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{
 "resourceType": "StructureDefinition",
 "id": "non-comparative-evidence",
 "text": {
 "status": "extensions",
 "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><table border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"border: 0px #F0F0F0 solid; font-size: 11px; font-family: verdana; vertical-align: top;\"><tr style=\"border: 1px #F0F0F0 solid; font-size: 11px; font-family: verdana; vertical-align: top\"><th style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"The logical name of the element\">Name</a></th><th style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"Information about the use of the element\">Flags</a></th><th style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"Minimum and Maximum # of times the the element can appear in the instance\">Card.</a></th><th style=\"width: 100px\" class=\"hierarchy\"><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"Reference to the type of the element\">Type</a></th><th style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"Additional information about the element\">Description &amp; Constraints</a><a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"Legend for this format\"><img src=\"data:image/png;base64,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\" alt=\"doco\" style=\"background-color: inherit\"/></a></th></tr><tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck1.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_resource.png\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Resource\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence\">Evidence</a><a name=\"Evidence\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..*</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"StructureDefinition-evidence-r6.html\">EvidenceR6</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Single evidence bit</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck03.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_slice.png\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Slice Definition\" class=\"hierarchy\"/> <a style=\"font-style: italic\" href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition\">Slices for variableDefinition</a><a name=\"Evidence.variableDefinition\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">2..*</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.5; font-style: italic\" href=\"http://hl7.org/fhir/R5/types.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Evidence variable such as population, exposure, or outcome Slice: Unordered, Open by value:note.text</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck035.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slicer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_slice_item.png\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Slice Item\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition:population\" title=\"Slice population\">variableDefinition:population</a><a name=\"Evidence.variableDefinition\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..*</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.5\" href=\"http://hl7.org/fhir/R5/types.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Evidence variable such as population, exposure, or outcome </td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0355.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline_slicer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_slice_item.png\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Slice Item\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition:population.extension:variableRoleCode\" title=\"Slice variableRoleCode\">extension:variableRoleCode</a><a name=\"Evidence.variableDefinition.extension\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.5\" href=\"StructureDefinition-variable-definition-variable-role-code.html\" title=\"Extension\">VariableDefinitionVariableRoleCode</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">population | exposure | outcome | covariate</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck03540.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline_slicer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition:population.extension:variableRoleCode.value[x]\">value[x]</a><a name=\"Evidence.variableDefinition.extension.value_x_\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.5\" href=\"http://hl7.org/fhir/R5/datatypes.html#code\">code</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Value of extension Required Pattern: population</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0354.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline_slicer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_slice_item.png\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Slice Item\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition:population.extension:roleSubtype\" title=\"Slice roleSubtype\">extension:roleSubtype</a><a name=\"Evidence.variableDefinition.extension\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.5\" href=\"StructureDefinition-variable-definition-role-subtype.html\" title=\"Extension\">VariableDefinitionRoleSubtype</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0354.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline_slicer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_slice_item.png\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Slice Item\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition:population.extension:comparatorCategory\" title=\"Slice comparatorCategory\">extension:comparatorCategory</a><a name=\"Evidence.variableDefinition.extension\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.5\" href=\"StructureDefinition-variable-definition-comparator-category.html\" title=\"Extension\">VariableDefinitionComparatorCategory</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">The reference value used for comparison</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0351.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline_slicer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition:population.note\">note</a><a name=\"Evidence.variableDefinition.note\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck03500.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline_slicer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition:population.note.text\">text</a><a name=\"Evidence.variableDefinition.note.text\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.5\" href=\"http://hl7.org/fhir/R5/datatypes.html#markdown\">markdown</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">The annotation - text content (as markdown) Required Pattern: population</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0350.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline_slicer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_reference.png\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Reference to another Resource\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition:population.observed\">observed</a><a name=\"Evidence.variableDefinition.observed\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R5/references.html\">Reference</a>(<a href=\"StructureDefinition-study-group.html\">StudyGroup</a> | <a href=\"StructureDefinition-exposure-group.html\">ExposureGroup</a> | <a href=\"StructureDefinition-comparator-group.html\">ComparatorGroup</a> | <a href=\"StructureDefinition-metaanalysis-study-group.html\">MetaanalysisStudyGroup</a>)</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Definition of the actual variable related to the statistic(s)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0340.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline_slicer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_reference.png\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Reference to another Resource\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition:population.intended\">intended</a><a name=\"Evidence.variableDefinition.intended\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R5/references.html\">Reference</a>(<a href=\"http://hl7.org/fhir/R5/group.html\">Group</a>)</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Definition of the intended variable related to the Evidence</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck025.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slicer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_slice_item.png\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Slice Item\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition:outcome\" title=\"Slice outcome\">variableDefinition:outcome</a><a name=\"Evidence.variableDefinition\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">S</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..*</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.5\" href=\"http://hl7.org/fhir/R5/types.html#BackboneElement\">BackboneElement</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Evidence variable such as population, exposure, or outcome </td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0255.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_slice_item.png\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Slice Item\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition:outcome.extension:variableRoleCode\" title=\"Slice variableRoleCode\">extension:variableRoleCode</a><a name=\"Evidence.variableDefinition.extension\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.5\" href=\"StructureDefinition-variable-definition-variable-role-code.html\" title=\"Extension\">VariableDefinitionVariableRoleCode</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">population | exposure | outcome | covariate</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck02540.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition:outcome.extension:variableRoleCode.value[x]\">value[x]</a><a name=\"Evidence.variableDefinition.extension.value_x_\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.5\" href=\"http://hl7.org/fhir/R5/datatypes.html#code\">code</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Value of extension Required Pattern: outcome</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0254.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_slice_item.png\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Slice Item\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition:outcome.extension:roleSubtype\" title=\"Slice roleSubtype\">extension:roleSubtype</a><a name=\"Evidence.variableDefinition.extension\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.5\" href=\"StructureDefinition-variable-definition-role-subtype.html\" title=\"Extension\">VariableDefinitionRoleSubtype</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0254.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_slice_item.png\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Slice Item\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition:outcome.extension:comparatorCategory\" title=\"Slice comparatorCategory\">extension:comparatorCategory</a><a name=\"Evidence.variableDefinition.extension\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.5\" href=\"StructureDefinition-variable-definition-comparator-category.html\" title=\"Extension\">VariableDefinitionComparatorCategory</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">The reference value used for comparison</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0251.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition:outcome.note\">note</a><a name=\"Evidence.variableDefinition.note\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck02500.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vline_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_element.gif\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Element\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition:outcome.note.text\">text</a><a name=\"Evidence.variableDefinition.note.text\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">1..1</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a style=\"opacity: 0.5\" href=\"http://hl7.org/fhir/R5/datatypes.html#markdown\">markdown</a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">The annotation - text content (as markdown) Required Pattern: outcome</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white\"><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0250.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_reference.png\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Reference to another Resource\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition:outcome.observed\">observed</a><a name=\"Evidence.variableDefinition.observed\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R5/references.html\">Reference</a>(<a href=\"StructureDefinition-variable-definition.html\">VariableDefinition</a>)</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Definition of the actual variable related to the statistic(s)</td></tr>\r\n<tr style=\"border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7\"><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0240.png)\" class=\"hierarchy\"><img src=\"tbl_spacer.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_blank.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"tbl_vjoin_end_slice.png\" alt=\".\" style=\"background-color: inherit\" class=\"hierarchy\"/><img src=\"icon_reference.png\" alt=\".\" style=\"background-color: #F7F7F7; background-color: inherit\" title=\"Reference to another Resource\" class=\"hierarchy\"/> <a href=\"StructureDefinition-non-comparative-evidence-definitions.html#Evidence.variableDefinition:outcome.intended\">intended</a><a name=\"Evidence.variableDefinition.intended\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"http://hl7.org/fhir/R5/references.html\">Reference</a>(<a href=\"http://hl7.org/fhir/R5/evidencevariable.html\">EvidenceVariable</a>)</td><td style=\"vertical-align: top; text-align : left; background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">Definition of the intended variable related to the Evidence</td></tr>\r\n<tr><td colspan=\"5\" class=\"hierarchy\"> <a href=\"https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views\" title=\"Legend for this format\"><img src=\"data:image/png;base64,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\" alt=\"doco\" style=\"background-color: inherit\"/> Documentation for this format</a></td></tr></table></div>"
 },
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-implements",
 "valueUri": "http://hl7.org/fhir/StructureDefinition/MetadataResource"
 },
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm",
 "valueInteger": 1
 },
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
 "valueCode": "cds"
 },
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status",
 "valueCode": "draft"
 }
 ],
 "url": "http://hl7.org/fhir/uv/ebm/StructureDefinition/non-comparative-evidence",
 "version": "1.0.0-ballot",
 "name": "NonComparativeEvidence",
 "status": "draft",
 "date": "2023-12-17T16:55:23+00:00",
 "publisher": "HL7 International / Clinical Decision Support",
 "contact": [
 {
 "name": "HL7 International / Clinical Decision Support",
 "telecom": [
 {
 "system": "url",
 "value": "http://www.hl7.org/Special/committees/dss"
 }
 ]
 }
 ],
 "description": "Profile of Evidence for Evidence Based Medicine IG. The NonComparativeEvidence Profile is used for evidence about a single group with no comparisons between groups.",
 "jurisdiction": [
 {
 "coding": [
 {
 "system": "http://unstats.un.org/unsd/methods/m49/m49.htm",
 "code": "001",
 "display": "World"
 }
 ]
 }
 ],
 "fhirVersion": "5.0.0",
 "mapping": [
 {
 "identity": "w5",
 "uri": "http://hl7.org/fhir/fivews",
 "name": "FiveWs Pattern Mapping"
 },
 {
 "identity": "objimpl",
 "uri": "http://hl7.org/fhir/object-implementation",
 "name": "Object Implementation Information"
 },
 {
 "identity": "rim",
 "uri": "http://hl7.org/v3",
 "name": "RIM Mapping"
 }
 ],
 "kind": "resource",
 "abstract": false,
 "type": "Evidence",
 "baseDefinition": "http://hl7.org/fhir/uv/ebm/StructureDefinition/evidence-r6",
 "derivation": "constraint",
 "snapshot": {
 "element": [
 {
 "id": "Evidence",
 "path": "Evidence",
 "short": "Single evidence bit",
 "definition": "The Evidence Resource provides a machine-interpretable expression of an evidence concept including the evidence variables (e.g., population, exposures/interventions, comparators, outcomes, measured variables, confounding variables), the statistics, and the certainty of this evidence.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence",
 "min": 0,
 "max": "*"
 },
 "constraint": [
 {
 "key": "cnl-0",
 "severity": "warning",
 "human": "Name should be usable as an identifier for the module by machine processing applications such as code generation",
 "expression": "name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$')",
 "source": "http://hl7.org/fhir/StructureDefinition/Evidence"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "w5",
 "map": "conformance.behavior,clinical.general"
 }
 ]
 },
 {
 "id": "Evidence.id",
 "path": "Evidence.id",
 "short": "Logical id of this artifact",
 "definition": "The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes.",
 "comment": "Within the context of the FHIR RESTful interactions, the resource has an id except for cases like the create and conditional update. Otherwise, the use of the resouce id depends on the given use case.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Resource.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "id"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true
 },
 {
 "id": "Evidence.meta",
 "path": "Evidence.meta",
 "short": "Metadata about the resource",
 "definition": "The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Resource.meta",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Meta"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true
 },
 {
 "id": "Evidence.implicitRules",
 "path": "Evidence.implicitRules",
 "short": "A set of rules under which this content was created",
 "definition": "A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc.",
 "comment": "Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of its narrative along with other profiles, value sets, etc.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Resource.implicitRules",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "uri"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": true,
 "isModifierReason": "This element is labeled as a modifier because the implicit rules may provide additional knowledge about the resource that modifies its meaning or interpretation",
 "isSummary": true
 },
 {
 "id": "Evidence.language",
 "path": "Evidence.language",
 "short": "Language of the resource content",
 "definition": "The base language in which the resource is written.",
 "comment": "Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource. Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute).",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Resource.language",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "code"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "Language"
 }
 ],
 "strength": "required",
 "description": "IETF language tag for a human language",
 "valueSet": "http://hl7.org/fhir/ValueSet/all-languages|5.0.0",
 "additional": [
 {
 "purpose": "starter",
 "valueSet": "http://hl7.org/fhir/ValueSet/languages"
 }
 ]
 }
 },
 {
 "id": "Evidence.text",
 "path": "Evidence.text",
 "short": "Text summary of the resource, for human interpretation",
 "definition": "A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it \"clinically safe\" for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety.",
 "comment": "Contained resources do not have a narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied). This may be necessary for data from legacy systems where information is captured as a \"text blob\" or where text is additionally entered raw or narrated and encoded information is added later.",
 "alias": [
 "narrative",
 "html",
 "xhtml",
 "display"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "DomainResource.text",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Narrative"
 }
 ],
 "condition": [
 "dom-6"
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "Act.text?"
 }
 ]
 },
 {
 "id": "Evidence.contained",
 "path": "Evidence.contained",
 "short": "Contained, inline Resources",
 "definition": "These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, nor can they have their own independent transaction scope. This is allowed to be a Parameters resource if and only if it is referenced by a resource that provides context/meaning.",
 "comment": "This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags in their meta elements, but SHALL NOT have security labels.",
 "alias": [
 "inline resources",
 "anonymous resources",
 "contained resources"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "DomainResource.contained",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Resource"
 }
 ],
 "condition": [
 "dom-2",
 "dom-4",
 "dom-3",
 "dom-5"
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Evidence.extension",
 "path": "Evidence.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the resource. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "DomainResource.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Evidence.modifierExtension",
 "path": "Evidence.modifierExtension",
 "short": "Extensions that cannot be ignored",
 "definition": "May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "DomainResource.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "mustSupport": false,
 "isModifier": true,
 "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the resource that contains them",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Evidence.url",
 "path": "Evidence.url",
 "short": "Canonical identifier for this evidence, represented as a globally unique URI",
 "definition": "An absolute URI that is used to identify this evidence when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which an authoritative instance of this summary is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the summary is stored on different servers.",
 "comment": "In some cases, the resource can no longer be found at the stated url, but the url itself cannot change. Implementations can use the meta.source element to indicate where the current master source of the resource can be found.",
 "requirements": "Allows the evidence to be referenced by a single globally unique identifier.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.url",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "uri"
 }
 ],
 "constraint": [
 {
 "key": "cnl-1",
 "severity": "warning",
 "human": "URL should not contain | or # - these characters make processing canonical references problematic",
 "expression": "exists() implies matches('^[^|# ]+$')",
 "source": "http://hl7.org/fhir/StructureDefinition/Evidence"
 },
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.identifier"
 }
 ]
 },
 {
 "id": "Evidence.identifier",
 "path": "Evidence.identifier",
 "short": "Additional identifier for the summary",
 "definition": "A formal identifier that is used to identify this summary when it is represented in other formats, or referenced in a specification, model, design or an instance.",
 "comment": "Typically, this is used for identifiers that can go in an HL7 V3 II (instance identifier) data type, and can then identify this summary outside of FHIR, where it is not possible to use the logical URI.",
 "requirements": "Allows externally provided and/or usable business identifiers to be easily associated with the module.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.identifier",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Identifier"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.identifier"
 },
 {
 "identity": "objimpl",
 "map": "no-gen-base"
 }
 ]
 },
 {
 "id": "Evidence.version",
 "path": "Evidence.version",
 "short": "Business version of this summary",
 "definition": "The identifier that is used to identify this version of the summary when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the summary author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence.",
 "comment": "The determination of when to create a new version of a resource (same url, new version) vs. defining a new artifact is up to the author. Considerations for making this decision are found in Technical and Business Versions.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.version",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.version"
 }
 ]
 },
 {
 "id": "Evidence.versionAlgorithm[x]",
 "path": "Evidence.versionAlgorithm[x]",
 "short": "How to compare versions",
 "definition": "Indicates the mechanism used to compare versions to determine which is more current.",
 "comment": "If set as a string, this is a FHIRPath expression that has two additional context variables passed in - %version1 and %version2 and will return a negative number if version1 is newer, a positive number if version2 is newer, and a 0 if the version ordering can't successfully be determined.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.versionAlgorithm[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 },
 {
 "code": "Coding"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "strength": "extensible",
 "valueSet": "http://hl7.org/fhir/ValueSet/version-algorithm"
 }
 },
 {
 "id": "Evidence.name",
 "path": "Evidence.name",
 "short": "Name for this summary (machine friendly)",
 "definition": "A natural language name identifying the evidence. This name should be usable as an identifier for the module by machine processing applications such as code generation.",
 "comment": "The name is not expected to be globally unique. The name should be a simple alphanumeric type name to ensure that it is machine-processing friendly.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.name",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "condition": [
 "cnl-0"
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.title",
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
 "valueBoolean": true
 },
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
 "valueBoolean": true
 }
 ],
 "path": "Evidence.title",
 "short": "Name for this summary (human friendly)",
 "definition": "A short, descriptive, user-friendly title for the summary.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.title",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true
 },
 {
 "id": "Evidence.citeAs[x]",
 "path": "Evidence.citeAs[x]",
 "short": "Citation for this evidence",
 "definition": "Citation Resource or display of suggested citation for this evidence.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.citeAs[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/Citation"
 ]
 },
 {
 "code": "markdown"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.status",
 "path": "Evidence.status",
 "short": "draft | active | retired | unknown",
 "definition": "The status of this summary. Enables tracking the life-cycle of the content.",
 "comment": "Allows filtering of summarys s that are appropriate for use versus not.\n\nSee guidance around (not) making local changes to elements [here](canonicalresource.html#localization).",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Evidence.status",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "code"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": true,
 "isModifierReason": "This is labeled as \"Is Modifier\" because applications should not use a retired {{title}} without due consideration",
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "PublicationStatus"
 }
 ],
 "strength": "required",
 "description": "The lifecycle status of an artifact.",
 "valueSet": "http://hl7.org/fhir/ValueSet/publication-status|5.0.0"
 },
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.status"
 }
 ]
 },
 {
 "id": "Evidence.experimental",
 "path": "Evidence.experimental",
 "short": "For testing purposes, not real usage",
 "definition": "A Boolean value to indicate that this resource is authored for testing purposes (or education/evaluation/marketing) and is not intended to be used for genuine usage.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.experimental",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "boolean"
 }
 ],
 "meaningWhenMissing": "If absent, this resource is treated as though it is not experimental.",
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.date",
 "path": "Evidence.date",
 "short": "Date last changed",
 "definition": "The date (and optionally time) when the summary was last significantly changed. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the summary changes.",
 "comment": "The date is often not tracked until the resource is published, but may be present on draft content. Note that this is not the same as the resource last-modified-date, since the resource may be a secondary representation of the summary. Additional specific dates may be added as extensions or be found by consulting Provenances associated with past versions of the resource.\n\nSee guidance around (not) making local changes to elements [here](canonicalresource.html#localization).",
 "alias": [
 "Revision Date"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.date",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "dateTime"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.recorded"
 }
 ]
 },
 {
 "id": "Evidence.approvalDate",
 "path": "Evidence.approvalDate",
 "short": "When the summary was approved by publisher",
 "definition": "The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage.",
 "comment": "The 'date' element may be more recent than the approval date because of minor changes or editorial corrections.\n\nSee guidance around (not) making local changes to elements [here](canonicalresource.html#localization).",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.approvalDate",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "date"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "objimpl",
 "map": "no-gen-base"
 }
 ]
 },
 {
 "id": "Evidence.lastReviewDate",
 "path": "Evidence.lastReviewDate",
 "short": "When the summary was last reviewed by the publisher",
 "definition": "The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date.",
 "comment": "If specified, this date follows the original approval date.\n\nSee guidance around (not) making local changes to elements [here](canonicalresource.html#localization).",
 "requirements": "Gives a sense of how \"current\" the content is. Resources that have not been reviewed in a long time may have a risk of being less appropriate/relevant.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.lastReviewDate",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "date"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "objimpl",
 "map": "no-gen-base"
 }
 ]
 },
 {
 "id": "Evidence.publisher",
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
 "valueBoolean": true
 },
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
 "valueBoolean": true
 }
 ],
 "path": "Evidence.publisher",
 "short": "Name of the publisher/steward (organization or individual)",
 "definition": "The name of the organization or individual responsible for the release and ongoing maintenance of the evidence.",
 "comment": "Usually an organization but may be an individual. The publisher (or steward) of the evidence is the organization or individual primarily responsible for the maintenance and upkeep of the evidence. This is not necessarily the same individual or organization that developed and initially authored the content. The publisher is the primary point of contact for questions or issues with the evidence. This item SHOULD be populated unless the information is available from context.",
 "requirements": "Helps establish the \"authority/credibility\" of the evidence. May also allow for contact.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.publisher",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.witness"
 }
 ]
 },
 {
 "id": "Evidence.contact",
 "path": "Evidence.contact",
 "short": "Contact details for the publisher",
 "definition": "Contact details to assist a user in finding and communicating with the publisher.",
 "comment": "Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see [Clinical Reasoning Module](clinicalreasoning-module.html)).\n\nSee guidance around (not) making local changes to elements [here](canonicalresource.html#localization).",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.contact",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "ContactDetail"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true
 },
 {
 "id": "Evidence.author",
 "path": "Evidence.author",
 "short": "Who authored the content",
 "definition": "An individiual, organization, or device primarily involved in the creation and maintenance of the content.",
 "comment": "Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see [Clinical Reasoning Module](clinicalreasoning-module.html)).",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.author",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "ContactDetail"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true
 },
 {
 "id": "Evidence.editor",
 "path": "Evidence.editor",
 "short": "Who edited the content",
 "definition": "An individiual, organization, or device primarily responsible for internal coherence of the content.",
 "comment": "Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see [Clinical Reasoning Module](clinicalreasoning-module.html)).",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.editor",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "ContactDetail"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.reviewer",
 "path": "Evidence.reviewer",
 "short": "Who reviewed the content",
 "definition": "An individiual, organization, or device primarily responsible for review of some aspect of the content.",
 "comment": "Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see [Clinical Reasoning Module](clinicalreasoning-module.html)).\n\nSee guidance around (not) making local changes to elements [here](canonicalresource.html#localization).",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.reviewer",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "ContactDetail"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.endorser",
 "path": "Evidence.endorser",
 "short": "Who endorsed the content",
 "definition": "An individiual, organization, or device responsible for officially endorsing the content for use in some setting.",
 "comment": "Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see [Clinical Reasoning Module](clinicalreasoning-module.html)).\n\nSee guidance around (not) making local changes to elements [here](canonicalresource.html#localization).",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.endorser",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "ContactDetail"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true
 },
 {
 "id": "Evidence.useContext",
 "path": "Evidence.useContext",
 "short": "The context that the content is intended to support",
 "definition": "The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate evidence instances.",
 "comment": "When multiple useContexts are specified, there is no expectation that all or any of the contexts apply.",
 "requirements": "Assist in searching for appropriate content.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.useContext",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "UsageContext"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true
 },
 {
 "id": "Evidence.purpose",
 "path": "Evidence.purpose",
 "short": "Why this Evidence is defined",
 "definition": "Explanation of why this Evidence is needed and why it has been designed as it has.",
 "comment": "This element does not describe the usage of the Evidence. Instead, it provides traceability of ''why'' the resource is either needed or ''why'' it is defined as it is. This may be used to point to source materials or specifications that drove the structure of this Evidence.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.purpose",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "markdown"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "w5",
 "map": "FiveWs.why[x]"
 },
 {
 "identity": "objimpl",
 "map": "no-gen-base"
 }
 ]
 },
 {
 "id": "Evidence.copyright",
 "path": "Evidence.copyright",
 "short": "Use and/or publishing restrictions",
 "definition": "A copyright statement relating to the Evidence and/or its contents. Copyright statements are generally legal restrictions on the use and publishing of the Evidence.",
 "comment": "The short copyright declaration (e.g. (c) '2015+ xyz organization' should be sent in the copyrightLabel element.",
 "requirements": "Consumers must be able to determine any legal restrictions on the use of the Evidence and/or its content.",
 "alias": [
 "License",
 "Restrictions"
 ],
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.copyright",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "markdown"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "objimpl",
 "map": "no-gen-base"
 }
 ]
 },
 {
 "id": "Evidence.copyrightLabel",
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
 "valueBoolean": true
 },
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
 "valueBoolean": true
 }
 ],
 "path": "Evidence.copyrightLabel",
 "short": "Copyright holder and year(s)",
 "definition": "A short string (<50 characters), suitable for inclusion in a page footer that identifies the copyright holder, effective period, and optionally whether rights are resctricted. (e.g. 'All rights reserved', 'Some rights reserved').",
 "comment": "The (c) symbol should NOT be included in this string. It will be added by software when rendering the notation. Full details about licensing, restrictions, warrantees, etc. goes in the more general 'copyright' element.",
 "requirements": "Defines the content expected to be rendered in all representations of the artifact.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.copyrightLabel",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.relatedArtifact",
 "path": "Evidence.relatedArtifact",
 "short": "Link or citation to artifact associated with the summary",
 "definition": "Link or citation to artifact associated with the summary.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.relatedArtifact",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "RelatedArtifact"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.description",
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
 "valueBoolean": true
 },
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
 "valueBoolean": true
 }
 ],
 "path": "Evidence.description",
 "short": "Description of the particular summary",
 "definition": "A free text natural language description of the evidence from a consumer's perspective.",
 "comment": "This description can be used to capture details such as comments about misuse, instructions for clinical use and interpretation, literature references, examples from the paper world, etc. It is not a rendering of the evidence as conveyed in the 'text' field of the resource itself. This item SHOULD be populated unless the information is available from context (e.g. the language of the evidence is presumed to be the predominant language in the place the evidence was created).",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.description",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "markdown"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.assertion",
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
 "valueBoolean": true
 },
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
 "valueBoolean": true
 }
 ],
 "path": "Evidence.assertion",
 "short": "Declarative description of the Evidence",
 "definition": "Declarative description of the Evidence.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.assertion",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "markdown"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.note",
 "path": "Evidence.note",
 "short": "Footnotes and/or explanatory notes",
 "definition": "Footnotes and/or explanatory notes.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.note",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Annotation"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.variableDefinition",
 "path": "Evidence.variableDefinition",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "note.text"
 }
 ],
 "rules": "open"
 },
 "short": "Evidence variable such as population, exposure, or outcome",
 "definition": "Evidence variable such as population, exposure, or outcome.",
 "min": 2,
 "max": "*",
 "base": {
 "path": "Evidence.variableDefinition",
 "min": 1,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.variableDefinition.id",
 "path": "Evidence.variableDefinition.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "Unique id for inter-element referencing",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "string"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "condition": [
 "ele-1"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition.extension",
 "path": "Evidence.variableDefinition.extension",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "url"
 }
 ],
 "ordered": false,
 "rules": "open"
 },
 "short": "Extension",
 "definition": "An Extension",
 "min": 1,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.variableDefinition.extension:variableRoleCode",
 "path": "Evidence.variableDefinition.extension",
 "sliceName": "variableRoleCode",
 "short": "population | exposure | outcome | covariate",
 "definition": "Classification of the role of the variable.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension",
 "profile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false
 },
 {
 "id": "Evidence.variableDefinition.extension:roleSubtype",
 "path": "Evidence.variableDefinition.extension",
 "sliceName": "roleSubtype",
 "short": "subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier",
 "definition": "Sub-classification of the role of the variable.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension",
 "profile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false
 },
 {
 "id": "Evidence.variableDefinition.extension:comparatorCategory",
 "path": "Evidence.variableDefinition.extension",
 "sliceName": "comparatorCategory",
 "short": "The reference value used for comparison",
 "definition": "The reference value used for comparison. Value should match EvidenceVariable.category.name in the EvidenceVariable referenced in the observed or intended element.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension",
 "profile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false
 },
 {
 "id": "Evidence.variableDefinition.modifierExtension",
 "path": "Evidence.variableDefinition.modifierExtension",
 "short": "Extensions that cannot be ignored even if unrecognized",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition.description",
 "path": "Evidence.variableDefinition.description",
 "short": "A text description or summary of the variable",
 "definition": "A text description or summary of the variable.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.variableDefinition.description",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "markdown"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.variableDefinition.note",
 "path": "Evidence.variableDefinition.note",
 "short": "Footnotes and/or explanatory notes",
 "definition": "Footnotes and/or explanatory notes.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.variableDefinition.note",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Annotation"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.variableDefinition.variableRole",
 "path": "Evidence.variableDefinition.variableRole",
 "short": "population | subpopulation | exposure | referenceExposure | measuredVariable | confounder",
 "definition": "population | subpopulation | exposure | referenceExposure | measuredVariable | confounder.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Evidence.variableDefinition.variableRole",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "EvidenceVariableRole"
 }
 ],
 "strength": "extensible",
 "description": "The role that the assertion variable plays.",
 "valueSet": "http://hl7.org/fhir/ValueSet/variable-role"
 }
 },
 {
 "id": "Evidence.variableDefinition.variableRole.id",
 "path": "Evidence.variableDefinition.variableRole.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "Unique id for inter-element referencing",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "id"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "condition": [
 "ele-1"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition.variableRole.extension",
 "path": "Evidence.variableDefinition.variableRole.extension",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "url"
 }
 ],
 "description": "Extensions are always sliced by (at least) url",
 "rules": "open"
 },
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition.variableRole.coding",
 "path": "Evidence.variableDefinition.variableRole.coding",
 "short": "Code defined by a terminology system",
 "definition": "A reference to a code defined by a terminology system.",
 "comment": "Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information. Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.",
 "requirements": "Allows for alternative encodings within a code system, and translations to other code systems.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "CodeableConcept.coding",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Coding"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "C*E.1-8, C*E.10-22"
 },
 {
 "identity": "rim",
 "map": "union(., ./translation)"
 },
 {
 "identity": "orim",
 "map": "fhir:CodeableConcept.coding rdfs:subPropertyOf dt:CD.coding"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition.variableRole.text",
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
 "valueBoolean": true
 }
 ],
 "path": "Evidence.variableDefinition.variableRole.text",
 "short": "Plain text representation of the concept",
 "definition": "A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.",
 "comment": "Very often the text is the same as a displayName of one of the codings.",
 "requirements": "The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "CodeableConcept.text",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "patternString": "Use extension:variableRoleCode instead.",
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "C*E.9. But note many systems use C*E.2 for this"
 },
 {
 "identity": "rim",
 "map": "./originalText[mediaType/code=\"text/plain\"]/data"
 },
 {
 "identity": "orim",
 "map": "fhir:CodeableConcept.text rdfs:subPropertyOf dt:CD.originalText"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition.observed",
 "path": "Evidence.variableDefinition.observed",
 "short": "Definition of the actual variable related to the statistic(s)",
 "definition": "Definition of the actual variable related to the statistic(s).",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.variableDefinition.observed",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/Group",
 "http://hl7.org/fhir/StructureDefinition/EvidenceVariable"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true
 },
 {
 "id": "Evidence.variableDefinition.intended",
 "path": "Evidence.variableDefinition.intended",
 "short": "Definition of the intended variable related to the Evidence",
 "definition": "Definition of the intended variable related to the Evidence.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.variableDefinition.intended",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/Group",
 "http://hl7.org/fhir/StructureDefinition/EvidenceVariable"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.variableDefinition.directnessMatch",
 "path": "Evidence.variableDefinition.directnessMatch",
 "short": "low | moderate | high | exact",
 "definition": "Indication of quality of match between intended variable to actual variable.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.variableDefinition.directnessMatch",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "EvidenceDirectness"
 }
 ],
 "strength": "extensible",
 "description": "The quality of how direct the match is.",
 "valueSet": "http://terminology.hl7.org/ValueSet/directness"
 }
 },
 {
 "id": "Evidence.variableDefinition:population",
 "path": "Evidence.variableDefinition",
 "sliceName": "population",
 "short": "Evidence variable such as population, exposure, or outcome",
 "definition": "Evidence variable such as population, exposure, or outcome.",
 "min": 1,
 "max": "*",
 "base": {
 "path": "Evidence.variableDefinition",
 "min": 1,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.variableDefinition:population.id",
 "path": "Evidence.variableDefinition.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "Unique id for inter-element referencing",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "string"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "condition": [
 "ele-1"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:population.extension",
 "path": "Evidence.variableDefinition.extension",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "url"
 }
 ],
 "ordered": false,
 "rules": "open"
 },
 "short": "Extension",
 "definition": "An Extension",
 "min": 1,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.variableDefinition:population.extension:variableRoleCode",
 "path": "Evidence.variableDefinition.extension",
 "sliceName": "variableRoleCode",
 "short": "population | exposure | outcome | covariate",
 "definition": "Classification of the role of the variable.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension",
 "profile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false
 },
 {
 "id": "Evidence.variableDefinition:population.extension:variableRoleCode.id",
 "path": "Evidence.variableDefinition.extension.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "Unique id for inter-element referencing",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "id"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "condition": [
 "ele-1"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:population.extension:variableRoleCode.extension",
 "path": "Evidence.variableDefinition.extension.extension",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "url"
 }
 ],
 "description": "Extensions are always sliced by (at least) url",
 "rules": "open"
 },
 "short": "Extension",
 "definition": "An Extension",
 "min": 0,
 "max": "0",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.variableDefinition:population.extension:variableRoleCode.url",
 "path": "Evidence.variableDefinition.extension.url",
 "representation": [
 "xmlAttr"
 ],
 "short": "identifies the meaning of the extension",
 "definition": "Source of the definition for the extension code - a logical name or a URL.",
 "comment": "The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Extension.url",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "uri"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "fixedUri": "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:population.extension:variableRoleCode.value[x]",
 "path": "Evidence.variableDefinition.extension.value[x]",
 "short": "Value of extension",
 "definition": "Value of extension - must be one of a constrained set of the data types (see [Extensibility](http://hl7.org/fhir/R5/extensibility.html) for a list).",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Extension.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "code"
 }
 ],
 "patternCode": "population",
 "condition": [
 "ext-1"
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:population.extension:roleSubtype",
 "path": "Evidence.variableDefinition.extension",
 "sliceName": "roleSubtype",
 "short": "subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier",
 "definition": "Sub-classification of the role of the variable.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension",
 "profile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false
 },
 {
 "id": "Evidence.variableDefinition:population.extension:comparatorCategory",
 "path": "Evidence.variableDefinition.extension",
 "sliceName": "comparatorCategory",
 "short": "The reference value used for comparison",
 "definition": "The reference value used for comparison. Value should match EvidenceVariable.category.name in the EvidenceVariable referenced in the observed or intended element.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension",
 "profile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false
 },
 {
 "id": "Evidence.variableDefinition:population.modifierExtension",
 "path": "Evidence.variableDefinition.modifierExtension",
 "short": "Extensions that cannot be ignored even if unrecognized",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:population.description",
 "path": "Evidence.variableDefinition.description",
 "short": "A text description or summary of the variable",
 "definition": "A text description or summary of the variable.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.variableDefinition.description",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "markdown"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.variableDefinition:population.note",
 "path": "Evidence.variableDefinition.note",
 "short": "Footnotes and/or explanatory notes",
 "definition": "Footnotes and/or explanatory notes.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.variableDefinition.note",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Annotation"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.variableDefinition:population.note.id",
 "path": "Evidence.variableDefinition.note.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "Unique id for inter-element referencing",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "id"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "condition": [
 "ele-1"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:population.note.extension",
 "path": "Evidence.variableDefinition.note.extension",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "url"
 }
 ],
 "description": "Extensions are always sliced by (at least) url",
 "rules": "open"
 },
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:population.note.author[x]",
 "path": "Evidence.variableDefinition.note.author[x]",
 "short": "Individual responsible for the annotation",
 "definition": "The individual responsible for making the annotation.",
 "comment": "Organization is used when there's no need for specific attribution as to who made the comment.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Annotation.author[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/Practitioner",
 "http://hl7.org/fhir/StructureDefinition/PractitionerRole",
 "http://hl7.org/fhir/StructureDefinition/Patient",
 "http://hl7.org/fhir/StructureDefinition/RelatedPerson",
 "http://hl7.org/fhir/StructureDefinition/Organization"
 ]
 },
 {
 "code": "string"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "Act.participant[typeCode=AUT].role"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:population.note.time",
 "path": "Evidence.variableDefinition.note.time",
 "short": "When the annotation was made",
 "definition": "Indicates when this particular annotation was made.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Annotation.time",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "dateTime"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "Act.effectiveTime"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:population.note.text",
 "path": "Evidence.variableDefinition.note.text",
 "short": "The annotation - text content (as markdown)",
 "definition": "The text of the annotation in markdown format.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Annotation.text",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "markdown"
 }
 ],
 "patternMarkdown": "population",
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "Act.text"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:population.variableRole",
 "path": "Evidence.variableDefinition.variableRole",
 "short": "population | subpopulation | exposure | referenceExposure | measuredVariable | confounder",
 "definition": "population | subpopulation | exposure | referenceExposure | measuredVariable | confounder.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Evidence.variableDefinition.variableRole",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "EvidenceVariableRole"
 }
 ],
 "strength": "extensible",
 "description": "The role that the assertion variable plays.",
 "valueSet": "http://hl7.org/fhir/ValueSet/variable-role"
 }
 },
 {
 "id": "Evidence.variableDefinition:population.variableRole.id",
 "path": "Evidence.variableDefinition.variableRole.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "Unique id for inter-element referencing",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "id"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "condition": [
 "ele-1"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:population.variableRole.extension",
 "path": "Evidence.variableDefinition.variableRole.extension",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "url"
 }
 ],
 "description": "Extensions are always sliced by (at least) url",
 "rules": "open"
 },
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:population.variableRole.coding",
 "path": "Evidence.variableDefinition.variableRole.coding",
 "short": "Code defined by a terminology system",
 "definition": "A reference to a code defined by a terminology system.",
 "comment": "Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information. Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.",
 "requirements": "Allows for alternative encodings within a code system, and translations to other code systems.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "CodeableConcept.coding",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Coding"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "C*E.1-8, C*E.10-22"
 },
 {
 "identity": "rim",
 "map": "union(., ./translation)"
 },
 {
 "identity": "orim",
 "map": "fhir:CodeableConcept.coding rdfs:subPropertyOf dt:CD.coding"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:population.variableRole.text",
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
 "valueBoolean": true
 }
 ],
 "path": "Evidence.variableDefinition.variableRole.text",
 "short": "Plain text representation of the concept",
 "definition": "A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.",
 "comment": "Very often the text is the same as a displayName of one of the codings.",
 "requirements": "The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "CodeableConcept.text",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "patternString": "Use extension:variableRoleCode instead.",
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "C*E.9. But note many systems use C*E.2 for this"
 },
 {
 "identity": "rim",
 "map": "./originalText[mediaType/code=\"text/plain\"]/data"
 },
 {
 "identity": "orim",
 "map": "fhir:CodeableConcept.text rdfs:subPropertyOf dt:CD.originalText"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:population.observed",
 "path": "Evidence.variableDefinition.observed",
 "short": "Definition of the actual variable related to the statistic(s)",
 "definition": "Definition of the actual variable related to the statistic(s).",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.variableDefinition.observed",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/study-group",
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/exposure-group",
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/comparator-group",
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/metaanalysis-study-group"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true
 },
 {
 "id": "Evidence.variableDefinition:population.intended",
 "path": "Evidence.variableDefinition.intended",
 "short": "Definition of the intended variable related to the Evidence",
 "definition": "Definition of the intended variable related to the Evidence.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.variableDefinition.intended",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/Group"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.variableDefinition:population.directnessMatch",
 "path": "Evidence.variableDefinition.directnessMatch",
 "short": "low | moderate | high | exact",
 "definition": "Indication of quality of match between intended variable to actual variable.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.variableDefinition.directnessMatch",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "EvidenceDirectness"
 }
 ],
 "strength": "extensible",
 "description": "The quality of how direct the match is.",
 "valueSet": "http://terminology.hl7.org/ValueSet/directness"
 }
 },
 {
 "id": "Evidence.variableDefinition:outcome",
 "path": "Evidence.variableDefinition",
 "sliceName": "outcome",
 "short": "Evidence variable such as population, exposure, or outcome",
 "definition": "Evidence variable such as population, exposure, or outcome.",
 "min": 1,
 "max": "*",
 "base": {
 "path": "Evidence.variableDefinition",
 "min": 1,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": true,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.variableDefinition:outcome.id",
 "path": "Evidence.variableDefinition.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "Unique id for inter-element referencing",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "string"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "condition": [
 "ele-1"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:outcome.extension",
 "path": "Evidence.variableDefinition.extension",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "url"
 }
 ],
 "ordered": false,
 "rules": "open"
 },
 "short": "Extension",
 "definition": "An Extension",
 "min": 1,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.variableDefinition:outcome.extension:variableRoleCode",
 "path": "Evidence.variableDefinition.extension",
 "sliceName": "variableRoleCode",
 "short": "population | exposure | outcome | covariate",
 "definition": "Classification of the role of the variable.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension",
 "profile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false
 },
 {
 "id": "Evidence.variableDefinition:outcome.extension:variableRoleCode.id",
 "path": "Evidence.variableDefinition.extension.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "Unique id for inter-element referencing",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "id"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "condition": [
 "ele-1"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:outcome.extension:variableRoleCode.extension",
 "path": "Evidence.variableDefinition.extension.extension",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "url"
 }
 ],
 "description": "Extensions are always sliced by (at least) url",
 "rules": "open"
 },
 "short": "Extension",
 "definition": "An Extension",
 "min": 0,
 "max": "0",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.variableDefinition:outcome.extension:variableRoleCode.url",
 "path": "Evidence.variableDefinition.extension.url",
 "representation": [
 "xmlAttr"
 ],
 "short": "identifies the meaning of the extension",
 "definition": "Source of the definition for the extension code - a logical name or a URL.",
 "comment": "The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Extension.url",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "uri"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "fixedUri": "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code",
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:outcome.extension:variableRoleCode.value[x]",
 "path": "Evidence.variableDefinition.extension.value[x]",
 "short": "Value of extension",
 "definition": "Value of extension - must be one of a constrained set of the data types (see [Extensibility](http://hl7.org/fhir/R5/extensibility.html) for a list).",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Extension.value[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "code"
 }
 ],
 "patternCode": "outcome",
 "condition": [
 "ext-1"
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:outcome.extension:roleSubtype",
 "path": "Evidence.variableDefinition.extension",
 "sliceName": "roleSubtype",
 "short": "subgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier",
 "definition": "Sub-classification of the role of the variable.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension",
 "profile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false
 },
 {
 "id": "Evidence.variableDefinition:outcome.extension:comparatorCategory",
 "path": "Evidence.variableDefinition.extension",
 "sliceName": "comparatorCategory",
 "short": "The reference value used for comparison",
 "definition": "The reference value used for comparison. Value should match EvidenceVariable.category.name in the EvidenceVariable referenced in the observed or intended element.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension",
 "profile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false
 },
 {
 "id": "Evidence.variableDefinition:outcome.modifierExtension",
 "path": "Evidence.variableDefinition.modifierExtension",
 "short": "Extensions that cannot be ignored even if unrecognized",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:outcome.description",
 "path": "Evidence.variableDefinition.description",
 "short": "A text description or summary of the variable",
 "definition": "A text description or summary of the variable.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.variableDefinition.description",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "markdown"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.variableDefinition:outcome.note",
 "path": "Evidence.variableDefinition.note",
 "short": "Footnotes and/or explanatory notes",
 "definition": "Footnotes and/or explanatory notes.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.variableDefinition.note",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Annotation"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.variableDefinition:outcome.note.id",
 "path": "Evidence.variableDefinition.note.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "Unique id for inter-element referencing",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "id"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "condition": [
 "ele-1"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:outcome.note.extension",
 "path": "Evidence.variableDefinition.note.extension",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "url"
 }
 ],
 "description": "Extensions are always sliced by (at least) url",
 "rules": "open"
 },
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:outcome.note.author[x]",
 "path": "Evidence.variableDefinition.note.author[x]",
 "short": "Individual responsible for the annotation",
 "definition": "The individual responsible for making the annotation.",
 "comment": "Organization is used when there's no need for specific attribution as to who made the comment.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Annotation.author[x]",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/Practitioner",
 "http://hl7.org/fhir/StructureDefinition/PractitionerRole",
 "http://hl7.org/fhir/StructureDefinition/Patient",
 "http://hl7.org/fhir/StructureDefinition/RelatedPerson",
 "http://hl7.org/fhir/StructureDefinition/Organization"
 ]
 },
 {
 "code": "string"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "Act.participant[typeCode=AUT].role"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:outcome.note.time",
 "path": "Evidence.variableDefinition.note.time",
 "short": "When the annotation was made",
 "definition": "Indicates when this particular annotation was made.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Annotation.time",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "dateTime"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "Act.effectiveTime"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:outcome.note.text",
 "path": "Evidence.variableDefinition.note.text",
 "short": "The annotation - text content (as markdown)",
 "definition": "The text of the annotation in markdown format.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Annotation.text",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "markdown"
 }
 ],
 "patternMarkdown": "outcome",
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "N/A"
 },
 {
 "identity": "rim",
 "map": "Act.text"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:outcome.variableRole",
 "path": "Evidence.variableDefinition.variableRole",
 "short": "population | subpopulation | exposure | referenceExposure | measuredVariable | confounder",
 "definition": "population | subpopulation | exposure | referenceExposure | measuredVariable | confounder.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Evidence.variableDefinition.variableRole",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "EvidenceVariableRole"
 }
 ],
 "strength": "extensible",
 "description": "The role that the assertion variable plays.",
 "valueSet": "http://hl7.org/fhir/ValueSet/variable-role"
 }
 },
 {
 "id": "Evidence.variableDefinition:outcome.variableRole.id",
 "path": "Evidence.variableDefinition.variableRole.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "Unique id for inter-element referencing",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "id"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "condition": [
 "ele-1"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:outcome.variableRole.extension",
 "path": "Evidence.variableDefinition.variableRole.extension",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "url"
 }
 ],
 "description": "Extensions are always sliced by (at least) url",
 "rules": "open"
 },
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:outcome.variableRole.coding",
 "path": "Evidence.variableDefinition.variableRole.coding",
 "short": "Code defined by a terminology system",
 "definition": "A reference to a code defined by a terminology system.",
 "comment": "Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information. Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.",
 "requirements": "Allows for alternative encodings within a code system, and translations to other code systems.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "CodeableConcept.coding",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Coding"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "C*E.1-8, C*E.10-22"
 },
 {
 "identity": "rim",
 "map": "union(., ./translation)"
 },
 {
 "identity": "orim",
 "map": "fhir:CodeableConcept.coding rdfs:subPropertyOf dt:CD.coding"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:outcome.variableRole.text",
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
 "valueBoolean": true
 }
 ],
 "path": "Evidence.variableDefinition.variableRole.text",
 "short": "Plain text representation of the concept",
 "definition": "A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.",
 "comment": "Very often the text is the same as a displayName of one of the codings.",
 "requirements": "The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "CodeableConcept.text",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "patternString": "Use extension:variableRoleCode instead.",
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "isModifier": false,
 "isSummary": true,
 "mapping": [
 {
 "identity": "v2",
 "map": "C*E.9. But note many systems use C*E.2 for this"
 },
 {
 "identity": "rim",
 "map": "./originalText[mediaType/code=\"text/plain\"]/data"
 },
 {
 "identity": "orim",
 "map": "fhir:CodeableConcept.text rdfs:subPropertyOf dt:CD.originalText"
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:outcome.observed",
 "path": "Evidence.variableDefinition.observed",
 "short": "Definition of the actual variable related to the statistic(s)",
 "definition": "Definition of the actual variable related to the statistic(s).",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.variableDefinition.observed",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": true
 },
 {
 "id": "Evidence.variableDefinition:outcome.intended",
 "path": "Evidence.variableDefinition.intended",
 "short": "Definition of the intended variable related to the Evidence",
 "definition": "Definition of the intended variable related to the Evidence.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.variableDefinition.intended",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/EvidenceVariable"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.variableDefinition:outcome.directnessMatch",
 "path": "Evidence.variableDefinition.directnessMatch",
 "short": "low | moderate | high | exact",
 "definition": "Indication of quality of match between intended variable to actual variable.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.variableDefinition.directnessMatch",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "EvidenceDirectness"
 }
 ],
 "strength": "extensible",
 "description": "The quality of how direct the match is.",
 "valueSet": "http://terminology.hl7.org/ValueSet/directness"
 }
 },
 {
 "id": "Evidence.synthesisType",
 "path": "Evidence.synthesisType",
 "short": "The method to combine studies",
 "definition": "The method to combine studies.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.synthesisType",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "SynthesisType"
 }
 ],
 "strength": "extensible",
 "description": "Types of combining results from a body of evidence (e.g. summary data meta-analysis).",
 "valueSet": "http://terminology.hl7.org/ValueSet/synthesis-type"
 }
 },
 {
 "id": "Evidence.studyDesign",
 "path": "Evidence.studyDesign",
 "short": "The design of the study that produced this evidence",
 "definition": "The design of the study that produced this evidence. The design is described with any number of study design characteristics.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.studyDesign",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "StudyDesign"
 }
 ],
 "strength": "extensible",
 "description": "This is a set of terms for study design characteristics.",
 "valueSet": "http://hl7.org/fhir/ValueSet/study-design"
 }
 },
 {
 "id": "Evidence.statistic",
 "path": "Evidence.statistic",
 "short": "Values and parameters for a single statistic",
 "definition": "Values and parameters for a single statistic.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.statistic",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.id",
 "path": "Evidence.statistic.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "Unique id for inter-element referencing",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "string"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "condition": [
 "ele-1"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.statistic.extension",
 "path": "Evidence.statistic.extension",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "url"
 }
 ],
 "ordered": false,
 "rules": "open"
 },
 "short": "Extension",
 "definition": "An Extension",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.extension:modelExpression",
 "path": "Evidence.statistic.extension",
 "sliceName": "modelExpression",
 "short": "The formula for analysis",
 "definition": "The formula for analysis.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension",
 "profile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-expression"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false
 },
 {
 "id": "Evidence.statistic.modifierExtension",
 "path": "Evidence.statistic.modifierExtension",
 "short": "Extensions that cannot be ignored even if unrecognized",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Evidence.statistic.description",
 "path": "Evidence.statistic.description",
 "short": "Description of content",
 "definition": "A description of the content value of the statistic.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.description",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "markdown"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.note",
 "path": "Evidence.statistic.note",
 "short": "Footnotes and/or explanatory notes",
 "definition": "Footnotes and/or explanatory notes.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.statistic.note",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Annotation"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.statisticType",
 "path": "Evidence.statistic.statisticType",
 "short": "Type of statistic, e.g., relative risk",
 "definition": "Type of statistic, e.g., relative risk.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.statisticType",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "StatisticType"
 }
 ],
 "strength": "extensible",
 "valueSet": "http://hl7.org/fhir/ValueSet/statistic-type"
 }
 },
 {
 "id": "Evidence.statistic.category",
 "path": "Evidence.statistic.category",
 "short": "Associated category for categorical variable",
 "definition": "When the measured variable is handled categorically, the category element is used to define which category the statistic is reporting.",
 "comment": "Simple strings can be used for descriptive purposes. Exact matching to EvidenceVariable.category.name for the Evidence.variableDefinition[variableRole=measuredVariable].observed=Reference(EvidenceVariable) could facilitate validation within datasets.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.category",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.quantity",
 "path": "Evidence.statistic.quantity",
 "short": "Statistic value",
 "definition": "Statistic value.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.quantity",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.numberOfEvents",
 "path": "Evidence.statistic.numberOfEvents",
 "short": "The number of events associated with the statistic",
 "definition": "The number of events associated with the statistic, where the unit of analysis is different from numberAffected, sampleSize.knownDataCount and sampleSize.numberOfParticipants.",
 "comment": "When the number of events is the statistic, use Evidence.statistic.quantity and set Evidence.statistic.type.coding.code=C25463 and Evidence.statistic.type.coding.display=Count. When the statistic is an Event Rate (where individual participants may have 2 or more events), use Evidence.statistic.numberOfEvents to record the total number of events rather than the number of participants with events.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.numberOfEvents",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "unsignedInt"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.numberAffected",
 "path": "Evidence.statistic.numberAffected",
 "short": "The number of participants affected",
 "definition": "The number of participants affected where the unit of analysis is the same as sampleSize.knownDataCount and sampleSize.numberOfParticipants.",
 "comment": "When the number affected is the statistic, use Evidence.statistic.quantity and set Evidence.statistic.type.coding.code=C25463 and Evidence.statistic.type.coding.display=Count. When the statistic is a Proportion, use Evidence.statistic.numberAffected and enter an integer as the value. When the statistic is an Event Rate (where individual participants may have 2 or more events), use Evidence.statistic.numberAffected to record the number of participants with events rather than the total number of events.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.numberAffected",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "unsignedInt"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.sampleSize",
 "path": "Evidence.statistic.sampleSize",
 "short": "Number of samples in the statistic",
 "definition": "Number of samples in the statistic.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.sampleSize",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.sampleSize.id",
 "path": "Evidence.statistic.sampleSize.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "Unique id for inter-element referencing",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "string"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "condition": [
 "ele-1"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.statistic.sampleSize.extension",
 "path": "Evidence.statistic.sampleSize.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.statistic.sampleSize.modifierExtension",
 "path": "Evidence.statistic.sampleSize.modifierExtension",
 "short": "Extensions that cannot be ignored even if unrecognized",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Evidence.statistic.sampleSize.description",
 "path": "Evidence.statistic.sampleSize.description",
 "short": "Textual description of sample size for statistic",
 "definition": "Human-readable summary of population sample size.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.sampleSize.description",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "markdown"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.sampleSize.note",
 "path": "Evidence.statistic.sampleSize.note",
 "short": "Footnote or explanatory note about the sample size",
 "definition": "Footnote or explanatory note about the sample size.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.statistic.sampleSize.note",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Annotation"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.sampleSize.numberOfStudies",
 "path": "Evidence.statistic.sampleSize.numberOfStudies",
 "short": "Number of contributing studies",
 "definition": "Number of participants in the population.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.sampleSize.numberOfStudies",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "unsignedInt"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.sampleSize.numberOfParticipants",
 "path": "Evidence.statistic.sampleSize.numberOfParticipants",
 "short": "Cumulative number of participants",
 "definition": "A human-readable string to clarify or explain concepts about the sample size.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.sampleSize.numberOfParticipants",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "unsignedInt"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.sampleSize.knownDataCount",
 "path": "Evidence.statistic.sampleSize.knownDataCount",
 "short": "Number of participants with known results for measured variables",
 "definition": "Number of participants with known results for measured variables.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.sampleSize.knownDataCount",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "unsignedInt"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.attributeEstimate",
 "path": "Evidence.statistic.attributeEstimate",
 "short": "An attribute of the Statistic",
 "definition": "A statistical attribute of the statistic such as a measure of heterogeneity.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.statistic.attributeEstimate",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.attributeEstimate.id",
 "path": "Evidence.statistic.attributeEstimate.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "Unique id for inter-element referencing",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "string"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "condition": [
 "ele-1"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.statistic.attributeEstimate.extension",
 "path": "Evidence.statistic.attributeEstimate.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.statistic.attributeEstimate.modifierExtension",
 "path": "Evidence.statistic.attributeEstimate.modifierExtension",
 "short": "Extensions that cannot be ignored even if unrecognized",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Evidence.statistic.attributeEstimate.description",
 "path": "Evidence.statistic.attributeEstimate.description",
 "short": "Textual description of the attribute estimate",
 "definition": "Human-readable summary of the estimate.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.attributeEstimate.description",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "markdown"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.attributeEstimate.note",
 "path": "Evidence.statistic.attributeEstimate.note",
 "short": "Footnote or explanatory note about the estimate",
 "definition": "Footnote or explanatory note about the estimate.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.statistic.attributeEstimate.note",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Annotation"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.attributeEstimate.type",
 "path": "Evidence.statistic.attributeEstimate.type",
 "short": "The type of attribute estimate, e.g., confidence interval or p value",
 "definition": "The type of attribute estimate, e.g., confidence interval or p value.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.attributeEstimate.type",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "AttributeEstimateType"
 }
 ],
 "strength": "extensible",
 "valueSet": "http://hl7.org/fhir/ValueSet/attribute-estimate-type"
 }
 },
 {
 "id": "Evidence.statistic.attributeEstimate.quantity",
 "path": "Evidence.statistic.attributeEstimate.quantity",
 "short": "The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure",
 "definition": "The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure.",
 "comment": "Often the p value",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.attributeEstimate.quantity",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.attributeEstimate.level",
 "path": "Evidence.statistic.attributeEstimate.level",
 "short": "Level of confidence interval, e.g., 0.95 for 95% confidence interval",
 "definition": "Use 95 for a 95% confidence interval.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.attributeEstimate.level",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "decimal"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.attributeEstimate.range",
 "path": "Evidence.statistic.attributeEstimate.range",
 "short": "Lower and upper bound values of the attribute estimate",
 "definition": "Lower bound of confidence interval.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.attributeEstimate.range",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Range"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.attributeEstimate.attributeEstimate",
 "path": "Evidence.statistic.attributeEstimate.attributeEstimate",
 "short": "A nested attribute estimate; which is the attribute estimate of an attribute estimate",
 "definition": "A nested attribute estimate; which is the attribute estimate of an attribute estimate.",
 "comment": "A nested attribute estimate; which is the attribute estimate of an attribute estimate",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.statistic.attributeEstimate.attributeEstimate",
 "min": 0,
 "max": "*"
 },
 "contentReference": "http://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate",
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.modelCharacteristic",
 "path": "Evidence.statistic.modelCharacteristic",
 "short": "An aspect of the statistical model",
 "definition": "A component of the method to generate the statistic.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.statistic.modelCharacteristic",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.id",
 "path": "Evidence.statistic.modelCharacteristic.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "Unique id for inter-element referencing",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "string"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "condition": [
 "ele-1"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.extension",
 "path": "Evidence.statistic.modelCharacteristic.extension",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "url"
 }
 ],
 "ordered": false,
 "rules": "open"
 },
 "short": "Extension",
 "definition": "An Extension",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.extension:valueQuantity",
 "path": "Evidence.statistic.modelCharacteristic.extension",
 "sliceName": "valueQuantity",
 "short": "Value as Quantity",
 "definition": "The specific value (when paired with code) as a Quantity",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension",
 "profile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-quantity"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.extension:valueRange",
 "path": "Evidence.statistic.modelCharacteristic.extension",
 "sliceName": "valueRange",
 "short": "Value as Range",
 "definition": "The specific value (when paired with code) as a Range",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension",
 "profile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-range"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.extension:valueCodeableConcept",
 "path": "Evidence.statistic.modelCharacteristic.extension",
 "sliceName": "valueCodeableConcept",
 "short": "Value as CodeableConcept",
 "definition": "The specific value (when paired with code) as a CodeableConcept",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension",
 "profile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-value-codeableconcept"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.extension:intended",
 "path": "Evidence.statistic.modelCharacteristic.extension",
 "sliceName": "intended",
 "short": "The plan for analysis",
 "definition": "The plan for analysis.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension",
 "profile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-intended"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.extension:applied",
 "path": "Evidence.statistic.modelCharacteristic.extension",
 "sliceName": "applied",
 "short": "The analysis that was applied",
 "definition": "The analysis that was applied.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension",
 "profile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-applied"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.extension:includeIf",
 "path": "Evidence.statistic.modelCharacteristic.extension",
 "sliceName": "includeIf",
 "short": "Condition upon which to include the variable or model characteristic in the analysis",
 "definition": "The condition upon which to include the variable or model characteristic in the analysis.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension",
 "profile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-include-if"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.modifierExtension",
 "path": "Evidence.statistic.modelCharacteristic.modifierExtension",
 "short": "Extensions that cannot be ignored even if unrecognized",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.code",
 "path": "Evidence.statistic.modelCharacteristic.code",
 "short": "Model specification",
 "definition": "Description of a component of the method to generate the statistic.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.modelCharacteristic.code",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "StatisticModelCode"
 }
 ],
 "strength": "extensible",
 "valueSet": "http://hl7.org/fhir/ValueSet/statistic-model-code"
 }
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.value",
 "path": "Evidence.statistic.modelCharacteristic.value",
 "short": "Numerical value to complete model specification",
 "definition": "Further specification of the quantified value of the component of the method to generate the statistic.",
 "min": 0,
 "max": "0",
 "base": {
 "path": "Evidence.statistic.modelCharacteristic.value",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "Quantity",
 "profile": [
 "http://hl7.org/fhir/StructureDefinition/SimpleQuantity"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.variable",
 "path": "Evidence.statistic.modelCharacteristic.variable",
 "short": "A variable adjusted for in the adjusted analysis",
 "definition": "A variable adjusted for in the adjusted analysis.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.statistic.modelCharacteristic.variable",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.variable.id",
 "path": "Evidence.statistic.modelCharacteristic.variable.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "Unique id for inter-element referencing",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "string"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "condition": [
 "ele-1"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.variable.extension",
 "path": "Evidence.statistic.modelCharacteristic.variable.extension",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "url"
 }
 ],
 "ordered": false,
 "rules": "open"
 },
 "short": "Extension",
 "definition": "An Extension",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.variable.extension:includeIf",
 "path": "Evidence.statistic.modelCharacteristic.variable.extension",
 "sliceName": "includeIf",
 "short": "Condition upon which to include the variable or model characteristic in the analysis",
 "definition": "The condition upon which to include the variable or model characteristic in the analysis.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension",
 "profile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-include-if"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.variable.modifierExtension",
 "path": "Evidence.statistic.modelCharacteristic.variable.modifierExtension",
 "short": "Extensions that cannot be ignored even if unrecognized",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.variable.variableDefinition",
 "path": "Evidence.statistic.modelCharacteristic.variable.variableDefinition",
 "short": "Description of the variable",
 "definition": "Description of the variable.",
 "min": 1,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.modelCharacteristic.variable.variableDefinition",
 "min": 1,
 "max": "1"
 },
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/Group",
 "http://hl7.org/fhir/StructureDefinition/EvidenceVariable"
 ]
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.variable.handling",
 "path": "Evidence.statistic.modelCharacteristic.variable.handling",
 "short": "continuous | dichotomous | ordinal | polychotomous",
 "definition": "How the variable is classified for use in adjusted analysis.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.statistic.modelCharacteristic.variable.handling",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "code"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "EvidenceVariableHandling"
 }
 ],
 "strength": "required",
 "valueSet": "http://hl7.org/fhir/ValueSet/variable-handling|5.0.0"
 }
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.variable.valueCategory",
 "path": "Evidence.statistic.modelCharacteristic.variable.valueCategory",
 "short": "Description for grouping of ordinal or polychotomous variables",
 "definition": "Description for grouping of ordinal or polychotomous variables.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.statistic.modelCharacteristic.variable.valueCategory",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.variable.valueQuantity",
 "path": "Evidence.statistic.modelCharacteristic.variable.valueQuantity",
 "short": "Discrete value for grouping of ordinal or polychotomous variables",
 "definition": "Discrete value for grouping of ordinal or polychotomous variables.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.statistic.modelCharacteristic.variable.valueQuantity",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Quantity"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.variable.valueRange",
 "path": "Evidence.statistic.modelCharacteristic.variable.valueRange",
 "short": "Range of values for grouping of ordinal or polychotomous variables",
 "definition": "Range of values for grouping of ordinal or polychotomous variables.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.statistic.modelCharacteristic.variable.valueRange",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Range"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.statistic.modelCharacteristic.attributeEstimate",
 "path": "Evidence.statistic.modelCharacteristic.attributeEstimate",
 "short": "An attribute of the statistic used as a model characteristic",
 "definition": "An attribute of the statistic used as a model characteristic.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.statistic.modelCharacteristic.attributeEstimate",
 "min": 0,
 "max": "*"
 },
 "contentReference": "http://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate",
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.certainty",
 "path": "Evidence.certainty",
 "short": "Certainty or quality of the evidence",
 "definition": "Assessment of certainty, confidence in the estimates, or quality of the evidence.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.certainty",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "BackboneElement"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.certainty.id",
 "path": "Evidence.certainty.id",
 "representation": [
 "xmlAttr"
 ],
 "short": "Unique id for inter-element referencing",
 "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Element.id",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
 "valueUrl": "string"
 }
 ],
 "code": "http://hl7.org/fhirpath/System.String"
 }
 ],
 "condition": [
 "ele-1"
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.certainty.extension",
 "path": "Evidence.certainty.extension",
 "short": "Additional content defined by implementations",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "alias": [
 "extensions",
 "user content"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "Element.extension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": false,
 "isSummary": false,
 "mapping": [
 {
 "identity": "rim",
 "map": "n/a"
 }
 ]
 },
 {
 "id": "Evidence.certainty.modifierExtension",
 "path": "Evidence.certainty.modifierExtension",
 "short": "Extensions that cannot be ignored even if unrecognized",
 "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
 "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
 "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
 "alias": [
 "extensions",
 "user content",
 "modifiers"
 ],
 "min": 0,
 "max": "*",
 "base": {
 "path": "BackboneElement.modifierExtension",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Extension"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 },
 {
 "key": "ext-1",
 "severity": "error",
 "human": "Must have either extensions or value[x], not both",
 "expression": "extension.exists() != value.exists()",
 "source": "http://hl7.org/fhir/StructureDefinition/Extension"
 }
 ],
 "isModifier": true,
 "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
 "isSummary": true,
 "mapping": [
 {
 "identity": "rim",
 "map": "N/A"
 }
 ]
 },
 {
 "id": "Evidence.certainty.description",
 "path": "Evidence.certainty.description",
 "short": "Textual description of certainty",
 "definition": "Textual description of certainty.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.certainty.description",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "markdown"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.certainty.note",
 "path": "Evidence.certainty.note",
 "short": "Footnotes and/or explanatory notes",
 "definition": "Footnotes and/or explanatory notes.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.certainty.note",
 "min": 0,
 "max": "*"
 },
 "type": [
 {
 "code": "Annotation"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.certainty.type",
 "path": "Evidence.certainty.type",
 "short": "Aspect of certainty being rated",
 "definition": "Aspect of certainty being rated.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.certainty.type",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "EvidenceCertaintyType"
 }
 ],
 "strength": "extensible",
 "description": "The aspect of quality, confidence, or certainty.",
 "valueSet": "http://hl7.org/fhir/ValueSet/certainty-type"
 }
 },
 {
 "id": "Evidence.certainty.rating",
 "path": "Evidence.certainty.rating",
 "short": "Assessment or judgement of the aspect",
 "definition": "Assessment or judgement of the aspect.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.certainty.rating",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "CodeableConcept"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false,
 "binding": {
 "extension": [
 {
 "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
 "valueString": "EvidenceCertaintyRating"
 }
 ],
 "strength": "extensible",
 "description": "The assessment of quality, confidence, or certainty.",
 "valueSet": "http://hl7.org/fhir/ValueSet/certainty-rating"
 }
 },
 {
 "id": "Evidence.certainty.rater",
 "path": "Evidence.certainty.rater",
 "short": "Individual or group who did the rating",
 "definition": "Individual or group who did the rating.",
 "min": 0,
 "max": "1",
 "base": {
 "path": "Evidence.certainty.rater",
 "min": 0,
 "max": "1"
 },
 "type": [
 {
 "code": "string"
 }
 ],
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 },
 {
 "id": "Evidence.certainty.subcomponent",
 "path": "Evidence.certainty.subcomponent",
 "short": "A domain or subdomain of certainty",
 "definition": "A domain or subdomain of certainty.",
 "min": 0,
 "max": "*",
 "base": {
 "path": "Evidence.certainty.subcomponent",
 "min": 0,
 "max": "*"
 },
 "contentReference": "http://hl7.org/fhir/StructureDefinition/Evidence#Evidence.certainty",
 "constraint": [
 {
 "key": "ele-1",
 "severity": "error",
 "human": "All FHIR elements must have a @value or children",
 "expression": "hasValue() or (children().count() > id.count())",
 "source": "http://hl7.org/fhir/StructureDefinition/Element"
 }
 ],
 "mustSupport": false,
 "isModifier": false,
 "isSummary": false
 }
 ]
 },
 "differential": {
 "element": [
 {
 "id": "Evidence",
 "path": "Evidence"
 },
 {
 "id": "Evidence.variableDefinition",
 "path": "Evidence.variableDefinition",
 "slicing": {
 "discriminator": [
 {
 "type": "value",
 "path": "note.text"
 }
 ],
 "rules": "open"
 },
 "min": 2
 },
 {
 "id": "Evidence.variableDefinition:population",
 "path": "Evidence.variableDefinition",
 "sliceName": "population",
 "min": 1,
 "max": "*",
 "mustSupport": true
 },
 {
 "id": "Evidence.variableDefinition:population.extension:variableRoleCode",
 "path": "Evidence.variableDefinition.extension",
 "sliceName": "variableRoleCode"
 },
 {
 "id": "Evidence.variableDefinition:population.extension:variableRoleCode.value[x]",
 "path": "Evidence.variableDefinition.extension.value[x]",
 "patternCode": "population"
 },
 {
 "id": "Evidence.variableDefinition:population.extension:roleSubtype",
 "path": "Evidence.variableDefinition.extension",
 "sliceName": "roleSubtype"
 },
 {
 "id": "Evidence.variableDefinition:population.extension:comparatorCategory",
 "path": "Evidence.variableDefinition.extension",
 "sliceName": "comparatorCategory"
 },
 {
 "id": "Evidence.variableDefinition:population.note.text",
 "path": "Evidence.variableDefinition.note.text",
 "patternMarkdown": "population"
 },
 {
 "id": "Evidence.variableDefinition:population.observed",
 "path": "Evidence.variableDefinition.observed",
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/study-group",
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/exposure-group",
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/comparator-group",
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/metaanalysis-study-group"
 ]
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:population.intended",
 "path": "Evidence.variableDefinition.intended",
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/Group"
 ]
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:outcome",
 "path": "Evidence.variableDefinition",
 "sliceName": "outcome",
 "min": 1,
 "max": "*",
 "mustSupport": true
 },
 {
 "id": "Evidence.variableDefinition:outcome.extension:variableRoleCode",
 "path": "Evidence.variableDefinition.extension",
 "sliceName": "variableRoleCode"
 },
 {
 "id": "Evidence.variableDefinition:outcome.extension:variableRoleCode.value[x]",
 "path": "Evidence.variableDefinition.extension.value[x]",
 "patternCode": "outcome"
 },
 {
 "id": "Evidence.variableDefinition:outcome.extension:roleSubtype",
 "path": "Evidence.variableDefinition.extension",
 "sliceName": "roleSubtype"
 },
 {
 "id": "Evidence.variableDefinition:outcome.extension:comparatorCategory",
 "path": "Evidence.variableDefinition.extension",
 "sliceName": "comparatorCategory"
 },
 {
 "id": "Evidence.variableDefinition:outcome.note.text",
 "path": "Evidence.variableDefinition.note.text",
 "patternMarkdown": "outcome"
 },
 {
 "id": "Evidence.variableDefinition:outcome.observed",
 "path": "Evidence.variableDefinition.observed",
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition"
 ]
 }
 ]
 },
 {
 "id": "Evidence.variableDefinition:outcome.intended",
 "path": "Evidence.variableDefinition.intended",
 "type": [
 {
 "code": "Reference",
 "targetProfile": [
 "http://hl7.org/fhir/StructureDefinition/EvidenceVariable"
 ]
 }
 ]
 }
 ]
 }
}

name : NonComparativeEvidence

{

}