{
  "resourceType": "StructureDefinition",
  "id": "pop-cancer-treatment-response",
  "url": "https://simplifier.net/pop/StructureDefinition/pop-cancer-treatment-response",
  "version": "0.0.1",
  "name": "CancerTreatmentResponse",
  "title": "Cancer Treatment Response",
  "status": "draft",
  "date": "2023-09-22T08:15:35.7518841+00:00",
  "publisher": "Precision Oncology Project (USZ)",
  "description": "Cancer treatment response monitoring by imaging techniques to assess and track the effectiveness of cancer therapies and their impact on tumor size and progression.",
  "fhirVersion": "4.0.1",
  "kind": "resource",
  "abstract": false,
  "type": "Observation",
  "baseDefinition": "http://hl7.org/fhir/StructureDefinition/Observation",
  "derivation": "constraint",
  "differential": {
    "element": [
      {
        "id": "Observation.category",
        "path": "Observation.category",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://terminology.hl7.org/CodeSystem/observation-category",
              "code": "imaging"
            }
          ]
        }
      },
      {
        "id": "Observation.code",
        "path": "Observation.code",
        "patternCodeableConcept": {
          "coding": [
            {
              "system": "http://snomed.info/sct",
              "code": "182985004"
            }
          ]
        }
      },
      {
        "id": "Observation.subject",
        "path": "Observation.subject",
        "type": [
          {
            "code": "Reference",
            "targetProfile": [
              "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-patient"
            ]
          }
        ]
      },
      {
        "id": "Observation.focus",
        "path": "Observation.focus",
        "type": [
          {
            "code": "Reference",
            "targetProfile": [
              "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-primary-cancer-condition",
              "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-secondary-cancer-condition"
            ]
          }
        ]
      },
      {
        "id": "Observation.effective[x]",
        "path": "Observation.effective[x]",
        "type": [
          {
            "code": "dateTime"
          }
        ]
      },
      {
        "id": "Observation.value[x]",
        "path": "Observation.value[x]",
        "short": "RECIST coded value",
        "type": [
          {
            "code": "CodeableConcept"
          }
        ],
        "binding": {
          "strength": "required",
          "description": "RECIST coded values",
          "valueSet": "http://loinc.org/vs/LL4721-8"
        }
      },
      {
        "id": "Observation.interpretation",
        "path": "Observation.interpretation",
        "short": "Intepretation of the RECIST value",
        "binding": {
          "strength": "required",
          "valueSet": "https://pop.org/fhir/ValueSets/pop-treatment-response-interpretations"
        }
      },
      {
        "id": "Observation.bodySite",
        "path": "Observation.bodySite",
        "binding": {
          "strength": "preferred",
          "description": "Codes describing anatomical locations",
          "valueSet": "http://hl7.org/fhir/us/mcode/ValueSet/mcode-radiotherapy-treatment-location-vs"
        }
      },
      {
        "id": "Observation.bodySite.extension:locationQualifier",
        "path": "Observation.bodySite.extension",
        "sliceName": "locationQualifier",
        "max": "1",
        "type": [
          {
            "code": "Extension",
            "profile": [
              "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-body-location-qualifier"
            ]
          }
        ],
        "isModifier": false
      },
      {
        "id": "Observation.bodySite.extension:lateralityQualifier",
        "path": "Observation.bodySite.extension",
        "sliceName": "lateralityQualifier",
        "max": "1",
        "type": [
          {
            "code": "Extension",
            "profile": [
              "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-laterality-qualifier"
            ]
          }
        ],
        "isModifier": false
      },
      {
        "id": "Observation.method",
        "path": "Observation.method",
        "binding": {
          "strength": "preferred",
          "valueSet": "https://pop.org/fhir/ValueSets/pop-cancer-treatment-response-observation-methods"
        }
      },
      {
        "id": "Observation.specimen",
        "path": "Observation.specimen",
        "max": "0"
      },
      {
        "id": "Observation.device",
        "path": "Observation.device",
        "max": "0"
      },
      {
        "id": "Observation.referenceRange",
        "path": "Observation.referenceRange",
        "max": "0"
      },
      {
        "id": "Observation.hasMember",
        "path": "Observation.hasMember",
        "max": "0"
      },
      {
        "id": "Observation.component",
        "path": "Observation.component",
        "max": "0"
      }
    ]
  }
}