<ResearchStudy xmlns="http://hl7.org/fhir">
  <id value="InstanceOfStudySPOVID" />
  <meta>
    <profile value="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-pr-mds-study" />
  </meta>
  <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-descriptions">
    <extension url="value">
      <valueString value="In a pilot study, the SPOVID project is investigating whether an individually tailored training program can safely and effectively improve the physical endurance of Long COVID-19 patients. To this end, the researchers observe fitness parameters of cardiovascular and lung function in particular over several months, but also the development of headache, fatigue and fatigue symptoms. From the results, they want to derive recommendations for personalized training programs." />
    </extension>
    <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-language">
      <valueCodeableConcept>
        <coding>
          <system value="http://terminology.hl7.org/CodeSystem/iso639-1" />
          <code value="en" />
          <display value="English" />
        </coding>
      </valueCodeableConcept>
    </extension>
  </extension>
  <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-study-admin-info">
    <extension url="status">
      <valueCoding>
        <system value="https://www.nfdi4health.de/fhir/metadataschema/CodeSystem/nfdi4health-cs-mds-study-status" />
        <code value="04" />
        <display value="Ongoing (III): Recruitment completed, but data collection ongoing" />
      </valueCoding>
    </extension>
    <extension url="statusWhenIntervention">
      <valueCoding>
        <system value="https://www.nfdi4health.de/fhir/metadataschema/CodeSystem/nfdi4health-cs-remaining-concepts" />
        <code value="014" />
        <display value="Intervention ongoing" />
      </valueCoding>
    </extension>
  </extension>
  <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-subject">
    <valueCoding>
      <system value="http://snomed.info/sct" />
      <code value="125676002" />
      <display value="Person (person)" />
    </valueCoding>
  </extension>
  <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-data-sharing-plan">
    <extension url="generally">
      <valueCoding>
        <system value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl" />
        <code value="C150084" />
        <display value="Undecided (Intellectual Product)" />
      </valueCoding>
    </extension>
  </extension>
  <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-groups-of-diseases">
    <extension url="generally">
      <valueCoding>
        <system value="http://hl7.org/fhir/sid/icd-10" />
        <code value="I" />
        <display value="Certain infectious and parasitic diseases" />
      </valueCoding>
    </extension>
  </extension>
  <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-data-source">
    <extension url="general">
      <valueCoding>
        <system value="https://www.nfdi4health.de/fhir/metadataschema/CodeSystem/nfdi4health-cs-remaining-concepts" />
        <code value="029" />
        <display value="Cognitive measurements" />
      </valueCoding>
    </extension>
    <extension url="general">
      <valueCoding>
        <system value="https://www.nfdi4health.de/fhir/metadataschema/CodeSystem/nfdi4health-cs-remaining-concepts" />
        <code value="032" />
        <display value="Physiological/Biochemical measurements" />
      </valueCoding>
    </extension>
  </extension>
  <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-study-interventional">
    <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-masking">
      <extension url="general">
        <valueBoolean value="false" />
      </extension>
    </extension>
    <extension url="offLabelUse">
      <valueCoding>
        <system value="http://snomed.info/sct" />
        <code value="385432009" />
        <display value="Not applicable (qualifier value)" />
      </valueCoding>
    </extension>
  </extension>
  <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-sampling">
    <extension url="method">
      <valueCoding>
        <system value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl" />
        <code value="C127781" />
        <display value="Non-Probability Sampling Method" />
      </valueCoding>
    </extension>
    <extension url="nonProbabilityMethod">
      <valueCoding>
        <system value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl" />
        <code value="C53204" />
        <display value="Convenience Sampling" />
      </valueCoding>
    </extension>
  </extension>
  <extension url="https://www.nfdi4health.de/fhir/StructureDefinition/nfdi4health-ex-mds-outcomemeasure-backport-r5">
    <extension url="name">
      <valueString value="test" />
    </extension>
    <extension url="type">
      <valueCodeableConcept>
        <coding>
          <system value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl" />
          <code value="C98772" />
          <display value="Primary Outcome Measure" />
        </coding>
      </valueCodeableConcept>
    </extension>
  </extension>
  <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-recruitment-backport-r5">
    <extension url="targetNumber">
      <valueUnsignedInt value="60" />
    </extension>
    <extension url="eligibility">
      <valueReference>
        <reference value="Group/InstanceOfGroupEligibilitySPOVID" />
      </valueReference>
    </extension>
    <extension url="actualGroup">
      <valueReference>
        <reference value="Group/InstanceOfGroupActualSPOVID" />
      </valueReference>
    </extension>
  </extension>
  <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-study-comparison-group-backport-r5">
    <extension url="name">
      <valueString value="Physical training group" />
    </extension>
    <extension url="type">
      <valueCodeableConcept>
        <coding>
          <system value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl" />
          <code value="C174267" />
          <display value="Active Comparator Arm" />
        </coding>
      </valueCodeableConcept>
    </extension>
    <extension url="description">
      <valueString value="Patients receive an individually tailored training program to improve physical endurance safely and effectively." />
    </extension>
    <extension url="intendedExposure">
      <valueReference>
        <reference value="EvidenceVariable/InstanceOfEvidenceVariableSPOVID" />
      </valueReference>
    </extension>
  </extension>
  <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-study-comparison-group-backport-r5">
    <extension url="name">
      <valueString value="Control group" />
    </extension>
    <extension url="type">
      <valueCodeableConcept>
        <coding>
          <system value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl" />
          <code value="C174270" />
          <display value="No Intervention Arm" />
        </coding>
      </valueCodeableConcept>
    </extension>
  </extension>
  <status value="active" />
  <primaryPurposeType>
    <coding>
      <system value="http://terminology.hl7.org/CodeSystem/research-study-prim-purp-type" />
      <code value="treatment" />
      <display value="Treatment" />
    </coding>
  </primaryPurposeType>
  <category>
    <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-study-type">
      <extension url="interventional">
        <valueCoding>
          <system value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl" />
          <code value="C17998" />
          <display value="Unknown" />
        </valueCoding>
      </extension>
    </extension>
    <coding>
      <system value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl" />
      <code value="C98388" />
      <display value="Interventional Study" />
    </coding>
  </category>
  <condition>
    <coding>
      <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-codeableconcept">
        <extension url="classification">
          <valueCoding>
            <system value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl" />
            <code value="C49469" />
            <display value="Systematized Nomenclature of Medicine Clinical Terms" />
          </valueCoding>
        </extension>
        <extension url="code">
          <valueUri value="http://snomed.info/id/739122008" />
        </extension>
      </extension>
    </coding>
    <text value="Cardiac physiological function" />
  </condition>
  <relatedArtifact>
    <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-related-artifact-nfdi">
      <extension url="identifier">
        <valueIdentifier>
          <type>
            <coding>
              <system value="https://www.nfdi4health.de/fhir/metadataschema/CodeSystem/nfdi4health-cs-remaining-concepts" />
              <code value="104" />
              <display value="NFDI4Health" />
            </coding>
          </type>
          <system value="https://csh.nfdi4health.de/resource/" />
          <value value="122" />
        </valueIdentifier>
      </extension>
      <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-related-artifact-reltype-nfdi-resource">
        <valueCoding>
          <system value="https://www.nfdi4health.de/fhir/metadataschema/CodeSystem/nfdi4health-cs-remaining-concepts" />
          <code value="075" />
          <display value="A is source of B" />
        </valueCoding>
      </extension>
    </extension>
    <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-related-artifact-non-nfdi">
      <extension url="identifier">
        <valueIdentifier>
          <type>
            <coding>
              <system value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl" />
              <code value="C17649" />
              <display value="Other" />
            </coding>
          </type>
          <value value="WHO/2019-nCoV/HHtransmission/2020.4" />
        </valueIdentifier>
      </extension>
      <extension url="https://www.nfdi4health.de/fhir/metadataschema/StructureDefinition/nfdi4health-ex-mds-related-artifact-reltype-non-nfdi-resource">
        <valueCoding>
          <system value="https://www.nfdi4health.de/fhir/metadataschema/CodeSystem/nfdi4health-cs-remaining-concepts" />
          <code value="072" />
          <display value="A is identical to B" />
        </valueCoding>
      </extension>
    </extension>
    <type value="documentation" />
    <url value="www.nfdi4health.de" />
  </relatedArtifact>
  <keyword>
    <coding>
      <system value="https://id.nlm.nih.gov/mesh/D000086382.html" />
    </coding>
    <text value="COVID-19" />
  </keyword>
  <keyword>
    <coding>
      <system value="https://id.nlm.nih.gov/mesh/T032041.html" />
    </coding>
    <text value="Pilot study" />
  </keyword>
  <keyword>
    <coding>
      <system value="https://id.nlm.nih.gov/mesh/D010806.html" />
    </coding>
    <text value="Physical Education and Training" />
  </keyword>
  <keyword>
    <coding>
      <system value="https://id.nlm.nih.gov/mesh/D015444.html" />
    </coding>
    <text value="Exercise" />
  </keyword>
  <keyword>
    <coding>
      <system value="https://id.nlm.nih.gov/mesh/D005081.html" />
    </coding>
    <text value="Exercise Therapy" />
  </keyword>
  <keyword>
    <coding>
      <system value="https://browser.ihtsdotools.org/?perspective=full&amp;conceptId1=68130003&amp;edition=MAIN/2023-07-31&amp;release=&amp;languages=en&amp;latestRedirect=false" />
    </coding>
    <text value="Physical activity (observable entity)" />
  </keyword>
  <keyword>
    <coding>
      <system value="https://browser.ihtsdotools.org/?perspective=full&amp;conceptId1=1119303003&amp;edition=MAIN/2023-07-31&amp;release=&amp;languages=en&amp;latestRedirect=false" />
    </coding>
    <text value="Post-acute COVID-19 (disorder)" />
  </keyword>
  <period>
    <start value="2008-01-05" />
    <end value="2022-11-30" />
  </period>
</ResearchStudy>