<CodeSystem xmlns="http://hl7.org/fhir">
  <id value="npcr-gleason-definition-type" />
  <url value="https://npcr.se/fhir/CodeSystem/npcr-gleason-definition-type" />
  <name value="NPCRGleasonDefinitionType" />
  <title value="NPCR Gleason Reporting Definition Type Code System" />
  <status value="draft" />
  <experimental value="false" />
  <description value="NPCR-internal code system representing the three ways by which a Gleason score can be reported for targeted biopsies, based on NPCR Variabelbeskrivning variable D_RiktGleasTyp (Gleason angivet för = 'Gleason reported as'). This variable is unique to targeted biopsies because MRI-guided targeted sampling can produce multiple lesion-specific Gleason scores, requiring a convention for which value to report at the targeted-biopsy-level summary.&#xA;&#xA;Applicable only to NPCRGleasonScoreTargetedBiopsyObservation — systematic and unclear biopsies do not have equivalent reporting conventions because they yield a single Gleason assessment per sample group.&#xA;&#xA;Historical note (per Variabelbeskrivning Kommentar): Option 1 was hidden 2023-06-19, replaced by option 3 (highest Gleason) as the preferred reporting method. Option 1 is retained for historical data compatibility.&#xA;&#xA;Clinical context (per NPCR Manual page 17): 'I första hand rapporteras Gleasongrad med den högsta gleasonsumman i en enskild biopsi, om detta inte anges i PAD-svaret rapporteras den sammanfattande Gleasongraden i de riktade biopsierna.' ('First preference is to report the Gleason with the highest Gleason sum in a single biopsy; if not stated in the PAD, report the summary Gleason in the targeted biopsies.')&#xA;&#xA;Terminology binding rationale: NPCR documentation does not provide an international code system binding for this reporting convention. This NPCR-internal CodeSystem preserves Variabelbeskrivning Listvärden values directly." />
  <caseSensitive value="true" />
  <content value="complete" />
  <count value="3" />
  <concept>
    <code value="1" />
    <display value="Gleason in the biopsy with the longest cancer lesion" />
    <definition value="Gleason score reported from the single biopsy core that contains the longest cancer extent (Gleasonsumma i biopsin med längsta cancerhärden). Hidden 2023-06-19 but retained for historical data compatibility." />
  </concept>
  <concept>
    <code value="2" />
    <display value="Summary Gleason for all targeted biopsies" />
    <definition value="Summary Gleason computed across multiple lesions from targeted biopsies, reporting the Gleason of the lesion with the highest Gleason sum (Sammanfattande Gleasonsumma i riktade biopsier). Used when the pathology report does not specify per-biopsy Gleason values for all targeted samples." />
  </concept>
  <concept>
    <code value="3" />
    <display value="Highest Gleason in a single biopsy" />
    <definition value="The single highest Gleason sum observed across all targeted biopsy cores (Högsta gleasonsumman i en enskild biopsi). Added 2023-06-19 as the preferred reporting method per NPCR Manual guidance." />
  </concept>
</CodeSystem>