
note0..*Annotation
sequenceΣ0..1integer
textS Σ0..1string
additionalInstructionΣ0..*CodeableConcept
patientInstructionΣ0..1string
timingS Σ0..1Timing
asNeededBooleanboolean
asNeededCodeableConceptCodeableConcept
systemS Σ1..1uri
versionΣ0..1string
codeS Σ1..1code
displayΣ0..1string
userSelectedΣ0..1boolean
textΣ0..1string
systemS Σ1..1uri
versionΣ0..1string
codeS Σ1..1code
displayΣ0..1string
userSelectedΣ0..1boolean
systemS Σ1..1uri
versionΣ0..1string
codeS Σ1..1code
displayΣ0..1string
userSelectedΣ0..1boolean
textΣ0..1string
methodΣ0..1CodeableConcept
typeΣ0..1CodeableConcept
doseRangeRange
doseQuantitySimpleQuantity
rateRatioRatio
rateRangeRange
rateQuantitySimpleQuantity
maxDosePerPeriodΣ I0..1Ratio
maxDosePerAdministrationΣ I0..1SimpleQuantity
maxDosePerLifetimeΣ I0..1SimpleQuantity


ValueSets

Valuesets are provided with ATC and OPS codes for some medications.


Canonical: https://www.netzwerk-universitaetsmedizin.de/fhir/ValueSet/pharmacological-therapy-snomed

ValueSet 'DrugTherapySnomed'

Version1.0.6
Published byBerlin Institute of Health at Charité (BIH)
StatusActive
ExperimentalFalse

Pharmacological therapy in the context of Covid-19, relevant SNOMED-Codes

Contact Information

Website: https://www.bihealth.org/en/re...

This value set includes codes from the following code systems:

  • The following codes from system: SNOMED_CT

    CodeDisplay
    768759001Product containing steroid (product)
    413591007Product containing atazanavir (medicinal product)
    424096001Product containing darunavir (medicinal product)
    14728000Product containing chloroquine (medicinal product)
    83490000Product containing hydroxychloroquine (medicinal product)
    96138006Product containing ivermectin (medicinal product)
    134573001Product containing lopinavir and ritonavir (medicinal product)
    78025001Product containing ganciclovir (medicinal product)
    386142008Product containing oseltamivir (medicinal product)
    870518005Product containing remdesivir (medicinal product)
    35063004Product containing ribavirin (medicinal product)
    444649004Product containing tocilizumab (medicinal product)
    763522001Product containing sarilumab (medicinal product)
    416587008Product containing calcineurin inhibitor (product)
    416897008Product containing tumor necrosis factor alpha inhibitor (product)
    430817009Product containing interleukin 1 receptor antagonist (product)
    703779004Product containing ruxolitinib (medicinal product)
    73133000Product containing colchicine (medicinal product)
    768865007Product containing interferon (product)
    88519001Product containing calcifediol (medicinal product)
    764877006Product containing zinc (medicinal product)
    1187214003Product containing camostat (medicinal product)
    1172871009Product containing favipiravir (medicinal product)
    1184610009Convalescent plasma (product)
    1162706008Product containing casirivimab and imdevimab (medicinal product)
    763701005Product containing baricitinib (medicinal product)
    704316006Product containing tofacitinib (medicinal product)
    1162693002Product containing sotrovimab (medicinal product)
    108693005Product containing ritonavir (medicinal product)
    96034006Product containing azithromycin (medicinal product)
    395279009Product containing anakinra (medicinal product)
    108622005Product containing budesonide (medicinal product)
    416739001Product containing ciclesonide (medicinal product)
    96213009Product containing fluvoxamine (medicinal product)
    46123006Product containing ascorbic acid (medicinal product)
    108943009Product containing colecalciferol (medicinal product)
    59187003Product containing dopamine (medicinal product)
    26523005Product containing dobutamine (medicinal product)
    108480007Product containing milrinone (medicinal product)
    442790008Product containing levosimendan (medicinal product)
    65502005Product containing epinephrine (medicinal product)
    111130009Product containing norepinephrine (medicinal product)
    772208008Product containing antidiuretic hormone (medicinal product)
    54765002Product containing phenylephrine (medicinal product)


Canonical: https://www.netzwerk-universitaetsmedizin.de/fhir/ValueSet/pharmacological-therapy-atc

ValueSet 'DrugTherapyATC'

Version1.0.6
Published byBerlin Institute of Health at Charité (BIH)
StatusActive
ExperimentalFalse

Pharmacological therapy in the context of Covid-19

Contact Information

Website: https://www.bihealth.org/en/re...

This value set includes codes from the following code systems:


Canonical: https://www.netzwerk-universitaetsmedizin.de/fhir/ValueSet/pharmacological-therapy-ops

ValueSet 'DrugTherapyOPS'

Version1.0.6
Published byBerlin Institute of Health at Charité (BIH)
StatusActive
ExperimentalFalse

Pharmacological therapy in the context of Covid-19, relevant OPS-Codes

Contact Information

Website: https://www.bihealth.org/en/re...

This value set includes codes from the following code systems:

  • The following codes from system: OPS

    CodeDisplay
    6-00a.gSarilumab, parenteral
    6-005.8Everolimus, oral
    6-005.7Certolizumab, parenteral
    6-005.2Golimumab, parenteral
    6-006.7Canakinumab, parenteral
    6-009.4Ruxolitinib, oral
  • Include codes from OPS where concept IsA 6-005.m
  • Include codes from OPS where concept IsA 6-005.n
  • Include codes from OPS where concept IsA 6-004.e
  • Include codes from OPS where concept IsA 6-001.d
  • Include codes from OPS where concept IsA 6-002.b
  • Include codes from OPS where concept IsA 6-001.e
  • The following codes from system: OPS

    CodeDisplay
    6-00a.gSarilumab, parenteral
    6-005.8Everolimus, oral
    6-005.7Certolizumab, parenteral
    6-005.2Golimumab, parenteral
    6-006.7Canakinumab, parenteral
    6-009.4Ruxolitinib, oral
  • Include codes from OPS where concept IsA 6-005.m
  • Include codes from OPS where concept IsA 6-005.n
  • Include codes from OPS where concept IsA 6-004.e
  • Include codes from OPS where concept IsA 6-001.d
  • Include codes from OPS where concept IsA 6-002.b
  • Include codes from OPS where concept IsA 6-001.e
  • The following codes from system: OPS

    CodeDisplay
    6-00a.gSarilumab, parenteral
    6-005.8Everolimus, oral
    6-005.7Certolizumab, parenteral
    6-005.2Golimumab, parenteral
    6-006.7Canakinumab, parenteral
    6-009.4Ruxolitinib, oral
  • Include codes from OPS where concept IsA 6-005.m
  • Include codes from OPS where concept IsA 6-005.n
  • Include codes from OPS where concept IsA 6-004.e
  • Include codes from OPS where concept IsA 6-001.d
  • Include codes from OPS where concept IsA 6-002.b
  • Include codes from OPS where concept IsA 6-001.e


Examples

Patient is taking atazanavir

{
    "resourceType": "MedicationStatement",
    "id": "pharmacological-therapy-atazanavir-active",
    "meta": {
        "profile":  [
            "https://www.netzwerk-universitaetsmedizin.de/fhir/StructureDefinition/pharmacological-therapy"
        ]
    },
    "status": "active",
    "medicationCodeableConcept": {
        "coding":  [
            {
                "code": "413591007",
                "system": "http://snomed.info/sct",
                "display": "Product containing atazanavir (medicinal product)"
            },
            {
                "code": "J05AE08",
                "system": "http://fhir.de/CodeSystem/bfarm/atc",
                "display": "Atazanavir"
            }
        ],
        "text": "Atazanavir"
    },
    "subject": {
        "reference": "Patient/gecco-patient"
    },
    "effectiveDateTime": "2020-10-19T08:43:33+02:00"
}