<status value="draft" /> <description value="Representing the Substances in the Norwegian Substance database" /> <fhirVersion value="4.0.1" /> <kind value="resource" /> <abstract value="false" /> <type value="SubstanceSpecification" /> <baseDefinition value="http://hl7.org/fhir/StructureDefinition/SubstanceSpecification" /> <derivation value="constraint" /> <differential> <element id="SubstanceSpecification"> <path value="SubstanceSpecification" /> <comment value="Based on ISO 11238" /> <alias value="SubstanceDefinition (FHIR R5)" /> </element> <element id="SubstanceSpecification.extension"> <path value="SubstanceSpecification.extension" /> <min value="1" /> </element> <element id="SubstanceSpecification.extension:SMSID"> <path value="SubstanceSpecification.extension" /> <sliceName value="SMSID" /> <short value="SPOR SMS ID" /> <definition value="The substance ID in the [EMA SPOR substances management services](https://spor.ema.europa.eu/smswi/#/). Identifies substnaces in EU marketing authorisations." /> <comment value="URL (preliminary): http://legemiddelverket.no/fhir/SAFEST/SMSID" /> <requirements value="Provides ability to map substances between different substance master data systems" /> <type> <code value="Extension" /> <profile value="http://noma.no/fhir/StructureDefinition/SubstanceIdentifierExtension_NOMA_v2_1" /> </type> <isModifier value="false" /> </element> <element id="SubstanceSpecification.extension:SMSID.value[x].period"> <path value="SubstanceSpecification.extension.value[x].period" /> <max value="0" /> </element> <element id="SubstanceSpecification.extension:UniiCode"> <path value="SubstanceSpecification.extension" /> <sliceName value="UniiCode" /> <short value="GSRS Substance ID" /> <definition value="The Unique Ingredient Identifier (UNII) generated by the [Global Substance Registration System (GSRS)](https://gsrs.ncats.nih.gov/) of the US Food and Drug Administration." /> <comment value="URL (preliminary): http://legemiddelverket.no/fhir/SAFEST/UniiCode" /> <requirements value="Provides ability to map substances between different susbtance master data systems" /> <type> <code value="Extension" /> <profile value="http://noma.no/fhir/StructureDefinition/SubstanceIdentifierExtension_NOMA_v2_1" /> </type> <isModifier value="false" /> </element> <element id="SubstanceSpecification.extension:UniiCode.value[x].period"> <path value="SubstanceSpecification.extension.value[x].period" /> <max value="0" /> </element> <element id="SubstanceSpecification.extension:FestId"> <path value="SubstanceSpecification.extension" /> <sliceName value="FestId" /> <short value="FEST substance ID" /> <definition value="The substance ID in the [FEST medicinal product master data](https://www.dmp.no/om-oss/distribusjon-av-legemiddeldata/fest)" /> <comment value="URL (preliminary): http://legemiddelverket.no/FEST/SubstansID" /> <min value="1" /> <type> <code value="Extension" /> <profile value="http://noma.no/fhir/StructureDefinition/SubstanceIdentifierExtension_NOMA_v2_1" /> </type> <isModifier value="false" /> </element> <element id="SubstanceSpecification.extension:FestId.value[x].period"> <path value="SubstanceSpecification.extension.value[x].period" /> <max value="0" /> </element> <element id="SubstanceSpecification.extension:classification"> <path value="SubstanceSpecification.extension" /> <sliceName value="classification" /> <short value="Classifies the substance" /> <definition value="Optional xtension for classifying substances." /> <comment value="##### Published (optional) classification categories: ###### **E-Number** The substance's [E-number(s)](https://ec.europa.eu/food/food-feed-portal/screen/food-additives/search). A substance can have multiple e-numbers. Cardinality: 0..* Code: The E-number Display: The E-number name (substance) Url (preliminary): https://simplifier.net/safest/e-number ###### **Is Therapeutic** Whether the substance is therapeutic (only published when "true"). Cardinality: 0..1 Code: "true" Display: "Er terapautisk del" Url (preliminary): https://simplifier.net/safest/activemoiety ###### **Is Prodrug** Whether the substance is a prodrug (only published when "true") Cardinality: 0..1 Code: "true" Display: "Er prodrug" Url (preliminary): ttps://simplifier.net/safest/prodrug ###### **Is Complex** Whether the substance is complex (only published when "true") Cardinality: 0..1 Code: "true" Display: "Er kompleks" Url (preliminary): https://simplifier.net/safest/complex ###### **ATC codes** All the substance's ATC code(s). Human codes only. Cardinality: 0..* Code: The ATC code Display: The (substance) name Urls (preliminary), one per first-level ATC: | First-level ATC category | Url | | :------- | :------ | | Alimentary tract and metabolism | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/dcedfe5f-d7dd-43f4-a351-8744395249dd | | Blood and blood forming organs | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/127f5448-fa44-4da4-9589-438749da0158 | | Cardiovascular system | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/e104a7eb-e832-4d57-946d-d402b71ecc22 | | Dermatologicals | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/f5a60497-f1c5-4163-ad34-a3c614d2f6b4 | | Genito urinary system and sex hormones | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/1fd6dad4-6b05-44ee-9a61-9409927bf195 | | Systemic hormonal preparations, excl. sex hormones and insulins | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/bd343711-ab45-4ebd-9f2c-b128f422645e | | Antiinfectives for systemic use | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/e9f15a26-d384-48c2-a74d-3fa95f44a9dc | | Antineoplastic and immunomodulating agents | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/849bc27b-a66d-49ad-9389-d8f19d63b480 | | Musculo-skeletal system | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/82311936-f7e3-4c24-8821-229f055f7c64 | | Nervous system | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/f7949a93-d26e-4235-ac5d-d2b898a7aad4 | | Antiparasitic products, insecticides and repellents | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/a9a04ea3-c412-4c27-b191-fddb4ae4d162 | | Respiratory system | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/451f509c-f18b-48e1-ac75-d1852b846eee | | Sensory organs | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/2949f36e-6b6f-496a-96c8-c61429e75797 | | Various | https://api.legemiddelverket.no/FHIR-R4/CodeSystem/e5390228-1602-4bef-8ca9-fca1771de4d1 |" /> <type> <code value="Extension" /> <profile value="http://noma.no/fhir/StructureDefinition/SubstanceSpecification_ClassificationExtension_NOMA_v2_1" /> </type> <isModifier value="false" /> </element> <element id="SubstanceSpecification.identifier"> <path value="SubstanceSpecification.identifier" /> <short value="Indentifier for the substance." /> <definition value="Identifier by which this substance is known, specific to NoMA's FHIR API Url (preliminary): http://legemiddelverket.no/fhir/SAFEST/SafestSubstanceDefinitionID Alternative (business) identifiers - SMS ID, UniiCode and FEST ID - are provided in the extension. since the identifier attribute can provide at most one identifier." /> <alias value="nomaSubstanceDefinitionID" /> <min value="1" /> </element> <element id="SubstanceSpecification.identifier.use"> <path value="SubstanceSpecification.identifier.use" /> <max value="0" /> </element> <element id="SubstanceSpecification.identifier.type"> <path value="SubstanceSpecification.identifier.type" /> <max value="0" /> </element> <element id="SubstanceSpecification.identifier.system"> <path value="SubstanceSpecification.identifier.system" /> <definition value="The namespace is preliminary and will be replaced with a stable "GUPRI"" /> <fixedUri value="http://legemiddelverket.no/fhir/SAFEST/SafestSubstanceDefinitionID" /> </element> <element id="SubstanceSpecification.identifier.period"> <path value="SubstanceSpecification.identifier.period" /> <max value="0" /> </element> <element id="SubstanceSpecification.identifier.assigner"> <path value="SubstanceSpecification.identifier.assigner" /> <max value="0" /> </element> <element id="SubstanceSpecification.type"> <path value="SubstanceSpecification.type" /> <short value="High level categorization, e.g. chemical, polymer or nucleic acid" /> <definition value="High level categorization, e.g. chemical, polymer or nucleic acid System URL: [https://mpd.noma.no/codesystem/substance-type](https://mpd.noma.no/codesystem/substance-type)" /> <alias value="category" /> <binding> <strength value="example" /> <description value="SPOR RMS Substance Types" /> <valueSet value="https://spor.ema.europa.eu/rmswi/#/lists/100000075826/terms" /> </binding> </element> <element id="SubstanceSpecification.type.coding.system"> <path value="SubstanceSpecification.type.coding.system" /> <definition value="The identification of the code system that defines the meaning of the symbol in the code. The system URL is preliminary and will be replaced with a stable "GUPRI"" /> <fixedUri value="https://api.legemiddelverket.no/FHIR-R4/CodeSystem/905de22c-b0f9-4ad5-bfcb-08e1d6fef20d" /> </element> <element id="SubstanceSpecification.status"> <path value="SubstanceSpecification.status" /> <max value="0" /> </element> <element id="SubstanceSpecification.domain"> <path value="SubstanceSpecification.domain" /> <max value="0" /> </element> <element id="SubstanceSpecification.description"> <path value="SubstanceSpecification.description" /> <max value="0" /> </element> <element id="SubstanceSpecification.source"> <path value="SubstanceSpecification.source" /> <max value="0" /> </element> <element id="SubstanceSpecification.comment"> <path value="SubstanceSpecification.comment" /> <max value="0" /> </element> <element id="SubstanceSpecification.moiety"> <path value="SubstanceSpecification.moiety" /> <max value="0" /> </element> <element id="SubstanceSpecification.property"> <path value="SubstanceSpecification.property" /> <max value="0" /> </element> <element id="SubstanceSpecification.referenceInformation"> <path value="SubstanceSpecification.referenceInformation" /> <max value="0" /> </element> <element id="SubstanceSpecification.structure"> <path value="SubstanceSpecification.structure" /> <max value="0" /> </element> <element id="SubstanceSpecification.code"> <path value="SubstanceSpecification.code" /> <max value="0" /> </element> <element id="SubstanceSpecification.name"> <path value="SubstanceSpecification.name" /> <definition value="Names applicable to this substance.. Provided in Norwegian, English and (if exists) Latin" /> </element> <element id="SubstanceSpecification.name.extension"> <path value="SubstanceSpecification.name.extension" /> <alias value="alias" /> </element> <element id="SubstanceSpecification.name.extension:alias"> <path value="SubstanceSpecification.name.extension" /> <sliceName value="alias" /> <type> <code value="Extension" /> <profile value="https://example.org/fhir/StructureDefinition/SubstanceSpecificationNameAliasNOMA" /> </type> <isModifier value="false" /> </element> <element id="SubstanceSpecification.name.language"> <path value="SubstanceSpecification.name.language" /> <definition value="Language of the name. Norwegian, English or (if exists) Latin" /> </element> <element id="SubstanceSpecification.molecularWeight"> <path value="SubstanceSpecification.molecularWeight" /> <max value="0" /> </element> <element id="SubstanceSpecification.relationship.relationship"> <path value="SubstanceSpecification.relationship.relationship" /> <alias value="type" /> </element> <element id="SubstanceSpecification.relationship.amount[x]"> <path value="SubstanceSpecification.relationship.amount[x]" /> <slicing> <discriminator> <type value="type" /> <path value="$this" /> </discriminator> <rules value="open" /> </slicing> <max value="0" /> </element> <element id="SubstanceSpecification.relationship.amount[x]:amountQuantity"> <path value="SubstanceSpecification.relationship.amount[x]" /> <sliceName value="amountQuantity" /> <max value="0" /> <type> <code value="Quantity" /> </type> </element> <element id="SubstanceSpecification.relationship.amount[x]:amountRange"> <path value="SubstanceSpecification.relationship.amount[x]" /> <sliceName value="amountRange" /> <max value="0" /> <type> <code value="Range" /> </type> </element> <element id="SubstanceSpecification.relationship.amount[x]:amountRatio"> <path value="SubstanceSpecification.relationship.amount[x]" /> <sliceName value="amountRatio" /> <max value="0" /> <type> <code value="Ratio" /> </type> </element> <element id="SubstanceSpecification.relationship.amount[x]:amountString"> <path value="SubstanceSpecification.relationship.amount[x]" /> <sliceName value="amountString" /> <max value="0" /> <type> <code value="string" /> </type> </element> <element id="SubstanceSpecification.nucleicAcid"> <path value="SubstanceSpecification.nucleicAcid" /> <max value="0" /> </element> <element id="SubstanceSpecification.polymer"> <path value="SubstanceSpecification.polymer" /> <max value="0" /> </element> <element id="SubstanceSpecification.protein"> <path value="SubstanceSpecification.protein" /> <max value="0" /> </element> <element id="SubstanceSpecification.sourceMaterial"> <path value="SubstanceSpecification.sourceMaterial" /> <max value="0" /> </element> </differential> </StructureDefinition>