{
  "resourceType": "StructureDefinition",
  "meta": {
    "lastUpdated": "2017-09-30T09:43:26.58+00:00"
  },
  "url": "StructureDefinition/Obs-DiscreteVariant_Differentials",
  "name": "Obs-DiscreteVariant_Differentials",
  "status": "draft",
  "date": "2017-09-28T02:23:34.177+00:00",
  "fhirVersion": "3.0.1",
  "kind": "resource",
  "abstract": false,
  "type": "Observation",
  "baseDefinition": "http://hl7.org/fhir/StructureDefinition/Observation",
  "derivation": "constraint",
  "differential": {
    "element": [
      {
        "id": "Observation.component",
        "path": "Observation.component",
        "slicing": {
          "description": "",
          "rules": "open"
        }
      },
      {
        "id": "Observation.component:Component",
        "path": "Observation.component",
        "sliceName": "Component",
        "max": "1"
      },
      {
        "id": "Observation.component:Component.code.coding",
        "path": "Observation.component.code.coding",
        "slicing": {
          "description": "\"DNA sequence variant ID :\nIdentifier for DNA sequence variant. If a germline variant, ClinVar or dbSNP identifier should be used. If a somatic variant, COSMIC identifier should be used, unless in ClinVar then either maybe used. Need to provide the code system used (ClinVar, dbSNP, COSMIC) LONIC Code: (48003-8 ).\"",
          "rules": "open"
        },
        "max": "1",
        "fixedCoding": {
          "system": "http://loinc.org",
          "code": "48003-8",
          "display": "DNAVariantID"
        }
      },
      {
        "id": "Observation.component:Component.value[x]:valueCodeableConcept",
        "path": "Observation.component.valueCodeableConcept",
        "sliceName": "valueCodeableConcept",
        "type": [
          {
            "code": "CodeableConcept"
          }
        ]
      },
      {
        "id": "Observation.component:Component.value[x]:valueCodeableConcept.coding",
        "path": "Observation.component.valueCodeableConcept.coding",
        "slicing": {
          "description": "",
          "rules": "open"
        },
        "fixedCoding": {
          "system": "http://www.ncbi.nlm.nih.gov/clinvar",
          "code": "51975-1"
        }
      },
      {
        "id": "Observation.component:Component",
        "path": "Observation.component",
        "sliceName": "Component",
        "max": "1"
      },
      {
        "id": "Observation.component:Component.code.coding",
        "path": "Observation.component.code.coding",
        "slicing": {
          "description": "",
          "rules": "open"
        },
        "max": "1",
        "fixedCoding": {
          "system": "http://loinc.org",
          "code": "48004-6",
          "display": "DNAChangeName"
        }
      },
      {
        "id": "Observation.component:Component.value[x]:valueCodeableConcept",
        "path": "Observation.component.valueCodeableConcept",
        "sliceName": "valueCodeableConcept",
        "type": [
          {
            "code": "CodeableConcept"
          }
        ]
      },
      {
        "id": "Observation.component:Component.value[x]:valueCodeableConcept.coding",
        "path": "Observation.component.valueCodeableConcept.coding",
        "slicing": {
          "description": "",
          "rules": "open"
        },
        "fixedCoding": {
          "system": "http://www.hgvs.org/mutnomen",
          "code": "c.1249C>T",
          "display": "c.1249C>T"
        }
      },
      {
        "id": "Observation.component:Component",
        "path": "Observation.component",
        "sliceName": "Component",
        "max": "1"
      },
      {
        "id": "Observation.component:Component.code.coding",
        "path": "Observation.component.code.coding",
        "slicing": {
          "description": "\"DNA sequence variant type :\nCodified type for associated DNA sequence variant. DNA sequence variants use the HGVS notation, which implies the DNA sequence variant type. LONIC Code: (48019-4 ).\"",
          "rules": "open"
        },
        "max": "1",
        "fixedCoding": {
          "system": "http://loinc.org",
          "code": "48019-4",
          "display": "DNAchangetype"
        }
      },
      {
        "id": "Observation.component:Component.value[x]:valueCodeableConcept",
        "path": "Observation.component.valueCodeableConcept",
        "sliceName": "valueCodeableConcept",
        "type": [
          {
            "code": "CodeableConcept"
          }
        ]
      },
      {
        "id": "valueCodeableConcept:valueCodeableConcept.coding",
        "path": "Observation.component.valueCodeableConcept.coding",
        "slicing": {
          "description": "",
          "rules": "open"
        },
        "fixedCoding": {
          "system": "http://loinc.org",
          "code": "LA6690-7",
          "display": "Substitution"
        }
      }
    ]
  }
}