{
  "resourceType": "StructureDefinition",
  "id": "mii-pr-molgen-mutationslast",
  "url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/mutationslast",
  "version": "2026.0.4",
  "name": "MII_PR_MolGen_Mutationslast",
  "title": "MII PR MolGen Mutationslast",
  "status": "active",
  "publisher": "Medizininformatik Initiative",
  "contact": [
    {
      "telecom": [
        {
          "system": "url",
          "value": "https://www.medizininformatik-initiative.de"
        }
      ]
    }
  ],
  "description": "Dieses Profil beschreibt die Gesamtzahl der in der DNA von Krebszellen gefundenen Mutationen.",
  "fhirVersion": "4.0.1",
  "mapping": [
    {
      "identity": "MII-KDS",
      "name": "MII KDS Mapping"
    }
  ],
  "kind": "resource",
  "abstract": false,
  "type": "Observation",
  "baseDefinition": "https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/mii-pr-molgen-molekularer-biomarker",
  "derivation": "constraint",
  "differential": {
    "element": [
      {
        "id": "Observation.status",
        "path": "Observation.status",
        "short": "Status",
        "_short": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Status"
                }
              ]
            }
          ]
        },
        "definition": "Status der Beobachtung",
        "_definition": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Status der Beobachtung"
                }
              ]
            }
          ]
        },
        "mustSupport": true
      },
      {
        "id": "Observation.code",
        "path": "Observation.code",
        "definition": "Code zur Identifizierung der Mutationslast",
        "_definition": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Code zur Identifizierung der Mutationslast"
                }
              ]
            }
          ]
        }
      },
      {
        "id": "Observation.subject",
        "path": "Observation.subject",
        "min": 1
      },
      {
        "id": "Observation.value[x]",
        "path": "Observation.value[x]",
        "slicing": {
          "discriminator": [
            {
              "type": "type",
              "path": "$this"
            }
          ],
          "ordered": false,
          "rules": "open"
        },
        "short": "Ergebniswert",
        "_short": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Ergebniswert"
                }
              ]
            }
          ]
        },
        "definition": "Der numerische Wert der Mutationslast in Mutationen pro Megabase",
        "_definition": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Der numerische Wert der Mutationslast in Mutationen pro Megabase"
                }
              ]
            }
          ]
        },
        "mustSupport": true
      },
      {
        "id": "Observation.value[x]:valueQuantity",
        "path": "Observation.value[x]",
        "sliceName": "valueQuantity",
        "min": 0,
        "max": "1",
        "type": [
          {
            "code": "Quantity"
          }
        ],
        "mapping": [
          {
            "identity": "MII-KDS",
            "map": "mide-dataelement-2012",
            "comment": "Mutationslast"
          }
        ]
      },
      {
        "id": "Observation.specimen",
        "path": "Observation.specimen",
        "short": "Probe",
        "_short": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Probe"
                }
              ]
            }
          ]
        },
        "definition": "Die untersuchte Tumorprobe",
        "_definition": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Die untersuchte Tumorprobe"
                }
              ]
            }
          ]
        },
        "mustSupport": true
      }
    ]
  }
}