{
  "resourceType": "StructureDefinition",
  "meta": {
    "lastUpdated": "2017-09-30T09:39:44.614+00:00"
  },
  "url": "StructureDefinition/Obs-AminoAcidChange_Differentials",
  "name": "Obs-AminoAcidChange_Differentials",
  "status": "draft",
  "date": "2017-09-28T01:37:16.832+00:00",
  "fhirVersion": "3.0.1",
  "kind": "resource",
  "abstract": false,
  "type": "Observation",
  "baseDefinition": "http://hl7.org/fhir/StructureDefinition/Observation",
  "derivation": "constraint",
  "snapshot": {},
  "differential": {
    "element": [
      {
        "id": "Observation.component",
        "path": "Observation.component",
        "slicing": {
          "description": "",
          "rules": "open"
        }
      },
      {
        "id": "Observation.component:Component",
        "path": "Observation.component",
        "sliceName": "Component",
        "max": "1"
      },
      {
        "id": "Observation.component:Component.code.coding",
        "path": "Observation.component.code.coding",
        "slicing": {
          "description": "\"HGVS nomenclature for observed Amino Acid Change :\nHuman Genome Variation Society (HGVS) nomenclature for an amino acid change. Reference sequence ID used for HGVS naming must be anotated. An amino acid is a sequence feature that corresponds to a single amino acid residue in a polypeptide (SO:0001237 ). LONIC Code: (48005-3 ).\"",
          "rules": "open"
        },
        "max": "1",
        "fixedCoding": {
          "system": "http://loinc.org",
          "code": "48005-3",
          "display": "AminoAcidChangeName"
        }
      },
      {
        "id": "Observation.component:Component.code.coding:Coding",
        "path": "Observation.component.code.coding",
        "sliceName": "Coding",
        "max": "1"
      },
      {
        "id": "Observation.component:Component.value[x]:valueCodeableConcept",
        "path": "Observation.component.valueCodeableConcept",
        "sliceName": "valueCodeableConcept",
        "type": [
          {
            "code": "CodeableConcept"
          }
        ]
      },
      {
        "id": "Observation.component:Component.value[x]:valueCodeableConcept.coding",
        "path": "Observation.component.valueCodeableConcept.coding",
        "slicing": {
          "description": "",
          "rules": "open"
        },
        "fixedCoding": {
          "system": "http://www.hgvs.org/mutnomen",
          "code": "p.Arg417Cys"
        }
      },
      {
        "id": "Observation.component:Component",
        "path": "Observation.component",
        "sliceName": "Component",
        "max": "1"
      },
      {
        "id": "Observation.component:Component.code.coding",
        "path": "Observation.component.code.coding",
        "slicing": {
          "description": "\"Amino Acid Change Type :\nCodified type for associated Amino Acid Change. LONIC Code: (48006-1 ).\"",
          "rules": "open"
        },
        "max": "1",
        "fixedCoding": {
          "system": "http://loinc.org",
          "code": "48006-1",
          "display": "AminoAcidChangeType"
        }
      },
      {
        "id": "Observation.component:Component.value[x]:valueCodeableConcept",
        "path": "Observation.component.valueCodeableConcept",
        "sliceName": "valueCodeableConcept",
        "type": [
          {
            "code": "CodeableConcept"
          }
        ]
      },
      {
        "id": "Observation.component:Component.value[x]:valueCodeableConcept.coding",
        "path": "Observation.component.valueCodeableConcept.coding",
        "slicing": {
          "description": "",
          "rules": "open"
        },
        "max": "1",
        "fixedCoding": {
          "system": "http://loinc.org",
          "code": "LA9658-1",
          "display": "Wild type"
        }
      }
    ]
  }
}