<ValueSet xmlns="http://hl7.org/fhir">
  <id value="spark757" />
  <meta>
    <versionId value="spark757" />
    <lastUpdated value="2015-10-02T12:29:22.932+00:00" />
    <profile value="http://hl7.org/fhir/StructureDefinition/valueset-shareable-definition" />
  </meta>
  <text>
    <status value="generated" />
    <div xmlns="http://www.w3.org/1999/xhtml">
      <p>Release Date: 2015-07-31</p>
      <p>OID for code system: 2.16.840.1.113883.5.1070</p>
      <h2>Description</h2>
      <p>
                  Identifies what sort of change is permitted or has occurred between the therapy that was ordered and the therapy that was/will be provided.
              <br /></p>
      <hr />
      <table class="grid">
        <tr>
          <td>
            <b>Level</b>
          </td>
          <td>
            <b>Code</b>
          </td>
          <td>
            <b>Display</b>
          </td>
          <td>
            <b>Definition</b>
          </td>
        </tr>
        <tr>
          <td>1</td>
          <td>
            <span style="color: grey">
              <i>(_ActSubstanceAdminSubstitutionCode)</i>
            </span>
          </td>
          <td>
            <a name="_ActSubstanceAdminSubstitutionCode"> </a>
          </td>
          <td>
                        
                           Description: Substitution occurred or is permitted with another product that may potentially have different ingredients, but having the same biological and therapeutic effects.
                  <br /></td>
        </tr>
        <tr>
          <td>2</td>
          <td>  E
                  <a name="E"></a></td>
          <td>equivalent</td>
          <td>
                        
                           Description: Substitution occurred or is permitted with another bioequivalent and therapeutically equivalent product.
                  <br /></td>
        </tr>
        <tr>
          <td>3</td>
          <td>    EC
                  <a name="EC"></a></td>
          <td>equivalent composition</td>
          <td>
                        
                           Description: 
                        
                  <br />

                        Substitution occurred or is permitted with another product that is a:
                  <br />

                        
                           pharmaceutical alternative containing the same active ingredient but is formulated with different salt, ester
                           pharmaceutical equivalent that has the same active ingredient, strength, dosage form and route of administration
                        
                        
                           Examples: 
                        
                  <br />

                        
                           
                              Pharmaceutical alternative: Erythromycin Ethylsuccinate for Erythromycin Stearate
                           
                              Pharmaceutical equivalent: Lisonpril for Zestril
                        
                     
                </td>
        </tr>
        <tr>
          <td>4</td>
          <td>      BC
                  <a name="BC"></a></td>
          <td>brand composition</td>
          <td>
                        
                           Description: 
                        
                  <br />

                        Substitution occurred or is permitted between equivalent Brands but not Generics
                  <br />

                        
                           Examples: 
                        
                  <br />

                        
                           Zestril  for Prinivil
                           Coumadin for Jantoven
                        
                     
                </td>
        </tr>
        <tr>
          <td>4</td>
          <td>      G
                  <a name="G"></a></td>
          <td>generic composition</td>
          <td>
                        
                           Description: Substitution occurred or is permitted between equivalent Generics but not Brands
                  <br />

                        
                           Examples: 
                        
                  <br />

                        
                           Lisnopril (Lupin Corp) for Lisnopril (Wockhardt Corp)
                        
                     
                </td>
        </tr>
        <tr>
          <td>3</td>
          <td>    TE
                  <a name="TE"></a></td>
          <td>therapeutic alternative</td>
          <td>
                        
                           Description: Substitution occurred or is permitted with another product having the same therapeutic objective and safety profile.
                  <br />

                        
                           Examples: 
                        
                  <br />

                        
                           ranitidine for Tagamet
                        
                     
                </td>
        </tr>
        <tr>
          <td>4</td>
          <td>      TB
                  <a name="TB"></a></td>
          <td>therapeutic brand</td>
          <td>
                        
                           Description: Substitution occurred or is permitted between therapeutically equivalent Brands but not Generics
                  <br />
&gt;
                           Examples: 
                        
                  <br />

                        
                           Zantac for Tagamet
                        
                     
                </td>
        </tr>
        <tr>
          <td>4</td>
          <td>      TG
                  <a name="TG"></a></td>
          <td>therapeutic generic</td>
          <td>
                        
                           Description: Substitution occurred or is permitted between therapeutically equivalent Generics but not Brands
                  <br />
&gt;
                           Examples: 
                        
                  <br />

                        
                           Ranitidine  for cimetidine
                        
                     
                </td>
        </tr>
        <tr>
          <td>2</td>
          <td>  F
                  <a name="F"></a></td>
          <td>formulary</td>
          <td>
                        
                           Description: This substitution was performed or is permitted based on formulary guidelines. 
                  <br /></td>
        </tr>
        <tr>
          <td>2</td>
          <td>  N
                  <a name="N"></a></td>
          <td>none</td>
          <td>
                        No substitution occurred or is permitted.
                  <br /></td>
        </tr>
      </table>
    </div>
  </text>
  <url value="http://hl7.org/fhir/ValueSet/v3-substanceAdminSubstitution" />
  <version value="2015-07-31" />
  <name value="v3 Code System substanceAdminSubstitution" />
  <status value="active" />
  <experimental value="false" />
  <publisher value="HL7, Inc" />
  <contact>
    <telecom>
      <system value="other" />
      <value value="http://hl7.org" />
    </telecom>
  </contact>
  <date value="2015-07-31" />
  <description value=" Identifies what sort of change is permitted or has occurred between the therapy that was ordered and the therapy that was/will be provided." />
  <codeSystem>
    <extension url="http://hl7.org/fhir/StructureDefinition/valueset-oid">
      <valueUri value="urn:oid:2.16.840.1.113883.5.1070" />
    </extension>
    <system value="http://hl7.org/fhir/v3/substanceAdminSubstitution" />
    <caseSensitive value="true" />
    <concept>
      <code value="_ActSubstanceAdminSubstitutionCode" />
      <abstract value="true" />
      <display value="ActSubstanceAdminSubstitutionCode" />
      <definition value="Description: Substitution occurred or is permitted with another product that may potentially have different ingredients, but having the same biological and therapeutic effects." />
      <concept>
        <code value="E" />
        <abstract value="false" />
        <display value="equivalent" />
        <definition value="Description: Substitution occurred or is permitted with another bioequivalent and therapeutically equivalent product." />
        <concept>
          <code value="EC" />
          <abstract value="false" />
          <display value="equivalent composition" />
          <definition value="Description:                                                    Substitution occurred or is permitted with another product that is a:                                                      pharmaceutical alternative containing the same active ingredient but is formulated with different salt, ester                            pharmaceutical equivalent that has the same active ingredient, strength, dosage form and route of administration                                                                              Examples:                                                                                                               Pharmaceutical alternative: Erythromycin Ethylsuccinate for Erythromycin Stearate                                                           Pharmaceutical equivalent: Lisonpril for Zestril" />
          <concept>
            <code value="BC" />
            <abstract value="false" />
            <display value="brand composition" />
            <definition value="Description:                                                    Substitution occurred or is permitted between equivalent Brands but not Generics                                                      Examples:                                                                                Zestril  for Prinivil                            Coumadin for Jantoven" />
          </concept>
          <concept>
            <code value="G" />
            <abstract value="false" />
            <display value="generic composition" />
            <definition value="Description: Substitution occurred or is permitted between equivalent Generics but not Brands                                                      Examples:                                                                                Lisnopril (Lupin Corp) for Lisnopril (Wockhardt Corp)" />
          </concept>
        </concept>
        <concept>
          <code value="TE" />
          <abstract value="false" />
          <display value="therapeutic alternative" />
          <definition value="Description: Substitution occurred or is permitted with another product having the same therapeutic objective and safety profile.                                                      Examples:                                                                                ranitidine for Tagamet" />
          <concept>
            <code value="TB" />
            <abstract value="false" />
            <display value="therapeutic brand" />
            <definition value="Description: Substitution occurred or is permitted between therapeutically equivalent Brands but not Generics &gt;                            Examples:                                                                                Zantac for Tagamet" />
          </concept>
          <concept>
            <code value="TG" />
            <abstract value="false" />
            <display value="therapeutic generic" />
            <definition value="Description: Substitution occurred or is permitted between therapeutically equivalent Generics but not Brands &gt;                            Examples:                                                                                Ranitidine  for cimetidine" />
          </concept>
        </concept>
      </concept>
      <concept>
        <code value="F" />
        <abstract value="false" />
        <display value="formulary" />
        <definition value="Description: This substitution was performed or is permitted based on formulary guidelines." />
      </concept>
      <concept>
        <code value="N" />
        <abstract value="false" />
        <display value="none" />
        <definition value="No substitution occurred or is permitted." />
      </concept>
    </concept>
  </codeSystem>
</ValueSet>