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{
  "resourceType": "StructureDefinition",
  "url": "http://uk-koeln.de/fhir/StructureDefinition/Observation/ish",
  "name": "IshObservation",
  "title": "CISH/FISH Befund",
  "status": "draft",
  "date": "2020-03-17",
  "fhirVersion": "4.0.1",
  "mapping": [
    {
      "identity": "workflow",
      "uri": "http://hl7.org/fhir/workflow",
      "name": "Workflow Pattern"
    },
    {
      "identity": "sct-concept",
      "uri": "http://snomed.info/conceptdomain",
      "name": "SNOMED CT Concept Domain Binding"
    },
    {
      "identity": "v2",
      "uri": "http://hl7.org/v2",
      "name": "HL7 v2 Mapping"
    },
    {
      "identity": "rim",
      "uri": "http://hl7.org/v3",
      "name": "RIM Mapping"
    },
    {
      "identity": "w5",
      "uri": "http://hl7.org/fhir/fivews",
      "name": "FiveWs Pattern Mapping"
    },
    {
      "identity": "sct-attr",
      "uri": "http://snomed.org/attributebinding",
      "name": "SNOMED CT Attribute Binding"
    }
  ],
  "kind": "resource",
  "abstract": false,
  "type": "Observation",
  "baseDefinition": "http://hl7.org/fhir/StructureDefinition/Observation",
  "derivation": "constraint",
  "differential": {
    "element": [
      {
        "id": "Observation",
        "path": "Observation",
        "constraint": [
          {
            "key": "amplifikation",
            "severity": "error",
            "human": "If Observation concerns MET, ALK or ROS1 then a different VS shall be bound",
            "expression": "Observation.code.coding.code.where(code = ‘MET’) implies Observation.component.ofType(CodeableConcept).coding.system.where(system = 'http://uk-koeln.de/fhir/ValueSet/nNGM/ergebnis-cish-met').exists() and Observation.code.coding.code.where(code = ‘MET’) implies Observation.component.ofType(CodableConcept).coding.system.where(system = ‘http://uk-koeln.de/fhir/ValueSet/amplification-met’).exists()"
          }
        ]
      },
      {
        "id": "Observation.extension",
        "path": "Observation.extension",
        "slicing": {
          "discriminator": [
            {
              "type": "value",
              "path": "url"
            }
          ],
          "rules": "open"
        }
      },
      {
        "id": "Observation.extension:episodeOfCare",
        "path": "Observation.extension",
        "sliceName": "episodeOfCare",
        "type": [
          {
            "code": "Extension",
            "profile": [
              "http://hl7.org/fhir/StructureDefinition/workflow-episodeOfCare"
            ]
          }
        ],
        "mustSupport": true
      },
      {
        "id": "Observation.status",
        "path": "Observation.status",
        "fixedCode": "final",
        "mustSupport": true
      },
      {
        "id": "Observation.category",
        "path": "Observation.category",
        "mustSupport": true
      },
      {
        "id": "Observation.category.coding",
        "path": "Observation.category.coding",
        "slicing": {
          "discriminator": [
            {
              "type": "value",
              "path": "system"
            }
          ],
          "rules": "open"
        }
      },
      {
        "id": "Observation.category.coding.system",
        "path": "Observation.category.coding.system",
        "fixedUri": "http://terminology.hl7.org/CodeSystem/observation-category"
      },
      {
        "id": "Observation.category.coding.code",
        "path": "Observation.category.coding.code",
        "fixedCode": "laboratory"
      },
      {
        "id": "Observation.code",
        "path": "Observation.code",
        "mustSupport": true,
        "binding": {
          "strength": "required",
          "valueSet": "http://uk-koeln.de/fhir/ValueSet/nNGM/molpatho-obs-codes"
        }
      },
      {
        "id": "Observation.subject",
        "path": "Observation.subject",
        "mustSupport": true
      },
      {
        "id": "Observation.issued",
        "path": "Observation.issued",
        "mustSupport": true
      },
      {
        "id": "Observation.value[x]",
        "path": "Observation.value[x]",
        "min": 1,
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "mustSupport": true,
        "binding": {
          "strength": "required",
          "valueSet": "http://uk-koeln.de/fhir/ValueSet/nNGM/ergebnis"
        }
      },
      {
        "id": "Observation.value[x].coding",
        "path": "Observation.value[x].coding",
        "min": 1
      },
      {
        "id": "Observation.interpretation",
        "path": "Observation.interpretation",
        "mustSupport": true
      },
      {
        "id": "Observation.interpretation.coding",
        "path": "Observation.interpretation.coding",
        "binding": {
          "strength": "extensible",
          "valueSet": "http://loinc.org/vs/LL2160-1"
        }
      },
      {
        "id": "Observation.method",
        "path": "Observation.method",
        "min": 1,
        "mustSupport": true
      },
      {
        "id": "Observation.method.coding.system",
        "path": "Observation.method.coding.system",
        "fixedUri": "http://ncit.nci.nih.gov"
      },
      {
        "id": "Observation.method.coding.code",
        "path": "Observation.method.coding.code",
        "fixedCode": "C23022"
      },
      {
        "id": "Observation.specimen",
        "path": "Observation.specimen",
        "mustSupport": true
      },
      {
        "id": "Observation.component",
        "path": "Observation.component",
        "slicing": {
          "discriminator": [
            {
              "type": "pattern",
              "path": "code"
            }
          ],
          "rules": "open"
        },
        "mustSupport": true
      },
      {
        "id": "Observation.component:phaenotyp",
        "path": "Observation.component",
        "sliceName": "phaenotyp",
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:phaenotyp.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://ncit.nci.nih.gov",
              "code": "C16977"
            }
          ]
        }
      },
      {
        "id": "Observation.component:phaenotyp.value[x]",
        "path": "Observation.component.value[x]",
        "min": 1,
        "type": [
          {
            "code": "string"
          }
        ],
        "binding": {
          "strength": "required",
          "valueSet": "http://uk-koeln.de/fhir/ValueSet/phenotypes"
        }
      },
      {
        "id": "Observation.component:kit",
        "path": "Observation.component",
        "sliceName": "kit",
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:kit.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://ncit.nci.nih.gov",
              "code": "C42793"
            }
          ]
        }
      },
      {
        "id": "Observation.component:kit.value[x]",
        "path": "Observation.component.value[x]",
        "min": 1,
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "binding": {
          "strength": "extensible",
          "valueSet": "http://uk-koeln.de/fhir/ValueSet/ish-fish-kits"
        }
      },
      {
        "id": "Observation.component:hersteller",
        "path": "Observation.component",
        "sliceName": "hersteller",
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:hersteller.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://ncit.nci.nih.gov",
              "code": "C25392"
            }
          ]
        }
      },
      {
        "id": "Observation.component:hersteller.value[x]",
        "path": "Observation.component.value[x]",
        "min": 1,
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "binding": {
          "strength": "extensible",
          "valueSet": "http://uk-koeln.de/fhir/ValueSet/hersteller-molpatho"
        }
      },
      {
        "id": "Observation.component:sop",
        "path": "Observation.component",
        "sliceName": "sop",
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:sop.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://ncit.nci.nih.gov",
              "code": "C48443"
            }
          ]
        }
      },
      {
        "id": "Observation.component:sop.value[x]",
        "path": "Observation.component.value[x]",
        "min": 1,
        "type": [
          {
            "code": "string"
          }
        ]
      },
      {
        "id": "Observation.component:standort",
        "path": "Observation.component",
        "sliceName": "standort",
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:standort.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://ncit.nci.nih.gov",
              "code": "C25341"
            }
          ]
        }
      },
      {
        "id": "Observation.component:standort.value[x]",
        "path": "Observation.component.value[x]",
        "min": 1,
        "type": [
          {
            "code": "string"
          }
        ]
      },
      {
        "id": "Observation.component:pos-tumor-zellen",
        "path": "Observation.component",
        "sliceName": "pos-tumor-zellen",
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:pos-tumor-zellen.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://ncit.nci.nih.gov",
              "code": "C70460"
            }
          ]
        }
      },
      {
        "id": "Observation.component:pos-tumor-zellen.code.coding",
        "path": "Observation.component.code.coding",
        "patternCoding": {
          "system": "http://ncit.nci.nih.gov",
          "code": "C70460"
        }
      },
      {
        "id": "Observation.component:pos-tumor-zellen.value[x]",
        "path": "Observation.component.value[x]",
        "min": 1,
        "type": [
          {
            "code": "Quantity"
          }
        ]
      },
      {
        "id": "Observation.component:pos-tumor-zellen.value[x].unit",
        "path": "Observation.component.value[x].unit",
        "fixedString": "%"
      },
      {
        "id": "Observation.component:pos-tumor-zellen.value[x].system",
        "path": "Observation.component.value[x].system",
        "fixedUri": "http://unitsofmeasure.org"
      },
      {
        "id": "Observation.component:pos-tumor-zellen.value[x].code",
        "path": "Observation.component.value[x].code",
        "fixedCode": "%"
      },
      {
        "id": "Observation.component:polysomie",
        "path": "Observation.component",
        "sliceName": "polysomie",
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:polysomie.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://ncit.nci.nih.gov",
              "code": "C36331"
            }
          ]
        }
      },
      {
        "id": "Observation.component:polysomie.value[x]",
        "path": "Observation.component.value[x]",
        "min": 1,
        "type": [
          {
            "code": "Quantity"
          }
        ]
      },
      {
        "id": "Observation.component:amplification-level",
        "path": "Observation.component",
        "sliceName": "amplification-level",
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:amplification-level.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://uk-koeln.de/fhir/CodeSystem/tbd-codes",
              "code": "amplification-level"
            }
          ]
        }
      },
      {
        "id": "Observation.component:amplification-level.value[x]",
        "path": "Observation.component.value[x]",
        "min": 1,
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "binding": {
          "strength": "extensible",
          "valueSet": "http://uk-koeln.de/fhir/ValueSet/high-medium-low"
        }
      },
      {
        "id": "Observation.component:flaeche",
        "path": "Observation.component",
        "sliceName": "flaeche",
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:flaeche.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://uk-koeln.de/fhir/CodeSystem/tbd-codes",
              "code": "tcell-surface-ratio"
            }
          ]
        }
      },
      {
        "id": "Observation.component:flaeche.value[x]",
        "path": "Observation.component.value[x]",
        "type": [
          {
            "code": "Ratio"
          }
        ]
      }
    ]
  }
}

name : IshObservation

{

}