{
  "resourceType": "StructureDefinition",
  "id": "mii-pr-molgen-molekularer-biomarker",
  "url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/mii-pr-molgen-molekularer-biomarker",
  "version": "2026.0.4",
  "name": "MII_PR_MolGen_MolekularerBiomarker",
  "title": "MII PR MolGen Molekulare Biomarker",
  "status": "active",
  "publisher": "Medizininformatik Initiative",
  "contact": [
    {
      "telecom": [
        {
          "system": "url",
          "value": "https://www.medizininformatik-initiative.de"
        }
      ]
    }
  ],
  "description": "Dieses Profil beschreibt molekulare Biomarker, z.B. genübergreifende Biomarker wie Tumormutationslast (TMB) oder Mikrosatelliteninstabilität (MSI). Es ist ein abstraktes Profil, konkrete Biomarker-Profile erben davon.",
  "fhirVersion": "4.0.1",
  "kind": "resource",
  "abstract": false,
  "type": "Observation",
  "baseDefinition": "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-biomarker",
  "derivation": "constraint",
  "differential": {
    "element": [
      {
        "id": "Observation.category",
        "path": "Observation.category",
        "short": "Kategorie",
        "_short": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Kategorie"
                }
              ]
            }
          ]
        },
        "definition": "Klassifizierung der Beobachtungsart",
        "_definition": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Klassifizierung der Beobachtungsart"
                }
              ]
            }
          ]
        },
        "mustSupport": true
      },
      {
        "id": "Observation.code",
        "path": "Observation.code",
        "short": "Code",
        "_short": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Code"
                }
              ]
            }
          ]
        },
        "definition": "Code zur Identifizierung des Biomarkers",
        "_definition": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Code zur Identifizierung des Biomarkers"
                }
              ]
            }
          ]
        },
        "mustSupport": true
      },
      {
        "id": "Observation.subject",
        "path": "Observation.subject",
        "short": "Patient",
        "_short": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Patient"
                }
              ]
            }
          ]
        },
        "definition": "Der Patient auf den sich die Beobachtung bezieht",
        "_definition": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Der Patient auf den sich die Beobachtung bezieht"
                }
              ]
            }
          ]
        },
        "type": [
          {
            "code": "Reference",
            "targetProfile": [
              "http://hl7.org/fhir/StructureDefinition/Patient",
              "http://hl7.org/fhir/StructureDefinition/Group"
            ]
          }
        ],
        "mustSupport": true
      },
      {
        "id": "Observation.encounter",
        "path": "Observation.encounter",
        "short": "Kontakt",
        "_short": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Kontakt"
                }
              ]
            }
          ]
        },
        "definition": "Der Kontakt in dessen Rahmen die Beobachtung gemacht wurde",
        "_definition": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Der Kontakt in dessen Rahmen die Beobachtung gemacht wurde"
                }
              ]
            }
          ]
        },
        "mustSupport": true
      },
      {
        "id": "Observation.effective[x]",
        "path": "Observation.effective[x]",
        "short": "Zeitpunkt der Beobachtung",
        "_short": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Zeitpunkt der Beobachtung"
                }
              ]
            }
          ]
        },
        "definition": "Klinisch relevanter Zeitpunkt der Beobachtung",
        "_definition": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Klinisch relevanter Zeitpunkt der Beobachtung"
                }
              ]
            }
          ]
        },
        "mustSupport": true
      },
      {
        "id": "Observation.issued",
        "path": "Observation.issued",
        "short": "Freigabedatum",
        "_short": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Freigabedatum"
                }
              ]
            }
          ]
        },
        "definition": "Datum und Uhrzeit der Freigabe",
        "_definition": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Datum und Uhrzeit der Freigabe"
                }
              ]
            }
          ]
        },
        "mustSupport": true
      },
      {
        "id": "Observation.derivedFrom",
        "path": "Observation.derivedFrom",
        "short": "Abgeleitet von",
        "_short": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Abgeleitet von"
                }
              ]
            }
          ]
        },
        "definition": "Referenzen zu anderen Beobachtungen von denen diese abgeleitet ist",
        "_definition": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Referenzen zu anderen Beobachtungen von denen diese abgeleitet ist"
                }
              ]
            }
          ]
        },
        "mustSupport": true
      },
      {
        "id": "Observation.derivedFrom:variant",
        "path": "Observation.derivedFrom",
        "sliceName": "variant",
        "type": [
          {
            "code": "Reference",
            "targetProfile": [
              "https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/variante"
            ]
          }
        ]
      },
      {
        "id": "Observation.component",
        "path": "Observation.component",
        "short": "Komponenten",
        "_short": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Komponenten"
                }
              ]
            }
          ]
        },
        "definition": "Einzelne Komponenten der Beobachtung",
        "_definition": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Einzelne Komponenten der Beobachtung"
                }
              ]
            }
          ]
        },
        "mustSupport": true
      },
      {
        "id": "Observation.component:gene-studied",
        "path": "Observation.component",
        "sliceName": "gene-studied",
        "short": "Untersuchtes Gen",
        "_short": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Untersuchtes Gen"
                }
              ]
            }
          ]
        },
        "definition": "Das untersuchte Gen",
        "_definition": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Das untersuchte Gen"
                }
              ]
            }
          ]
        },
        "mustSupport": true
      },
      {
        "id": "Observation.component:biomarker-category",
        "path": "Observation.component",
        "sliceName": "biomarker-category",
        "short": "Biomarker-Kategorie",
        "_short": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Biomarker-Kategorie"
                }
              ]
            }
          ]
        },
        "definition": "Die Kategorie des molekularen Biomarkers",
        "_definition": {
          "extension": [
            {
              "url": "http://hl7.org/fhir/StructureDefinition/translation",
              "extension": [
                {
                  "url": "lang",
                  "valueCode": "de-DE"
                },
                {
                  "url": "content",
                  "valueString": "Die Kategorie des molekularen Biomarkers"
                }
              ]
            }
          ]
        },
        "mustSupport": true
      }
    ]
  }
}