Dose syntax implementation guidance for FHIR STU3

This guidance is under active development by NHS Digital and content may be added or updated on a regular basis.

Fully Coded Examples

The following medicationRequest examples are fully machine-readable in that they do not include any free-text instructions within either additionalInstruction, patientInstruction or text.

Examples use combinations of the following elements of the CareConnect medicationRequest and FHIR Dosage structure;

  • form
  • method
  • doseQuantity
  • frequency, period and frequencyMax
  • when
  • route
  • site
  • asNeededBoolean
  • boundsDuration
  • count
  • event

Where clinically appropriate, each example is shown as both a dose-based and product-based instruction.

Important: Examples are not complete with respect to all mandatory or required data for a CareConnect implementation but instead highlight the variety of use of the FHIR Dosage structure

Oxytetracycline, 250mg, oral, 6 hourly

Product-based instruction using a VMP. Dose expressed 6 hourly. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="720b6ba6-19e5-4168-a412-e5cb1332837a" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="324095003" />
                    <display value="Oxytetracycline 250mg tablets" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <frequency value="1" />
                <period value="6" />
                <periodUnit value="h" />
            </repeat>
        </timing>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="26643006" />
                <display value="oral" />
            </coding>
        </route>
        <doseQuantity>
            <value value="1" />
            <unit value="tablet" />
            <system value="http://snomed.info/sct" />
            <code value="428673006" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "720b6ba6-19e5-4168-a412-e5cb1332837a",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "324095003",
                        "display": "Oxytetracycline 250mg tablets"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "frequency": 1,
                    "period": 6,
                    "periodUnit": "h"
                }
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "26643006",
                        "display": "oral"
                    }
                ]
            },
            "doseQuantity": {
                "value": 1,
                "unit": "tablet",
                "system": "http://snomed.info/sct",
                "code": "428673006"
            }
        }
    ]
}
MedicationRequest.id[0]720b6ba6-19e5-4168-a412-e5cb1332837a
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]324095003
MedicationRequest.contained[0].code[0].coding[0].display[0]Oxytetracycline 250mg tablets
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]6
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]h
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]26643006
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]oral
MedicationRequest.dosageInstruction[0].dose[0].value[0]1
MedicationRequest.dosageInstruction[0].dose[0].unit[0]tablet
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].dose[0].code[0]428673006
MedicationRequest
Dose-based instruction using a VTM. Dose expressed 6 hourly. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="b13724a0-7433-4c01-9c88-968baf91c6b4" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="22969001" />
                    <display value="Oxytetracycline" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <frequency value="1" />
                <period value="6" />
                <periodUnit value="h" />
            </repeat>
        </timing>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="26643006" />
                <display value="oral" />
            </coding>
        </route>
        <doseQuantity>
            <value value="250" />
            <unit value="milligram" />
            <system value="http://unitsofmeasure.org" />
            <code value="mg" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "b13724a0-7433-4c01-9c88-968baf91c6b4",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "22969001",
                        "display": "Oxytetracycline"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "frequency": 1,
                    "period": 6,
                    "periodUnit": "h"
                }
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "26643006",
                        "display": "oral"
                    }
                ]
            },
            "doseQuantity": {
                "value": 250,
                "unit": "milligram",
                "system": "http://unitsofmeasure.org",
                "code": "mg"
            }
        }
    ]
}
MedicationRequest.id[0]b13724a0-7433-4c01-9c88-968baf91c6b4
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]22969001
MedicationRequest.contained[0].code[0].coding[0].display[0]Oxytetracycline
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]6
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]h
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]26643006
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]oral
MedicationRequest.dosageInstruction[0].dose[0].value[0]250
MedicationRequest.dosageInstruction[0].dose[0].unit[0]milligram
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].dose[0].code[0]mg
MedicationRequest

Omeprazole, 10mg, gastro-resistant, oral, once daily

Product-based instruction using a VMP. Dose expressed per day. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="d8360782-bbcb-486d-bcad-e268e68d5a74" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="407846000" />
                    <display value="Omeprazole 10mg gastro-resistant tablets" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <frequency value="1" />
                <period value="1" />
                <periodUnit value="d" />
            </repeat>
        </timing>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="26643006" />
                <display value="oral" />
            </coding>
        </route>
        <doseQuantity>
            <value value="1" />
            <unit value="tablet" />
            <system value="http://snomed.info/sct" />
            <code value="428673006" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "d8360782-bbcb-486d-bcad-e268e68d5a74",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "407846000",
                        "display": "Omeprazole 10mg gastro-resistant tablets"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "frequency": 1,
                    "period": 1,
                    "periodUnit": "d"
                }
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "26643006",
                        "display": "oral"
                    }
                ]
            },
            "doseQuantity": {
                "value": 1,
                "unit": "tablet",
                "system": "http://snomed.info/sct",
                "code": "428673006"
            }
        }
    ]
}
MedicationRequest.id[0]d8360782-bbcb-486d-bcad-e268e68d5a74
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]407846000
MedicationRequest.contained[0].code[0].coding[0].display[0]Omeprazole 10mg gastro-resistant tablets
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]26643006
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]oral
MedicationRequest.dosageInstruction[0].dose[0].value[0]1
MedicationRequest.dosageInstruction[0].dose[0].unit[0]tablet
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].dose[0].code[0]428673006
MedicationRequest
Dose-based instruction using a VTM. Dose expressed per day. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="4de51441-b8af-4362-a825-3efbba3a645b" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="25673006" />
                    <display value="Omeprazole" />
                </coding>
            </code>
            <form>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="385059007" />
                    <display value="gastro-resistant tablet" />
                </coding>
            </form>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <frequency value="1" />
                <period value="1" />
                <periodUnit value="d" />
            </repeat>
        </timing>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="26643006" />
                <display value="oral" />
            </coding>
        </route>
        <doseQuantity>
            <value value="10" />
            <unit value="milligram" />
            <system value="http://unitsofmeasure.org" />
            <code value="mg" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "4de51441-b8af-4362-a825-3efbba3a645b",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "25673006",
                        "display": "Omeprazole"
                    }
                ]
            },
            "form": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "385059007",
                        "display": "gastro-resistant tablet"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "frequency": 1,
                    "period": 1,
                    "periodUnit": "d"
                }
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "26643006",
                        "display": "oral"
                    }
                ]
            },
            "doseQuantity": {
                "value": 10,
                "unit": "milligram",
                "system": "http://unitsofmeasure.org",
                "code": "mg"
            }
        }
    ]
}
MedicationRequest.id[0]4de51441-b8af-4362-a825-3efbba3a645b
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]25673006
MedicationRequest.contained[0].code[0].coding[0].display[0]Omeprazole
MedicationRequest.contained[0].form[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].form[0].coding[0].code[0]385059007
MedicationRequest.contained[0].form[0].coding[0].display[0]gastro-resistant tablet
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]26643006
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]oral
MedicationRequest.dosageInstruction[0].dose[0].value[0]10
MedicationRequest.dosageInstruction[0].dose[0].unit[0]milligram
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].dose[0].code[0]mg
MedicationRequest

Trimethoprim, 200mg, oral, twice a day, for 3 days

Product-based instruction using an AMP. Dose expressed per day. Duration of 3 days. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="10169939-6a5b-47ae-b820-524b584eecc8" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="28917911000001104" />
                    <display value="Trimethoprim 100mg tablets (Crescent Pharma Ltd)" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <boundsDuration>
                    <value value="3" />
                    <unit value="day" />
                    <system value="http://unitsofmeasure.org" />
                    <code value="d" />
                </boundsDuration>
                <frequency value="2" />
                <period value="1" />
                <periodUnit value="d" />
            </repeat>
        </timing>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="26643006" />
                <display value="oral" />
            </coding>
        </route>
        <doseQuantity>
            <value value="2" />
            <unit value="tablet" />
            <system value="http://snomed.info/sct" />
            <code value="428673006" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "10169939-6a5b-47ae-b820-524b584eecc8",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "28917911000001104",
                        "display": "Trimethoprim 100mg tablets (Crescent Pharma Ltd)"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "boundsDuration": {
                        "value": 3,
                        "unit": "day",
                        "system": "http://unitsofmeasure.org",
                        "code": "d"
                    },
                    "frequency": 2,
                    "period": 1,
                    "periodUnit": "d"
                }
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "26643006",
                        "display": "oral"
                    }
                ]
            },
            "doseQuantity": {
                "value": 2,
                "unit": "tablet",
                "system": "http://snomed.info/sct",
                "code": "428673006"
            }
        }
    ]
}
MedicationRequest.id[0]10169939-6a5b-47ae-b820-524b584eecc8
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]28917911000001104
MedicationRequest.contained[0].code[0].coding[0].display[0]Trimethoprim 100mg tablets (Crescent Pharma Ltd)
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].bounds[0].value[0]3
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].bounds[0].unit[0]day
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].bounds[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].bounds[0].code[0]d
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]2
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]26643006
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]oral
MedicationRequest.dosageInstruction[0].dose[0].value[0]2
MedicationRequest.dosageInstruction[0].dose[0].unit[0]tablet
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].dose[0].code[0]428673006
MedicationRequest
Dose-based instruction using a VTM. Dose expressed per day. Duration of 3 days. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="b65fd46e-4f4e-4676-b135-852ca16f2c91" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="32792001" />
                    <display value="Trimethoprim" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <boundsDuration>
                    <value value="3" />
                    <unit value="day" />
                    <system value="http://unitsofmeasure.org" />
                    <code value="d" />
                </boundsDuration>
                <frequency value="2" />
                <period value="1" />
                <periodUnit value="d" />
            </repeat>
        </timing>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="26643006" />
                <display value="oral" />
            </coding>
        </route>
        <doseQuantity>
            <value value="200" />
            <unit value="milligram" />
            <system value="http://unitsofmeasure.org" />
            <code value="mg" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
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    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "32792001",
                        "display": "Trimethoprim"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "boundsDuration": {
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                        "unit": "day",
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                        "code": "d"
                    },
                    "frequency": 2,
                    "period": 1,
                    "periodUnit": "d"
                }
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "26643006",
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                    }
                ]
            },
            "doseQuantity": {
                "value": 200,
                "unit": "milligram",
                "system": "http://unitsofmeasure.org",
                "code": "mg"
            }
        }
    ]
}
MedicationRequest.id[0]b65fd46e-4f4e-4676-b135-852ca16f2c91
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]32792001
MedicationRequest.contained[0].code[0].coding[0].display[0]Trimethoprim
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].bounds[0].value[0]3
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].bounds[0].unit[0]day
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].bounds[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].bounds[0].code[0]d
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]2
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]26643006
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]oral
MedicationRequest.dosageInstruction[0].dose[0].value[0]200
MedicationRequest.dosageInstruction[0].dose[0].unit[0]milligram
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].dose[0].code[0]mg
MedicationRequest

Sodium citrate / Micralax Micro-enema enema, once daily

Product-based instruction using an AMP. Dose expressed per day. 
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    <id value="d62bbf77-c6b5-4bac-a66f-147a869eacc7" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="3351711000001106" />
                    <display value="Micralax Micro-enema 5ml (RPH Pharmaceuticals AB)" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <frequency value="1" />
                <period value="1" />
                <periodUnit value="d" />
            </repeat>
        </timing>
    </dosageInstruction>
</MedicationRequest>

{
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    "id": "d62bbf77-c6b5-4bac-a66f-147a869eacc7",
    "contained":  [
        {
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            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "3351711000001106",
                        "display": "Micralax Micro-enema 5ml (RPH Pharmaceuticals AB)"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "frequency": 1,
                    "period": 1,
                    "periodUnit": "d"
                }
            }
        }
    ]
}
MedicationRequest.id[0]d62bbf77-c6b5-4bac-a66f-147a869eacc7
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]3351711000001106
MedicationRequest.contained[0].code[0].coding[0].display[0]Micralax Micro-enema 5ml (RPH Pharmaceuticals AB)
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest
Dose-based instruction using a VTM. Dose expressed per day. Duration of 3 days. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="63df7dcc-fc54-4eb2-8907-b53b09115bb6" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="412547001" />
                    <display value="Sodium citrate" />
                </coding>
            </code>
            <form>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="385186005" />
                    <display value="Enema" />
                </coding>
            </form>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <frequency value="1" />
                <period value="1" />
                <periodUnit value="d" />
            </repeat>
        </timing>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="37161004" />
                <display value="Rectal" />
            </coding>
        </route>
        <doseQuantity>
            <value value="450" />
            <unit value="milligram" />
            <system value="http://unitsofmeasure.org" />
            <code value="mg" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
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    "id": "63df7dcc-fc54-4eb2-8907-b53b09115bb6",
    "contained":  [
        {
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            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "412547001",
                        "display": "Sodium citrate"
                    }
                ]
            },
            "form": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "385186005",
                        "display": "Enema"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
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    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "frequency": 1,
                    "period": 1,
                    "periodUnit": "d"
                }
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "37161004",
                        "display": "Rectal"
                    }
                ]
            },
            "doseQuantity": {
                "value": 450,
                "unit": "milligram",
                "system": "http://unitsofmeasure.org",
                "code": "mg"
            }
        }
    ]
}
MedicationRequest.id[0]63df7dcc-fc54-4eb2-8907-b53b09115bb6
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]412547001
MedicationRequest.contained[0].code[0].coding[0].display[0]Sodium citrate
MedicationRequest.contained[0].form[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].form[0].coding[0].code[0]385186005
MedicationRequest.contained[0].form[0].coding[0].display[0]Enema
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]37161004
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]Rectal
MedicationRequest.dosageInstruction[0].dose[0].value[0]450
MedicationRequest.dosageInstruction[0].dose[0].unit[0]milligram
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].dose[0].code[0]mg
MedicationRequest

Diprobase ointment, 1 application, Topical, 3 times a day

Product-based instruction using an AMP. Where no dose quantity. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="dad3ae68-f7d7-4bad-8d6d-09e114842b53" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="3491511000001101" />
                    <display value="Diprobase ointment (Bayer Plc)" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <frequency value="3" />
                <period value="1" />
                <periodUnit value="d" />
            </repeat>
        </timing>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="6064005" />
                <display value="Topical" />
            </coding>
        </route>
        <doseQuantity>
            <value value="1" />
            <unit value="application" />
            <system value="http://snomed.info/sct" />
            <code value="10692211000001108" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
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    "id": "dad3ae68-f7d7-4bad-8d6d-09e114842b53",
    "contained":  [
        {
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            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "3491511000001101",
                        "display": "Diprobase ointment (Bayer Plc)"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "frequency": 3,
                    "period": 1,
                    "periodUnit": "d"
                }
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "6064005",
                        "display": "Topical"
                    }
                ]
            },
            "doseQuantity": {
                "value": 1,
                "unit": "application",
                "system": "http://snomed.info/sct",
                "code": "10692211000001108"
            }
        }
    ]
}
MedicationRequest.id[0]dad3ae68-f7d7-4bad-8d6d-09e114842b53
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]3491511000001101
MedicationRequest.contained[0].code[0].coding[0].display[0]Diprobase ointment (Bayer Plc)
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]3
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]6064005
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]Topical
MedicationRequest.dosageInstruction[0].dose[0].value[0]1
MedicationRequest.dosageInstruction[0].dose[0].unit[0]application
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].dose[0].code[0]10692211000001108
MedicationRequest
Dose-based instruction using a VTM. Where no dose quantity.

The VTM related to the Diprobase AMP’s is a multi-ingredient concept “White soft paraffin + Liquid paraffin” and cannot be used as a prescribing concept.

Beclometasone 0.025% cream, Apply Thigh, twice a day

Product-based instruction using a VMP. Body site identified. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="1c7d802c-71b2-4ac1-9cf2-8423e38b95fe" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="331792000" />
                    <display value="Beclometasone 0.025% cream" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <frequency value="2" />
                <period value="1" />
                <periodUnit value="d" />
            </repeat>
        </timing>
        <site>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="68367000" />
                <display value="Thigh" />
            </coding>
            <text value="Thigh" />
        </site>
        <method>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="417924000" />
                <display value="Apply" />
            </coding>
        </method>
    </dosageInstruction>
</MedicationRequest>

{
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    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "331792000",
                        "display": "Beclometasone 0.025% cream"
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                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
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    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "frequency": 2,
                    "period": 1,
                    "periodUnit": "d"
                }
            },
            "site": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "68367000",
                        "display": "Thigh"
                    }
                ],
                "text": "Thigh"
            },
            "method": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "417924000",
                        "display": "Apply"
                    }
                ]
            }
        }
    ]
}
MedicationRequest.id[0]1c7d802c-71b2-4ac1-9cf2-8423e38b95fe
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]331792000
MedicationRequest.contained[0].code[0].coding[0].display[0]Beclometasone 0.025% cream
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]2
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[0].site[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].site[0].coding[0].code[0]68367000
MedicationRequest.dosageInstruction[0].site[0].coding[0].display[0]Thigh
MedicationRequest.dosageInstruction[0].site[0].text[0]Thigh
MedicationRequest.dosageInstruction[0].method[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].method[0].coding[0].code[0]417924000
MedicationRequest.dosageInstruction[0].method[0].coding[0].display[0]Apply
MedicationRequest
Dose-based instruction using a VTM. Body site identified.

Where a concentration is required it is expected that the prescribing concept would be a VMP or AMP.

Zopiclone 3.75mg tablets, 1 tablet, at BEDTIME, PRN, oral

Product-based instruction using a VMP. When required dosing. 
<!--  Zopiclone 3.75mg tablets, 1 tablet, at BEDTIME, PRN, oral  -->
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="c804eca2-8b32-44d7-b654-b88bb9b1edd2" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="321177003" />
                    <display value="Zopiclone 3.75mg tablets" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <frequency value="1" />
                <period value="1" />
                <periodUnit value="d" />
                <when value="HS" />
            </repeat>
        </timing>
        <asNeededBoolean value="true" />
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="26643006" />
                <display value="oral" />
            </coding>
        </route>
        <doseQuantity>
            <value value="1" />
            <unit value="tablet" />
            <system value="http://snomed.info/sct" />
            <code value="428673006" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "c804eca2-8b32-44d7-b654-b88bb9b1edd2",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "321177003",
                        "display": "Zopiclone 3.75mg tablets"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "frequency": 1,
                    "period": 1,
                    "periodUnit": "d",
                    "when":  [
                        "HS"
                    ]
                }
            },
            "asNeededBoolean": true,
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "26643006",
                        "display": "oral"
                    }
                ]
            },
            "doseQuantity": {
                "value": 1,
                "unit": "tablet",
                "system": "http://snomed.info/sct",
                "code": "428673006"
            }
        }
    ]
}
MedicationRequest.id[0]c804eca2-8b32-44d7-b654-b88bb9b1edd2
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]321177003
MedicationRequest.contained[0].code[0].coding[0].display[0]Zopiclone 3.75mg tablets
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].when[0]HS
MedicationRequest.dosageInstruction[0].asNeeded[0]True
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]26643006
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]oral
MedicationRequest.dosageInstruction[0].dose[0].value[0]1
MedicationRequest.dosageInstruction[0].dose[0].unit[0]tablet
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].dose[0].code[0]428673006
MedicationRequest

Ibuprofen 400mg orally three times daily for 5 days to start tomorrow

Dose-based instruction using a VTM. Specified start date and course length. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="23406593-8209-4b3f-8afd-4bd9e8f72212" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="38268001" />
                    <display value="Ibuprofen" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <boundsPeriod>
                    <start value="2019-03-10" />
                    <end value="2019-03-14" />
                </boundsPeriod>
                <frequency value="3" />
                <period value="1" />
                <periodUnit value="d" />
            </repeat>
        </timing>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="26643006" />
                <display value="oral" />
            </coding>
        </route>
        <doseQuantity>
            <value value="400" />
            <unit value="milligram" />
            <system value="http://unitsofmeasure.org" />
            <code value="mg" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "23406593-8209-4b3f-8afd-4bd9e8f72212",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "38268001",
                        "display": "Ibuprofen"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "boundsPeriod": {
                        "start": "2019-03-10",
                        "end": "2019-03-14"
                    },
                    "frequency": 3,
                    "period": 1,
                    "periodUnit": "d"
                }
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "26643006",
                        "display": "oral"
                    }
                ]
            },
            "doseQuantity": {
                "value": 400,
                "unit": "milligram",
                "system": "http://unitsofmeasure.org",
                "code": "mg"
            }
        }
    ]
}
MedicationRequest.id[0]23406593-8209-4b3f-8afd-4bd9e8f72212
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]38268001
MedicationRequest.contained[0].code[0].coding[0].display[0]Ibuprofen
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].bounds[0].start[0]2019-03-10
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].bounds[0].end[0]2019-03-14
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]3
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]26643006
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]oral
MedicationRequest.dosageInstruction[0].dose[0].value[0]400
MedicationRequest.dosageInstruction[0].dose[0].unit[0]milligram
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].dose[0].code[0]mg
MedicationRequest
For this example, assume today’s date is 9th March 2019, hence ‘tomorrow’ is 10th March 2019.

Timolol 0.1% gel eye drops, 1 drop in the left eye once daily

Product-based instruction using a VMP. Body site identified. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="e8534d74-1b23-4a1a-90dd-04c71dad2f5f" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="496811000001108" />
                    <display value="Timolol 0.1% gel eye drops" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <frequency value="1" />
                <period value="1" />
                <periodUnit value="d" />
            </repeat>
        </timing>
        <site>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="8966001" />
                <display value="Left eye" />
            </coding>
        </site>
        <doseQuantity>
            <value value="1" />
            <unit value="Drop" />
            <system value="http://snomed.info/sct" />
            <code value="404218003" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "e8534d74-1b23-4a1a-90dd-04c71dad2f5f",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "496811000001108",
                        "display": "Timolol 0.1% gel eye drops"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "frequency": 1,
                    "period": 1,
                    "periodUnit": "d"
                }
            },
            "site": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "8966001",
                        "display": "Left eye"
                    }
                ]
            },
            "doseQuantity": {
                "value": 1,
                "unit": "Drop",
                "system": "http://snomed.info/sct",
                "code": "404218003"
            }
        }
    ]
}
MedicationRequest.id[0]e8534d74-1b23-4a1a-90dd-04c71dad2f5f
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]496811000001108
MedicationRequest.contained[0].code[0].coding[0].display[0]Timolol 0.1% gel eye drops
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[0].site[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].site[0].coding[0].code[0]8966001
MedicationRequest.dosageInstruction[0].site[0].coding[0].display[0]Left eye
MedicationRequest.dosageInstruction[0].dose[0].value[0]1
MedicationRequest.dosageInstruction[0].dose[0].unit[0]Drop
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].dose[0].code[0]404218003
MedicationRequest
For this example, assume today’s date is 9th March 2019, hence ‘tomorrow’ is 10th March 2019.

Epoetin alfa, 4500units, ONCE a DAY, subcutaneous injection

Dose-based instruction using a VTM. Route and method identified. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="a8ca980c-72aa-11e7-8cf7-a6006ad3dba0" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="108964008" />
                    <display value="Epoetin alfa" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <frequency value="1" />
                <period value="1" />
                <periodUnit value="d" />
            </repeat>
        </timing>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="34206005" />
                <display value="subcutaneous route" />
            </coding>
        </route>
        <method>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="422145002" />
                <display value="inject" />
            </coding>
        </method>
        <doseQuantity>
            <value value="4500" />
            <unit value="unit" />
            <system value="http://snomed.info/sct" />
            <code value="767525000" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "a8ca980c-72aa-11e7-8cf7-a6006ad3dba0",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "108964008",
                        "display": "Epoetin alfa"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "frequency": 1,
                    "period": 1,
                    "periodUnit": "d"
                }
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "34206005",
                        "display": "subcutaneous route"
                    }
                ]
            },
            "method": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "422145002",
                        "display": "inject"
                    }
                ]
            },
            "doseQuantity": {
                "value": 4500,
                "unit": "unit",
                "system": "http://snomed.info/sct",
                "code": "767525000"
            }
        }
    ]
}
MedicationRequest.id[0]a8ca980c-72aa-11e7-8cf7-a6006ad3dba0
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]108964008
MedicationRequest.contained[0].code[0].coding[0].display[0]Epoetin alfa
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]34206005
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]subcutaneous route
MedicationRequest.dosageInstruction[0].method[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].method[0].coding[0].code[0]422145002
MedicationRequest.dosageInstruction[0].method[0].coding[0].display[0]inject
MedicationRequest.dosageInstruction[0].dose[0].value[0]4500
MedicationRequest.dosageInstruction[0].dose[0].unit[0]unit
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].dose[0].code[0]767525000
MedicationRequest

Morphine modified release capsule, 20mg orally every 12 hours

Dose-based instruction sing a VTM with a specific form. Dose expressed as hourly dose interval. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="cec8f082-4c5b-4ccd-9187-c066c8057498" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="73572009" />
                    <display value="Morphine" />
                </coding>
            </code>
            <form>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="385054002" />
                    <display value="Modified-release capsule" />
                </coding>
            </form>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <frequency value="1" />
                <period value="12" />
                <periodUnit value="h" />
            </repeat>
        </timing>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="26643006" />
                <display value="oral" />
            </coding>
        </route>
        <doseQuantity>
            <value value="20" />
            <unit value="milligram" />
            <system value="http://unitsofmeasure.org" />
            <code value="mg" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "cec8f082-4c5b-4ccd-9187-c066c8057498",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "73572009",
                        "display": "Morphine"
                    }
                ]
            },
            "form": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "385054002",
                        "display": "Modified-release capsule"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "frequency": 1,
                    "period": 12,
                    "periodUnit": "h"
                }
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "26643006",
                        "display": "oral"
                    }
                ]
            },
            "doseQuantity": {
                "value": 20,
                "unit": "milligram",
                "system": "http://unitsofmeasure.org",
                "code": "mg"
            }
        }
    ]
}
MedicationRequest.id[0]cec8f082-4c5b-4ccd-9187-c066c8057498
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]73572009
MedicationRequest.contained[0].code[0].coding[0].display[0]Morphine
MedicationRequest.contained[0].form[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].form[0].coding[0].code[0]385054002
MedicationRequest.contained[0].form[0].coding[0].display[0]Modified-release capsule
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]12
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]h
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]26643006
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]oral
MedicationRequest.dosageInstruction[0].dose[0].value[0]20
MedicationRequest.dosageInstruction[0].dose[0].unit[0]milligram
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].dose[0].code[0]mg
MedicationRequest

Morphine, 30mg, intrav, injection, four times a day, for 1 day

Dose-based instruction using a VTM. Route and method identified and course duration. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="1558295a-9213-44cb-81e1-e1ab8fcc3e81" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="73572009" />
                    <display value="Morphine" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <boundsDuration>
                    <value value="1" />
                    <unit value="day" />
                    <system value="http://unitsofmeasure.org" />
                    <code value="d" />
                </boundsDuration>
                <frequency value="4" />
                <period value="1" />
                <periodUnit value="d" />
            </repeat>
        </timing>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="47625008" />
                <display value="intravenous route" />
            </coding>
        </route>
        <method>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="422145002" />
                <display value="inject" />
            </coding>
        </method>
        <doseQuantity>
            <value value="30" />
            <unit value="milligram" />
            <system value="http://unitsofmeasure.org" />
            <code value="mg" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "1558295a-9213-44cb-81e1-e1ab8fcc3e81",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "73572009",
                        "display": "Morphine"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "boundsDuration": {
                        "value": 1,
                        "unit": "day",
                        "system": "http://unitsofmeasure.org",
                        "code": "d"
                    },
                    "frequency": 4,
                    "period": 1,
                    "periodUnit": "d"
                }
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "47625008",
                        "display": "intravenous route"
                    }
                ]
            },
            "method": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "422145002",
                        "display": "inject"
                    }
                ]
            },
            "doseQuantity": {
                "value": 30,
                "unit": "milligram",
                "system": "http://unitsofmeasure.org",
                "code": "mg"
            }
        }
    ]
}
MedicationRequest.id[0]1558295a-9213-44cb-81e1-e1ab8fcc3e81
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]73572009
MedicationRequest.contained[0].code[0].coding[0].display[0]Morphine
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].bounds[0].value[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].bounds[0].unit[0]day
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].bounds[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].bounds[0].code[0]d
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]4
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]47625008
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]intravenous route
MedicationRequest.dosageInstruction[0].method[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].method[0].coding[0].code[0]422145002
MedicationRequest.dosageInstruction[0].method[0].coding[0].display[0]inject
MedicationRequest.dosageInstruction[0].dose[0].value[0]30
MedicationRequest.dosageInstruction[0].dose[0].unit[0]milligram
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].dose[0].code[0]mg
MedicationRequest

Zoladex 3.6mg implant SafeSystem pre-filled syringes (AstraZeneca UK Ltd), one to be given by IM injection into the anterior abdominal wall on 1st November 2019

Product-based instruction using an AMP. Identified route, method and site. Specific date. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="905d34ad-ea20-4371-8bf7-5208fbf146ce" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="824211000001107" />
                    <display value="Zoladex 3.6mg implant SafeSystem pre-filled syringes (AstraZeneca UK Ltd)" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <event value="2019-11-01" />
            <repeat>
                <count value="1" />
            </repeat>
        </timing>
        <site>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="59380008" />
                <display value="Anterior abdominal wall structure" />
            </coding>
        </site>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="78421000" />
                <display value="intramuscular route" />
            </coding>
        </route>
        <method>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="422145002" />
                <display value="inject" />
            </coding>
        </method>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "905d34ad-ea20-4371-8bf7-5208fbf146ce",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "824211000001107",
                        "display": "Zoladex 3.6mg implant SafeSystem pre-filled syringes (AstraZeneca UK Ltd)"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "event":  [
                    "2019-11-01"
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                "repeat": {
                    "count": 1
                }
            },
            "site": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "59380008",
                        "display": "Anterior abdominal wall structure"
                    }
                ]
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "78421000",
                        "display": "intramuscular route"
                    }
                ]
            },
            "method": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "422145002",
                        "display": "inject"
                    }
                ]
            }
        }
    ]
}
MedicationRequest.id[0]905d34ad-ea20-4371-8bf7-5208fbf146ce
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MedicationRequest.contained[0].code[0].coding[0].code[0]824211000001107
MedicationRequest.contained[0].code[0].coding[0].display[0]Zoladex 3.6mg implant SafeSystem pre-filled syringes (AstraZeneca UK Ltd)
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
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MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].event[0]2019-11-01
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].count[0]1
MedicationRequest.dosageInstruction[0].site[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].site[0].coding[0].code[0]59380008
MedicationRequest.dosageInstruction[0].site[0].coding[0].display[0]Anterior abdominal wall structure
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]78421000
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]intramuscular route
MedicationRequest.dosageInstruction[0].method[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].method[0].coding[0].code[0]422145002
MedicationRequest.dosageInstruction[0].method[0].coding[0].display[0]inject
MedicationRequest

Hyoscine 1mg/72hours transdermal patches, one patch to be applied once every 3 days

Product-based instruction using a VMP. Dosing every 3 days. Specific method. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="a8ca980c-72aa-11e7-8cf7-a6006ad3dba0" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="322087003" />
                    <display value="Hyoscine 1mg/72hours transdermal patches" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <frequency value="1" />
                <period value="3" />
                <periodUnit value="d" />
            </repeat>
        </timing>
        <method>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="417924000" />
                <display value="Apply" />
            </coding>
        </method>
        <doseQuantity>
            <value value="1" />
            <unit value="patch" />
            <system value="http://snomed.info/sct" />
            <code value="733005001" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "a8ca980c-72aa-11e7-8cf7-a6006ad3dba0",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "322087003",
                        "display": "Hyoscine 1mg/72hours transdermal patches"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
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            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
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                    "period": 3,
                    "periodUnit": "d"
                }
            },
            "method": {
                "coding":  [
                    {
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                        "code": "417924000",
                        "display": "Apply"
                    }
                ]
            },
            "doseQuantity": {
                "value": 1,
                "unit": "patch",
                "system": "http://snomed.info/sct",
                "code": "733005001"
            }
        }
    ]
}
MedicationRequest.id[0]a8ca980c-72aa-11e7-8cf7-a6006ad3dba0
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]322087003
MedicationRequest.contained[0].code[0].coding[0].display[0]Hyoscine 1mg/72hours transdermal patches
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]3
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[0].method[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].method[0].coding[0].code[0]417924000
MedicationRequest.dosageInstruction[0].method[0].coding[0].display[0]Apply
MedicationRequest.dosageInstruction[0].dose[0].value[0]1
MedicationRequest.dosageInstruction[0].dose[0].unit[0]patch
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].dose[0].code[0]733005001
MedicationRequest

Co-trimoxazole 80mg/400mg tablets (Actavis UK Ltd), one tablet to be taken twice daily on Mondays, Wednesdays and Fridays

Product-based instruction using an AMP. Dosing given only on specific days. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="a8ca980c-72aa-11e7-8cf7-a6006ad3dba0" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="688711000001107" />
                    <display value="Co-trimoxazole 80mg/400mg tablets (Actavis UK Ltd)" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <frequency value="2" />
                <period value="1" />
                <periodUnit value="d" />
                <dayOfWeek value="mon" />
                <dayOfWeek value="wed" />
                <dayOfWeek value="fri" />
            </repeat>
        </timing>
        <doseQuantity>
            <value value="1" />
            <unit value="tablet" />
            <system value="http://snomed.info/sct" />
            <code value="428673006" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "a8ca980c-72aa-11e7-8cf7-a6006ad3dba0",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "688711000001107",
                        "display": "Co-trimoxazole 80mg/400mg tablets (Actavis UK Ltd)"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "frequency": 2,
                    "period": 1,
                    "periodUnit": "d",
                    "dayOfWeek":  [
                        "mon",
                        "wed",
                        "fri"
                    ]
                }
            },
            "doseQuantity": {
                "value": 1,
                "unit": "tablet",
                "system": "http://snomed.info/sct",
                "code": "428673006"
            }
        }
    ]
}
MedicationRequest.id[0]a8ca980c-72aa-11e7-8cf7-a6006ad3dba0
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]688711000001107
MedicationRequest.contained[0].code[0].coding[0].display[0]Co-trimoxazole 80mg/400mg tablets (Actavis UK Ltd)
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]2
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].dayOfWeek[0]mon
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].dayOfWeek[1]wed
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].dayOfWeek[2]fri
MedicationRequest.dosageInstruction[0].dose[0].value[0]1
MedicationRequest.dosageInstruction[0].dose[0].unit[0]tablet
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].dose[0].code[0]428673006
MedicationRequest

Furosemide 40mg tablets, take two in the morning and one at midday for one week

Product-based prescription demonstrating concurrent dosing schedules. 
<!--  Example use of the FHIR STU3 Dosage using multiple parallel sequences  -->
<!--  Furosemide 40mg tablets, take two in the morning and one at midday for one week  -->
<!--  Using a contained Medication resource  -->
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="79159c4f-13c4-457a-8962-67fa22432c15" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="317972000" />
                    <display value="Furosemide 40mg tablets" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <sequence value="1" />
        <timing>
            <repeat>
                <boundsDuration>
                    <value value="1" />
                    <unit value="week" />
                    <system value="http://unitsofmeasure.org" />
                    <code value="wk" />
                </boundsDuration>
                <frequency value="1" />
                <period value="1" />
                <periodUnit value="d" />
                <when value="MORN" />
            </repeat>
        </timing>
        <doseQuantity>
            <value value="2" />
            <unit value="tablet" />
            <system value="http://snomed.info/sct" />
            <code value="428673006" />
        </doseQuantity>
    </dosageInstruction>
    <dosageInstruction>
        <sequence value="1" />
        <timing>
            <repeat>
                <boundsDuration>
                    <value value="1" />
                    <unit value="week" />
                    <system value="http://unitsofmeasure.org" />
                    <code value="wk" />
                </boundsDuration>
                <frequency value="1" />
                <period value="1" />
                <periodUnit value="d" />
                <timeOfDay value="12:00:00" />
            </repeat>
        </timing>
        <doseQuantity>
            <value value="1" />
            <unit value="tablet" />
            <system value="http://snomed.info/sct" />
            <code value="428673006" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
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    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "317972000",
                        "display": "Furosemide 40mg tablets"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "sequence": 1,
            "timing": {
                "repeat": {
                    "boundsDuration": {
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                        "unit": "week",
                        "system": "http://unitsofmeasure.org",
                        "code": "wk"
                    },
                    "frequency": 1,
                    "period": 1,
                    "periodUnit": "d",
                    "when":  [
                        "MORN"
                    ]
                }
            },
            "doseQuantity": {
                "value": 2,
                "unit": "tablet",
                "system": "http://snomed.info/sct",
                "code": "428673006"
            }
        },
        {
            "sequence": 1,
            "timing": {
                "repeat": {
                    "boundsDuration": {
                        "value": 1,
                        "unit": "week",
                        "system": "http://unitsofmeasure.org",
                        "code": "wk"
                    },
                    "frequency": 1,
                    "period": 1,
                    "periodUnit": "d",
                    "timeOfDay":  [
                        "12:00:00"
                    ]
                }
            },
            "doseQuantity": {
                "value": 1,
                "unit": "tablet",
                "system": "http://snomed.info/sct",
                "code": "428673006"
            }
        }
    ]
}
MedicationRequest.id[0]79159c4f-13c4-457a-8962-67fa22432c15
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]317972000
MedicationRequest.contained[0].code[0].coding[0].display[0]Furosemide 40mg tablets
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].sequence[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].bounds[0].value[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].bounds[0].unit[0]week
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].bounds[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].bounds[0].code[0]wk
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].when[0]MORN
MedicationRequest.dosageInstruction[0].dose[0].value[0]2
MedicationRequest.dosageInstruction[0].dose[0].unit[0]tablet
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].dose[0].code[0]428673006
MedicationRequest.dosageInstruction[1].sequence[0]1
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].bounds[0].value[0]1
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].bounds[0].unit[0]week
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].bounds[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].bounds[0].code[0]wk
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].frequency[0]1
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].timeOfDay[0]12:00:00
MedicationRequest.dosageInstruction[1].dose[0].value[0]1
MedicationRequest.dosageInstruction[1].dose[0].unit[0]tablet
MedicationRequest.dosageInstruction[1].dose[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[1].dose[0].code[0]428673006
MedicationRequest
Example use of the FHIR STU3 Dosage using multiple parallel sequences, using a contained `Medication` resource.

Metformin 500mg tablets, initially 500 mg once daily for 1 week, dose to be taken with breakfast, then 500 mg twice daily for week, dose to be taken with breakfast and evening meal, then 500 mg 3 times a day, dose to be taken with breakfast, lunch and evening meal; maximum 2 g per day

Product-based prescription demonstrating sequential dosing schedules for an increasing dose. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="921aa4f4-c84e-4bf6-bc86-279d53e28d76" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="325278007" />
                    <display value="Metformin 500mg tablets" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <sequence value="1" />
        <timing>
            <repeat>
                <duration value="1" />
                <durationUnit value="wk" />
                <frequency value="1" />
                <period value="1" />
                <periodUnit value="d" />
                <when value="CM" />
            </repeat>
        </timing>
        <doseQuantity>
            <value value="500" />
            <unit value="milligram" />
            <system value="http://unitsofmeasure.org" />
            <code value="mg" />
        </doseQuantity>
        <maxDosePerPeriod>
            <numerator>
                <value value="2" />
                <unit value="gram" />
                <system value="http://unitsofmeasure.org" />
                <code value="g" />
            </numerator>
            <denominator>
                <value value="1" />
                <unit value="day" />
                <system value="http://unitsofmeasure.org" />
                <code value="d" />
            </denominator>
        </maxDosePerPeriod>
    </dosageInstruction>
    <dosageInstruction>
        <sequence value="2" />
        <timing>
            <repeat>
                <duration value="1" />
                <durationUnit value="wk" />
                <frequency value="2" />
                <period value="1" />
                <periodUnit value="d" />
                <when value="CM" />
                <when value="CV" />
            </repeat>
        </timing>
        <doseQuantity>
            <value value="500" />
            <unit value="milligram" />
            <system value="http://unitsofmeasure.org" />
            <code value="mg" />
        </doseQuantity>
        <maxDosePerPeriod>
            <numerator>
                <value value="2" />
                <unit value="gram" />
                <system value="http://unitsofmeasure.org" />
                <code value="g" />
            </numerator>
            <denominator>
                <value value="1" />
                <unit value="day" />
                <system value="http://unitsofmeasure.org" />
                <code value="d" />
            </denominator>
        </maxDosePerPeriod>
    </dosageInstruction>
    <dosageInstruction>
        <sequence value="3" />
        <timing>
            <repeat>
                <duration value="1" />
                <durationUnit value="wk" />
                <frequency value="2" />
                <period value="1" />
                <periodUnit value="d" />
                <when value="CM" />
                <when value="CV" />
            </repeat>
        </timing>
        <doseQuantity>
            <value value="500" />
            <unit value="milligram" />
            <system value="http://unitsofmeasure.org" />
            <code value="mg" />
        </doseQuantity>
        <maxDosePerPeriod>
            <numerator>
                <value value="2" />
                <unit value="gram" />
                <system value="http://unitsofmeasure.org" />
                <code value="g" />
            </numerator>
            <denominator>
                <value value="1" />
                <unit value="day" />
                <system value="http://unitsofmeasure.org" />
                <code value="d" />
            </denominator>
        </maxDosePerPeriod>
    </dosageInstruction>
    <dosageInstruction>
        <sequence value="4" />
        <timing>
            <repeat>
                <duration value="1" />
                <durationUnit value="wk" />
                <frequency value="3" />
                <period value="1" />
                <periodUnit value="d" />
                <when value="CM" />
                <when value="CV" />
                <when value="CD" />
            </repeat>
        </timing>
        <doseQuantity>
            <value value="500" />
            <unit value="milligram" />
            <system value="http://unitsofmeasure.org" />
            <code value="mg" />
        </doseQuantity>
        <maxDosePerPeriod>
            <numerator>
                <value value="2" />
                <unit value="gram" />
                <system value="http://unitsofmeasure.org" />
                <code value="g" />
            </numerator>
            <denominator>
                <value value="1" />
                <unit value="day" />
                <system value="http://unitsofmeasure.org" />
                <code value="d" />
            </denominator>
        </maxDosePerPeriod>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "921aa4f4-c84e-4bf6-bc86-279d53e28d76",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "325278007",
                        "display": "Metformin 500mg tablets"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "sequence": 1,
            "timing": {
                "repeat": {
                    "duration": 1,
                    "durationUnit": "wk",
                    "frequency": 1,
                    "period": 1,
                    "periodUnit": "d",
                    "when":  [
                        "CM"
                    ]
                }
            },
            "doseQuantity": {
                "value": 500,
                "unit": "milligram",
                "system": "http://unitsofmeasure.org",
                "code": "mg"
            },
            "maxDosePerPeriod": {
                "numerator": {
                    "value": 2,
                    "unit": "gram",
                    "system": "http://unitsofmeasure.org",
                    "code": "g"
                },
                "denominator": {
                    "value": 1,
                    "unit": "day",
                    "system": "http://unitsofmeasure.org",
                    "code": "d"
                }
            }
        },
        {
            "sequence": 2,
            "timing": {
                "repeat": {
                    "duration": 1,
                    "durationUnit": "wk",
                    "frequency": 2,
                    "period": 1,
                    "periodUnit": "d",
                    "when":  [
                        "CM",
                        "CV"
                    ]
                }
            },
            "doseQuantity": {
                "value": 500,
                "unit": "milligram",
                "system": "http://unitsofmeasure.org",
                "code": "mg"
            },
            "maxDosePerPeriod": {
                "numerator": {
                    "value": 2,
                    "unit": "gram",
                    "system": "http://unitsofmeasure.org",
                    "code": "g"
                },
                "denominator": {
                    "value": 1,
                    "unit": "day",
                    "system": "http://unitsofmeasure.org",
                    "code": "d"
                }
            }
        },
        {
            "sequence": 3,
            "timing": {
                "repeat": {
                    "duration": 1,
                    "durationUnit": "wk",
                    "frequency": 2,
                    "period": 1,
                    "periodUnit": "d",
                    "when":  [
                        "CM",
                        "CV"
                    ]
                }
            },
            "doseQuantity": {
                "value": 500,
                "unit": "milligram",
                "system": "http://unitsofmeasure.org",
                "code": "mg"
            },
            "maxDosePerPeriod": {
                "numerator": {
                    "value": 2,
                    "unit": "gram",
                    "system": "http://unitsofmeasure.org",
                    "code": "g"
                },
                "denominator": {
                    "value": 1,
                    "unit": "day",
                    "system": "http://unitsofmeasure.org",
                    "code": "d"
                }
            }
        },
        {
            "sequence": 4,
            "timing": {
                "repeat": {
                    "duration": 1,
                    "durationUnit": "wk",
                    "frequency": 3,
                    "period": 1,
                    "periodUnit": "d",
                    "when":  [
                        "CM",
                        "CV",
                        "CD"
                    ]
                }
            },
            "doseQuantity": {
                "value": 500,
                "unit": "milligram",
                "system": "http://unitsofmeasure.org",
                "code": "mg"
            },
            "maxDosePerPeriod": {
                "numerator": {
                    "value": 2,
                    "unit": "gram",
                    "system": "http://unitsofmeasure.org",
                    "code": "g"
                },
                "denominator": {
                    "value": 1,
                    "unit": "day",
                    "system": "http://unitsofmeasure.org",
                    "code": "d"
                }
            }
        }
    ]
}
MedicationRequest.id[0]921aa4f4-c84e-4bf6-bc86-279d53e28d76
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]325278007
MedicationRequest.contained[0].code[0].coding[0].display[0]Metformin 500mg tablets
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].sequence[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].duration[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].durationUnit[0]wk
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].when[0]CM
MedicationRequest.dosageInstruction[0].dose[0].value[0]500
MedicationRequest.dosageInstruction[0].dose[0].unit[0]milligram
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].dose[0].code[0]mg
MedicationRequest.dosageInstruction[0].maxDosePerPeriod[0].numerator[0].value[0]2
MedicationRequest.dosageInstruction[0].maxDosePerPeriod[0].numerator[0].unit[0]gram
MedicationRequest.dosageInstruction[0].maxDosePerPeriod[0].numerator[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].maxDosePerPeriod[0].numerator[0].code[0]g
MedicationRequest.dosageInstruction[0].maxDosePerPeriod[0].denominator[0].value[0]1
MedicationRequest.dosageInstruction[0].maxDosePerPeriod[0].denominator[0].unit[0]day
MedicationRequest.dosageInstruction[0].maxDosePerPeriod[0].denominator[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].maxDosePerPeriod[0].denominator[0].code[0]d
MedicationRequest.dosageInstruction[1].sequence[0]2
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].duration[0]1
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].durationUnit[0]wk
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].frequency[0]2
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].when[0]CM
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].when[1]CV
MedicationRequest.dosageInstruction[1].dose[0].value[0]500
MedicationRequest.dosageInstruction[1].dose[0].unit[0]milligram
MedicationRequest.dosageInstruction[1].dose[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[1].dose[0].code[0]mg
MedicationRequest.dosageInstruction[1].maxDosePerPeriod[0].numerator[0].value[0]2
MedicationRequest.dosageInstruction[1].maxDosePerPeriod[0].numerator[0].unit[0]gram
MedicationRequest.dosageInstruction[1].maxDosePerPeriod[0].numerator[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[1].maxDosePerPeriod[0].numerator[0].code[0]g
MedicationRequest.dosageInstruction[1].maxDosePerPeriod[0].denominator[0].value[0]1
MedicationRequest.dosageInstruction[1].maxDosePerPeriod[0].denominator[0].unit[0]day
MedicationRequest.dosageInstruction[1].maxDosePerPeriod[0].denominator[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[1].maxDosePerPeriod[0].denominator[0].code[0]d
MedicationRequest.dosageInstruction[2].sequence[0]3
MedicationRequest.dosageInstruction[2].timing[0].repeat[0].duration[0]1
MedicationRequest.dosageInstruction[2].timing[0].repeat[0].durationUnit[0]wk
MedicationRequest.dosageInstruction[2].timing[0].repeat[0].frequency[0]2
MedicationRequest.dosageInstruction[2].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[2].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[2].timing[0].repeat[0].when[0]CM
MedicationRequest.dosageInstruction[2].timing[0].repeat[0].when[1]CV
MedicationRequest.dosageInstruction[2].dose[0].value[0]500
MedicationRequest.dosageInstruction[2].dose[0].unit[0]milligram
MedicationRequest.dosageInstruction[2].dose[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[2].dose[0].code[0]mg
MedicationRequest.dosageInstruction[2].maxDosePerPeriod[0].numerator[0].value[0]2
MedicationRequest.dosageInstruction[2].maxDosePerPeriod[0].numerator[0].unit[0]gram
MedicationRequest.dosageInstruction[2].maxDosePerPeriod[0].numerator[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[2].maxDosePerPeriod[0].numerator[0].code[0]g
MedicationRequest.dosageInstruction[2].maxDosePerPeriod[0].denominator[0].value[0]1
MedicationRequest.dosageInstruction[2].maxDosePerPeriod[0].denominator[0].unit[0]day
MedicationRequest.dosageInstruction[2].maxDosePerPeriod[0].denominator[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[2].maxDosePerPeriod[0].denominator[0].code[0]d
MedicationRequest.dosageInstruction[3].sequence[0]4
MedicationRequest.dosageInstruction[3].timing[0].repeat[0].duration[0]1
MedicationRequest.dosageInstruction[3].timing[0].repeat[0].durationUnit[0]wk
MedicationRequest.dosageInstruction[3].timing[0].repeat[0].frequency[0]3
MedicationRequest.dosageInstruction[3].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[3].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[3].timing[0].repeat[0].when[0]CM
MedicationRequest.dosageInstruction[3].timing[0].repeat[0].when[1]CV
MedicationRequest.dosageInstruction[3].timing[0].repeat[0].when[2]CD
MedicationRequest.dosageInstruction[3].dose[0].value[0]500
MedicationRequest.dosageInstruction[3].dose[0].unit[0]milligram
MedicationRequest.dosageInstruction[3].dose[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[3].dose[0].code[0]mg
MedicationRequest.dosageInstruction[3].maxDosePerPeriod[0].numerator[0].value[0]2
MedicationRequest.dosageInstruction[3].maxDosePerPeriod[0].numerator[0].unit[0]gram
MedicationRequest.dosageInstruction[3].maxDosePerPeriod[0].numerator[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[3].maxDosePerPeriod[0].numerator[0].code[0]g
MedicationRequest.dosageInstruction[3].maxDosePerPeriod[0].denominator[0].value[0]1
MedicationRequest.dosageInstruction[3].maxDosePerPeriod[0].denominator[0].unit[0]day
MedicationRequest.dosageInstruction[3].maxDosePerPeriod[0].denominator[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[3].maxDosePerPeriod[0].denominator[0].code[0]d
MedicationRequest

Metoclopramide, orally 10mg to be taken when required for nausea up to three times daily

Dose-based prescription with when required dosing and daily maximum frequency. 
<!--  Metoclopramide, orally 10mg to be taken when required for nausea up to three times daily  -->
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="e02e462c-12db-4162-95f6-0436a60c5bc4" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="56549003" />
                    <display value="Metoclopramide" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <frequencyMax value="3" />
                <period value="1" />
                <periodUnit value="d" />
            </repeat>
        </timing>
        <asNeededCodeableConcept>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="422587007" />
                <display value="nausea" />
            </coding>
        </asNeededCodeableConcept>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="26643006" />
                <display value="oral" />
            </coding>
        </route>
        <doseQuantity>
            <value value="10" />
            <unit value="milligram" />
            <system value="http://unitsofmeasure.org" />
            <code value="mg" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "e02e462c-12db-4162-95f6-0436a60c5bc4",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "56549003",
                        "display": "Metoclopramide"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "frequencyMax": 3,
                    "period": 1,
                    "periodUnit": "d"
                }
            },
            "asNeededCodeableConcept": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "422587007",
                        "display": "nausea"
                    }
                ]
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "26643006",
                        "display": "oral"
                    }
                ]
            },
            "doseQuantity": {
                "value": 10,
                "unit": "milligram",
                "system": "http://unitsofmeasure.org",
                "code": "mg"
            }
        }
    ]
}
MedicationRequest.id[0]e02e462c-12db-4162-95f6-0436a60c5bc4
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]56549003
MedicationRequest.contained[0].code[0].coding[0].display[0]Metoclopramide
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequencyMax[0]3
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[0].asNeeded[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].asNeeded[0].coding[0].code[0]422587007
MedicationRequest.dosageInstruction[0].asNeeded[0].coding[0].display[0]nausea
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]26643006
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]oral
MedicationRequest.dosageInstruction[0].dose[0].value[0]10
MedicationRequest.dosageInstruction[0].dose[0].unit[0]milligram
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].dose[0].code[0]mg
MedicationRequest

Aspirin suppository, 600mg rectally every 4 hours. Maximum 3.6gm per 24 hours

Dose-based prescription with maximum dose. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="41dab799-fdbb-4a1e-bee2-a1a73dacac8d" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="7947003" />
                    <display value="Aspirin" />
                </coding>
            </code>
            <form>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="385194003" />
                    <display value="suppository" />
                </coding>
            </form>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <frequency value="1" />
                <period value="4" />
                <periodUnit value="h" />
            </repeat>
        </timing>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="37161004" />
                <display value="Rectal" />
            </coding>
        </route>
        <doseQuantity>
            <value value="600" />
            <unit value="milligram" />
            <system value="http://unitsofmeasure.org" />
            <code value="mg" />
        </doseQuantity>
        <maxDosePerPeriod>
            <numerator>
                <value value="3.6" />
                <unit value="gram" />
                <system value="http://unitsofmeasure.org" />
                <code value="g" />
            </numerator>
            <denominator>
                <value value="24" />
                <unit value="hour" />
                <system value="http://unitsofmeasure.org" />
                <code value="h" />
            </denominator>
        </maxDosePerPeriod>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "41dab799-fdbb-4a1e-bee2-a1a73dacac8d",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "7947003",
                        "display": "Aspirin"
                    }
                ]
            },
            "form": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "385194003",
                        "display": "suppository"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "frequency": 1,
                    "period": 4,
                    "periodUnit": "h"
                }
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "37161004",
                        "display": "Rectal"
                    }
                ]
            },
            "doseQuantity": {
                "value": 600,
                "unit": "milligram",
                "system": "http://unitsofmeasure.org",
                "code": "mg"
            },
            "maxDosePerPeriod": {
                "numerator": {
                    "value": 3.6,
                    "unit": "gram",
                    "system": "http://unitsofmeasure.org",
                    "code": "g"
                },
                "denominator": {
                    "value": 24,
                    "unit": "hour",
                    "system": "http://unitsofmeasure.org",
                    "code": "h"
                }
            }
        }
    ]
}
MedicationRequest.id[0]41dab799-fdbb-4a1e-bee2-a1a73dacac8d
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]7947003
MedicationRequest.contained[0].code[0].coding[0].display[0]Aspirin
MedicationRequest.contained[0].form[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].form[0].coding[0].code[0]385194003
MedicationRequest.contained[0].form[0].coding[0].display[0]suppository
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]4
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]h
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]37161004
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]Rectal
MedicationRequest.dosageInstruction[0].dose[0].value[0]600
MedicationRequest.dosageInstruction[0].dose[0].unit[0]milligram
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].dose[0].code[0]mg
MedicationRequest.dosageInstruction[0].maxDosePerPeriod[0].numerator[0].value[0]3.6
MedicationRequest.dosageInstruction[0].maxDosePerPeriod[0].numerator[0].unit[0]gram
MedicationRequest.dosageInstruction[0].maxDosePerPeriod[0].numerator[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].maxDosePerPeriod[0].numerator[0].code[0]g
MedicationRequest.dosageInstruction[0].maxDosePerPeriod[0].denominator[0].value[0]24
MedicationRequest.dosageInstruction[0].maxDosePerPeriod[0].denominator[0].unit[0]hour
MedicationRequest.dosageInstruction[0].maxDosePerPeriod[0].denominator[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].maxDosePerPeriod[0].denominator[0].code[0]h
MedicationRequest

Glucose 5% infusion 500ml bags, 500ml, intravenous, continuous infusion, over 8 hours

Non dm+d (ingredient) based prescription. Route, method and dose duration. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="6b122dc2-89b2-4f93-9139-3012f6669857" />
    <contained>
        <Medication>
            <id value="med1" />
            <form>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="14964511000001102" />
                    <display value="Infusion" />
                </coding>
            </form>
            <ingredient>
                <itemCodeableConcept>
                    <coding>
                        <system value="http://snomed.info/sct" />
                        <code value="768547002" />
                        <display value="Anhydrous Glucose" />
                    </coding>
                </itemCodeableConcept>
                <amount>
                    <numerator>
                        <value value="50" />
                        <unit value="gram" />
                        <system value="http://unitsofmeasure.org" />
                        <code value="g" />
                    </numerator>
                    <denominator>
                        <value value="1" />
                        <unit value="liter" />
                        <system value="http://unitsofmeasure.org" />
                        <code value="L" />
                    </denominator>
                </amount>
            </ingredient>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <duration value="8" />
                <durationUnit value="h" />
            </repeat>
        </timing>
        <method>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="261754007" />
                <display value="Continuous infusion" />
            </coding>
        </method>
        <rateRatio>
            <numerator>
                <value value="100" />
                <unit value="millilitre" />
                <system value="http://unitsofmeasure.org" />
                <code value="mL" />
            </numerator>
            <denominator>
                <value value="1" />
                <unit value="hour" />
                <system value="http://unitsofmeasure.org" />
                <code value="h" />
            </denominator>
        </rateRatio>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "6b122dc2-89b2-4f93-9139-3012f6669857",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "form": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "14964511000001102",
                        "display": "Infusion"
                    }
                ]
            },
            "ingredient":  [
                {
                    "itemCodeableConcept": {
                        "coding":  [
                            {
                                "system": "http://snomed.info/sct",
                                "code": "768547002",
                                "display": "Anhydrous Glucose"
                            }
                        ]
                    },
                    "amount": {
                        "numerator": {
                            "value": 50,
                            "unit": "gram",
                            "system": "http://unitsofmeasure.org",
                            "code": "g"
                        },
                        "denominator": {
                            "value": 1,
                            "unit": "liter",
                            "system": "http://unitsofmeasure.org",
                            "code": "L"
                        }
                    }
                }
            ]
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "duration": 8,
                    "durationUnit": "h"
                }
            },
            "method": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "261754007",
                        "display": "Continuous infusion"
                    }
                ]
            },
            "rateRatio": {
                "numerator": {
                    "value": 100,
                    "unit": "millilitre",
                    "system": "http://unitsofmeasure.org",
                    "code": "mL"
                },
                "denominator": {
                    "value": 1,
                    "unit": "hour",
                    "system": "http://unitsofmeasure.org",
                    "code": "h"
                }
            }
        }
    ]
}
MedicationRequest.id[0]6b122dc2-89b2-4f93-9139-3012f6669857
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].form[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].form[0].coding[0].code[0]14964511000001102
MedicationRequest.contained[0].form[0].coding[0].display[0]Infusion
MedicationRequest.contained[0].ingredient[0].item[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].ingredient[0].item[0].coding[0].code[0]768547002
MedicationRequest.contained[0].ingredient[0].item[0].coding[0].display[0]Anhydrous Glucose
MedicationRequest.contained[0].ingredient[0].amount[0].numerator[0].value[0]50
MedicationRequest.contained[0].ingredient[0].amount[0].numerator[0].unit[0]gram
MedicationRequest.contained[0].ingredient[0].amount[0].numerator[0].system[0]http://unitsofmeasure.org
MedicationRequest.contained[0].ingredient[0].amount[0].numerator[0].code[0]g
MedicationRequest.contained[0].ingredient[0].amount[0].denominator[0].value[0]1
MedicationRequest.contained[0].ingredient[0].amount[0].denominator[0].unit[0]liter
MedicationRequest.contained[0].ingredient[0].amount[0].denominator[0].system[0]http://unitsofmeasure.org
MedicationRequest.contained[0].ingredient[0].amount[0].denominator[0].code[0]L
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].duration[0]8
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].durationUnit[0]h
MedicationRequest.dosageInstruction[0].method[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].method[0].coding[0].code[0]261754007
MedicationRequest.dosageInstruction[0].method[0].coding[0].display[0]Continuous infusion
MedicationRequest.dosageInstruction[0].rate[0].numerator[0].value[0]100
MedicationRequest.dosageInstruction[0].rate[0].numerator[0].unit[0]millilitre
MedicationRequest.dosageInstruction[0].rate[0].numerator[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].rate[0].numerator[0].code[0]mL
MedicationRequest.dosageInstruction[0].rate[0].denominator[0].value[0]1
MedicationRequest.dosageInstruction[0].rate[0].denominator[0].unit[0]hour
MedicationRequest.dosageInstruction[0].rate[0].denominator[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].rate[0].denominator[0].code[0]h
MedicationRequest

Voluven 10% infusion 500ml Freeflex bags (Fresenius Kabi Ltd), infuse intravenously at a rate of 30ml/kg for 10 hours

Product-based prescription. Route method, dose duration, and dose expressed a rate ratio.

Note The rateRatio could also be modelled using a UCUM unit within a doseQuantity. In this example we are using the slightly more complex rateRatio structre.

<doseQuantity>
  <value value="30"/>
  <unit value="millilitres per kilogram"/>
  <system value="http://unitsofmeasure.org"/>
  <code value="ml/kg"/>
</doseQuantity>



<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="10850aa9-133b-4a33-aea7-5bef3b71ab9b" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="21514511000001103" />
                    <display value="Voluven 10% infusion 500ml Freeflex bags (Fresenius Kabi Ltd)" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <duration value="10" />
                <durationUnit value="h" />
            </repeat>
        </timing>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="47625008" />
                <display value="intravenous" />
            </coding>
        </route>
        <method>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="129330003" />
                <display value="infusion" />
            </coding>
        </method>
        <rateRatio>
            <numerator>
                <value value="30" />
                <unit value="millilitre" />
                <system value="http://unitsofmeasure.org" />
                <code value="mL" />
            </numerator>
            <denominator>
                <value value="1" />
                <unit value="kilogram" />
                <system value="http://unitsofmeasure.org" />
                <code value="kg" />
            </denominator>
        </rateRatio>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "10850aa9-133b-4a33-aea7-5bef3b71ab9b",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "21514511000001103",
                        "display": "Voluven 10% infusion 500ml Freeflex bags (Fresenius Kabi Ltd)"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "duration": 10,
                    "durationUnit": "h"
                }
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "47625008",
                        "display": "intravenous"
                    }
                ]
            },
            "method": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "129330003",
                        "display": "infusion"
                    }
                ]
            },
            "rateRatio": {
                "numerator": {
                    "value": 30,
                    "unit": "millilitre",
                    "system": "http://unitsofmeasure.org",
                    "code": "mL"
                },
                "denominator": {
                    "value": 1,
                    "unit": "kilogram",
                    "system": "http://unitsofmeasure.org",
                    "code": "kg"
                }
            }
        }
    ]
}
MedicationRequest.id[0]10850aa9-133b-4a33-aea7-5bef3b71ab9b
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]21514511000001103
MedicationRequest.contained[0].code[0].coding[0].display[0]Voluven 10% infusion 500ml Freeflex bags (Fresenius Kabi Ltd)
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].duration[0]10
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].durationUnit[0]h
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]47625008
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]intravenous
MedicationRequest.dosageInstruction[0].method[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].method[0].coding[0].code[0]129330003
MedicationRequest.dosageInstruction[0].method[0].coding[0].display[0]infusion
MedicationRequest.dosageInstruction[0].rate[0].numerator[0].value[0]30
MedicationRequest.dosageInstruction[0].rate[0].numerator[0].unit[0]millilitre
MedicationRequest.dosageInstruction[0].rate[0].numerator[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].rate[0].numerator[0].code[0]mL
MedicationRequest.dosageInstruction[0].rate[0].denominator[0].value[0]1
MedicationRequest.dosageInstruction[0].rate[0].denominator[0].unit[0]kilogram
MedicationRequest.dosageInstruction[0].rate[0].denominator[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].rate[0].denominator[0].code[0]kg
MedicationRequest

Hydroxocobalamin 10mg/2ml solution for injection ampoules, one to be given by IM injection into the shoulder, 3 times per week for 6 doses, then every 3 months, starting on 1st November 2019

Product-based prescription with course length as number of doses, sequential dosing. 
<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="6062d3bb-f6cf-41ec-aa71-dcd42299b10f" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="24856311000001103" />
                    <display value="Hydroxocobalamin 10mg/2ml solution for injection ampoules" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <sequence value="1" />
        <timing>
            <repeat>
                <count value="6" />
                <frequency value="3" />
                <period value="1" />
                <periodUnit value="wk" />
            </repeat>
        </timing>
        <site>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="16982005" />
                <display value="Shoulder" />
            </coding>
        </site>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="78421000" />
                <display value="intramuscular route" />
            </coding>
        </route>
        <doseQuantity>
            <value value="1" />
            <unit value="ampoule" />
            <system value="http://snomed.info/sct" />
            <code value="413516001" />
        </doseQuantity>
    </dosageInstruction>
    <dosageInstruction>
        <sequence value="2" />
        <timing>
            <repeat>
                <boundsPeriod>
                    <start value="2019-11-01" />
                </boundsPeriod>
                <frequency value="1" />
                <period value="3" />
                <periodUnit value="mo" />
            </repeat>
        </timing>
        <site>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="16982005" />
                <display value="Shoulder" />
            </coding>
        </site>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="78421000" />
                <display value="intramuscular route" />
            </coding>
        </route>
        <doseQuantity>
            <value value="1" />
            <unit value="ampoule" />
            <system value="http://snomed.info/sct" />
            <code value="413516001" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "6062d3bb-f6cf-41ec-aa71-dcd42299b10f",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "24856311000001103",
                        "display": "Hydroxocobalamin 10mg/2ml solution for injection ampoules"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "sequence": 1,
            "timing": {
                "repeat": {
                    "count": 6,
                    "frequency": 3,
                    "period": 1,
                    "periodUnit": "wk"
                }
            },
            "site": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "16982005",
                        "display": "Shoulder"
                    }
                ]
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "78421000",
                        "display": "intramuscular route"
                    }
                ]
            },
            "doseQuantity": {
                "value": 1,
                "unit": "ampoule",
                "system": "http://snomed.info/sct",
                "code": "413516001"
            }
        },
        {
            "sequence": 2,
            "timing": {
                "repeat": {
                    "boundsPeriod": {
                        "start": "2019-11-01"
                    },
                    "frequency": 1,
                    "period": 3,
                    "periodUnit": "mo"
                }
            },
            "site": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "16982005",
                        "display": "Shoulder"
                    }
                ]
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "78421000",
                        "display": "intramuscular route"
                    }
                ]
            },
            "doseQuantity": {
                "value": 1,
                "unit": "ampoule",
                "system": "http://snomed.info/sct",
                "code": "413516001"
            }
        }
    ]
}
MedicationRequest.id[0]6062d3bb-f6cf-41ec-aa71-dcd42299b10f
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]24856311000001103
MedicationRequest.contained[0].code[0].coding[0].display[0]Hydroxocobalamin 10mg/2ml solution for injection ampoules
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].sequence[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].count[0]6
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]3
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]wk
MedicationRequest.dosageInstruction[0].site[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].site[0].coding[0].code[0]16982005
MedicationRequest.dosageInstruction[0].site[0].coding[0].display[0]Shoulder
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]78421000
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]intramuscular route
MedicationRequest.dosageInstruction[0].dose[0].value[0]1
MedicationRequest.dosageInstruction[0].dose[0].unit[0]ampoule
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].dose[0].code[0]413516001
MedicationRequest.dosageInstruction[1].sequence[0]2
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].bounds[0].start[0]2019-11-01
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].frequency[0]1
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].period[0]3
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].periodUnit[0]mo
MedicationRequest.dosageInstruction[1].site[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[1].site[0].coding[0].code[0]16982005
MedicationRequest.dosageInstruction[1].site[0].coding[0].display[0]Shoulder
MedicationRequest.dosageInstruction[1].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[1].route[0].coding[0].code[0]78421000
MedicationRequest.dosageInstruction[1].route[0].coding[0].display[0]intramuscular route
MedicationRequest.dosageInstruction[1].dose[0].value[0]1
MedicationRequest.dosageInstruction[1].dose[0].unit[0]ampoule
MedicationRequest.dosageInstruction[1].dose[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[1].dose[0].code[0]413516001
MedicationRequest

Insulin lispro, 16units to be given by subcutaneous injection at meal times

<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="95542550-a4ad-4807-b1af-fcaff9980f9e" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="388454007" />
                    <display value="Insulin lispro" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="9999999999" />
        </identifier>
    </subject>
    <dosageInstruction>
        <timing>
            <repeat>
                <when value="C" />
            </repeat>
        </timing>
        <route>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="34206005" />
                <display value="subcutaneous" />
            </coding>
        </route>
        <method>
            <coding>
                <system value="http://snomed.info/sct" />
                <code value="422145002" />
                <display value="inject" />
            </coding>
        </method>
        <doseQuantity>
            <value value="16" />
            <unit value="Unit" />
            <system value="http://snomed.info/sct" />
            <code value="767525000" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "95542550-a4ad-4807-b1af-fcaff9980f9e",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "388454007",
                        "display": "Insulin lispro"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "9999999999"
        }
    },
    "dosageInstruction":  [
        {
            "timing": {
                "repeat": {
                    "when":  [
                        "C"
                    ]
                }
            },
            "route": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "34206005",
                        "display": "subcutaneous"
                    }
                ]
            },
            "method": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "422145002",
                        "display": "inject"
                    }
                ]
            },
            "doseQuantity": {
                "value": 16,
                "unit": "Unit",
                "system": "http://snomed.info/sct",
                "code": "767525000"
            }
        }
    ]
}
MedicationRequest.id[0]95542550-a4ad-4807-b1af-fcaff9980f9e
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]388454007
MedicationRequest.contained[0].code[0].coding[0].display[0]Insulin lispro
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]9999999999
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].when[0]C
MedicationRequest.dosageInstruction[0].route[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].route[0].coding[0].code[0]34206005
MedicationRequest.dosageInstruction[0].route[0].coding[0].display[0]subcutaneous
MedicationRequest.dosageInstruction[0].method[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].method[0].coding[0].code[0]422145002
MedicationRequest.dosageInstruction[0].method[0].coding[0].display[0]inject
MedicationRequest.dosageInstruction[0].dose[0].value[0]16
MedicationRequest.dosageInstruction[0].dose[0].unit[0]Unit
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://snomed.info/sct
MedicationRequest.dosageInstruction[0].dose[0].code[0]767525000
MedicationRequest

Levothyroxine 100mcg on one day alternating with 125mcg on another day

The dose should be 100mcg/125mcg, and it the label on the dispensed item for the patient will likely by a VTM such as:

Levothyroxine sodium 100mcg tablets - one to be taken daily and Levothyroxine sodium 25mcg tablets - one to be taken on alternate days

To account for this, the example below shows how to describe a dose instruction containing concurrent sequences.

<MedicationRequest xmlns="http://hl7.org/fhir">
    <id value="efaae147-81bb-4abd-b1d4-dd394a7ffc0c" />
    <contained>
        <Medication>
            <id value="med1" />
            <code>
                <coding>
                    <system value="http://snomed.info/sct" />
                    <code value="126202002" />
                    <display value="Levothyroxine sodium" />
                </coding>
            </code>
        </Medication>
    </contained>
    <status value="active" />
    <intent value="order" />
    <medicationReference>
        <reference value="#med1" />
    </medicationReference>
    <subject>
        <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number" />
            <value value="4857773456" />
        </identifier>
    </subject>
    <dosageInstruction>
        <sequence value="1" />
        <timing>
            <repeat>
                <frequency value="1" />
                <period value="1" />
                <periodUnit value="d" />
            </repeat>
        </timing>
        <doseQuantity>
            <value value="100" />
            <unit value="microgram" />
            <system value="http://unitsofmeasure.org" />
            <code value="ug" />
        </doseQuantity>
    </dosageInstruction>
    <dosageInstruction>
        <sequence value="1" />
        <timing>
            <repeat>
                <frequency value="1" />
                <period value="2" />
                <periodUnit value="d" />
            </repeat>
        </timing>
        <doseQuantity>
            <value value="25" />
            <unit value="microgram" />
            <system value="http://unitsofmeasure.org" />
            <code value="ug" />
        </doseQuantity>
    </dosageInstruction>
</MedicationRequest>

{
    "resourceType": "MedicationRequest",
    "id": "efaae147-81bb-4abd-b1d4-dd394a7ffc0c",
    "contained":  [
        {
            "resourceType": "Medication",
            "id": "med1",
            "code": {
                "coding":  [
                    {
                        "system": "http://snomed.info/sct",
                        "code": "126202002",
                        "display": "Levothyroxine sodium"
                    }
                ]
            }
        }
    ],
    "status": "active",
    "intent": "order",
    "medicationReference": {
        "reference": "#med1"
    },
    "subject": {
        "identifier": {
            "system": "https://fhir.nhs.uk/Id/nhs-number",
            "value": "4857773456"
        }
    },
    "dosageInstruction":  [
        {
            "sequence": 1,
            "timing": {
                "repeat": {
                    "frequency": 1,
                    "period": 1,
                    "periodUnit": "d"
                }
            },
            "doseQuantity": {
                "value": 100,
                "unit": "microgram",
                "system": "http://unitsofmeasure.org",
                "code": "ug"
            }
        },
        {
            "sequence": 1,
            "timing": {
                "repeat": {
                    "frequency": 1,
                    "period": 2,
                    "periodUnit": "d"
                }
            },
            "doseQuantity": {
                "value": 25,
                "unit": "microgram",
                "system": "http://unitsofmeasure.org",
                "code": "ug"
            }
        }
    ]
}
MedicationRequest.id[0]efaae147-81bb-4abd-b1d4-dd394a7ffc0c
MedicationRequest.contained[0].id[0]med1
MedicationRequest.contained[0].code[0].coding[0].system[0]http://snomed.info/sct
MedicationRequest.contained[0].code[0].coding[0].code[0]126202002
MedicationRequest.contained[0].code[0].coding[0].display[0]Levothyroxine sodium
MedicationRequest.status[0]active
MedicationRequest.intent[0]order
MedicationRequest.medication[0].reference[0]#med1
MedicationRequest.subject[0].identifier[0].system[0]https://fhir.nhs.uk/Id/nhs-number
MedicationRequest.subject[0].identifier[0].value[0]4857773456
MedicationRequest.dosageInstruction[0].sequence[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].frequency[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].period[0]1
MedicationRequest.dosageInstruction[0].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[0].dose[0].value[0]100
MedicationRequest.dosageInstruction[0].dose[0].unit[0]microgram
MedicationRequest.dosageInstruction[0].dose[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[0].dose[0].code[0]ug
MedicationRequest.dosageInstruction[1].sequence[0]1
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].frequency[0]1
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].period[0]2
MedicationRequest.dosageInstruction[1].timing[0].repeat[0].periodUnit[0]d
MedicationRequest.dosageInstruction[1].dose[0].value[0]25
MedicationRequest.dosageInstruction[1].dose[0].unit[0]microgram
MedicationRequest.dosageInstruction[1].dose[0].system[0]http://unitsofmeasure.org
MedicationRequest.dosageInstruction[1].dose[0].code[0]ug
MedicationRequest
Levothyroxine sodium - 100 microgram - once a day, and 25 microgram - every 2 days
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