<status value="draft" /> <experimental value="false" /> <date value="2017-05-20T00:00:00+00:00" /> <publisher value="HL7 Clinical Genomics WG" /> <description value="Observation-related profiles" /> <fhirVersion value="4.0.1" /> <mapping> <identity value="v2-cg-results" /> <uri value="http://unknown.org/V2-CG-Results" /> <name value="V2-CG-Results" /> </mapping> <mapping> <identity value="workflow" /> <uri value="http://hl7.org/fhir/workflow" /> <name value="Workflow Pattern" /> </mapping> <mapping> <identity value="sct-concept" /> <uri value="http://snomed.info/conceptdomain" /> <name value="SNOMED CT Concept Domain Binding" /> </mapping> <mapping> <identity value="v2" /> <uri value="http://hl7.org/v2" /> <name value="HL7 v2 Mapping" /> </mapping> <mapping> <identity value="rim" /> <uri value="http://hl7.org/v3" /> <name value="RIM Mapping" /> </mapping> <mapping> <identity value="w5" /> <uri value="http://hl7.org/fhir/fivews" /> <name value="FiveWs Pattern Mapping" /> </mapping> <mapping> <identity value="sct-attr" /> <uri value="http://snomed.org/attributebinding" /> <name value="SNOMED CT Attribute Binding" /> </mapping> <kind value="resource" /> <abstract value="false" /> <type value="Observation" /> <baseDefinition value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/medication-implication" /> <derivation value="constraint" /> <snapshot /> <differential> <element id="Observation"> <path value="Observation" /> <short value="Medication Efficacy" /> <definition value="Finding of the expected implication of a particular genotype on the efficacy of a particular medication for the subject." /> <mustSupport value="false" /> </element> <element id="Observation.code"> <path value="Observation.code" /> <short value="Genomic variation's effect on drug efficacy" /> <definition value="Predicted phenotype for ability of drug to bind to intended site in order to deliver intended affect. A single marker interpretation value known to allow (responsive) or prevent (resistant) the drug to perform." /> <min value="1" /> <max value="1" /> <type> <code value="CodeableConcept" /> </type> <patternCodeableConcept> <coding> <system value="http://loinc.org" /> <code value="51961-1" /> </coding> </patternCodeableConcept> <mustSupport value="false" /> </element> <element id="Observation.valueCodeableConcept"> <path value="Observation.valueCodeableConcept" /> <short value="Resistant | Responsive | Presumed resistant | Presumed responsive | Unknown significance | Non-Responsive | Presumed non-responsive" /> <definition value="Drug efficacy marker interpretation, based on LOINC LL539-8. Look to http://build.fhir.org/ig/HL7/genomics-reporting/task-med-chg.html for guidance. If the variant is predicted to not have an effect then Responsive is the proper choice. Non-responsive implies complete resistance, whereas Resistant indicates residual drug efficacy." /> <min value="1" /> <max value="1" /> <type> <code value="CodeableConcept" /> </type> <mustSupport value="false" /> <binding> <strength value="preferred" /> <description value="Genotype Medication Efficacy values" /> <valueSet value="http://loinc.org/vs/LL539-8" /> </binding> <mapping> <identity value="v2-cg-results" /> <map value="F.4" /> </mapping> </element> </differential> </StructureDefinition>

Name	Card.	Type	Description & Constraints
Observation	0 .. *		Medication Efficacy
code	1..1	CodeableConcept	Genomic variation's effect on drug efficacy Required Pattern: At least the following
coding	1..*	Coding	Code defined by a terminology system Fixed Value: (complex)
system	1..1	uri	Identity of the terminology system Fixed Value: http://loinc.org
code	1..1	code	Symbol in syntax defined by the system Fixed Value: 51961-1
valueCodeableConcept	1..1	CodeableConcept	Resistant \| Responsive \| Presumed resistant \| Presumed responsive \| Unknown significance \| Non-Responsive \| Presumed non-responsive Binding: LOINC Answer List LL539-8 (preferred)
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