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{
  "resourceType": "StructureDefinition",
  "id": "Profile-nNGM-Observation-Histologie",
  "url": "http://uk-koeln.de/fhir/StructureDefinition/Observation/nNGM/histologie",
  "version": "1.0.0",
  "name": "Profile_nNGM_Observation_Histologie",
  "title": "Profile - nNGM - Observation - Histologie",
  "status": "active",
  "description": "Dieses Profil beschreibt die Klassifikation (Morphologie), Topographie und die Histopathologische Differenzierung (Grading) der Tumorerkankung innerhalb des nNGM Projektes.",
  "fhirVersion": "4.0.1",
  "mapping": [
    {
      "identity": "workflow",
      "uri": "http://hl7.org/fhir/workflow",
      "name": "Workflow Pattern"
    },
    {
      "identity": "sct-concept",
      "uri": "http://snomed.info/conceptdomain",
      "name": "SNOMED CT Concept Domain Binding"
    },
    {
      "identity": "v2",
      "uri": "http://hl7.org/v2",
      "name": "HL7 v2 Mapping"
    },
    {
      "identity": "rim",
      "uri": "http://hl7.org/v3",
      "name": "RIM Mapping"
    },
    {
      "identity": "w5",
      "uri": "http://hl7.org/fhir/fivews",
      "name": "FiveWs Pattern Mapping"
    },
    {
      "identity": "sct-attr",
      "uri": "http://snomed.org/attributebinding",
      "name": "SNOMED CT Attribute Binding"
    }
  ],
  "kind": "resource",
  "abstract": false,
  "type": "Observation",
  "baseDefinition": "http://hl7.org/fhir/StructureDefinition/Observation",
  "derivation": "constraint",
  "differential": {
    "element": [
      {
        "id": "Observation.status",
        "path": "Observation.status",
        "fixedCode": "final"
      },
      {
        "id": "Observation.category",
        "path": "Observation.category",
        "min": 1,
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://terminology.hl7.org/CodeSystem/observation-category",
              "code": "laboratory"
            }
          ]
        }
      },
      {
        "id": "Observation.code.coding",
        "path": "Observation.code.coding",
        "slicing": {
          "discriminator": [
            {
              "type": "pattern",
              "path": "$this"
            }
          ],
          "rules": "open"
        },
        "min": 1
      },
      {
        "id": "Observation.code.coding:loinc",
        "path": "Observation.code.coding",
        "sliceName": "loinc",
        "min": 1,
        "patternCoding": {
          "system": "http://loinc.org",
          "code": "59847-4"
        }
      },
      {
        "id": "Observation.subject",
        "path": "Observation.subject",
        "label": "Patient",
        "short": "Ein Bezug zum Patienten muss stets gegeben sein",
        "min": 1,
        "type": [
          {
            "code": "Reference",
            "targetProfile": [
              "http://uk-koeln.de/fhir/StructureDefinition/Patient/nNGM/pseudonymisiert"
            ]
          }
        ],
        "mustSupport": true
      },
      {
        "id": "Observation.effective[x]",
        "path": "Observation.effective[x]",
        "type": [
          {
            "code": "dateTime"
          }
        ],
        "mustSupport": true
      },
      {
        "id": "Observation.value[x]",
        "path": "Observation.value[x]",
        "label": "Klassifikation",
        "min": 1,
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "mustSupport": true,
        "binding": {
          "strength": "required",
          "valueSet": "http://uk-koeln.de/fhir/ValueSet/nNGM/histologie-klassifikation"
        }
      },
      {
        "id": "Observation.bodySite",
        "path": "Observation.bodySite",
        "label": "Lokalisation",
        "mustSupport": true,
        "binding": {
          "strength": "extensible",
          "valueSet": "http://uk-koeln.de/fhir/ValueSet/icd-o-3-topologie"
        }
      },
      {
        "id": "Observation.specimen",
        "path": "Observation.specimen",
        "label": "Tumormaterial",
        "type": [
          {
            "code": "Reference",
            "targetProfile": [
              "http://uk-koeln.de/fhir/StructureDefinition/nNGM/Specimen"
            ]
          }
        ],
        "mustSupport": true
      },
      {
        "id": "Observation.component",
        "path": "Observation.component",
        "slicing": {
          "discriminator": [
            {
              "type": "value",
              "path": "code.coding.code"
            }
          ],
          "rules": "open"
        }
      },
      {
        "id": "Observation.component:grading",
        "path": "Observation.component",
        "sliceName": "grading",
        "max": "1"
      },
      {
        "id": "Observation.component:grading.code.coding.system",
        "path": "Observation.component.code.coding.system",
        "fixedUri": "http://loinc.org"
      },
      {
        "id": "Observation.component:grading.code.coding.code",
        "path": "Observation.component.code.coding.code",
        "fixedCode": "59542-1"
      },
      {
        "id": "Observation.component:grading.value[x]",
        "path": "Observation.component.value[x]",
        "label": "Grading",
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "mustSupport": true,
        "binding": {
          "strength": "required",
          "valueSet": "http://uk-koeln.de/fhir/ValueSet/nNGM/grading"
        }
      },
      {
        "id": "Observation.component:grading.referenceRange",
        "path": "Observation.component.referenceRange",
        "contentReference": "http://hl7.org/fhir/StructureDefinition/Observation#Observation.referenceRange"
      },
      {
        "id": "Observation.component:growthPatternInAdenocarcinomaLepidic",
        "path": "Observation.component",
        "sliceName": "growthPatternInAdenocarcinomaLepidic",
        "max": "1"
      },
      {
        "id": "Observation.component:growthPatternInAdenocarcinomaLepidic.code.coding.system",
        "path": "Observation.component.code.coding.system",
        "fixedUri": "http://snomed.info/sct"
      },
      {
        "id": "Observation.component:growthPatternInAdenocarcinomaLepidic.code.coding.code",
        "path": "Observation.component.code.coding.code",
        "fixedCode": "112677002"
      },
      {
        "id": "Observation.component:growthPatternInAdenocarcinomaLepidic.value[x]",
        "path": "Observation.component.value[x]",
        "label": "Wachstumsmuster bei Adenokarzinom lepidisch",
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          {
            "code": "Quantity"
          }
        ],
        "mustSupport": true
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        "path": "Observation.component.value[x].value",
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        "path": "Observation.component.value[x].unit",
        "min": 1,
        "fixedString": "%"
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      {
        "id": "Observation.component:growthPatternInAdenocarcinomaLepidic.value[x].system",
        "path": "Observation.component.value[x].system",
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        "fixedUri": "http://unitsofmeasure.org"
      },
      {
        "id": "Observation.component:growthPatternInAdenocarcinomaLepidic.referenceRange",
        "path": "Observation.component.referenceRange",
        "contentReference": "http://hl7.org/fhir/StructureDefinition/Observation#Observation.referenceRange"
      },
      {
        "id": "Observation.component:growthPatternInAdenocarcinomaAcinar",
        "path": "Observation.component",
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        "max": "1"
      },
      {
        "id": "Observation.component:growthPatternInAdenocarcinomaAcinar.code.coding.system",
        "path": "Observation.component.code.coding.system",
        "fixedUri": "http://snomed.info/sct"
      },
      {
        "id": "Observation.component:growthPatternInAdenocarcinomaAcinar.code.coding.code",
        "path": "Observation.component.code.coding.code",
        "fixedCode": "128703004"
      },
      {
        "id": "Observation.component:growthPatternInAdenocarcinomaAcinar.value[x]",
        "path": "Observation.component.value[x]",
        "label": "Wachstumsmuster bei Adenokarzinom azinär",
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          {
            "code": "Quantity"
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        ],
        "mustSupport": true
      },
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      },
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        "id": "Observation.component:growthPatternInAdenocarcinomaAcinar.referenceRange",
        "path": "Observation.component.referenceRange",
        "contentReference": "http://hl7.org/fhir/StructureDefinition/Observation#Observation.referenceRange"
      },
      {
        "id": "Observation.component:growthPatternInAdenocarcinomaPapillary",
        "path": "Observation.component",
        "sliceName": "growthPatternInAdenocarcinomaPapillary",
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      },
      {
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        "path": "Observation.component.code.coding.system",
        "fixedUri": "http://snomed.info/sct"
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        "path": "Observation.component.code.coding.code",
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      },
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        "id": "Observation.component:growthPatternInAdenocarcinomaPapillary.value[x]",
        "path": "Observation.component.value[x]",
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        "path": "Observation.component.referenceRange",
        "contentReference": "http://hl7.org/fhir/StructureDefinition/Observation#Observation.referenceRange"
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        "path": "Observation.component",
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        "path": "Observation.component.code.coding.code",
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      },
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        "id": "Observation.component:growthPatternInAdenocarcinomaMicropapillary.value[x]",
        "path": "Observation.component.value[x]",
        "label": "Wachstumsmuster bei Adenokarzinom mikropapillär",
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        "contentReference": "http://hl7.org/fhir/StructureDefinition/Observation#Observation.referenceRange"
      },
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      },
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        "path": "Observation.component.code.coding.code",
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      },
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            "code": "Quantity"
          }
        ],
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        "path": "Observation.component.referenceRange",
        "contentReference": "http://hl7.org/fhir/StructureDefinition/Observation#Observation.referenceRange"
      },
      {
        "id": "Observation.component:percentageOfSignetRingCellCarcinoma",
        "path": "Observation.component",
        "sliceName": "percentageOfSignetRingCellCarcinoma",
        "max": "1"
      },
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        "id": "Observation.component:percentageOfSignetRingCellCarcinoma.code.coding.system",
        "path": "Observation.component.code.coding.system",
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      },
      {
        "id": "Observation.component:percentageOfSignetRingCellCarcinoma.code.coding.code",
        "path": "Observation.component.code.coding.code",
        "fixedCode": "87737001"
      },
      {
        "id": "Observation.component:percentageOfSignetRingCellCarcinoma.value[x]",
        "path": "Observation.component.value[x]",
        "label": "Anteil an Siegelringzellkarzinomen",
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          {
            "code": "Quantity"
          }
        ],
        "mustSupport": true
      },
      {
        "id": "Observation.component:percentageOfSignetRingCellCarcinoma.value[x].value",
        "path": "Observation.component.value[x].value",
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        "fixedString": "%"
      },
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        "id": "Observation.component:percentageOfSignetRingCellCarcinoma.value[x].system",
        "path": "Observation.component.value[x].system",
        "min": 1,
        "fixedUri": "http://unitsofmeasure.org"
      },
      {
        "id": "Observation.component:percentageOfSignetRingCellCarcinoma.referenceRange",
        "path": "Observation.component.referenceRange",
        "contentReference": "http://hl7.org/fhir/StructureDefinition/Observation#Observation.referenceRange"
      }
    ]
  }
}

name : Profile_nNGM_Observation_Histologie

{

}