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{
 "resourceType": "StructureDefinition",
 "id": "obs-described-variant",
 "text": {
 "status": "generated",
 "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"border: 0px #F0F0F0 solid; font-size: 11px; font-family: verdana; vertical-align: top;\"><tr style=\"border: 1px #F0F0F0 solid; font-size: 11px; font-family: verdana; vertical-align: top;\"><th style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://build.fhir.org/formats.html#table\" title=\"The logical name of the element\">Name</a></th><th style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://build.fhir.org/formats.html#table\" title=\"Information about the use of the element\">Flags</a></th><th style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://build.fhir.org/formats.html#table\" title=\"Minimum and Maximum # of times the the element can appear in the instance\">Card.</a></th><th style=\"width: 100px\" class=\"hierarchy\"><a href=\"http://build.fhir.org/formats.html#table\" title=\"Reference to the type of the element\">Type</a></th><th style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://build.fhir.org/formats.html#table\" title=\"Additional information about the element\">Description &amp; Constraints</a><a href=\"http://build.fhir.org/formats.html#table\" title=\"Legend for this format\"><img src=\"http://build.fhir.org/help16.png\" alt=\"doco\" style=\"background-color: inherit\"/></a></th></tr><tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck1.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation\" title=\"Details about a set of changes in the tested sample compared to a reference sequence.\">Observation</a><a name=\"Observation\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..*</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Described Variant (Discrete or Structural)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.code\" title=\"Where testing scenarios are intended to assess the prescence or absence of a known set of DNA variants (e.g. tumor profiling using genotyping technology), then the Genetic Variant Assessment is used in conjunction with answer list supports structured communication of these findings. Of note, 'No Call' is different from 'Absent', because 'No Call' did not result in the determination of the marker's presents or absents. This may be due to test failure or specimen specific context which renders the test ineffective.\">code</a><a name=\"Observation.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Genetic variant assessment Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;TBD-Described&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.valueCodeableConcept\" title=\"Indicates whether the indicated variation was found or not.\">valueCodeableConcept</a><a name=\"Observation.valueCodeableConcept\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Quantity\">Quantity</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#string\">string</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#boolean\">boolean</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#integer\">integer</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Ratio\">Ratio</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SampledData\">SampledData</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#time\">time</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#dateTime\">dateTime</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Period\">Period</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Present|Absent|No call|Indeterminate Binding: <a href=\"https://r.details.loinc.org/AnswerList/LL1971-2.html\">LOINC Answer List LL1971-2</a> (<a href=\"http://build.fhir.org/terminologies.html#required\" title=\"To be conformant, the concept in this element SHALL be from the specified value set\">required</a>)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.method\" title=\"Indicates the method of variant analysis.\">method</a><a name=\"Observation.method\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Sequencing | Oligo aCGH | SNP array | BAC aCGH |Curated|+ Binding: <a href=\"https://r.details.loinc.org/AnswerList/LL4048-6.html\">LOINC Answer List LL4048-6</a> (<a href=\"http://build.fhir.org/terminologies.html#required\" title=\"To be conformant, the concept in this element SHALL be from the specified value set\">required</a>)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck12.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_slice.png\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Slice Definition\" class=\"hierarchy\"/> <a style=\"font-style: italic\" href=\"{{[id]}}-definitions.html#Observation.component\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4; font-style: italic\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Slice: Unordered, Open by pattern:code</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:dna-chg\" title=\"Slice dna-chg: Human Genome Variation Society (HGVS) nomenclature for a single DNA marker. The use of the nomenclature must be extended to describe non-variations (aka. wild types) see samples for wild type examples.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Transcript DNA change (cHGVS)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:dna-chg.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;48004-6&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:dna-chg.valueCodeableConcept\">valueCodeableConcept</a><a name=\"Observation.component.valueCodeableConcept\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Quantity\">Quantity</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#string\">string</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#boolean\">boolean</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#integer\">integer</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Ratio\">Ratio</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SampledData\">SampledData</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#time\">time</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#dateTime\">dateTime</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Period\">Period</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Binding: <a href=\"http://build.fhir.org/terminologies.html#unbound\">(unbound)</a> (<a href=\"http://build.fhir.org/terminologies.html#example\" title=\"Instances are not expected or even encouraged to draw from the specified value set. The value set merely provides examples of the types of concepts intended to be included.\">example</a>)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:dna-chg-type\" title=\"Slice dna-chg-type: Codified type for associated DNA Marker. DNA Marker's use the HGVS notation which implies the DNA Marker Type, but the concurrent use of this code will allow a standard and explicit type for technical and display convenience.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">DNA change type</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:dna-chg-type.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;48019-4&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:dna-chg-type.valueCodeableConcept\" title=\"Type of DNA variation reported.\">valueCodeableConcept</a><a name=\"Observation.component.valueCodeableConcept\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Quantity\">Quantity</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#string\">string</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#boolean\">boolean</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#integer\">integer</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Ratio\">Ratio</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SampledData\">SampledData</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#time\">time</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#dateTime\">dateTime</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Period\">Period</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Wild type | Deletion | Duplication | Insertion | Insertion/Deletion | Inversion | Substitution | Copy number gain + Binding: <a href=\"https://r.details.loinc.org/AnswerList/LL4033-8.html\">LOINC Answer List LL4033-8</a> (<a href=\"http://build.fhir.org/terminologies.html#required\" title=\"To be conformant, the concept in this element SHALL be from the specified value set\">required</a>)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:variation-code\" title=\"Slice variation-code: This term is used to report the unique identifier of the simple variant found in this study.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Simple var ID</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:variation-code.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;81252-9&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:variation-code.valueCodeableConcept\">valueCodeableConcept</a><a name=\"Observation.component.valueCodeableConcept\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Quantity\">Quantity</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#string\">string</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#boolean\">boolean</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#integer\">integer</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Ratio\">Ratio</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SampledData\">SampledData</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#time\">time</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#dateTime\">dateTime</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Period\">Period</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Binding: <a href=\"http://build.fhir.org/terminologies.html#unbound\">(unbound)</a> (<a href=\"http://build.fhir.org/terminologies.html#example\" title=\"Instances are not expected or even encouraged to draw from the specified value set. The value set merely provides examples of the types of concepts intended to be included.\">example</a>)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:dbsnp-id\" title=\"Slice dbSNP-id: The unique identifier for the variant represented as a small nucleotide polymorphism (SNP). The dbSNP ID is used routinely as the base identifier in pharmacogenomics as well as arrCGH studies. For example, for the simple variant NM_014049.4(ACAD9):c.1249C&gt;T (p.Arg417Cys), the dbSNP ID is 368949613. [http://www.ncbi.nlm.nih.gov/clinvar/variation/30880/].\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">dbSNP ID</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:dbsnp-id.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;81255-2&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:dbsnp-id.valueCodeableConcept\">valueCodeableConcept</a><a name=\"Observation.component.valueCodeableConcept\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Quantity\">Quantity</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#string\">string</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#boolean\">boolean</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#integer\">integer</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Ratio\">Ratio</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SampledData\">SampledData</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#time\">time</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#dateTime\">dateTime</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Period\">Period</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Binding: <a href=\"http://build.fhir.org/terminologies.html#unbound\">(unbound)</a> (<a href=\"http://build.fhir.org/terminologies.html#example\" title=\"Instances are not expected or even encouraged to draw from the specified value set. The value set merely provides examples of the types of concepts intended to be included.\">example</a>)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:genomic-dna-chg\" title=\"Slice genomic-dna-chg: The name of a structural variant reported using HGVS nomenclature.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Genomica DNA change (gHGVS)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:genomic-dna-chg.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;81290-9&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:genomic-dna-chg.valueCodeableConcept\">valueCodeableConcept</a><a name=\"Observation.component.valueCodeableConcept\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Quantity\">Quantity</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#string\">string</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#boolean\">boolean</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#integer\">integer</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Ratio\">Ratio</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SampledData\">SampledData</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#time\">time</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#dateTime\">dateTime</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Period\">Period</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Binding: <a href=\"http://build.fhir.org/terminologies.html#unbound\">(unbound)</a> (<a href=\"http://build.fhir.org/terminologies.html#example\" title=\"Instances are not expected or even encouraged to draw from the specified value set. The value set merely provides examples of the types of concepts intended to be included.\">example</a>)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:genomic-source-class\" title=\"Slice genomic-source-class: The genomic class of the specimen being analyzed: Germline for inherited genome, somatic for cancer genome, and prenatal for fetal genome.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Genomic source class</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:genomic-source-class.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;48002-0&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:genomic-source-class.valueCodeableConcept\" title=\"MG_2_Genetic variant source.\">valueCodeableConcept</a><a name=\"Observation.component.valueCodeableConcept\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Quantity\">Quantity</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#string\">string</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#boolean\">boolean</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#integer\">integer</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Ratio\">Ratio</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SampledData\">SampledData</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#time\">time</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#dateTime\">dateTime</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Period\">Period</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Germline | Somatic | Fetal | Likely germline | Likely somatic |Likely fetal | Unknown genomic origin | De novo Binding: <a href=\"https://r.details.loinc.org/AnswerList/LL378-1.html\">LOINC Answer List LL378-1</a> (<a href=\"http://build.fhir.org/terminologies.html#required\" title=\"To be conformant, the concept in this element SHALL be from the specified value set\">required</a>)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:amino-acid-chg\" title=\"Slice amino-acid-chg: Human Genome Variation Society (HGVS) nomenclature for an amino acid sequence. This value is derivable from the DNA Marker value if available. It is provided for convenience. The use of the nomenclature must be extended to describe non-variations (aka. wild types) see samples for wild type examples.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Amino acid change (pHGVS)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:amino-acid-chg.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;48005-3&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:amino-acid-chg.valueCodeableConcept\">valueCodeableConcept</a><a name=\"Observation.component.valueCodeableConcept\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Quantity\">Quantity</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#string\">string</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#boolean\">boolean</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#integer\">integer</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Ratio\">Ratio</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SampledData\">SampledData</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#time\">time</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#dateTime\">dateTime</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Period\">Period</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Binding: <a href=\"http://build.fhir.org/terminologies.html#unbound\">(unbound)</a> (<a href=\"http://build.fhir.org/terminologies.html#example\" title=\"Instances are not expected or even encouraged to draw from the specified value set. The value set merely provides examples of the types of concepts intended to be included.\">example</a>)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:amino-acid-chg-type\" title=\"Slice amino-acid-chg-type: Codified type for associated Amino Acid Marker. Amino Acid Marker's use the HGVS notation which implies the Amino Acid Marker Type, but the concurrent use of this code will allow a standard and explicit type for technical and display convenience.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Amino acid change type</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:amino-acid-chg-type.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;48006-1&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:amino-acid-chg-type.valueCodeableConcept\" title=\"MG_4_Amino acid change type.\">valueCodeableConcept</a><a name=\"Observation.component.valueCodeableConcept\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Quantity\">Quantity</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#string\">string</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#boolean\">boolean</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#integer\">integer</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Ratio\">Ratio</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SampledData\">SampledData</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#time\">time</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#dateTime\">dateTime</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Period\">Period</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Wild type | Deletion | Duplication | Frameshift | Initiating Methionine | Insertion | Insertion and Deletion | Missense | Silent | Stop Codon Mutation Binding: <a href=\"https://r.details.loinc.org/AnswerList/LL380-7.html\">LOINC Answer List LL380-7</a> (<a href=\"http://build.fhir.org/terminologies.html#required\" title=\"To be conformant, the concept in this element SHALL be from the specified value set\">required</a>)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:transcript-ref-seq\" title=\"Slice transcript-ref-seq: This field carries the ID for the transcribed reference sequence, which is the part of the genomic reference sequence that is converted to messenger RNA (i.e., after the introns are removed).\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Transcript reference sequence ID</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:transcript-ref-seq.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;51958-7&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:transcript-ref-seq.valueCodeableConcept\">valueCodeableConcept</a><a name=\"Observation.component.valueCodeableConcept\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Quantity\">Quantity</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#string\">string</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#boolean\">boolean</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#integer\">integer</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Ratio\">Ratio</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SampledData\">SampledData</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#time\">time</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#dateTime\">dateTime</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Period\">Period</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Binding: <a href=\"http://build.fhir.org/terminologies.html#unbound\">(unbound)</a> (<a href=\"http://build.fhir.org/terminologies.html#example\" title=\"Instances are not expected or even encouraged to draw from the specified value set. The value set merely provides examples of the types of concepts intended to be included.\">example</a>)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:genomic-ref-seq\" title=\"Slice genomic-ref-seq: This field carries the ID for the genomic reference sequence. The genomic reference sequence is a contiguous stretch of chromosome DNA that spans all of the exons of the gene and includes transcribed and non transcribed stretches. For this ID use either the NCBI genomic nucleotide RefSeq IDs with their version number (see: NCBI.NLM.NIH.Gov/RefSeq) or use the LRG identifiers, without transcript (t or p) extensions -- when they become available. (See- Report sponsored by GEN2PHEN at the European Bioinformatics Institute at Hinxton UK April 24-25, 2008).\rThe NCI RefSeq genomic IDs are distinguished by a prefix of&quot;NG&quot; for genes from the nuclear chromosomes and prefix of &quot;NC&quot; for genes from mitochondria. The LRG Identifiers have a prefix of &quot;LRG_&quot; Mitochondrial genes are not in the scope of LRG.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Genomic reference sequence ID</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:genomic-ref-seq.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;48013-7&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:genomic-ref-seq.valueCodeableConcept\">valueCodeableConcept</a><a name=\"Observation.component.valueCodeableConcept\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Quantity\">Quantity</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#string\">string</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#boolean\">boolean</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#integer\">integer</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Ratio\">Ratio</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SampledData\">SampledData</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#time\">time</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#dateTime\">dateTime</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Period\">Period</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Binding: <a href=\"http://build.fhir.org/terminologies.html#unbound\">(unbound)</a> (<a href=\"http://build.fhir.org/terminologies.html#example\" title=\"Instances are not expected or even encouraged to draw from the specified value set. The value set merely provides examples of the types of concepts intended to be included.\">example</a>)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allelic-frequency\" title=\"Slice allelic-frequency: \">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Allelic Frequency</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allelic-frequency.code\" title=\"The allelic frequency is the relative frequency of a particular allele in the population, expressed as a number from 0 to 1.\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Allelic frequency [NFr] Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;81258-6&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck141.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allelic-frequency.valueQuantity\">valueQuantity</a><a name=\"Observation.component.valueQuantity\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Quantity\">Quantity</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck1410.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allelic-frequency.valueQuantity.value\">value</a><a name=\"Observation.component.valueQuantity.value\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#decimal\">decimal</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck1410.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_primitive.png\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Primitive Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allelic-frequency.valueQuantity.system\">system</a><a name=\"Observation.component.valueQuantity.system\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#uri\">uri</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Fixed Value: http://unitsofmeasure.org</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck1400.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_primitive.png\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Primitive Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allelic-frequency.valueQuantity.code\">code</a><a name=\"Observation.component.valueQuantity.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#code\">code</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Fixed Value: %</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allelic-phase\" title=\"Slice allelic-phase: The period of stage of an allele.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Allelic phase</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allelic-phase.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;82120-7&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allelic-phase.valueCodeableConcept\">valueCodeableConcept</a><a name=\"Observation.component.valueCodeableConcept\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Quantity\">Quantity</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#string\">string</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#boolean\">boolean</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#integer\">integer</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Ratio\">Ratio</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SampledData\">SampledData</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#time\">time</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#dateTime\">dateTime</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Period\">Period</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1st set of variants is cis relation to each other | 2nd set of variants is cis relation to each other | 3rd set of variants is cis relation to each other | 4th set of variants is cis relation to each other | 5th set of variants is cis relation to each other | Maternal | Paternal | Unknown | Other, please specify Binding: <a href=\"https://r.details.loinc.org/AnswerList/LL4025-4.html\">LOINC Answer List LL4025-4</a> (<a href=\"http://build.fhir.org/terminologies.html#required\" title=\"To be conformant, the concept in this element SHALL be from the specified value set\">required</a>)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allelic-phase-basis\" title=\"Slice allelic-phase-basis: The evidential basis on which the allelic phase and/or the allelic state was concluded.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Basis for allelic phase</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allelic-phase-basis.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;82309-6&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allelic-phase-basis.valueCodeableConcept\">valueCodeableConcept</a><a name=\"Observation.component.valueCodeableConcept\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Quantity\">Quantity</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#string\">string</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#boolean\">boolean</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#integer\">integer</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Ratio\">Ratio</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SampledData\">SampledData</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#time\">time</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#dateTime\">dateTime</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Period\">Period</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Binding: <a href=\"https://r.details.loinc.org/AnswerList/LL4050-2.html\">LOINC Answer List LL4050-2</a> (<a href=\"http://build.fhir.org/terminologies.html#required\" title=\"To be conformant, the concept in this element SHALL be from the specified value set\">required</a>)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allelic-read-depth\" title=\"Slice allelic-read-depth: Specifies the number of reads that identified the allele in question whether it consists of one or a small sequence of contiguous nucleotides. Different methods and purposes require different numbers of reads to be acceptable. Often &gt;400, sometimes as few as 2-4.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..*</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allelic-read-depth.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;82121-5&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allelic-read-depth.valueQuantity\">valueQuantity</a><a name=\"Observation.component.valueQuantity\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://build.fhir.org/datatypes.html#Count\" title=\"Quantity\">Count</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allelic-state\" title=\"Slice allelic-state: The level of occurrence of a single DNA Marker within a set of chromosomes. Heterozygous indicates the DNA Marker is only present in one of the two genes contained in homologous chromosomes. Homozygous indicates the DNA Marker is present in both genes contained in homologous chromosomes. Hemizygous indicates the DNA Marker exists in the only single copy of a gene in a non-homologous chromosome (The male X and Y chromosome are non-homologous). Hemiplasmic indicates that the DNA Marker is present in some but not all of the copies of mitochondrial DNA. Homoplasmic indicates that the DNA Maker is present in all of the copies of mitochondrial DNA.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Allelic state</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allelic-state.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;53034-5&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allelic-state.valueCodeableConcept\" title=\"The relationship between the alleles found at the same locus on different chromosomes.\">valueCodeableConcept</a><a name=\"Observation.component.valueCodeableConcept\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Quantity\">Quantity</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#string\">string</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#boolean\">boolean</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#integer\">integer</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Ratio\">Ratio</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SampledData\">SampledData</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#time\">time</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#dateTime\">dateTime</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Period\">Period</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Heteroplasmic | Homoplasmic | Homozygous | Heterozygous | Hemizygous Binding: <a href=\"https://r.details.loinc.org/AnswerList/LL381-5.html\">LOINC Answer List LL381-5</a> (<a href=\"http://build.fhir.org/terminologies.html#required\" title=\"To be conformant, the concept in this element SHALL be from the specified value set\">required</a>)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:copy-number\" title=\"Slice copy-number: The copy number of the large variant. In HGVS, this is the numeric value following the “X”. It is a unit-less value. Note that a copy number of 1 implies a deletion. The copy number can usually be inferred from the HGVS or ISCN fields.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Genomic structural variant copy number</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:copy-number.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;82155-3&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:copy-number.valueQuantity\">valueQuantity</a><a name=\"Observation.component.valueQuantity\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://build.fhir.org/datatypes.html#Count\" title=\"Quantity\">Count</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:arrcgh-ratio\" title=\"Slice arrCGH-ratio: todo.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Structural variant reported arrCGH [Ratio]</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:arrcgh-ratio.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;81299-0&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:arrcgh-ratio.valueQuantity\">valueQuantity</a><a name=\"Observation.component.valueQuantity\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://build.fhir.org/datatypes.html#SimpleQuantity\" title=\"Quantity\">SimpleQuantity</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:ref-allele\" title=\"Slice ref-allele: Reference values (&quot;normal&quot;) examined within the Reference Sequence.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Genomic ref allele</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:ref-allele.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;69547-8&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:ref-allele.valueString\">valueString</a><a name=\"Observation.component.valueString\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Quantity\">Quantity</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#string\">string</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#boolean\">boolean</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#integer\">integer</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Ratio\">Ratio</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SampledData\">SampledData</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#time\">time</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#dateTime\">dateTime</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Period\">Period</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:alt-allele\" title=\"Slice alt-allele: The genomic alternate allele is the contiguous segment of DNA in the test sample that differs from the reference allele at the same location and thus defines a variant.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Genomic alt allele</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:alt-allele.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;69551-0&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:alt-allele.valueString\">valueString</a><a name=\"Observation.component.valueString\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Quantity\">Quantity</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#string\">string</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#boolean\">boolean</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#integer\">integer</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Ratio\">Ratio</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SampledData\">SampledData</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#time\">time</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#dateTime\">dateTime</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Period\">Period</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:coordinate-system\" title=\"Slice coordinate-system: Base number of coordinate system (0 for 0-based numbering or interbase coordinate system, inclusive start, exclusive end, 1 for 1-based numbering or base coordinate system, inclusive start, inclusive end).\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Coordinate System</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:coordinate-system.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;TBD&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:coordinate-system.valueCodeableConcept\">valueCodeableConcept</a><a name=\"Observation.component.valueCodeableConcept\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Quantity\">Quantity</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#string\">string</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#boolean\">boolean</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#integer\">integer</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Ratio\">Ratio</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SampledData\">SampledData</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#time\">time</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#dateTime\">dateTime</a>, <a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Period\">Period</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Binding: <a href=\"valueset-genetic-coordinate-system.html\">GeneticCoordinateSystem</a> (<a href=\"http://build.fhir.org/terminologies.html#required\" title=\"To be conformant, the concept in this element SHALL be from the specified value set\">required</a>)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allele-start-end\" title=\"Slice allele-start-end: The genomic allele location is the first genomic position in the reference allele that contains a change from the reference allele. For example, for the simple variant NM_014049.4(ACAD9):c.1249C&gt;T (p.Arg417Cys), the genomic allele location is Chr3: 128906220 on Assembly GRCh38.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Genomic Allele start-end</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allele-start-end.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;81254-5&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck141.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allele-start-end.valueRange\">valueRange</a><a name=\"Observation.component.valueRange\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck1410.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allele-start-end.valueRange.low\">low</a><a name=\"Observation.component.valueRange.low\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SimpleQuantity\" title=\"Quantity\">SimpleQuantity</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Genomic Allele start</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck1400.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:allele-start-end.valueRange.high\">high</a><a name=\"Observation.component.valueRange.high\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SimpleQuantity\" title=\"Quantity\">SimpleQuantity</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Genomic Allele end</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:variant-length\" title=\"Slice variant-length: Length of the structural variant, which information may be ascertained in some but not all types of structural variants.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Structural variant length</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:variant-length.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;81300-6&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck140.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:variant-length.valueQuantity\">valueQuantity</a><a name=\"Observation.component.valueQuantity\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://build.fhir.org/datatypes.html#Count\" title=\"Quantity\">Count</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck15.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:outer-start-end\" title=\"Slice outer-start-end: The genomic coordinates of the widest genomic range in which the structural variant might reside.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Structural variant outer start and end</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck150.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:outer-start-end.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;81301-4&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck141.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:outer-start-end.valueRange\">valueRange</a><a name=\"Observation.component.valueRange\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck1410.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:outer-start-end.valueRange.low\">low</a><a name=\"Observation.component.valueRange.low\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SimpleQuantity\" title=\"Quantity\">SimpleQuantity</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck1400.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:outer-start-end.valueRange.high\">high</a><a name=\"Observation.component.valueRange.high\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SimpleQuantity\" title=\"Quantity\">SimpleQuantity</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck05.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:inner-start-end\" title=\"Slice inner-start-end: The genomic coordinates of the narrowest genomic range in which the structural variant might reside.\">component</a><a name=\"Observation.component\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Structural variant inner start and end</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck050.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_datatype.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:inner-start-end.code\">code</a><a name=\"Observation.component.code\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Required Pattern: {&quot;coding&quot;:[{&quot;system&quot;:&quot;http://loinc.org&quot;,&quot;code&quot;:&quot;81302-2&quot;}]}</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck041.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:inner-start-end.valueRange\">valueRange</a><a name=\"Observation.component.valueRange\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#Range\">Range</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0410.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:inner-start-end.valueRange.low\">low</a><a name=\"Observation.component.valueRange.low\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SimpleQuantity\" title=\"Quantity\">SimpleQuantity</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white;\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0400.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"{{[id]}}-definitions.html#Observation.component:inner-start-end.valueRange.high\">high</a><a name=\"Observation.component.valueRange.high\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.4\" href=\"http://build.fhir.org/datatypes.html#SimpleQuantity\" title=\"Quantity\">SimpleQuantity</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/></tr>\r\n<tr><td colspan=\"5\" class=\"hierarchy\"> <a href=\"http://build.fhir.org/formats.html#table\" title=\"Legend for this format\"><img src=\"http://build.fhir.org/help16.png\" alt=\"doco\" style=\"background-color: inherit\"/> Documentation for this format</a></td></tr></table></div>"
 },
 "url": "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/obs-described-variant",
 "version": "2018may",
 "name": "Described Variant (Discrete or Structural)",
 "status": "draft",
 "date": "2017-05-20",
 "publisher": "HL7 Clinical Genomics WG",
 "description": "Observation-related profiles",
 "fhirVersion": "3.3.0",
 "mapping": [
 {
 "identity": "v2-cg-results",
 "uri": "http://unknown.org/V2-CG-Results",
 "name": "V2-CG-Results"
 },
 {
 "identity": "workflow",
 "uri": "http://hl7.org/fhir/workflow",
 "name": "Workflow Pattern"
 },
 {
 "identity": "sct-concept",
 "uri": "http://snomed.info/conceptdomain",
 "name": "SNOMED CT Concept Domain Binding"
 },
 {
 "identity": "v2",
 "uri": "http://hl7.org/v2",
 "name": "HL7 v2 Mapping"
 },
 {
 "identity": "rim",
 "uri": "http://hl7.org/v3",
 "name": "RIM Mapping"
 },
 {
 "identity": "w5",
 "uri": "http://hl7.org/fhir/fivews",
 "name": "FiveWs Pattern"
 },
 {
 "identity": "sct-attr",
 "uri": "http://snomed.info/sct",
 "name": "SNOMED CT Attribute Binding"
 }
 ],
 "kind": "resource",
 "abstract": false,
 "type": "Observation",
 "baseDefinition": "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/obs-comp-gen-finding",
 "derivation": "constraint",
 "snapshot": {
 "element": [
 {
 "id": "Observation",
 "path": "Observation",
 "short": "Described Variant (Discrete or Structural)",
 "definition": "Details about a set of changes in the tested sample compared to a reference sequence.",
 "comment": "This can be a simple/discrete (relatively short) or structural (potentially very large) variant.",
 "alias": [
 "Vital Signs",
 "Measurement",
 "Results",
 "Tests"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation",
 "min": 0,
 "max": "*"
 },
 "constraint": [
 {
 "key": "dom-2",
 "severity": "error",
 "human": "If the resource is contained in another resource, it SHALL NOT contain nested Resources",
 "expression": "contained.contained.empty()",
 "xpath": "not(parent::f:contained and f:contained)",
 "source": "DomainResource"
 },
 {
 "key": "dom-1",
 "severity": "error",
 "human": "If the resource is contained in another resource, it SHALL NOT contain any narrative",
 "expression": "contained.text.empty()",
 "xpath": "not(parent::f:contained and f:text)",
 "source": "DomainResource"
 },
 {
 "key": "dom-4",
 "severity": "error",
 "human": "If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated",
 "expression": "contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()",
 "xpath": "not(exists(f:contained/*/f:meta/f:versionId)) and not(exists(f:contained/*/f:meta/f:lastUpdated))",
 "source": "DomainResource"
 },
 {
 "key": "dom-3",
 "severity": "error",
 "human": "If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource",
 "expression": "contained.all(('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists())",
 "xpath": "not(exists(for $contained in f:contained return $contained[not(parent::*/descendant::f:reference/@value=concat('#', $contained/*/id/@value) or descendant::f:reference[@value='#'])]))",
 "source": "DomainResource"
 },
 {
 "key": "obs-7",
 "severity": "error",
 "human": "If Observation.code is the same as a Observation.component.code then the value element associated with the code SHALL NOT be present",
 "expression": "value.empty() or component.code.where( (coding.code = %resource.code.coding.code) and (coding.system = %resource.code.coding.system)).empty()",
 "xpath": "not(f:*[starts-with(local-name(.), 'value')] and (for $coding in f:code/f:coding return f:component/f:code/f:coding[f:code/@value=$coding/f:code/@value] [f:system/@value=$coding/f:system/@value]))",
 "source": "Observation"
 },
 {
 "key": "obs-6",
 "severity": "error",
 "human": "dataAbsentReason SHALL only be present if Observation.value[x] is not present",
 "expression": "dataAbsentReason.empty() or value.empty()",
 "xpath": "not(exists(f:dataAbsentReason)) or (not(exists(*[starts-with(local-name(.), 'value')])))",
 "source": "Observation"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "Entity. Role, or Act"
 },
 {
 "identity": "workflow",
 "map": "Event"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity|"
 },
 {
 "identity": "v2",
 "map": "OBX"
 },
 {
 "identity": "rim",
 "map": "Observation[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.id",
 "path": "Observation.id",
 "short": "Logical id of this artifact",
 "definition": "The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes.",
 "comment": "The only time that a resource does not have an id is when it is being submitted to the server using a create operation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Resource.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "id"
 }
 ],
 "isModifier": false,
 "isSummary": true
 },
 {
 "id": "Observation.meta",
 "path": "Observation.meta",
 "short": "Metadata about the resource",
 "definition": "The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Resource.meta",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Meta"
 }
 ],
 "isModifier": false,
 "isSummary": true
 },
 {
 "id": "Observation.implicitRules",
 "path": "Observation.implicitRules",
 "short": "A set of rules under which this content was created",
 "definition": "A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc.",
 "comment": "Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of it's narrative along with other profiles, value sets, etc.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Resource.implicitRules",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "uri"
 }
 ],
 "isModifier": true,
 "isModifierReason": "This element is labeled as a modifier because the implicit rules may provide additional knowledge about the resource that modifies it's meaning or interpretation",
 "isSummary": true
 },
 {
 "id": "Observation.language",
 "path": "Observation.language",
 "short": "Language of the resource content",
 "definition": "The base language in which the resource is written.",
 "comment": "Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource. Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute).",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Resource.language",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "code"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-maxValueSet",
 "valueReference": {
 "reference": "http://hl7.org/fhir/ValueSet/all-languages"
 }
 },
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "Language"
 },
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-isCommonBinding",
 "valueBoolean": true
 }
 ],
 "strength": "extensible",
 "description": "A human language.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/languages"
 }
 },
 {
 "id": "Observation.text",
 "path": "Observation.text",
 "short": "Text summary of the resource, for human interpretation",
 "definition": "A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it \"clinically safe\" for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety.",
 "comment": "Contained resources do not have narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied). This may be necessary for data from legacy systems where information is captured as a \"text blob\" or where text is additionally entered raw or narrated and encoded in formation is added later.",
 "alias": [
 "narrative",
 "html",
 "xhtml",
 "display"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "DomainResource.text",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Narrative"
 }
 ],
 "condition": [
 "dom-1"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "Act.text?"
 }
 ]
 },
 {
 "id": "Observation.contained",
 "path": "Observation.contained",
 "short": "Contained, inline Resources",
 "definition": "These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, and nor can they have their own independent transaction scope.",
 "comment": "This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again.",
 "alias": [
 "inline resources",
 "anonymous resources",
 "contained resources"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "DomainResource.contained",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Resource"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.extension",
 "path": "Observation.extension",
 "slicing": {
 "id": "3",
 "discriminator": [
 {
 "type": "value",
 "path": "url"
 }
 ],
 "ordered": false,
 "rules": "open"
 },
 "short": "Extension",
 "definition": "An Extension",
 "min": 0,
 "max": "*",
 "base": {
 "path": "DomainResource.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Observation.extension:bodystructure",
 "path": "Observation.extension",
 "sliceName": "bodyStructure",
 "short": "Extension",
 "definition": "Allows associating observations to a particular portion of the patient - a fetus, a tumor, a lesion, etc.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "DomainResource.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension",
 "profile": [
 "http://hl7.org/fhir/StructureDefinition/body-structure"
 ]
 }
 ],
 "condition": [
 "ele-1"
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "xpath": "exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])",
 "source": "Extension"
 }
 ],
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.modifierExtension",
 "path": "Observation.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the resource, and that modifies the understanding of the element that contains it. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "DomainResource.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "Not known why this is labelled a modifier",
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.identifier",
 "path": "Observation.identifier",
 "short": "Business Identifier for observation",
 "definition": "A unique identifier assigned to this observation.",
 "requirements": "Allows observations to be distinguished and referenced.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.identifier",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Identifier"
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "workflow",
 "map": "Event.identifier"
 },
 {
 "identity": "w5",
 "map": "FiveWs.identifier"
 },
 {
 "identity": "v2",
 "map": "OBX.21 For OBX segments from systems without OBX-21 support a combination of ORC/OBR and OBX must be negotiated between trading partners to uniquely identify the OBX segment. Depending on how V2 has been implemented each of these may be an option: 1) OBR-3 + OBX-3 + OBX-4 or 2) OBR-3 + OBR-4 + OBX-3 + OBX-4 or 2) some other way to uniquely ID the OBR/ORC + OBX-3 + OBX-4."
 },
 {
 "identity": "rim",
 "map": "id"
 }
 ]
 },
 {
 "id": "Observation.basedOn",
 "path": "Observation.basedOn",
 "short": "Fulfills plan, proposal or order",
 "definition": "A plan, proposal or order that is fulfilled in whole or in part by this event.",
 "requirements": "Allows tracing of authorization for the event and tracking whether proposals/recommendations were acted upon.",
 "alias": [
 "Fulfills"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.basedOn",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/CarePlan",
 "http://hl7.org/fhir/StructureDefinition/DeviceRequest",
 "http://hl7.org/fhir/StructureDefinition/ImmunizationRecommendation",
 "http://hl7.org/fhir/StructureDefinition/MedicationRequest",
 "http://hl7.org/fhir/StructureDefinition/NutritionOrder",
 "http://hl7.org/fhir/StructureDefinition/ServiceRequest"
 ]
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "workflow",
 "map": "Event.basedOn"
 },
 {
 "identity": "v2",
 "map": "ORC"
 },
 {
 "identity": "rim",
 "map": ".inboundRelationship[typeCode=COMP].source[moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.partOf",
 "path": "Observation.partOf",
 "short": "Part of referenced event",
 "definition": "A larger event of which this particular Observation is a component or step. For example, an observation as part of a procedure.",
 "comment": "To link an Observation to an Encounter use `context`. See the [Notes](observation.html#obsgrouping) below for guidance on referencing another Observation.",
 "alias": [
 "Container"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.partOf",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/MedicationAdministration",
 "http://hl7.org/fhir/StructureDefinition/MedicationDispense",
 "http://hl7.org/fhir/StructureDefinition/MedicationStatement",
 "http://hl7.org/fhir/StructureDefinition/Procedure",
 "http://hl7.org/fhir/StructureDefinition/Immunization",
 "http://hl7.org/fhir/StructureDefinition/ImagingStudy"
 ]
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "workflow",
 "map": "Event.partOf"
 },
 {
 "identity": "v2",
 "map": "Varies by domain"
 },
 {
 "identity": "rim",
 "map": ".outboundRelationship[typeCode=FLFS].target"
 }
 ]
 },
 {
 "id": "Observation.status",
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-display-hint",
 "valueString": "default: final"
 }
 ],
 "path": "Observation.status",
 "short": "registered | preliminary | final | amended +",
 "definition": "The status of the result value.",
 "comment": "… This should generally be 'completed' or 'revised'.",
 "requirements": "Need to track the status of individual results. Some results are finalized before the whole report is finalized.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.status",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "code"
 }
 ],
 "mustSupport": true,
 "isModifier": true,
 "isModifierReason": "This element is labeled as a modifier because it is a status element that contains status entered-in-error which means that the resource should not be treated as valid",
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationStatus"
 }
 ],
 "strength": "required",
 "description": "Codes providing the status of an observation.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-status"
 },
 "mapping": [
 {
 "identity": "workflow",
 "map": "Event.status"
 },
 {
 "identity": "w5",
 "map": "FiveWs.status"
 },
 {
 "identity": "sct-concept",
 "map": "< 445584004 |Report by finality status|"
 },
 {
 "identity": "v2",
 "map": "OBX-11"
 },
 {
 "identity": "rim",
 "map": "status Amended & Final are differentiated by whether it is the subject of a ControlAct event with a type of \"revise\""
 }
 ]
 },
 {
 "id": "Observation.category",
 "path": "Observation.category",
 "short": "Classification of type of observation",
 "definition": "A code that classifies the general type of observation being made.",
 "comment": "… This should be populated with 'lab'.",
 "requirements": "Used for filtering what observations are retrieved and displayed.",
 "min": 1,
 "max": "*",
 "base": {
 "path": "Observation.category",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://hl7.org/fhir/observation-category",
 "code": "laboratory"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCategory"
 }
 ],
 "strength": "preferred",
 "description": "Codes for high level observation categories.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-category"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.class"
 },
 {
 "identity": "rim",
 "map": ".outboundRelationship[typeCode=\"COMP].target[classCode=\"LIST\", moodCode=\"EVN\"].code"
 }
 ]
 },
 {
 "id": "Observation.code",
 "path": "Observation.code",
 "short": "Genetic variant assessment",
 "definition": "Where testing scenarios are intended to assess the prescence or absence of a known set of DNA variants (e.g. tumor profiling using genotyping technology), then the Genetic Variant Assessment is used in conjunction with answer list supports structured communication of these findings. Of note, 'No Call' is different from 'Absent', because 'No Call' did not result in the determination of the marker's presents or absents. This may be due to test failure or specimen specific context which renders the test ineffective.",
 "comment": "*All* code-value and, if present, component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "alias": [
 "Name"
 ],
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "TBD-Described"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "workflow",
 "map": "Event.code"
 },
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR < 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 },
 {
 "identity": "sct-attr",
 "map": "116680003 |Is a|"
 }
 ]
 },
 {
 "id": "Observation.subject",
 "path": "Observation.subject",
 "short": "Who and/or what this is about",
 "definition": "The patient, or group of patients, location, or device whose characteristics (direct or indirect) are described by the observation and into whose record the observation is placed. Comments: Indirect characteristics may be those of a specimen, fetus, donor, other observer (for example a relative or EMT), or any observation made about the subject.",
 "comment": "… This must be the same patient as on the DiagnosticReport unless combining data from multiple fetuses or family members in a single report.",
 "requirements": "Observations have no value if you don't know who or what they're about.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.subject",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/Patient",
 "http://hl7.org/fhir/StructureDefinition/Group",
 "http://hl7.org/fhir/StructureDefinition/Location"
 ]
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "workflow",
 "map": "Event.subject"
 },
 {
 "identity": "w5",
 "map": "FiveWs.subject[x]"
 },
 {
 "identity": "v2",
 "map": "PID-3"
 },
 {
 "identity": "rim",
 "map": "participation[typeCode=RTGT] "
 },
 {
 "identity": "w5",
 "map": "FiveWs.subject"
 }
 ]
 },
 {
 "id": "Observation.focus",
 "path": "Observation.focus",
 "short": "The \"focal point\" of the observation",
 "definition": "The actual focus of an observation when it is not the patient of record. The focus is point of attention when the observation representing something or someone associated with the patient. It could be a spouse or parent, a fetus or donor. The focus of an observation could be an existing condition, an intervention, the subject's diet, another observation of the subject, or a body structure such as tumor or implanted device. An example use case would be using the Observation resource to capture whether the mother is trained to change her child's tracheostomy tube. In this example, the child is the patient of record and the mother is the focus.",
 "comment": "Typically, an observation is made about the subject - a patient, or group of patients, location, or device - and the distinction between the subject and what is directly measured for an observation is specified in the observation code itself ( e.g., \"Blood Glucose\") and does not need to be represented separately using this element. Use `specimen` if a reference to a specimen is required. If a code is required instead of a resource use either `bodysite` for bodysites or the standard extension [focus-code](extension-observation-focus-code.html).",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.focus",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/Resource"
 ]
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.subject[x]"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "participation[typeCode=SBJ]"
 },
 {
 "identity": "w5",
 "map": "FiveWs.subject"
 }
 ]
 },
 {
 "id": "Observation.context",
 "path": "Observation.context",
 "short": "Healthcare event during which this observation is made",
 "definition": "The healthcare event (e.g. a patient and healthcare provider interaction) during which this observation is made.",
 "comment": "This will typically be the encounter the event occurred within, but some events may be initiated prior to or after the official completion of an encounter or episode but still be tied to the context of the encounter or episode (e.g. pre-admission laboratory tests).",
 "requirements": "For some observations it may be important to know the link between an observation and a particular encounter.",
 "alias": [
 "Encounter"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.context",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/Encounter",
 "http://hl7.org/fhir/StructureDefinition/EpisodeOfCare"
 ]
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "workflow",
 "map": "Event.context"
 },
 {
 "identity": "w5",
 "map": "FiveWs.context"
 },
 {
 "identity": "v2",
 "map": "PV1"
 },
 {
 "identity": "rim",
 "map": "inboundRelationship[typeCode=COMP].source[classCode=ENC, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.effective[x]",
 "path": "Observation.effective[x]",
 "short": "Assessment of overall results",
 "definition": "The time or time-period the observed value is asserted as being true. For biological subjects - e.g. human patients - this is usually called the \"physiologically relevant time\". This is usually either the time of the procedure or of specimen collection, but very often the source of the date/time is not known, only the date/time itself.",
 "comment": "At least a date should be present unless this observation is a historical report. For recording imprecise or \"fuzzy\" times (For example, a blood glucose measurement taken \"after breakfast\") use the [Timing](datatypes.html#timing) datatype which allow the measurement to be tied to regular life events.",
 "requirements": "Knowing when an observation was deemed true is important to its relevance as well as determining trends.",
 "alias": [
 "Occurrence"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.effective[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 },
 {
 "code": "Timing"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "workflow",
 "map": "Event.occurrence[x]"
 },
 {
 "identity": "w5",
 "map": "FiveWs.done[x]"
 },
 {
 "identity": "v2",
 "map": "OBX-14, and/or OBX-19 after v2.4 (depends on who observation made)"
 },
 {
 "identity": "rim",
 "map": "effectiveTime"
 }
 ]
 },
 {
 "id": "Observation.issued",
 "path": "Observation.issued",
 "short": "Assessment of deletion/duplication results",
 "definition": "The date and time this version of the observation was made available to providers, typically after the results have been reviewed and verified.",
 "comment": "For Observations that don’t require review and verification, it may be the same as the [`lastUpdated` ](resource-definitions.html#Meta.lastUpdated) time of the resource itself. For Observations that do require review and verification for certain updates, it might not be the same as the `lastUpdated` time of the resource itself due to a non-clinically significant update that doesn’t require the new version to be reviewed and verified again.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.issued",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "instant"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.recorded"
 },
 {
 "identity": "v2",
 "map": "OBR.22 (or MSH.7), or perhaps OBX-19 (depends on who observation made)"
 },
 {
 "identity": "rim",
 "map": "participation[typeCode=AUT].time"
 }
 ]
 },
 {
 "id": "Observation.performer",
 "path": "Observation.performer",
 "short": "Genes, drugs and/or conditions tested with no findings",
 "definition": "Summary of all genes, drugs and/or conditions tested for for which there were no significant/reported findings. Allows indication of what was tested for in a relatively efficient manner.",
 "requirements": "May give a degree of confidence in the observation and also indicates where follow-up questions should be directed.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.performer",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/Practitioner",
 "http://hl7.org/fhir/StructureDefinition/Organization",
 "http://hl7.org/fhir/StructureDefinition/Patient",
 "http://hl7.org/fhir/StructureDefinition/RelatedPerson"
 ]
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "workflow",
 "map": "Event.performer.actor"
 },
 {
 "identity": "w5",
 "map": "FiveWs.actor"
 },
 {
 "identity": "v2",
 "map": "OBX.15 / (Practitioner) OBX-16, PRT-5:PRT-4='RO' / (Device) OBX-18 , PRT-10:PRT-4='EQUIP' / (Organization) OBX-23, PRT-8:PRT-4='PO'"
 },
 {
 "identity": "rim",
 "map": "participation[typeCode=PRF]"
 }
 ]
 },
 {
 "id": "Observation.value[x]",
 "path": "Observation.value[x]",
 "short": "Present|Absent|No call|Indeterminate",
 "definition": "Indicates whether the indicated variation was found or not.",
 "comment": "If not searching for specific variations and merely reporting what's found, this element should be set to \"Present\".",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "condition": [
 "obs-7"
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "required",
 "description": "Genetic Variant Assessment",
 "valueSetCanonical": "http://loinc.org/vs/LL1971-2"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.21"
 }
 ]
 },
 {
 "id": "Observation.dataAbsentReason",
 "path": "Observation.dataAbsentReason",
 "short": "Why the result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.value[x] is missing.",
 "comment": "Null or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"specimen unsatisfactory\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Note that an observation may only be reported if there are values to report. For example differential cell counts values may be reported only when > 0. Because of these options, use-case agreements are required to interpret general observations for null or exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.interpretation",
 "path": "Observation.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.comment",
 "path": "Observation.comment",
 "short": "Comments about result",
 "definition": "May include statements about significant, unexpected or unreliable values, or information about the source of the value where this may be relevant to the interpretation of the result.",
 "requirements": "Need to be able to provide free text additional information.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.comment",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "NTE.3 (partner NTE to OBX, or sometimes another (child?) OBX)"
 },
 {
 "identity": "rim",
 "map": "subjectOf.observationEvent[code=\"annotation\"].value"
 }
 ]
 },
 {
 "id": "Observation.bodySite",
 "path": "Observation.bodySite",
 "short": "Observed body part",
 "definition": "Indicates the site on the subject's body where the observation was made (i.e. the target site).",
 "comment": "Only used if not implicit in code found in Observation.code. In many systems, this may be represented as a related observation instead of an inline component. \n\nIf the use case requires BodySite to be handled as a separate resource (e.g. to identify and track separately) then use the standard extension[ body-structure](extension-body-structure.html).",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.bodySite",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "BodySite"
 }
 ],
 "strength": "example",
 "description": "Codes describing anatomical locations. May include laterality.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/body-site"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 123037004 |Body structure|"
 },
 {
 "identity": "v2",
 "map": "OBX-20"
 },
 {
 "identity": "rim",
 "map": "targetSiteCode"
 },
 {
 "identity": "sct-attr",
 "map": "718497002 |Inherent location|"
 }
 ]
 },
 {
 "id": "Observation.method",
 "path": "Observation.method",
 "short": "Sequencing | Oligo aCGH | SNP array | BAC aCGH |Curated|+",
 "definition": "Indicates the method of variant analysis.",
 "comment": "Only used if not implicit in code for Observation.code.",
 "requirements": "In some cases, method can impact results and is thus used for determining whether results can be compared or determining significance of results.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.method",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "strength": "required",
 "description": "Variant analysis method type",
 "valueSetCanonical": "http://loinc.org/vs/LL4048-6"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX-17"
 },
 {
 "identity": "rim",
 "map": "methodCode"
 }
 ]
 },
 {
 "id": "Observation.specimen",
 "path": "Observation.specimen",
 "short": "Specimen examined",
 "definition": "The specimen examined to determine genetic information.",
 "comment": "Should only be used if not implicit in code found in `Observation.code`. Observations are not made on specimens themselves; they are made on a subject, but in many cases by the means of a specimen. Note that although specimens are often involved, they are not always tracked and reported explicitly. Also note that observation resources may be used in contexts that track the specimen explicitly (e.g. Diagnostic Report).",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.specimen",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/Specimen"
 ]
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 123038009 |Specimen|"
 },
 {
 "identity": "v2",
 "map": "SPM segment"
 },
 {
 "identity": "rim",
 "map": "participation[typeCode=SPC].specimen"
 },
 {
 "identity": "sct-attr",
 "map": "704319004 |Inherent in|"
 }
 ]
 },
 {
 "id": "Observation.device",
 "path": "Observation.device",
 "short": "(Measurement) Device",
 "definition": "The device used to generate the observation data.",
 "comment": "An extension should be used if further typing of the device is needed. Devices used to support obtaining an observation can be represented using an extension or the [Provenance](provenance.html) resource. (e.g., a device gateway such as a smart phone).",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.device",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/Device",
 "http://hl7.org/fhir/StructureDefinition/DeviceComponent",
 "http://hl7.org/fhir/StructureDefinition/DeviceMetric"
 ]
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 49062001 |Device|"
 },
 {
 "identity": "v2",
 "map": "OBX-17 / PRT -10"
 },
 {
 "identity": "rim",
 "map": "participation[typeCode=DEV]"
 },
 {
 "identity": "sct-attr",
 "map": "424226004 |Using device|"
 }
 ]
 },
 {
 "id": "Observation.referenceRange",
 "path": "Observation.referenceRange",
 "short": "Provides guide for interpretation",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.referenceRange",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 },
 {
 "key": "obs-3",
 "severity": "error",
 "human": "Must have at least a low or a high or text",
 "expression": "low.exists() or high.exists() or text.exists()",
 "xpath": "(exists(f:low) or exists(f:high)or exists(f:text))"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.referenceRange.id",
 "path": "Observation.referenceRange.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.referenceRange.extension",
 "path": "Observation.referenceRange.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.referenceRange.modifierExtension",
 "path": "Observation.referenceRange.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.referenceRange.low",
 "path": "Observation.referenceRange.low",
 "short": "Low Range, if relevant",
 "definition": "The value of the low bound of the reference range. The low bound of the reference range endpoint is inclusive of the value (e.g. reference range is >=5 - <=9). If the low bound is omitted, it is assumed to be meaningless (e.g. reference range is <=2.3).",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.referenceRange.low",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity",
 "profile": [
 "http://hl7.org/fhir/StructureDefinition/SimpleQuantity"
 ]
 }
 ],
 "condition": [
 "obs-3"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX-7"
 },
 {
 "identity": "rim",
 "map": "value:IVL_PQ.low"
 }
 ]
 },
 {
 "id": "Observation.referenceRange.high",
 "path": "Observation.referenceRange.high",
 "short": "High Range, if relevant",
 "definition": "The value of the high bound of the reference range. The high bound of the reference range endpoint is inclusive of the value (e.g. reference range is >=5 - <=9). If the high bound is omitted, it is assumed to be meaningless (e.g. reference range is >= 2.3).",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.referenceRange.high",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity",
 "profile": [
 "http://hl7.org/fhir/StructureDefinition/SimpleQuantity"
 ]
 }
 ],
 "condition": [
 "obs-3"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX-7"
 },
 {
 "identity": "rim",
 "map": "value:IVL_PQ.high"
 }
 ]
 },
 {
 "id": "Observation.referenceRange.type",
 "path": "Observation.referenceRange.type",
 "short": "Reference range qualifier",
 "definition": "Codes to indicate the what part of the targeted reference population it applies to. For example, the normal or therapeutic range.",
 "comment": "This SHOULD be populated if there is more than one range. If this element is not present then the normal range is assumed.",
 "requirements": "Need to be able to say what kind of reference range this is - normal, recommended, therapeutic, etc., - for proper interpretation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.referenceRange.type",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationRangeMeaning"
 }
 ],
 "strength": "extensible",
 "description": "Code for the meaning of a reference range.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/referencerange-meaning"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values| OR \r< 365860008 |General clinical state finding| \rOR \r< 250171008 |Clinical history or observation findings| OR \r< 415229000 |Racial group| OR \r< 365400002 |Finding of puberty stage| OR\r< 443938003 |Procedure carried out on subject|"
 },
 {
 "identity": "v2",
 "map": "OBX-10"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 }
 ]
 },
 {
 "id": "Observation.referenceRange.appliesTo",
 "path": "Observation.referenceRange.appliesTo",
 "short": "Reference range population",
 "definition": "Codes to indicate the target population this reference range applies to. For example, a reference range may be based on the normal population or a particular sex or race.",
 "comment": "This SHOULD be populated if there is more than one range. If this element is not present then the normal population is assumed.",
 "requirements": "Need to be able to identify the target population for proper interpretation.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.referenceRange.appliesTo",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationRangeType"
 }
 ],
 "strength": "example",
 "description": "Codes identifying the population the reference range applies to.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/referencerange-appliesto"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values| OR \r< 365860008 |General clinical state finding| \rOR \r< 250171008 |Clinical history or observation findings| OR \r< 415229000 |Racial group| OR \r< 365400002 |Finding of puberty stage| OR\r< 443938003 |Procedure carried out on subject|"
 },
 {
 "identity": "v2",
 "map": "OBX-10"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 }
 ]
 },
 {
 "id": "Observation.referenceRange.age",
 "path": "Observation.referenceRange.age",
 "short": "Applicable age range, if relevant",
 "definition": "The age at which this reference range is applicable. This is a neonatal age (e.g. number of weeks at term) if the meaning says so.",
 "requirements": "Some analytes vary greatly over age.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.referenceRange.age",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Range"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=PRCN].targetObservationCriterion[code=\"age\"].value"
 }
 ]
 },
 {
 "id": "Observation.referenceRange.text",
 "path": "Observation.referenceRange.text",
 "short": "Text based reference range in an observation",
 "definition": "Text based reference range in an observation which may be used when a quantitative range is not appropriate for an observation. An example would be a reference value of \"Negative\" or a list or table of \"normals\".",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.referenceRange.text",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX-7"
 },
 {
 "identity": "rim",
 "map": "value:ST"
 }
 ]
 },
 {
 "id": "Observation.hasMember",
 "path": "Observation.hasMember",
 "short": "Related resource that belongs to the Observation group",
 "definition": "This observation is a group observation (e.g. a battery, a panel of tests, a set of vital sign measurements) that includes the target as a member of the group.",
 "comment": "When using this element, an observation will typically have either a value or a set of related resources, although both may be present in some cases. For a discussion on the ways Observations can assembled in groups together, see [Notes](observation.html#obsgrouping) below.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.hasMember",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/Observation",
 "http://hl7.org/fhir/StructureDefinition/QuestionnaireResponse",
 "http://hl7.org/fhir/StructureDefinition/Sequence"
 ]
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "Relationships established by OBX-4 usage"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship"
 }
 ]
 },
 {
 "id": "Observation.derivedFrom",
 "path": "Observation.derivedFrom",
 "slicing": {
 "discriminator": [
 {
 "type": "type",
 "path": "$this"
 },
 {
 "type": "pattern",
 "path": "resolve().code"
 }
 ],
 "rules": "open"
 },
 "short": "Related measurements the observation is made from",
 "definition": "The target resource that represents a measurement from which this observation value is derived. For example, a calculated anion gap or a fetal measurement based on an ultrasound image.",
 "comment": "All the reference choices that are listed in this element can represent clinical observations and other measurements that may be the source for a derived value. The most common reference will be another Observation. For a discussion on the ways Observations can assembled in groups together, see [Notes](observation.html#obsgrouping) below.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.derivedFrom",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/DocumentReference",
 "http://hl7.org/fhir/StructureDefinition/ImagingStudy",
 "http://hl7.org/fhir/StructureDefinition/Media",
 "http://hl7.org/fhir/StructureDefinition/QuestionnaireResponse",
 "http://hl7.org/fhir/StructureDefinition/Observation",
 "http://hl7.org/fhir/StructureDefinition/Sequence"
 ]
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "Relationships established by OBX-4 usage"
 },
 {
 "identity": "rim",
 "map": ".targetObservation"
 }
 ]
 },
 {
 "id": "Observation.derivedFrom:sequence",
 "path": "Observation.derivedFrom",
 "sliceName": "sequence",
 "short": "Sequence",
 "definition": "Sequence that supports the finding.",
 "comment": "All the reference choices that are listed in this element can represent clinical observations and other measurements that may be the source for a derived value. The most common reference will be another Observation. For a discussion on the ways Observations can assembled in groups together, see [Notes](observation.html#obsgrouping) below.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.derivedFrom",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/sequence"
 ]
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "Relationships established by OBX-4 usage"
 },
 {
 "identity": "rim",
 "map": ".targetObservation"
 }
 ]
 },
 {
 "id": "Observation.component",
 "path": "Observation.component",
 "slicing": {
 "discriminator": [
 {
 "type": "pattern",
 "path": "code"
 }
 ],
 "rules": "open"
 },
 "short": "Component results",
 "definition": "Some observations have multiple component observations. These component observations are expressed as separate code value pairs that share the same attributes. Examples include systolic and diastolic component observations for blood pressure measurement and multiple component observations for genetics observations.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 }
 ]
 },
 {
 "id": "Observation.component.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:gene-studied",
 "path": "Observation.component",
 "sliceName": "gene-studied",
 "short": "Gene studied ID",
 "definition": "HUGO Gene Nomenclature Committee (HGNC) identifier for a gene. List the gene(s) examined in full or in part by the study. If the study addresses multiple genes, these can be recorded in one OBX as a list seperated by repeat delimiters or in mulltiple OBX's with one gene per OBX. The recommended coding system will use the HGNC gene symbol as the display text and HGNC gene ID as the code.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:gene-studied.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:gene-studied.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:gene-studied.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:gene-studied.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "48018-6"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:gene-studied.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "example",
 "description": "Binding not yet defined"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "A.4"
 }
 ]
 },
 {
 "id": "Observation.component:gene-studied.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:gene-studied.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:gene-studied.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:chromosome-location",
 "path": "Observation.component",
 "sliceName": "chromosome-location",
 "short": "Cytogenetic (chromosome) location",
 "definition": "Some observations have multiple component observations. These component observations are expressed as separate code value pairs that share the same attributes. Examples include systolic and diastolic component observations for blood pressure measurement and multiple component observations for genetics observations.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:chromosome-location.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:chromosome-location.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:chromosome-location.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:chromosome-location.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "48001-2"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:chromosome-location.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "example",
 "description": "Binding not yet defined"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.17"
 }
 ]
 },
 {
 "id": "Observation.component:chromosome-location.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:chromosome-location.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:chromosome-location.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:dna-region-name",
 "path": "Observation.component",
 "sliceName": "dna-region-name",
 "short": "Description of ranges of DNA sequences examined",
 "definition": "This term is used to report a narrative description of the range(s) of DNA sequences examined in this sequencing study. Genetic test reports only rarely include explicit numeric ranges (which would be reported using [LOINC: 51959-5] ) beause they are often proprietary, and more often describe the regions examined in narrative. For example, \"all coding regions and appropriate flanking regions.\" To report the region of interest (e.g., in terms of introns and exons) rather than the specific DNA sequences examined, [LOINC: 47999-8] may be used.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:dna-region-name.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:dna-region-name.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:dna-region-name.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:dna-region-name.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81293-3"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:dna-region-name.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "example",
 "description": "Binding not yet defined"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "A.7"
 }
 ]
 },
 {
 "id": "Observation.component:dna-region-name.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:dna-region-name.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:dna-region-name.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg",
 "path": "Observation.component",
 "sliceName": "dna-chg",
 "short": "Transcript DNA change (cHGVS)",
 "definition": "Human Genome Variation Society (HGVS) nomenclature for a single DNA marker. The use of the nomenclature must be extended to describe non-variations (aka. wild types) see samples for wild type examples.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "48004-6"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "example",
 "description": "Binding not yet defined"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.5 (includes A.13 in version)"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg-type",
 "path": "Observation.component",
 "sliceName": "dna-chg-type",
 "short": "DNA change type",
 "definition": "Codified type for associated DNA Marker. DNA Marker's use the HGVS notation which implies the DNA Marker Type, but the concurrent use of this code will allow a standard and explicit type for technical and display convenience.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg-type.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg-type.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg-type.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg-type.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "48019-4"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg-type.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Wild type | Deletion | Duplication | Insertion | Insertion/Deletion | Inversion | Substitution | Copy number gain +",
 "definition": "Type of DNA variation reported.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "required",
 "description": "DNA change type values",
 "valueSetCanonical": "http://loinc.org/vs/LL4033-8"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.7"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg-type.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg-type.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg-type.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:variation-code",
 "path": "Observation.component",
 "sliceName": "variation-code",
 "short": "Simple var ID",
 "definition": "This term is used to report the unique identifier of the simple variant found in this study.",
 "comment": "If this is present, the components can be omitted but they might be included to avoid a need to look up the information in a registry. Typically only one code would be present, though multiple codings expressing the variant in different code systems are possible.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:variation-code.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:variation-code.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:variation-code.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:variation-code.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81252-9"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:variation-code.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "example",
 "description": "Binding not yet defined"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.2, B.16 (A.16 in coding.version)"
 }
 ]
 },
 {
 "id": "Observation.component:variation-code.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:variation-code.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:variation-code.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:dbsnp-id",
 "path": "Observation.component",
 "sliceName": "dbSNP-id",
 "short": "dbSNP ID",
 "definition": "The unique identifier for the variant represented as a small nucleotide polymorphism (SNP). The dbSNP ID is used routinely as the base identifier in pharmacogenomics as well as arrCGH studies. For example, for the simple variant NM_014049.4(ACAD9):c.1249C>T (p.Arg417Cys), the dbSNP ID is 368949613. [http://www.ncbi.nlm.nih.gov/clinvar/variation/30880/].",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:dbsnp-id.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:dbsnp-id.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:dbsnp-id.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:dbsnp-id.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81255-2"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:dbsnp-id.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "example",
 "description": "Binding not yet defined"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.15 (includes A.14 in version)"
 }
 ]
 },
 {
 "id": "Observation.component:dbsnp-id.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:dbsnp-id.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:dbsnp-id.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-dna-chg",
 "path": "Observation.component",
 "sliceName": "genomic-dna-chg",
 "short": "Genomica DNA change (gHGVS)",
 "definition": "The name of a structural variant reported using HGVS nomenclature.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-dna-chg.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-dna-chg.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-dna-chg.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-dna-chg.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81290-9"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-dna-chg.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "example",
 "description": "Binding not yet defined"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.10 (includes A.13 in version)"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-dna-chg.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-dna-chg.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-dna-chg.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-source-class",
 "path": "Observation.component",
 "sliceName": "genomic-source-class",
 "short": "Genomic source class",
 "definition": "The genomic class of the specimen being analyzed: Germline for inherited genome, somatic for cancer genome, and prenatal for fetal genome.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-source-class.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-source-class.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-source-class.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-source-class.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "48002-0"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-source-class.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Germline | Somatic | Fetal | Likely germline | Likely somatic |Likely fetal | Unknown genomic origin | De novo",
 "definition": "MG_2_Genetic variant source.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "required",
 "description": "Genomic source class values",
 "valueSetCanonical": "http://loinc.org/vs/LL378-1"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.18"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-source-class.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-source-class.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-source-class.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg",
 "path": "Observation.component",
 "sliceName": "amino-acid-chg",
 "short": "Amino acid change (pHGVS)",
 "definition": "Human Genome Variation Society (HGVS) nomenclature for an amino acid sequence. This value is derivable from the DNA Marker value if available. It is provided for convenience. The use of the nomenclature must be extended to describe non-variations (aka. wild types) see samples for wild type examples.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "48005-3"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "example",
 "description": "Binding not yet defined"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.6 (includes A.13 in version)"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg-type",
 "path": "Observation.component",
 "sliceName": "amino-acid-chg-type",
 "short": "Amino acid change type",
 "definition": "Codified type for associated Amino Acid Marker. Amino Acid Marker's use the HGVS notation which implies the Amino Acid Marker Type, but the concurrent use of this code will allow a standard and explicit type for technical and display convenience.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg-type.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg-type.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg-type.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg-type.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "48006-1"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg-type.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Wild type | Deletion | Duplication | Frameshift | Initiating Methionine | Insertion | Insertion and Deletion | Missense | Silent | Stop Codon Mutation",
 "definition": "MG_4_Amino acid change type.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "required",
 "description": "Amino acid change type values",
 "valueSetCanonical": "http://loinc.org/vs/LL380-7"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.8"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg-type.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg-type.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg-type.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:transcript-ref-seq",
 "path": "Observation.component",
 "sliceName": "transcript-ref-seq",
 "short": "Transcript reference sequence ID",
 "definition": "This field carries the ID for the transcribed reference sequence, which is the part of the genomic reference sequence that is converted to messenger RNA (i.e., after the introns are removed).",
 "comment": "Only needed if the transcript sequence or genomic reference sequence versions don't indicate the version.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:transcript-ref-seq.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:transcript-ref-seq.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:transcript-ref-seq.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:transcript-ref-seq.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "51958-7"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:transcript-ref-seq.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "example",
 "description": "Binding not yet defined"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.4"
 }
 ]
 },
 {
 "id": "Observation.component:transcript-ref-seq.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:transcript-ref-seq.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:transcript-ref-seq.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-ref-seq",
 "path": "Observation.component",
 "sliceName": "genomic-ref-seq",
 "short": "Genomic reference sequence ID",
 "definition": "This field carries the ID for the genomic reference sequence. The genomic reference sequence is a contiguous stretch of chromosome DNA that spans all of the exons of the gene and includes transcribed and non transcribed stretches. For this ID use either the NCBI genomic nucleotide RefSeq IDs with their version number (see: NCBI.NLM.NIH.Gov/RefSeq) or use the LRG identifiers, without transcript (t or p) extensions -- when they become available. (See- Report sponsored by GEN2PHEN at the European Bioinformatics Institute at Hinxton UK April 24-25, 2008).\rThe NCI RefSeq genomic IDs are distinguished by a prefix of\"NG\" for genes from the nuclear chromosomes and prefix of \"NC\" for genes from mitochondria. The LRG Identifiers have a prefix of \"LRG_\" Mitochondrial genes are not in the scope of LRG.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-ref-seq.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-ref-seq.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-ref-seq.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-ref-seq.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "48013-7"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-ref-seq.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "example",
 "description": "Binding not yet defined"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.9"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-ref-seq.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-ref-seq.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-ref-seq.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-frequency",
 "path": "Observation.component",
 "sliceName": "allelic-frequency",
 "short": "Allelic Frequency",
 "definition": "Some observations have multiple component observations. These component observations are expressed as separate code value pairs that share the same attributes. Examples include systolic and diastolic component observations for blood pressure measurement and multiple component observations for genetics observations.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-frequency.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-frequency.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-frequency.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-frequency.code",
 "path": "Observation.component.code",
 "short": "Allelic frequency [NFr]",
 "definition": "The allelic frequency is the relative frequency of a particular allele in the population, expressed as a number from 0 to 1.",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81258-6"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-frequency.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.22, C.4"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-frequency.value[x].id",
 "path": "Observation.component.value[x].id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-frequency.value[x].extension",
 "path": "Observation.component.value[x].extension",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "url"
 }
 ],
 "description": "Extensions are always sliced by (at least) url",
 "rules": "open"
 },
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-frequency.value[x].value",
 "path": "Observation.component.value[x].value",
 "short": "Numerical value (with implicit precision)",
 "definition": "The value of the measured amount. The value includes an implicit precision in the presentation of the value.",
 "comment": "The implicit precision in the value should always be honored. Monetary values have their own rules for handling precision (refer to standard accounting text books).",
 "requirements": "Precision is handled implicitly in almost all cases of measurement.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Quantity.value",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "decimal"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "SN.2 / CQ - N/A"
 },
 {
 "identity": "rim",
 "map": "PQ.value, CO.value, MO.value, IVL.high or IVL.low depending on the value"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-frequency.value[x].comparator",
 "path": "Observation.component.value[x].comparator",
 "short": "< | <= | >= | > - how to understand the value",
 "definition": "How the value should be understood and represented - whether the actual value is greater or less than the stated value due to measurement issues; e.g. if the comparator is \"<\" , then the real value is < stated value.",
 "requirements": "Need a framework for handling measures where the value is <5ug/L or >400mg/L due to the limitations of measuring methodology.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Quantity.comparator",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "code"
 }
 ],
 "meaningWhenMissing": "If there is no comparator, then there is no modification of the value",
 "isModifier": true,
 "isModifierReason": "This is labeled as \"Is Modifier\" because the comparator modifies the interpretation of the value significantly. If there is no comparator, then there is no modification of the value",
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "QuantityComparator"
 }
 ],
 "strength": "required",
 "description": "How the Quantity should be understood and represented.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/quantity-comparator"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "SN.1 / CQ.1"
 },
 {
 "identity": "rim",
 "map": "IVL properties"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-frequency.value[x].unit",
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
 "valueBoolean": true
 }
 ],
 "path": "Observation.component.value[x].unit",
 "short": "Unit representation",
 "definition": "A human-readable form of the unit.",
 "requirements": "There are many representations for units of measure and in many contexts, particular representations are fixed and required. I.e. mcg for micrograms.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Quantity.unit",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "(see OBX.6 etc.) / CQ.2"
 },
 {
 "identity": "rim",
 "map": "PQ.unit"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-frequency.value[x].system",
 "path": "Observation.component.value[x].system",
 "short": "System that defines coded unit form",
 "definition": "The identification of the system that provides the coded form of the unit.",
 "requirements": "Need to know the system that defines the coded form of the unit.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Quantity.system",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "uri"
 }
 ],
 "fixedUri": "http://unitsofmeasure.org",
 "condition": [
 "qty-3"
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "(see OBX.6 etc.) / CQ.2"
 },
 {
 "identity": "rim",
 "map": "CO.codeSystem, PQ.translation.codeSystem"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-frequency.value[x].code",
 "path": "Observation.component.value[x].code",
 "short": "Coded form of the unit",
 "definition": "A computer processable form of the unit in some unit representation system.",
 "comment": "The preferred system is UCUM, but SNOMED CT can also be used (for customary units) or ISO 4217 for currency. The context of use may additionally require a code from a particular system.",
 "requirements": "Need a computable form of the unit that is fixed across all forms. UCUM provides this for quantities, but SNOMED CT provides many units of interest.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Quantity.code",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "code"
 }
 ],
 "fixedCode": "%",
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "(see OBX.6 etc.) / CQ.2"
 },
 {
 "identity": "rim",
 "map": "PQ.code, MO.currency, PQ.translation.code"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-frequency.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-frequency.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-frequency.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase",
 "path": "Observation.component",
 "sliceName": "allelic-phase",
 "short": "Allelic phase",
 "definition": "The period of stage of an allele.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "82120-7"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase.value[x]",
 "path": "Observation.component.value[x]",
 "short": "1st set of variants is cis relation to each other | 2nd set of variants is cis relation to each other | 3rd set of variants is cis relation to each other | 4th set of variants is cis relation to each other | 5th set of variants is cis relation to each other | Maternal | Paternal | Unknown | Other, please specify",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "required",
 "description": "Allelic phase values",
 "valueSetCanonical": "http://loinc.org/vs/LL4025-4"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.26"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase-basis",
 "path": "Observation.component",
 "sliceName": "allelic-phase-basis",
 "short": "Basis for allelic phase",
 "definition": "The evidential basis on which the allelic phase and/or the allelic state was concluded.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase-basis.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase-basis.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase-basis.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase-basis.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "82309-6"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase-basis.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "required",
 "description": "Allelic phase basis values",
 "valueSetCanonical": "http://loinc.org/vs/LL4050-2"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.27, C.7"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase-basis.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase-basis.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase-basis.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-read-depth",
 "path": "Observation.component",
 "sliceName": "allelic-read-depth",
 "short": "Component results",
 "definition": "Specifies the number of reads that identified the allele in question whether it consists of one or a small sequence of contiguous nucleotides. Different methods and purposes require different numbers of reads to be acceptable. Often >400, sometimes as few as 2-4.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-read-depth.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-read-depth.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-read-depth.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-read-depth.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "82121-5"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-read-depth.valueQuantity",
 "path": "Observation.component.valueQuantity",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity",
 "profile": [
 "http://hl7.org/fhir/StructureDefinition/Count"
 ]
 }
 ],
 "constraint": [
 {
 "key": "qty-3",
 "severity": "error",
 "human": "If a code for the unit is present, the system SHALL also be present",
 "expression": "code.empty() or system.exists()",
 "xpath": "not(exists(f:code)) or exists(f:system)",
 "source": "Quantity"
 },
 {
 "key": "cnt-3",
 "severity": "error",
 "human": "There SHALL be a code with a value of \"1\" if there is a value and it SHALL be an expression of length. If system is present, it SHALL be UCUM. If present, the value SHALL a whole number.",
 "expression": "(code.exists() or value.empty()) and (system.empty() or system = %ucum) and (code.empty() or code = '1') and (value.empty() or value.hasValue().not() or value.toString().contains('.').not())",
 "xpath": "(f:code or not(f:value)) and (not(exists(f:system)) or (f:system/@value='http://unitsofmeasure.org' and f:code/@value='1')) and not(contains(f:value/@value, '.'))",
 "source": "Count"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "SN (see also Range) or CQ"
 },
 {
 "identity": "rim",
 "map": "PQ, IVL<PQ>, MO, CO, depending on the values"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.27, C.7"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-read-depth.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-read-depth.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-read-depth.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-state",
 "path": "Observation.component",
 "sliceName": "allelic-state",
 "short": "Allelic state",
 "definition": "The level of occurrence of a single DNA Marker within a set of chromosomes. Heterozygous indicates the DNA Marker is only present in one of the two genes contained in homologous chromosomes. Homozygous indicates the DNA Marker is present in both genes contained in homologous chromosomes. Hemizygous indicates the DNA Marker exists in the only single copy of a gene in a non-homologous chromosome (The male X and Y chromosome are non-homologous). Hemiplasmic indicates that the DNA Marker is present in some but not all of the copies of mitochondrial DNA. Homoplasmic indicates that the DNA Maker is present in all of the copies of mitochondrial DNA.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-state.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-state.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-state.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-state.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "53034-5"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-state.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Heteroplasmic | Homoplasmic | Homozygous | Heterozygous | Hemizygous",
 "definition": "The relationship between the alleles found at the same locus on different chromosomes.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "required",
 "description": "Allelic state type values",
 "valueSetCanonical": "http://loinc.org/vs/LL381-5"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.23, C.6"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-state.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-state.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-state.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:copy-number",
 "path": "Observation.component",
 "sliceName": "copy-number",
 "short": "Genomic structural variant copy number",
 "definition": "The copy number of the large variant. In HGVS, this is the numeric value following the “X”. It is a unit-less value. Note that a copy number of 1 implies a deletion. The copy number can usually be inferred from the HGVS or ISCN fields.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:copy-number.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:copy-number.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:copy-number.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:copy-number.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "82155-3"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:copy-number.valueQuantity",
 "path": "Observation.component.valueQuantity",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity",
 "profile": [
 "http://hl7.org/fhir/StructureDefinition/Count"
 ]
 }
 ],
 "constraint": [
 {
 "key": "qty-3",
 "severity": "error",
 "human": "If a code for the unit is present, the system SHALL also be present",
 "expression": "code.empty() or system.exists()",
 "xpath": "not(exists(f:code)) or exists(f:system)",
 "source": "Quantity"
 },
 {
 "key": "cnt-3",
 "severity": "error",
 "human": "There SHALL be a code with a value of \"1\" if there is a value and it SHALL be an expression of length. If system is present, it SHALL be UCUM. If present, the value SHALL a whole number.",
 "expression": "(code.exists() or value.empty()) and (system.empty() or system = %ucum) and (code.empty() or code = '1') and (value.empty() or value.hasValue().not() or value.toString().contains('.').not())",
 "xpath": "(f:code or not(f:value)) and (not(exists(f:system)) or (f:system/@value='http://unitsofmeasure.org' and f:code/@value='1')) and not(contains(f:value/@value, '.'))",
 "source": "Count"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "SN (see also Range) or CQ"
 },
 {
 "identity": "rim",
 "map": "PQ, IVL<PQ>, MO, CO, depending on the values"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.28"
 }
 ]
 },
 {
 "id": "Observation.component:copy-number.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:copy-number.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:copy-number.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:arrcgh-ratio",
 "path": "Observation.component",
 "sliceName": "arrCGH-ratio",
 "short": "Structural variant reported arrCGH [Ratio]",
 "definition": "todo.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:arrcgh-ratio.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:arrcgh-ratio.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:arrcgh-ratio.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:arrcgh-ratio.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81299-0"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:arrcgh-ratio.valueQuantity",
 "path": "Observation.component.valueQuantity",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity",
 "profile": [
 "http://hl7.org/fhir/StructureDefinition/SimpleQuantity"
 ]
 }
 ],
 "condition": [
 "ele-1"
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 },
 {
 "key": "qty-3",
 "severity": "error",
 "human": "If a code for the unit is present, the system SHALL also be present",
 "expression": "code.empty() or system.exists()",
 "xpath": "not(exists(f:code)) or exists(f:system)",
 "source": "Quantity"
 },
 {
 "key": "sqty-1",
 "severity": "error",
 "human": "The comparator is not used on a SimpleQuantity",
 "expression": "comparator.empty()",
 "xpath": "not(exists(f:comparator))",
 "source": "Quantity"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 },
 {
 "identity": "v2",
 "map": "SN (see also Range) or CQ"
 },
 {
 "identity": "rim",
 "map": "PQ, IVL<PQ>, MO, CO, depending on the values"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.29"
 }
 ]
 },
 {
 "id": "Observation.component:arrcgh-ratio.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:arrcgh-ratio.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:arrcgh-ratio.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:ref-allele",
 "path": "Observation.component",
 "sliceName": "ref-allele",
 "short": "Genomic ref allele",
 "definition": "Reference values (\"normal\") examined within the Reference Sequence.",
 "comment": "This is used in a genotyping test to define the reference and variable nucleotide strings. That is if the sequence variation is an insertion, then Reference Nucleotide will be blank and Variable Nucleotide will contain the inserted nucleotides. In contrast, if the sequence variation is a deletion, then the Reference Nucleotide will contain the deleted nucliotieds, and the Variable Nucleotide will be blank.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.9"
 }
 ]
 },
 {
 "id": "Observation.component:ref-allele.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:ref-allele.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:ref-allele.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:ref-allele.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "69547-8"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:ref-allele.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 }
 ]
 },
 {
 "id": "Observation.component:ref-allele.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:ref-allele.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:ref-allele.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:alt-allele",
 "path": "Observation.component",
 "sliceName": "alt-allele",
 "short": "Genomic alt allele",
 "definition": "The genomic alternate allele is the contiguous segment of DNA in the test sample that differs from the reference allele at the same location and thus defines a variant.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.11"
 }
 ]
 },
 {
 "id": "Observation.component:alt-allele.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:alt-allele.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:alt-allele.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:alt-allele.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "69551-0"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:alt-allele.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 }
 ]
 },
 {
 "id": "Observation.component:alt-allele.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:alt-allele.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:alt-allele.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:coordinate-system",
 "path": "Observation.component",
 "sliceName": "coordinate-system",
 "short": "Coordinate System",
 "definition": "Base number of coordinate system (0 for 0-based numbering or interbase coordinate system, inclusive start, exclusive end, 1 for 1-based numbering or base coordinate system, inclusive start, inclusive end).",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:coordinate-system.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:coordinate-system.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:coordinate-system.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:coordinate-system.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "TBD"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:coordinate-system.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 },
 {
 "code": "CodeableConcept"
 },
 {
 "code": "string"
 },
 {
 "code": "boolean"
 },
 {
 "code": "integer"
 },
 {
 "code": "Range"
 },
 {
 "code": "Ratio"
 },
 {
 "code": "SampledData"
 },
 {
 "code": "time"
 },
 {
 "code": "dateTime"
 },
 {
 "code": "Period"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "required",
 "description": "Base coordinate systems start and end measurements for variants",
 "valueSetCanonical": "ValueSet/genetic-coordinate-system"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 }
 ]
 },
 {
 "id": "Observation.component:coordinate-system.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:coordinate-system.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:coordinate-system.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:allele-start-end",
 "path": "Observation.component",
 "sliceName": "allele-start-end",
 "short": "Genomic Allele start-end",
 "definition": "The genomic allele location is the first genomic position in the reference allele that contains a change from the reference allele. For example, for the simple variant NM_014049.4(ACAD9):c.1249C>T (p.Arg417Cys), the genomic allele location is Chr3: 128906220 on Assembly GRCh38.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.10"
 }
 ]
 },
 {
 "id": "Observation.component:allele-start-end.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:allele-start-end.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:allele-start-end.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:allele-start-end.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81254-5"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:allele-start-end.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Range"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 }
 ]
 },
 {
 "id": "Observation.component:allele-start-end.value[x].id",
 "path": "Observation.component.value[x].id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:allele-start-end.value[x].extension",
 "path": "Observation.component.value[x].extension",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "url"
 }
 ],
 "description": "Extensions are always sliced by (at least) url",
 "rules": "open"
 },
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:allele-start-end.value[x].low",
 "path": "Observation.component.value[x].low",
 "short": "Genomic Allele start",
 "definition": "The low limit. The boundary is inclusive.",
 "comment": "If the low element is missing, the low boundary is not known.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Range.low",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity",
 "profile": [
 "http://hl7.org/fhir/StructureDefinition/SimpleQuantity"
 ]
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "NR.1"
 },
 {
 "identity": "rim",
 "map": "./low"
 }
 ]
 },
 {
 "id": "Observation.component:allele-start-end.value[x].high",
 "path": "Observation.component.value[x].high",
 "short": "Genomic Allele end",
 "definition": "The high limit. The boundary is inclusive.",
 "comment": "If the high element is missing, the high boundary is not known.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Range.high",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity",
 "profile": [
 "http://hl7.org/fhir/StructureDefinition/SimpleQuantity"
 ]
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "NR.2"
 },
 {
 "identity": "rim",
 "map": "./high"
 }
 ]
 },
 {
 "id": "Observation.component:allele-start-end.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:allele-start-end.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:allele-start-end.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:variant-length",
 "path": "Observation.component",
 "sliceName": "variant-length",
 "short": "Structural variant length",
 "definition": "Length of the structural variant, which information may be ascertained in some but not all types of structural variants.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:variant-length.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:variant-length.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:variant-length.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:variant-length.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81300-6"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:variant-length.valueQuantity",
 "path": "Observation.component.valueQuantity",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity",
 "profile": [
 "http://hl7.org/fhir/StructureDefinition/Count"
 ]
 }
 ],
 "constraint": [
 {
 "key": "qty-3",
 "severity": "error",
 "human": "If a code for the unit is present, the system SHALL also be present",
 "expression": "code.empty() or system.exists()",
 "xpath": "not(exists(f:code)) or exists(f:system)",
 "source": "Quantity"
 },
 {
 "key": "cnt-3",
 "severity": "error",
 "human": "There SHALL be a code with a value of \"1\" if there is a value and it SHALL be an expression of length. If system is present, it SHALL be UCUM. If present, the value SHALL a whole number.",
 "expression": "(code.exists() or value.empty()) and (system.empty() or system = %ucum) and (code.empty() or code = '1') and (value.empty() or value.hasValue().not() or value.toString().contains('.').not())",
 "xpath": "(f:code or not(f:value)) and (not(exists(f:system)) or (f:system/@value='http://unitsofmeasure.org' and f:code/@value='1')) and not(contains(f:value/@value, '.'))",
 "source": "Count"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "SN (see also Range) or CQ"
 },
 {
 "identity": "rim",
 "map": "PQ, IVL<PQ>, MO, CO, depending on the values"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.30"
 }
 ]
 },
 {
 "id": "Observation.component:variant-length.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:variant-length.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:variant-length.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:outer-start-end",
 "path": "Observation.component",
 "sliceName": "outer-start-end",
 "short": "Structural variant outer start and end",
 "definition": "The genomic coordinates of the widest genomic range in which the structural variant might reside.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:outer-start-end.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:outer-start-end.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:outer-start-end.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:outer-start-end.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81301-4"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:outer-start-end.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Range"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.31"
 }
 ]
 },
 {
 "id": "Observation.component:outer-start-end.value[x].id",
 "path": "Observation.component.value[x].id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:outer-start-end.value[x].extension",
 "path": "Observation.component.value[x].extension",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "url"
 }
 ],
 "description": "Extensions are always sliced by (at least) url",
 "rules": "open"
 },
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:outer-start-end.value[x].low",
 "path": "Observation.component.value[x].low",
 "short": "Low limit",
 "definition": "The low limit. The boundary is inclusive.",
 "comment": "If the low element is missing, the low boundary is not known.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Range.low",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity",
 "profile": [
 "http://hl7.org/fhir/StructureDefinition/SimpleQuantity"
 ]
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "NR.1"
 },
 {
 "identity": "rim",
 "map": "./low"
 }
 ]
 },
 {
 "id": "Observation.component:outer-start-end.value[x].high",
 "path": "Observation.component.value[x].high",
 "short": "High limit",
 "definition": "The high limit. The boundary is inclusive.",
 "comment": "If the high element is missing, the high boundary is not known.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Range.high",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity",
 "profile": [
 "http://hl7.org/fhir/StructureDefinition/SimpleQuantity"
 ]
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "NR.2"
 },
 {
 "identity": "rim",
 "map": "./high"
 }
 ]
 },
 {
 "id": "Observation.component:outer-start-end.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:outer-start-end.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:outer-start-end.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 },
 {
 "id": "Observation.component:inner-start-end",
 "path": "Observation.component",
 "sliceName": "inner-start-end",
 "short": "Structural variant inner start and end",
 "definition": "The genomic coordinates of the narrowest genomic range in which the structural variant might reside.",
 "comment": "For a discussion on the ways Observations can be assembled in groups together see [Notes](observation.html#notes) below.",
 "requirements": "Component observations share the same attributes in the Observation resource as the primary observation and are always treated a part of a single observation (they are not separable). However, the reference range for the primary observation value is not inherited by the component values and is required when appropriate for each component observation.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() | (children().count() > id.count())",
 "xpath": "@value|f:*|h:div",
 "source": "Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "containment by OBX-4?"
 },
 {
 "identity": "rim",
 "map": "outBoundRelationship[typeCode=COMP]"
 }
 ]
 },
 {
 "id": "Observation.component:inner-start-end.id",
 "path": "Observation.component.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:inner-start-end.extension",
 "path": "Observation.component.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:inner-start-end.modifierExtension",
 "path": "Observation.component.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "modifierExtension is reserved for use where modifier extensions must be used",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Observation.component:inner-start-end.code",
 "path": "Observation.component.code",
 "short": "Type of component observation (code / type)",
 "definition": "Describes what was observed. Sometimes this is called the observation \"code\".",
 "comment": "*All* code-value and component.code-component.value pairs need to be taken into account to correctly understand the meaning of the observation.",
 "requirements": "Knowing what kind of observation is being made is essential to understanding the observation.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81302-2"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationCode"
 }
 ],
 "strength": "example",
 "description": "Codes identifying names of simple observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-codes"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.what[x]"
 },
 {
 "identity": "sct-concept",
 "map": "< 363787002 |Observable entity| OR \r< 386053000 |Evaluation procedure|"
 },
 {
 "identity": "v2",
 "map": "OBX-3"
 },
 {
 "identity": "rim",
 "map": "code"
 }
 ]
 },
 {
 "id": "Observation.component:inner-start-end.value[x]",
 "path": "Observation.component.value[x]",
 "short": "Actual component result",
 "definition": "The information determined as a result of making the observation, if the information has a simple value.",
 "comment": "Used when observation has a set of component observations. An observation may have both a value (e.g. an Apgar score) and component observations (the observations from which the Apgar score was derived). If a value is present, the datatype for this element should be determined by Observation.code. A CodeableConcept with just a text would be used instead of a string if the field was usually coded, or if the type associated with the Observation.code defines a coded value. For additional guidance, see the [Notes section](observation.html#notes) below.",
 "requirements": "An observation exists to have a value, though it might not if it is in error, or if it represents a group of observations.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Observation.component.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Range"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "363714003 |Interprets| < 441742003 |Evaluation finding|"
 },
 {
 "identity": "v2",
 "map": "OBX.2, OBX.5, OBX.6"
 },
 {
 "identity": "rim",
 "map": "value"
 },
 {
 "identity": "sct-attr",
 "map": "363714003 |Interprets|"
 },
 {
 "identity": "v2-cg-results",
 "map": "B.32"
 }
 ]
 },
 {
 "id": "Observation.component:inner-start-end.value[x].id",
 "path": "Observation.component.value[x].id",
 "representation": [
 "xmlAttr"
 ],
 "short": "xml:id (or equivalent in JSON)",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:inner-start-end.value[x].extension",
 "path": "Observation.component.value[x].extension",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "url"
 }
 ],
 "description": "Extensions are always sliced by (at least) url",
 "rules": "open"
 },
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Observation.component:inner-start-end.value[x].low",
 "path": "Observation.component.value[x].low",
 "short": "Low limit",
 "definition": "The low limit. The boundary is inclusive.",
 "comment": "If the low element is missing, the low boundary is not known.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Range.low",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity",
 "profile": [
 "http://hl7.org/fhir/StructureDefinition/SimpleQuantity"
 ]
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "NR.1"
 },
 {
 "identity": "rim",
 "map": "./low"
 }
 ]
 },
 {
 "id": "Observation.component:inner-start-end.value[x].high",
 "path": "Observation.component.value[x].high",
 "short": "High limit",
 "definition": "The high limit. The boundary is inclusive.",
 "comment": "If the high element is missing, the high boundary is not known.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Range.high",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity",
 "profile": [
 "http://hl7.org/fhir/StructureDefinition/SimpleQuantity"
 ]
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "NR.2"
 },
 {
 "identity": "rim",
 "map": "./high"
 }
 ]
 },
 {
 "id": "Observation.component:inner-start-end.dataAbsentReason",
 "path": "Observation.component.dataAbsentReason",
 "short": "Why the component result is missing",
 "definition": "Provides a reason why the expected value in the element Observation.component.value[x] is missing.",
 "comment": "\"Null\" or exceptional values can be represented two ways in FHIR Observations. One way is to simply include them in the value set and represent the exceptions in the value. For example, measurement values for a serology test could be \"detected\", \"not detected\", \"inconclusive\", or \"test not done\". \n\nThe alternate way is to use the value element for actual observations and use the explicit dataAbsentReason element to record exceptional values. For example, the dataAbsentReason code \"error\" could be used when the measurement was not completed. Because of these options, use-case agreements are required to interpret general observations for exceptional values.",
 "requirements": "For many results it is necessary to handle exceptional values in measurements.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.dataAbsentReason",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "condition": [
 "obs-6"
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationValueAbsentReason"
 }
 ],
 "strength": "extensible",
 "description": "Codes specifying why the result (`Observation.value[x]`) is missing.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/data-absent-reason"
 },
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "value.nullFlavor"
 }
 ]
 },
 {
 "id": "Observation.component:inner-start-end.interpretation",
 "path": "Observation.component.interpretation",
 "short": "High, low, normal, etc.",
 "definition": "The assessment made based on the result of the observation. Intended as a simple compact code often placed adjacent to the result value in reports and flow sheets to signal the meaning/normalcy status of the result. Otherwise known as abnormal flag.",
 "comment": "The component interpretation applies only to the individual component value. For an overall interpretation all components together use the Observation.interpretation element.",
 "requirements": "For some results, particularly numeric results, an interpretation is necessary to fully understand the significance of a result.",
 "alias": [
 "Abnormal Flag"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Observation.component.interpretation",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "ObservationInterpretation"
 }
 ],
 "strength": "extensible",
 "description": "Codes identifying interpretations of observations.",
 "valueSetCanonical": "http://hl7.org/fhir/ValueSet/observation-interpretation"
 },
 "mapping": [
 {
 "identity": "sct-concept",
 "map": "< 260245000 |Findings values|"
 },
 {
 "identity": "v2",
 "map": "OBX-8"
 },
 {
 "identity": "rim",
 "map": "interpretationCode"
 },
 {
 "identity": "sct-attr",
 "map": "363713009 |Has interpretation|"
 }
 ]
 },
 {
 "id": "Observation.component:inner-start-end.referenceRange",
 "path": "Observation.component.referenceRange",
 "short": "Provides guide for interpretation of component result",
 "definition": "Guidance on how to interpret the value by comparison to a normal or recommended range.",
 "comment": "Most observations only have one generic reference range. Systems MAY choose to restrict to only supplying the relevant reference range based on knowledge about the patient (e.g., specific to the patient's age, gender, weight and other factors), but this might not be possible or appropriate. Whenever more than one reference range is supplied, the differences between them SHOULD be provided in the reference range and/or age properties.",
 "requirements": "Knowing what values are considered \"normal\" can help evaluate the significance of a particular result. Need to be able to provide multiple reference ranges for different contexts.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Observation.component.referenceRange",
 "min": 0,
 "max": "*"
 },
 "contentReference": "#Observation.referenceRange",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "v2",
 "map": "OBX.7"
 },
 {
 "identity": "rim",
 "map": "outboundRelationship[typeCode=REFV]/target[classCode=OBS, moodCode=EVN]"
 }
 ]
 }
 ]
 },
 "differential": {
 "element": [
 {
 "id": "Observation",
 "path": "Observation",
 "short": "Described Variant (Discrete or Structural)",
 "definition": "Details about a set of changes in the tested sample compared to a reference sequence.",
 "comment": "This can be a simple/discrete (relatively short) or structural (potentially very large) variant.",
 "mustSupport": false,
 "isModifier": false
 },
 {
 "id": "Observation.code",
 "path": "Observation.code",
 "short": "Genetic variant assessment",
 "definition": "Where testing scenarios are intended to assess the prescence or absence of a known set of DNA variants (e.g. tumor profiling using genotyping technology), then the Genetic Variant Assessment is used in conjunction with answer list supports structured communication of these findings. Of note, 'No Call' is different from 'Absent', because 'No Call' did not result in the determination of the marker's presents or absents. This may be due to test failure or specimen specific context which renders the test ineffective.",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "TBD-Described"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.valueCodeableConcept",
 "path": "Observation.valueCodeableConcept",
 "short": "Present|Absent|No call|Indeterminate",
 "definition": "Indicates whether the indicated variation was found or not.",
 "comment": "If not searching for specific variations and merely reporting what's found, this element should be set to \"Present\".",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "binding": {
 "strength": "required",
 "description": "Genetic Variant Assessment",
 "valueSetCanonical": "http://loinc.org/vs/LL1971-2"
 },
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.21"
 }
 ]
 },
 {
 "id": "Observation.method",
 "path": "Observation.method",
 "short": "Sequencing | Oligo aCGH | SNP array | BAC aCGH |Curated|+",
 "definition": "Indicates the method of variant analysis.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "binding": {
 "strength": "required",
 "description": "Variant analysis method type",
 "valueSetCanonical": "http://loinc.org/vs/LL4048-6"
 }
 },
 {
 "id": "Observation.component",
 "path": "Observation.component",
 "slicing": {
 "discriminator": [
 {
 "type": "pattern",
 "path": "code"
 }
 ],
 "rules": "open"
 },
 "mustSupport": false,
 "isModifier": false
 },
 {
 "id": "Observation.component:dna-chg",
 "path": "Observation.component",
 "sliceName": "dna-chg",
 "short": "Transcript DNA change (cHGVS)",
 "definition": "Human Genome Variation Society (HGVS) nomenclature for a single DNA marker. The use of the nomenclature must be extended to describe non-variations (aka. wild types) see samples for wild type examples.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:dna-chg.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "48004-6"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:dna-chg.valueCodeableConcept",
 "path": "Observation.component.valueCodeableConcept",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "binding": {
 "strength": "example",
 "description": "Binding not yet defined"
 },
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.5 (includes A.13 in version)"
 }
 ]
 },
 {
 "id": "Observation.component:dna-chg-type",
 "path": "Observation.component",
 "sliceName": "dna-chg-type",
 "short": "DNA change type",
 "definition": "Codified type for associated DNA Marker. DNA Marker's use the HGVS notation which implies the DNA Marker Type, but the concurrent use of this code will allow a standard and explicit type for technical and display convenience.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:dna-chg-type.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "48019-4"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:dna-chg-type.valueCodeableConcept",
 "path": "Observation.component.valueCodeableConcept",
 "short": "Wild type | Deletion | Duplication | Insertion | Insertion/Deletion | Inversion | Substitution | Copy number gain +",
 "definition": "Type of DNA variation reported.",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "binding": {
 "strength": "required",
 "description": "DNA change type values",
 "valueSetCanonical": "http://loinc.org/vs/LL4033-8"
 },
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.7"
 }
 ]
 },
 {
 "id": "Observation.component:variation-code",
 "path": "Observation.component",
 "sliceName": "variation-code",
 "short": "Simple var ID",
 "definition": "This term is used to report the unique identifier of the simple variant found in this study.",
 "comment": "If this is present, the components can be omitted but they might be included to avoid a need to look up the information in a registry. Typically only one code would be present, though multiple codings expressing the variant in different code systems are possible.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:variation-code.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81252-9"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:variation-code.valueCodeableConcept",
 "path": "Observation.component.valueCodeableConcept",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "binding": {
 "strength": "example",
 "description": "Binding not yet defined"
 },
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.2, B.16 (A.16 in coding.version)"
 }
 ]
 },
 {
 "id": "Observation.component:dbsnp-id",
 "path": "Observation.component",
 "sliceName": "dbSNP-id",
 "short": "dbSNP ID",
 "definition": "The unique identifier for the variant represented as a small nucleotide polymorphism (SNP). The dbSNP ID is used routinely as the base identifier in pharmacogenomics as well as arrCGH studies. For example, for the simple variant NM_014049.4(ACAD9):c.1249C>T (p.Arg417Cys), the dbSNP ID is 368949613. [http://www.ncbi.nlm.nih.gov/clinvar/variation/30880/].",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:dbsnp-id.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81255-2"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:dbsnp-id.valueCodeableConcept",
 "path": "Observation.component.valueCodeableConcept",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "binding": {
 "strength": "example",
 "description": "Binding not yet defined"
 },
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.15 (includes A.14 in version)"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-dna-chg",
 "path": "Observation.component",
 "sliceName": "genomic-dna-chg",
 "short": "Genomica DNA change (gHGVS)",
 "definition": "The name of a structural variant reported using HGVS nomenclature.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:genomic-dna-chg.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81290-9"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:genomic-dna-chg.valueCodeableConcept",
 "path": "Observation.component.valueCodeableConcept",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "binding": {
 "strength": "example",
 "description": "Binding not yet defined"
 },
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.10 (includes A.13 in version)"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-source-class",
 "path": "Observation.component",
 "sliceName": "genomic-source-class",
 "short": "Genomic source class",
 "definition": "The genomic class of the specimen being analyzed: Germline for inherited genome, somatic for cancer genome, and prenatal for fetal genome.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:genomic-source-class.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "48002-0"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:genomic-source-class.valueCodeableConcept",
 "path": "Observation.component.valueCodeableConcept",
 "short": "Germline | Somatic | Fetal | Likely germline | Likely somatic |Likely fetal | Unknown genomic origin | De novo",
 "definition": "MG_2_Genetic variant source.",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "binding": {
 "strength": "required",
 "description": "Genomic source class values",
 "valueSetCanonical": "http://loinc.org/vs/LL378-1"
 },
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.18"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg",
 "path": "Observation.component",
 "sliceName": "amino-acid-chg",
 "short": "Amino acid change (pHGVS)",
 "definition": "Human Genome Variation Society (HGVS) nomenclature for an amino acid sequence. This value is derivable from the DNA Marker value if available. It is provided for convenience. The use of the nomenclature must be extended to describe non-variations (aka. wild types) see samples for wild type examples.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:amino-acid-chg.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "48005-3"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:amino-acid-chg.valueCodeableConcept",
 "path": "Observation.component.valueCodeableConcept",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "binding": {
 "strength": "example",
 "description": "Binding not yet defined"
 },
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.6 (includes A.13 in version)"
 }
 ]
 },
 {
 "id": "Observation.component:amino-acid-chg-type",
 "path": "Observation.component",
 "sliceName": "amino-acid-chg-type",
 "short": "Amino acid change type",
 "definition": "Codified type for associated Amino Acid Marker. Amino Acid Marker's use the HGVS notation which implies the Amino Acid Marker Type, but the concurrent use of this code will allow a standard and explicit type for technical and display convenience.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:amino-acid-chg-type.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "48006-1"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:amino-acid-chg-type.valueCodeableConcept",
 "path": "Observation.component.valueCodeableConcept",
 "short": "Wild type | Deletion | Duplication | Frameshift | Initiating Methionine | Insertion | Insertion and Deletion | Missense | Silent | Stop Codon Mutation",
 "definition": "MG_4_Amino acid change type.",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "binding": {
 "strength": "required",
 "description": "Amino acid change type values",
 "valueSetCanonical": "http://loinc.org/vs/LL380-7"
 },
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.8"
 }
 ]
 },
 {
 "id": "Observation.component:transcript-ref-seq",
 "path": "Observation.component",
 "sliceName": "transcript-ref-seq",
 "short": "Transcript reference sequence ID",
 "definition": "This field carries the ID for the transcribed reference sequence, which is the part of the genomic reference sequence that is converted to messenger RNA (i.e., after the introns are removed).",
 "comment": "Only needed if the transcript sequence or genomic reference sequence versions don't indicate the version.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:transcript-ref-seq.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "51958-7"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:transcript-ref-seq.valueCodeableConcept",
 "path": "Observation.component.valueCodeableConcept",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "binding": {
 "strength": "example",
 "description": "Binding not yet defined"
 },
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.4"
 }
 ]
 },
 {
 "id": "Observation.component:genomic-ref-seq",
 "path": "Observation.component",
 "sliceName": "genomic-ref-seq",
 "short": "Genomic reference sequence ID",
 "definition": "This field carries the ID for the genomic reference sequence. The genomic reference sequence is a contiguous stretch of chromosome DNA that spans all of the exons of the gene and includes transcribed and non transcribed stretches. For this ID use either the NCBI genomic nucleotide RefSeq IDs with their version number (see: NCBI.NLM.NIH.Gov/RefSeq) or use the LRG identifiers, without transcript (t or p) extensions -- when they become available. (See- Report sponsored by GEN2PHEN at the European Bioinformatics Institute at Hinxton UK April 24-25, 2008).\rThe NCI RefSeq genomic IDs are distinguished by a prefix of\"NG\" for genes from the nuclear chromosomes and prefix of \"NC\" for genes from mitochondria. The LRG Identifiers have a prefix of \"LRG_\" Mitochondrial genes are not in the scope of LRG.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:genomic-ref-seq.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "48013-7"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:genomic-ref-seq.valueCodeableConcept",
 "path": "Observation.component.valueCodeableConcept",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "binding": {
 "strength": "example",
 "description": "Binding not yet defined"
 },
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.9"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-frequency",
 "path": "Observation.component",
 "sliceName": "allelic-frequency",
 "short": "Allelic Frequency",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:allelic-frequency.code",
 "path": "Observation.component.code",
 "short": "Allelic frequency [NFr]",
 "definition": "The allelic frequency is the relative frequency of a particular allele in the population, expressed as a number from 0 to 1.",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81258-6"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:allelic-frequency.valueQuantity",
 "path": "Observation.component.valueQuantity",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.22, C.4"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-frequency.valueQuantity.value",
 "path": "Observation.component.valueQuantity.value",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:allelic-frequency.valueQuantity.system",
 "path": "Observation.component.valueQuantity.system",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "uri"
 }
 ],
 "fixedUri": "http://unitsofmeasure.org",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:allelic-frequency.valueQuantity.code",
 "path": "Observation.component.valueQuantity.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "code"
 }
 ],
 "fixedCode": "%",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:allelic-phase",
 "path": "Observation.component",
 "sliceName": "allelic-phase",
 "short": "Allelic phase",
 "definition": "The period of stage of an allele.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:allelic-phase.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "82120-7"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:allelic-phase.valueCodeableConcept",
 "path": "Observation.component.valueCodeableConcept",
 "short": "1st set of variants is cis relation to each other | 2nd set of variants is cis relation to each other | 3rd set of variants is cis relation to each other | 4th set of variants is cis relation to each other | 5th set of variants is cis relation to each other | Maternal | Paternal | Unknown | Other, please specify",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "binding": {
 "strength": "required",
 "description": "Allelic phase values",
 "valueSetCanonical": "http://loinc.org/vs/LL4025-4"
 },
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.26"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-phase-basis",
 "path": "Observation.component",
 "sliceName": "allelic-phase-basis",
 "short": "Basis for allelic phase",
 "definition": "The evidential basis on which the allelic phase and/or the allelic state was concluded.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:allelic-phase-basis.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "82309-6"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:allelic-phase-basis.valueCodeableConcept",
 "path": "Observation.component.valueCodeableConcept",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "binding": {
 "strength": "required",
 "description": "Allelic phase basis values",
 "valueSetCanonical": "http://loinc.org/vs/LL4050-2"
 },
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.27, C.7"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-read-depth",
 "path": "Observation.component",
 "sliceName": "allelic-read-depth",
 "definition": "Specifies the number of reads that identified the allele in question whether it consists of one or a small sequence of contiguous nucleotides. Different methods and purposes require different numbers of reads to be acceptable. Often >400, sometimes as few as 2-4.",
 "min": 0,
 "max": "*",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:allelic-read-depth.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "82121-5"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:allelic-read-depth.valueQuantity",
 "path": "Observation.component.valueQuantity",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "Quantity",
 "profile": [
 "http://hl7.org/fhir/StructureDefinition/Count"
 ]
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.27, C.7"
 }
 ]
 },
 {
 "id": "Observation.component:allelic-state",
 "path": "Observation.component",
 "sliceName": "allelic-state",
 "short": "Allelic state",
 "definition": "The level of occurrence of a single DNA Marker within a set of chromosomes. Heterozygous indicates the DNA Marker is only present in one of the two genes contained in homologous chromosomes. Homozygous indicates the DNA Marker is present in both genes contained in homologous chromosomes. Hemizygous indicates the DNA Marker exists in the only single copy of a gene in a non-homologous chromosome (The male X and Y chromosome are non-homologous). Hemiplasmic indicates that the DNA Marker is present in some but not all of the copies of mitochondrial DNA. Homoplasmic indicates that the DNA Maker is present in all of the copies of mitochondrial DNA.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:allelic-state.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "53034-5"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:allelic-state.valueCodeableConcept",
 "path": "Observation.component.valueCodeableConcept",
 "short": "Heteroplasmic | Homoplasmic | Homozygous | Heterozygous | Hemizygous",
 "definition": "The relationship between the alleles found at the same locus on different chromosomes.",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "binding": {
 "strength": "required",
 "description": "Allelic state type values",
 "valueSetCanonical": "http://loinc.org/vs/LL381-5"
 },
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.23, C.6"
 }
 ]
 },
 {
 "id": "Observation.component:copy-number",
 "path": "Observation.component",
 "sliceName": "copy-number",
 "short": "Genomic structural variant copy number",
 "definition": "The copy number of the large variant. In HGVS, this is the numeric value following the “X”. It is a unit-less value. Note that a copy number of 1 implies a deletion. The copy number can usually be inferred from the HGVS or ISCN fields.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:copy-number.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "82155-3"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:copy-number.valueQuantity",
 "path": "Observation.component.valueQuantity",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "Quantity",
 "profile": [
 "http://hl7.org/fhir/StructureDefinition/Count"
 ]
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.28"
 }
 ]
 },
 {
 "id": "Observation.component:arrcgh-ratio",
 "path": "Observation.component",
 "sliceName": "arrCGH-ratio",
 "short": "Structural variant reported arrCGH [Ratio]",
 "definition": "todo.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:arrcgh-ratio.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81299-0"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:arrcgh-ratio.valueQuantity",
 "path": "Observation.component.valueQuantity",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "Quantity",
 "profile": [
 "http://hl7.org/fhir/StructureDefinition/SimpleQuantity"
 ]
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.29"
 }
 ]
 },
 {
 "id": "Observation.component:ref-allele",
 "path": "Observation.component",
 "sliceName": "ref-allele",
 "short": "Genomic ref allele",
 "definition": "Reference values (\"normal\") examined within the Reference Sequence.",
 "comment": "This is used in a genotyping test to define the reference and variable nucleotide strings. That is if the sequence variation is an insertion, then Reference Nucleotide will be blank and Variable Nucleotide will contain the inserted nucleotides. In contrast, if the sequence variation is a deletion, then the Reference Nucleotide will contain the deleted nucliotieds, and the Variable Nucleotide will be blank.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.9"
 }
 ]
 },
 {
 "id": "Observation.component:ref-allele.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "69547-8"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:ref-allele.valueString",
 "path": "Observation.component.valueString",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:alt-allele",
 "path": "Observation.component",
 "sliceName": "alt-allele",
 "short": "Genomic alt allele",
 "definition": "The genomic alternate allele is the contiguous segment of DNA in the test sample that differs from the reference allele at the same location and thus defines a variant.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.11"
 }
 ]
 },
 {
 "id": "Observation.component:alt-allele.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "69551-0"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:alt-allele.valueString",
 "path": "Observation.component.valueString",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:coordinate-system",
 "path": "Observation.component",
 "sliceName": "coordinate-system",
 "short": "Coordinate System",
 "definition": "Base number of coordinate system (0 for 0-based numbering or interbase coordinate system, inclusive start, exclusive end, 1 for 1-based numbering or base coordinate system, inclusive start, inclusive end).",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:coordinate-system.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "TBD"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:coordinate-system.valueCodeableConcept",
 "path": "Observation.component.valueCodeableConcept",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "binding": {
 "strength": "required",
 "description": "Base coordinate systems start and end measurements for variants",
 "valueSetCanonical": "ValueSet/genetic-coordinate-system"
 }
 },
 {
 "id": "Observation.component:allele-start-end",
 "path": "Observation.component",
 "sliceName": "allele-start-end",
 "short": "Genomic Allele start-end",
 "definition": "The genomic allele location is the first genomic position in the reference allele that contains a change from the reference allele. For example, for the simple variant NM_014049.4(ACAD9):c.1249C>T (p.Arg417Cys), the genomic allele location is Chr3: 128906220 on Assembly GRCh38.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.10"
 }
 ]
 },
 {
 "id": "Observation.component:allele-start-end.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81254-5"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:allele-start-end.valueRange",
 "path": "Observation.component.valueRange",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:allele-start-end.valueRange.low",
 "path": "Observation.component.valueRange.low",
 "short": "Genomic Allele start",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:allele-start-end.valueRange.high",
 "path": "Observation.component.valueRange.high",
 "short": "Genomic Allele end",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:variant-length",
 "path": "Observation.component",
 "sliceName": "variant-length",
 "short": "Structural variant length",
 "definition": "Length of the structural variant, which information may be ascertained in some but not all types of structural variants.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:variant-length.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81300-6"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:variant-length.valueQuantity",
 "path": "Observation.component.valueQuantity",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "Quantity",
 "profile": [
 "http://hl7.org/fhir/StructureDefinition/Count"
 ]
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.30"
 }
 ]
 },
 {
 "id": "Observation.component:outer-start-end",
 "path": "Observation.component",
 "sliceName": "outer-start-end",
 "short": "Structural variant outer start and end",
 "definition": "The genomic coordinates of the widest genomic range in which the structural variant might reside.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:outer-start-end.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81301-4"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:outer-start-end.valueRange",
 "path": "Observation.component.valueRange",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.31"
 }
 ]
 },
 {
 "id": "Observation.component:outer-start-end.valueRange.low",
 "path": "Observation.component.valueRange.low",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:outer-start-end.valueRange.high",
 "path": "Observation.component.valueRange.high",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:inner-start-end",
 "path": "Observation.component",
 "sliceName": "inner-start-end",
 "short": "Structural variant inner start and end",
 "definition": "The genomic coordinates of the narrowest genomic range in which the structural variant might reside.",
 "min": 0,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:inner-start-end.code",
 "path": "Observation.component.code",
 "min": 1,
 "max": "1",
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "patternCodeableConcept": {
 "coding": [
 {
 "system": "http://loinc.org",
 "code": "81302-2"
 }
 ]
 },
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:inner-start-end.valueRange",
 "path": "Observation.component.valueRange",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false,
 "mapping": [
 {
 "identity": "v2-cg-results",
 "map": "B.32"
 }
 ]
 },
 {
 "id": "Observation.component:inner-start-end.valueRange.low",
 "path": "Observation.component.valueRange.low",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 },
 {
 "id": "Observation.component:inner-start-end.valueRange.high",
 "path": "Observation.component.valueRange.high",
 "min": 1,
 "max": "1",
 "mustSupport": true,
 "isModifier": false
 }
 ]
 }
}

name : Described Variant (Discrete or Structural)

{

}