{
  "resourceType": "StructureDefinition",
  "id": "Profile-nNGM-MedicationStatement-Medication",
  "url": "http://uk-koeln.de/fhir/StructureDefinition/Profile-nNGM-MedicationStatement-Medication",
  "version": "0.1.0",
  "name": "Profile_nNGM_MedicationStatement_Medication",
  "title": "Profile - nNGM - MedicationStatement - Medikation",
  "status": "active",
  "date": "2025-10-31",
  "publisher": "nNGM Konsortium",
  "description": "Medikation der Systemische Therapie. Dieses Profil beschreibt die konkreten Medikationen/Schemata, die im Rahmen der systemischen Therapie dokumentiert wurden. Medikation der Systemische Therapie. Dieses Profil beschreibt die konkreten Medikationen/Schemata, die im Rahmen der systemischen Therapie dokumentiert wurden.",
  "fhirVersion": "4.0.1",
  "mapping": [
    {
      "identity": "nNGM-Schema",
      "name": "systemTherapy"
    }
  ],
  "kind": "resource",
  "abstract": false,
  "type": "MedicationStatement",
  "baseDefinition": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-systemtherapie-medication-statement",
  "derivation": "constraint",
  "differential": {
    "element": [
      {
        "id": "MedicationStatement",
        "path": "MedicationStatement",
        "mapping": [
          {
            "identity": "nNGM-Schema",
            "map": "systemTherapyLine",
            "comment": "Systemische Therapielinie"
          }
        ]
      },
      {
        "id": "MedicationStatement.extension:CyclesCount",
        "path": "MedicationStatement.extension",
        "sliceName": "CyclesCount",
        "type": [
          {
            "code": "Extension",
            "profile": [
              "http://uk-koeln.de/fhir/StructureDefinition/Extension/nNGM/nngm-ex-systemischetherapie-cyclescount"
            ]
          }
        ],
        "mustSupport": true,
        "mapping": [
          {
            "identity": "nNGM-Schema",
            "map": "cyclesCount",
            "comment": "Anzahl der Zyklen"
          }
        ]
      },
      {
        "id": "MedicationStatement.extension:CyclesCount.value[x]",
        "path": "MedicationStatement.extension.value[x]",
        "slicing": {
          "discriminator": [
            {
              "type": "type",
              "path": "$this"
            }
          ],
          "rules": "open"
        },
        "min": 1,
        "mustSupport": true,
        "mapping": [
          {
            "identity": "nNGM-Schema",
            "map": "cyclesCount",
            "comment": "Anzahl der Zyklen"
          }
        ]
      },
      {
        "id": "MedicationStatement.extension:CyclesCount.value[x]:valueDecimal",
        "path": "MedicationStatement.extension.value[x]",
        "sliceName": "valueDecimal",
        "min": 1,
        "mustSupport": true,
        "mapping": [
          {
            "identity": "nNGM-Schema",
            "map": "cyclesCount",
            "comment": "Anzahl der Zyklen"
          }
        ]
      },
      {
        "id": "MedicationStatement.extension:MaintainceTherapy",
        "path": "MedicationStatement.extension",
        "sliceName": "MaintainceTherapy",
        "short": "Ist Erhaltungstherapie",
        "definition": "Ist Erhaltungstherapie",
        "max": "1",
        "type": [
          {
            "code": "Extension",
            "profile": [
              "http://uk-koeln.de/fhir/StructureDefinition/nNGM/nngm-ex-systemischetherapie-ismaintaincetherapy"
            ]
          }
        ],
        "mustSupport": true,
        "mapping": [
          {
            "identity": "nNGM-Schema",
            "map": "MaintainceTherapy",
            "comment": "Ist Erhaltungstherapie"
          }
        ]
      },
      {
        "id": "MedicationStatement.extension:MaintainceTherapy.value[x]",
        "path": "MedicationStatement.extension.value[x]",
        "slicing": {
          "discriminator": [
            {
              "type": "type",
              "path": "$this"
            }
          ],
          "rules": "open"
        },
        "min": 1,
        "mustSupport": true,
        "mapping": [
          {
            "identity": "nNGM-Schema",
            "map": "MaintainceTherapy",
            "comment": "Ist Erhaltungstherapie"
          }
        ]
      },
      {
        "id": "MedicationStatement.extension:MaintainceTherapy.value[x]:valueBoolean",
        "path": "MedicationStatement.extension.value[x]",
        "sliceName": "valueBoolean",
        "min": 1,
        "mustSupport": true,
        "mapping": [
          {
            "identity": "nNGM-Schema",
            "map": "MaintainceTherapy",
            "comment": "Ist Erhaltungstherapie"
          }
        ]
      },
      {
        "id": "MedicationStatement.extension:offLabelUse",
        "path": "MedicationStatement.extension",
        "sliceName": "offLabelUse",
        "short": "Ist Off-Label-Use",
        "definition": "Ist Off-Label-Use",
        "type": [
          {
            "code": "Extension",
            "profile": [
              "http://uk-koeln.de/fhir/StructureDefinition/nNGM/nngm-ex-systemischetherapie-offlabeluse"
            ]
          }
        ],
        "mustSupport": true,
        "mapping": [
          {
            "identity": "nNGM-Schema",
            "map": "offLabelUse",
            "comment": "Ist Off-Label-Use"
          }
        ]
      },
      {
        "id": "MedicationStatement.extension:offLabelUse.value[x]",
        "path": "MedicationStatement.extension.value[x]",
        "slicing": {
          "discriminator": [
            {
              "type": "type",
              "path": "$this"
            }
          ],
          "rules": "open"
        },
        "min": 1,
        "mustSupport": true,
        "mapping": [
          {
            "identity": "nNGM-Schema",
            "map": "offLabelUse",
            "comment": "Ist Off-Label-Use"
          }
        ]
      },
      {
        "id": "MedicationStatement.extension:offLabelUse.value[x]:valueBoolean",
        "path": "MedicationStatement.extension.value[x]",
        "sliceName": "valueBoolean",
        "min": 1,
        "mustSupport": true,
        "mapping": [
          {
            "identity": "nNGM-Schema",
            "map": "offLabelUse",
            "comment": "Ist Off-Label-Use"
          }
        ]
      },
      {
        "id": "MedicationStatement.partOf:systemischeTherapie",
        "path": "MedicationStatement.partOf",
        "sliceName": "systemischeTherapie",
        "type": [
          {
            "code": "Reference",
            "targetProfile": [
              "http://uk-koeln.de/fhir/StructureDefinition/Profile-nNGM-Procedure-Systemische-Therapie",
              "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-systemische-therapie"
            ]
          }
        ]
      },
      {
        "id": "MedicationStatement.partOf:systemischeTherapie.reference",
        "path": "MedicationStatement.partOf.reference",
        "mustSupport": true,
        "mapping": [
          {
            "identity": "nNGM-Schema",
            "map": "systemTherapyLine",
            "comment": "Referenz auf Systemische Therapielinie"
          }
        ]
      },
      {
        "id": "MedicationStatement.medication[x]:medicationCodeableConcept",
        "path": "MedicationStatement.medication[x]",
        "sliceName": "medicationCodeableConcept"
      },
      {
        "id": "MedicationStatement.medication[x]:medicationCodeableConcept.coding",
        "path": "MedicationStatement.medication[x].coding",
        "slicing": {
          "discriminator": [
            {
              "type": "type",
              "path": "$this"
            }
          ],
          "rules": "open"
        }
      },
      {
        "id": "MedicationStatement.medication[x]:medicationCodeableConcept.coding:atcClassDe",
        "path": "MedicationStatement.medication[x].coding",
        "sliceName": "atcClassDe",
        "short": "Therapieschema",
        "definition": "Vollstaendiger ATC-Katalog Version 2026 mit Einzelwirkstoffen (7-stellige Codes) und Wirkstoffklassen (3-stellige Codes).",
        "binding": {
          "strength": "required",
          "valueSet": "http://uk-koeln.de/fhir/ValueSet/nNGM/nngm-vs-atc-2026"
        },
        "mapping": [
          {
            "identity": "nNGM-Schema",
            "map": "therapyName",
            "comment": "Therapieschema"
          }
        ]
      },
      {
        "id": "MedicationStatement.medication[x]:medicationCodeableConcept.coding:atcClassDe.code",
        "path": "MedicationStatement.medication[x].coding.code",
        "binding": {
          "strength": "required",
          "valueSet": "http://uk-koeln.de/fhir/ValueSet/nNGM/nngm-vs-atc-2026"
        },
        "mapping": [
          {
            "identity": "nNGM-Schema",
            "map": "therapyName",
            "comment": "Therapieschema der systemischen Therapie"
          }
        ]
      },
      {
        "id": "MedicationStatement.medication[x]:medicationCodeableConcept.text",
        "path": "MedicationStatement.medication[x].text",
        "short": "Wirkstoff",
        "definition": "Freitext zur Spezifikation der Wirkstoffe bei Verwendung von 3-stelligen ATC-Codes (Wirkstoffklassen) im Therapieschema.",
        "maxLength": 200,
        "mustSupport": true,
        "mapping": [
          {
            "identity": "nNGM-Schema",
            "map": "wirkstoff",
            "comment": "Wirkstoff"
          }
        ]
      },
      {
        "id": "MedicationStatement.subject",
        "path": "MedicationStatement.subject",
        "type": [
          {
            "code": "Reference",
            "targetProfile": [
              "http://hl7.org/fhir/StructureDefinition/Patient",
              "http://uk-koeln.de/fhir/StructureDefinition/Patient/nNGM/pseudonymisiert",
              "http://uk-koeln.de/fhir/StructureDefinition/Patient/nNGM/patient"
            ]
          }
        ]
      },
      {
        "id": "MedicationStatement.subject.reference",
        "path": "MedicationStatement.subject.reference",
        "mustSupport": true
      },
      {
        "id": "MedicationStatement.effective[x]:effectivePeriod",
        "path": "MedicationStatement.effective[x]",
        "sliceName": "effectivePeriod"
      },
      {
        "id": "MedicationStatement.effective[x]:effectivePeriod.start",
        "path": "MedicationStatement.effective[x].start",
        "min": 1,
        "mapping": [
          {
            "identity": "nNGM-Schema",
            "map": "therapyStart; noTherapyStart",
            "comment": "Systemische Therapie Beginn"
          }
        ]
      },
      {
        "id": "MedicationStatement.effective[x]:effectivePeriod.end",
        "path": "MedicationStatement.effective[x].end",
        "mapping": [
          {
            "identity": "nNGM-Schema",
            "map": "therapyEnd; noTherapyEnd",
            "comment": "Systemische Therapie Ende"
          }
        ]
      },
      {
        "id": "MedicationStatement.note.text",
        "path": "MedicationStatement.note.text",
        "mapping": [
          {
            "identity": "nNGM-Schema",
            "map": "note",
            "comment": "Bermerkungen"
          }
        ]
      }
    ]
  }
}