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{
  "resourceType": "StructureDefinition",
  "id": "Profile-nNGM-Observation-LiquidBiopsy",
  "url": "http://uk-koeln.de/fhir/StructureDefinition/Observation/liquid-biopsy",
  "version": "1.0.0",
  "name": "Profile_nNGM_Observation_LiquidBiopsy",
  "title": "Profile - nNGM - Observation - LiquidBiopsy",
  "status": "active",
  "fhirVersion": "4.0.1",
  "mapping": [
    {
      "identity": "workflow",
      "uri": "http://hl7.org/fhir/workflow",
      "name": "Workflow Pattern"
    },
    {
      "identity": "sct-concept",
      "uri": "http://snomed.info/conceptdomain",
      "name": "SNOMED CT Concept Domain Binding"
    },
    {
      "identity": "v2",
      "uri": "http://hl7.org/v2",
      "name": "HL7 v2 Mapping"
    },
    {
      "identity": "rim",
      "uri": "http://hl7.org/v3",
      "name": "RIM Mapping"
    },
    {
      "identity": "w5",
      "uri": "http://hl7.org/fhir/fivews",
      "name": "FiveWs Pattern Mapping"
    },
    {
      "identity": "sct-attr",
      "uri": "http://snomed.org/attributebinding",
      "name": "SNOMED CT Attribute Binding"
    }
  ],
  "kind": "resource",
  "abstract": false,
  "type": "Observation",
  "baseDefinition": "http://hl7.org/fhir/StructureDefinition/Observation",
  "derivation": "constraint",
  "differential": {
    "element": [
      {
        "id": "Observation.extension",
        "path": "Observation.extension",
        "slicing": {
          "discriminator": [
            {
              "type": "value",
              "path": "url"
            }
          ],
          "rules": "open"
        },
        "mustSupport": true
      },
      {
        "id": "Observation.extension:episodeOfCare",
        "path": "Observation.extension",
        "sliceName": "episodeOfCare",
        "type": [
          {
            "code": "Extension",
            "profile": [
              "http://hl7.org/fhir/StructureDefinition/workflow-episodeOfCare"
            ]
          }
        ],
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.status",
        "path": "Observation.status",
        "mustSupport": true
      },
      {
        "id": "Observation.status.extension",
        "path": "Observation.status.extension",
        "slicing": {
          "discriminator": [
            {
              "type": "value",
              "path": "url"
            }
          ],
          "rules": "open"
        },
        "mustSupport": true
      },
      {
        "id": "Observation.status.extension:statusAbschluss",
        "path": "Observation.status.extension",
        "sliceName": "statusAbschluss",
        "type": [
          {
            "code": "Extension",
            "profile": [
              "http://uk-koeln.de/fhir/StructureDefinition/Extension/nNGM/statusAbschluss"
            ]
          }
        ],
        "mustSupport": true
      },
      {
        "id": "Observation.category",
        "path": "Observation.category",
        "mustSupport": true,
        "min": "2",
        "slicing": {
          "discriminator": [
            {
              "type": "pattern",
              "path": "$this"
            }
          ],
          "rules": "open"
        }
      },
      {
        "id": "Observation.category:laboratory",
        "path": "Observation.category",
        "sliceName": "laboratory",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://terminology.hl7.org/CodeSystem/observation-category",
              "code": "laboratory"
            }
          ]
        },
        "min": "1",
        "max": "1"
      },
      {
        "id": "Observation.category:liquidBiopsy",
        "path": "Observation.category",
        "sliceName": "liquidBiopsy",
        "min": "1",
        "max": "1",
        "binding": {
          "strength": "required",
          "valueSet": "http://uk-koeln.de/fhir/ValueSet/nNGM/anforderung-liquidBiopsy"
        }
      },
      {
        "id": "Observation.code",
        "path": "Observation.code",
        "mustSupport": true,
        "binding": {
          "strength": "required",
          "valueSet": "http://uk-koeln.de/fhir/ValueSet/nNGM/molpatho-obs-codes"
        }
      },
      {
        "id": "Observation.code.coding",
        "path": "Observation.code.coding",
        "min": 1,
        "max": "1",
        "mustSupport": true,
        "slicing": {
          "discriminator": [
            {
              "type": "pattern",
              "path": "$this"
            }
          ],
          "rules": "open"
        }
      },
      {
        "id": "Observation.code.coding:liquidBiopsy",
        "path": "Observation.code.coding",
        "min": 1,
        "max": "1",
        "mustSupport": true,
        "sliceName": "liquidBiopsy",
        "patternCoding": {
          "system": "http://uk-koeln.de/fhir/CodeSystem/nNGM/molpatho-obs-codes",
          "code": "Liquid Biopsy"
        }
      },
      {
        "id": "Observation.subject",
        "path": "Observation.subject",
        "min": 1,
        "mustSupport": true
      },
      {
        "id": "Observation.effective[x]",
        "path": "Observation.effective[x]",
        "type": [
          {
            "code": "dateTime"
          }
        ],
        "mustSupport": true,
        "min": 1
      },
      {
        "id": "Observation.issued",
        "path": "Observation.issued",
        "mustSupport": true
      },
      {
        "id": "Observation.performer",
        "path": "Observation.performer",
        "mustSupport": true
      },
      {
        "id": "Observation.interpretation",
        "path": "Observation.interpretation",
        "binding": {
          "strength": "extensible",
          "valueSet": "http://loinc.org/vs/LL2160-1"
        },
        "mustSupport": true
      },
      {
        "id": "Observation.method",
        "path": "Observation.method",
        "mustSupport": true
      },
      {
        "id": "Observation.method.coding",
        "path": "Observation.method.coding",
        "slicing": {
          "discriminator": [
            {
              "type": "pattern",
              "path": "$this"
            }
          ],
          "rules": "open"
        }
      },
      {
        "id": "Observation.method.coding:ncit",
        "path": "Observation.method.coding",
        "sliceName": "ncit",
        "max": "1",
        "patternCoding": {
          "system": "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
          "code": "C101293"
        }
      },
      {
        "id": "Observation.specimen",
        "path": "Observation.specimen",
        "mustSupport": true
      },
      {
        "id": "Observation.component",
        "path": "Observation.component",
        "slicing": {
          "discriminator": [
            {
              "type": "pattern",
              "path": "code"
            }
          ],
          "rules": "open"
        },
        "mustSupport": true
      },
      {
        "id": "Observation.component:sop",
        "path": "Observation.component",
        "sliceName": "sop",
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:sop.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
              "code": "C48443"
            }
          ]
        }
      },
      {
        "id": "Observation.component:sop.value[x]",
        "path": "Observation.component.value[x]",
        "min": 1,
        "type": [
          {
            "code": "string"
          }
        ]
      },
      {
        "id": "Observation.component:assay",
        "path": "Observation.component",
        "sliceName": "assay",
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:assay.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
              "code": "C60819"
            }
          ]
        }
      },
      {
        "id": "Observation.component:assay.value[x]",
        "path": "Observation.component.value[x]",
        "min": 1,
        "type": [
          {
            "code": "CodeableConcept"
          }
        ]
      },
      {
        "id": "Observation.component:assay.value[x]:valueCodeableConcept",
        "path": "Observation.component.value[x]",
        "min": 1,
        "sliceName": "valueCodeableConcept",
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "binding": {
          "strength": "extensible",
          "valueSet": "http://uk-koeln.de/fhir/ValueSet/nNGM/ngs-assays"
        }
      },
      {
        "id": "Observation.component:hersteller",
        "path": "Observation.component",
        "sliceName": "hersteller",
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:hersteller.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
              "code": "C25392"
            }
          ]
        }
      },
      {
        "id": "Observation.component:hersteller.value[x]",
        "path": "Observation.component.value[x]",
        "min": 1,
        "type": [
          {
            "code": "CodeableConcept"
          }
        ]
      },
      {
        "id": "Observation.component:hersteller.value[x]:valueCodeableConcept",
        "path": "Observation.component.value[x]",
        "min": 1,
        "sliceName": "valueCodeableConcept",
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "binding": {
          "strength": "extensible",
          "valueSet": "http://uk-koeln.de/fhir/ValueSet/nNGM/hersteller-molpatho"
        }
      },
      {
        "id": "Observation.component:phaenotyp",
        "path": "Observation.component",
        "sliceName": "phaenotyp",
        "mustSupport": true
      },
      {
        "id": "Observation.component:phaenotyp.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
              "code": "C16977"
            }
          ]
        }
      },
      {
        "id": "Observation.component:phaenotyp.value[x]",
        "path": "Observation.component.value[x]",
        "min": 1,
        "type": [
          {
            "code": "CodeableConcept"
          }
        ]
      },
      {
        "id": "Observation.component:phaenotyp.value[x]:valueCodeableConcept",
        "path": "Observation.component.value[x]",
        "sliceName": "valueCodeableConcept",
        "min": 1,
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "binding": {
          "strength": "required",
          "valueSet": "http://uk-koeln.de/fhir/ValueSet/nNGM/phenotypes"
        }
      },
      {
        "id": "Observation.component:gene-studied",
        "path": "Observation.component",
        "sliceName": "gene-studied",
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:gene-studied.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "48018-6"
            }
          ]
        }
      },
      {
        "id": "Observation.component:gene-studied.value[x]",
        "path": "Observation.component.value[x]",
        "min": 1,
        "type": [
          {
            "code": "CodeableConcept"
          }
        ]
      },
      {
        "id": "Observation.component:gene-studied.value[x]:valueCodeableConcept",
        "path": "Observation.component.value[x]",
        "sliceName": "valueCodeableConcept",
        "min": 1,
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "binding": {
          "strength": "extensible",
          "valueSet": "http://hl7.org/fhir/uv/genomics-reporting/ValueSet/hgnc"
        }
      },
      {
        "id": "Observation.component:exon",
        "path": "Observation.component",
        "sliceName": "exon",
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:exon.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
              "code": "C13231"
            }
          ]
        }
      },
      {
        "id": "Observation.component:exon.value[x]",
        "path": "Observation.component.value[x]",
        "min": 1,
        "type": [
          {
            "code": "integer"
          }
        ]
      },
      {
        "id": "Observation.component:dna-chg",
        "path": "Observation.component",
        "sliceName": "dna-chg",
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:dna-chg.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "48004-6"
            }
          ]
        }
      },
      {
        "id": "Observation.component:dna-chg.value[x]",
        "path": "Observation.component.value[x]",
        "min": 1,
        "type": [
          {
            "code": "string"
          }
        ]
      },
      {
        "id": "Observation.component:amino-acid-chg",
        "path": "Observation.component",
        "sliceName": "amino-acid-chg",
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:amino-acid-chg.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "48005-3"
            }
          ]
        }
      },
      {
        "id": "Observation.component:amino-acid-chg.value[x]",
        "path": "Observation.component.value[x]",
        "min": 1,
        "type": [
          {
            "code": "string"
          }
        ]
      }
    ]
  }
}

name : Profile_nNGM_Observation_LiquidBiopsy

{

}