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{
  "resourceType": "StructureDefinition",
  "id": "mii-pr-mtb-immunohistochemistry-pdl1",
  "url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry-pdl1",
  "version": "2024.0.0-ballot",
  "name": "MII_PR_MTB_Immunohistochemistry_PDL1",
  "title": "MII PR MTB Immunohistochemistry",
  "status": "draft",
  "publisher": "Medizininformatik Initiative",
  "contact": [
    {
      "telecom": [
        {
          "system": "url",
          "value": "https://www.medizininformatik-initiative.de"
        }
      ]
    }
  ],
  "description": "Immunhistorchemistry report",
  "fhirVersion": "4.0.1",
  "kind": "resource",
  "abstract": false,
  "type": "Observation",
  "baseDefinition": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry",
  "derivation": "constraint",
  "differential": {
    "element": [
      {
        "id": "Observation.effective[x]",
        "path": "Observation.effective[x]",
        "type": [
          {
            "code": "dateTime"
          }
        ],
        "mustSupport": true
      },
      {
        "id": "Observation.specimen",
        "path": "Observation.specimen",
        "short": "Probe",
        "definition": "Probe"
      },
      {
        "id": "Observation.component",
        "path": "Observation.component",
        "slicing": {
          "discriminator": [
            {
              "type": "value",
              "path": "code"
            }
          ],
          "description": "Immunohistochemische Ergebnisse",
          "rules": "open",
          "ordered": false
        }
      },
      {
        "id": "Observation.component:tps-score",
        "path": "Observation.component",
        "sliceName": "tps-score",
        "short": "TPS-Score",
        "definition": "Tumor Proportion Score (TPS) - Score für PD-L1-Expression in Tumorzellen. Der TPS ist der Anteil der PD-L1-positiven Tumorzellen im Verhältnis zu den Gesamtzellen. Der TPS wird in Prozent angegeben. Ein TPS von 1% oder mehr gilt als positiv.",
        "min": 0,
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:tps-score.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "code": "C184941",
              "system": "https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html",
              "display": "PD-L1 Tumor Proportion Score"
            }
          ]
        },
        "mustSupport": true
      },
      {
        "id": "Observation.component:tps-score.value[x]",
        "path": "Observation.component.value[x]",
        "slicing": {
          "discriminator": [
            {
              "type": "type",
              "path": "$this"
            }
          ],
          "ordered": false,
          "rules": "open"
        }
      },
      {
        "id": "Observation.component:tps-score.value[x]:valueQuantity",
        "path": "Observation.component.value[x]",
        "sliceName": "valueQuantity",
        "min": 0,
        "max": "1",
        "type": [
          {
            "code": "Quantity"
          }
        ],
        "mustSupport": true
      },
      {
        "id": "Observation.component:tps-score.interpretation",
        "path": "Observation.component.interpretation",
        "mustSupport": true
      },
      {
        "id": "Observation.component:cps-score",
        "path": "Observation.component",
        "sliceName": "cps-score",
        "short": "CPS-Score",
        "definition": "Combined Positive Score (CPS) - Score für PD-L1-Expression in Tumorzellen und Immunzellen. Der CPS ist der Anteil der PD-L1-positiven Tumorzellen und Immunzellen im Verhältnis zu den Gesamtzellen. Der CPS wird in Prozent angegeben. Ein CPS von 1% oder mehr gilt als positiv.",
        "min": 0,
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:cps-score.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "code": "C176582",
              "system": "https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html",
              "display": "PD-L1 Combined Positive Score"
            }
          ]
        },
        "mustSupport": true
      },
      {
        "id": "Observation.component:cps-score.value[x]",
        "path": "Observation.component.value[x]",
        "slicing": {
          "discriminator": [
            {
              "type": "type",
              "path": "$this"
            }
          ],
          "ordered": false,
          "rules": "open"
        }
      },
      {
        "id": "Observation.component:cps-score.value[x]:valueQuantity",
        "path": "Observation.component.value[x]",
        "sliceName": "valueQuantity",
        "min": 0,
        "max": "1",
        "type": [
          {
            "code": "Quantity"
          }
        ],
        "mustSupport": true
      },
      {
        "id": "Observation.component:cps-score.interpretation",
        "path": "Observation.component.interpretation",
        "mustSupport": true
      },
      {
        "id": "Observation.component:ics-score",
        "path": "Observation.component",
        "sliceName": "ics-score",
        "short": "ICS-Score",
        "definition": "Immune Cell Score (ICS) - Score für PD-L1-Expression in Immunzellen. Der ICS ist der Anteil der PD-L1-positiven Immunzellen im Verhältnis zu den Gesamtzellen. Der ICS wird in Prozent angegeben. Ein ICS von 1% oder mehr gilt als positiv.",
        "min": 0,
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:ics-score.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "code": "C199175",
              "system": "https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html",
              "display": "Cells.programmed cell death ligand 1/Viable tumor cells in Tissue by Immune stain"
            }
          ]
        },
        "mustSupport": true
      },
      {
        "id": "Observation.component:ics-score.value[x]",
        "path": "Observation.component.value[x]",
        "slicing": {
          "discriminator": [
            {
              "type": "type",
              "path": "$this"
            }
          ],
          "ordered": false,
          "rules": "open"
        }
      },
      {
        "id": "Observation.component:ics-score.value[x]:valueQuantity",
        "path": "Observation.component.value[x]",
        "sliceName": "valueQuantity",
        "min": 0,
        "max": "1",
        "type": [
          {
            "code": "Quantity"
          }
        ],
        "mustSupport": true
      },
      {
        "id": "Observation.component:ics-score.interpretation",
        "path": "Observation.component.interpretation",
        "mustSupport": true
      },
      {
        "id": "Observation.component:tc-score",
        "path": "Observation.component",
        "sliceName": "tc-score",
        "short": "TC-Score / TPS-Score",
        "definition": "Tumor Cell Score (TC-Score) - Score für PD-L1-Expression in Tumorzellen. Der TC-Score ist der Anteil der PD-L1-positiven Tumorzellen im Verhältnis zu den Gesamtzellen. Der TC-Score wird in Prozent angegeben. Ein TC-Score von 1% oder mehr gilt als positiv.",
        "min": 0,
        "max": "1",
        "mustSupport": true
      },
      {
        "id": "Observation.component:tc-score.code",
        "path": "Observation.component.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "code": "83053-9",
              "system": "http://loinc.org",
              "display": "Cells.programmed cell death ligand 1/Viable tumor cells in Tissue by Immune stain"
            }
          ]
        },
        "mustSupport": true
      },
      {
        "id": "Observation.component:tc-score.value[x]",
        "path": "Observation.component.value[x]",
        "slicing": {
          "discriminator": [
            {
              "type": "type",
              "path": "$this"
            }
          ],
          "ordered": false,
          "rules": "open"
        }
      },
      {
        "id": "Observation.component:tc-score.value[x]:valueQuantity",
        "path": "Observation.component.value[x]",
        "sliceName": "valueQuantity",
        "min": 0,
        "max": "1",
        "type": [
          {
            "code": "Quantity"
          }
        ],
        "mustSupport": true
      },
      {
        "id": "Observation.component:tc-score.interpretation",
        "path": "Observation.component.interpretation",
        "mustSupport": true
      }
    ]
  }
}

name : MII_PR_MTB_Immunohistochemistry_PDL1

{

}