Extension: Wirkstoffrelation


Beschreibung

Die Extension Wirkstoffrelation erlaubt es, Referenzen zwischen den Wirkstoffen abzubilden. Somit kann ein Wirkstoff, der als "genauer" Wirkstoff klassifiziert ist, eindeutig einem "allgemeinen" Wirkstoff zugeordnet werden. Dies erlaubt bspw. die Umrechnung, dass "10mg Bisoprolol hemifumarat" "8,49mg Bisoprolol" entsprechen.

NameStatusVersionCanonicalBasis
MII_EX_Medikation_Wirkstoffrelationactive2024.0.0https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/wirkstoffrelationhttp://hl7.org/fhir/StructureDefinition/Extension

Inhalt

id0..1string
id0..1string
extensionI0..0Extension
url1..1uriFixed Value
valueReferenceReference(Medication | Substance)
id0..1string
extensionI0..0Extension
url1..1uriFixed Value
valueUriuri
url1..1uriFixed Value

Die Extension ermöglicht die Zuordnung von einem genauem Wirkstoff (z.B. Salz, Ester) zu einem allgemeinem Wirkstoff.

<StructureDefinition xmlns="http://hl7.org/fhir">
    <id value="mii-ex-medikation-wirkstoffrelation" />
    <url value="https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/wirkstoffrelation" />
    <version value="2024.0.0" />
    <name value="MII_EX_Medikation_Wirkstoffrelation">
        <extension url="http://hl7.org/fhir/StructureDefinition/translation">
            <extension url="lang">
                <valueCode value="en-US" />
            </extension>
            <extension url="content">
                <valueString value="MII_EX_Medikation_IngredientRelation" />
            </extension>
        </extension>
    </name>
    <title value="MII EX Medikation Wirkstoffrelation">
        <extension url="http://hl7.org/fhir/StructureDefinition/translation">
            <extension url="lang">
                <valueCode value="en-US" />
            </extension>
            <extension url="content">
                <valueString value="MII EX Medikation Ingredient Relation" />
            </extension>
        </extension>
    </title>
    <status value="active" />
    <experimental value="false" />
    <date value="2024-05-29" />
    <publisher value="Medizininformatik Initiative" />
    <contact>
        <telecom>
            <system value="url" />
            <value value="https://www.medizininformatik-initiative.de" />
        </telecom>
    </contact>
    <description value="Die Extension erm&#246;glicht die Zuordnung von einem genauem Wirkstoff (z.B. Salz, Ester) zu einem allgemeinem Wirkstoff.">
        <extension url="http://hl7.org/fhir/StructureDefinition/translation">
            <extension url="lang">
                <valueCode value="en-US" />
            </extension>
            <extension url="content">
                <valueString value="The extension enables the assignment of an exact substance e.g. salt, ester to a general substance." />
            </extension>
        </extension>
    </description>
    <copyright value="This specification is licensed under Creative Commons &quot;No Rights Reserved&quot; (CC0)." />
    <fhirVersion value="4.0.1" />
    <kind value="complex-type" />
    <abstract value="false" />
    <context>
        <type value="element" />
        <expression value="Medication.ingredient" />
    </context>
    <type value="Extension" />
    <baseDefinition value="http://hl7.org/fhir/StructureDefinition/Extension" />
    <derivation value="constraint" />
    <differential>
        <element id="Extension.extension:ingredientReference">
            <path value="Extension.extension" />
            <sliceName value="ingredientReference" />
            <min value="0" />
            <max value="1" />
        </element>
        <element id="Extension.extension:ingredientReference.extension">
            <path value="Extension.extension.extension" />
            <max value="0" />
        </element>
        <element id="Extension.extension:ingredientReference.url">
            <path value="Extension.extension.url" />
            <fixedUri value="ingredientReference" />
        </element>
        <element id="Extension.extension:ingredientReference.value[x]">
            <path value="Extension.extension.value[x]" />
            <type>
                <code value="Reference" />
                <targetProfile value="http://hl7.org/fhir/StructureDefinition/Medication" />
                <targetProfile value="http://hl7.org/fhir/StructureDefinition/Substance" />
            </type>
        </element>
        <element id="Extension.extension:ingredientUri">
            <path value="Extension.extension" />
            <sliceName value="ingredientUri" />
            <min value="0" />
            <max value="1" />
        </element>
        <element id="Extension.extension:ingredientUri.extension">
            <path value="Extension.extension.extension" />
            <max value="0" />
        </element>
        <element id="Extension.extension:ingredientUri.url">
            <path value="Extension.extension.url" />
            <fixedUri value="ingredientUri" />
        </element>
        <element id="Extension.extension:ingredientUri.value[x]">
            <path value="Extension.extension.value[x]" />
            <type>
                <code value="uri" />
            </type>
        </element>
        <element id="Extension.url">
            <path value="Extension.url" />
            <fixedUri value="https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/wirkstoffrelation" />
        </element>
        <element id="Extension.value[x]">
            <path value="Extension.value[x]" />
            <max value="0" />
        </element>
    </differential>
</StructureDefinition>
{
    "resourceType": "StructureDefinition",
    "id": "mii-ex-medikation-wirkstoffrelation",
    "url": "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/wirkstoffrelation",
    "version": "2024.0.0",
    "name": "MII_EX_Medikation_Wirkstoffrelation",
    "_name": {
        "extension":  [
            {
                "url": "http://hl7.org/fhir/StructureDefinition/translation",
                "extension":  [
                    {
                        "url": "lang",
                        "valueCode": "en-US"
                    },
                    {
                        "url": "content",
                        "valueString": "MII_EX_Medikation_IngredientRelation"
                    }
                ]
            }
        ]
    },
    "title": "MII EX Medikation Wirkstoffrelation",
    "_title": {
        "extension":  [
            {
                "url": "http://hl7.org/fhir/StructureDefinition/translation",
                "extension":  [
                    {
                        "url": "lang",
                        "valueCode": "en-US"
                    },
                    {
                        "url": "content",
                        "valueString": "MII EX Medikation Ingredient Relation"
                    }
                ]
            }
        ]
    },
    "status": "active",
    "experimental": false,
    "date": "2024-05-29",
    "publisher": "Medizininformatik Initiative",
    "contact":  [
        {
            "telecom":  [
                {
                    "system": "url",
                    "value": "https://www.medizininformatik-initiative.de"
                }
            ]
        }
    ],
    "description": "Die Extension ermöglicht die Zuordnung von einem genauem Wirkstoff (z.B. Salz, Ester) zu einem allgemeinem Wirkstoff.",
    "_description": {
        "extension":  [
            {
                "url": "http://hl7.org/fhir/StructureDefinition/translation",
                "extension":  [
                    {
                        "url": "lang",
                        "valueCode": "en-US"
                    },
                    {
                        "url": "content",
                        "valueString": "The extension enables the assignment of an exact substance e.g. salt, ester to a general substance."
                    }
                ]
            }
        ]
    },
    "copyright": "This specification is licensed under Creative Commons \"No Rights Reserved\" (CC0).",
    "fhirVersion": "4.0.1",
    "kind": "complex-type",
    "abstract": false,
    "context":  [
        {
            "type": "element",
            "expression": "Medication.ingredient"
        }
    ],
    "type": "Extension",
    "baseDefinition": "http://hl7.org/fhir/StructureDefinition/Extension",
    "derivation": "constraint",
    "differential": {
        "element":  [
            {
                "id": "Extension.extension:ingredientReference",
                "path": "Extension.extension",
                "sliceName": "ingredientReference",
                "min": 0,
                "max": "1"
            },
            {
                "id": "Extension.extension:ingredientReference.extension",
                "path": "Extension.extension.extension",
                "max": "0"
            },
            {
                "id": "Extension.extension:ingredientReference.url",
                "path": "Extension.extension.url",
                "fixedUri": "ingredientReference"
            },
            {
                "id": "Extension.extension:ingredientReference.value[x]",
                "path": "Extension.extension.value[x]",
                "type":  [
                    {
                        "code": "Reference",
                        "targetProfile":  [
                            "http://hl7.org/fhir/StructureDefinition/Medication",
                            "http://hl7.org/fhir/StructureDefinition/Substance"
                        ]
                    }
                ]
            },
            {
                "id": "Extension.extension:ingredientUri",
                "path": "Extension.extension",
                "sliceName": "ingredientUri",
                "min": 0,
                "max": "1"
            },
            {
                "id": "Extension.extension:ingredientUri.extension",
                "path": "Extension.extension.extension",
                "max": "0"
            },
            {
                "id": "Extension.extension:ingredientUri.url",
                "path": "Extension.extension.url",
                "fixedUri": "ingredientUri"
            },
            {
                "id": "Extension.extension:ingredientUri.value[x]",
                "path": "Extension.extension.value[x]",
                "type":  [
                    {
                        "code": "uri"
                    }
                ]
            },
            {
                "id": "Extension.url",
                "path": "Extension.url",
                "fixedUri": "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/wirkstoffrelation"
            },
            {
                "id": "Extension.value[x]",
                "path": "Extension.value[x]",
                "max": "0"
            }
        ]
    }
}

Beispiele

Beispiel

Beispiel Medication-Ressource mit Liste von Wirkstoffen in Medication.ingredient. Klassifizierung jedes Wirkstofftyps mittels Wirkstofftyp-Extension. Zusätzlich Wirkstoffrelation-Extension zur Darstellung, dass eine Brausetablette 2945.15 mg Calcium lactate gluconate (id:ing_1, Typ:PIN) und 300 mg Calcium carbonate (id:ing_2, Typ:PIN) enthält entsprechend 500 mg Calcium (id:ing_3, Typ:IN):

{
    "resourceType": "Medication",
    "id": "mii-exa-medikation-medication-calcium",
    "meta": {
        "profile":  [
            "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/Medication"
        ]
    },
    "code": {
        "coding":  [
            {
                "code": "00169644",
                "system": "http://fhir.de/CodeSystem/ifa/pzn",
                "display": "CALCIUM SANDOZ forte Brausetabletten"
            },
            {
                "code": "A12AA20",
                "system": "http://fhir.de/CodeSystem/bfarm/atc",
                "version": "2023",
                "display": "Calcium (verschiedene Salze in Kombination)"
            },
            {
                "code": "A12AA20",
                "system": "http://www.whocc.no/atc",
                "version": "2023",
                "display": "calcium (different salts in combination)"
            }
        ]
    },
    "form": {
        "coding":  [
            {
                "code": "10222000",
                "system": "http://standardterms.edqm.eu",
                "display": "Effervescent tablet"
            }
        ]
    },
    "ingredient":  [
        {
            "id": "ing_1",
            "extension":  [
                {
                    "url": "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/wirkstofftyp",
                    "valueCoding": {
                        "code": "PIN",
                        "system": "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/CodeSystem/wirkstofftyp"
                    }
                }
            ],
            "itemCodeableConcept": {
                "coding":  [
                    {
                        "code": "472LWJ3Y9N",
                        "system": "http://fdasis.nlm.nih.gov",
                        "display": "CALCIUM LACTATE GLUCONATE"
                    },
                    {
                        "code": "11116-97-5",
                        "system": "urn:oid:2.16.840.1.113883.6.61",
                        "display": "Calcium lactate gluconate"
                    },
                    {
                        "code": "422232005",
                        "system": "http://snomed.info/sct",
                        "display": "Calcium lactate gluconate (substance)"
                    }
                ]
            },
            "strength": {
                "numerator": {
                    "value": 2945.15,
                    "code": "mg",
                    "system": "http://unitsofmeasure.org",
                    "unit": "milligram"
                },
                "denominator": {
                    "value": 1,
                    "code": "10222000",
                    "system": "http://standardterms.edqm.eu",
                    "unit": "Effervescent tablet"
                }
            }
        },
        {
            "id": "ing_2",
            "extension":  [
                {
                    "url": "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/wirkstofftyp",
                    "valueCoding": {
                        "code": "PIN",
                        "system": "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/CodeSystem/wirkstofftyp"
                    }
                }
            ],
            "itemCodeableConcept": {
                "coding":  [
                    {
                        "code": "H0G9379FGK",
                        "system": "http://fdasis.nlm.nih.gov",
                        "display": "CALCIUM CARBONATE"
                    },
                    {
                        "code": "471-34-1",
                        "system": "urn:oid:2.16.840.1.113883.6.61",
                        "display": "Calcium carbonate"
                    },
                    {
                        "code": "387307005",
                        "system": "http://snomed.info/sct",
                        "display": "Calcium carbonate (substance)"
                    }
                ]
            },
            "strength": {
                "numerator": {
                    "value": 300,
                    "code": "mg",
                    "system": "http://unitsofmeasure.org",
                    "unit": "milligram"
                },
                "denominator": {
                    "value": 1,
                    "code": "10222000",
                    "system": "http://standardterms.edqm.eu",
                    "unit": "Effervescent tablet"
                }
            }
        },
        {
            "id": "ing_3",
            "extension":  [
                {
                    "url": "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/wirkstofftyp",
                    "valueCoding": {
                        "code": "IN",
                        "system": "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/CodeSystem/wirkstofftyp"
                    }
                },
                {
                    "extension":  [
                        {
                            "url": "ingredientUri",
                            "valueUri": "#ing_1"
                        }
                    ],
                    "url": "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/wirkstoffrelation"
                },
                {
                    "extension":  [
                        {
                            "url": "ingredientUri",
                            "valueUri": "#ing_2"
                        }
                    ],
                    "url": "https://www.medizininformatik-initiative.de/fhir/core/modul-medikation/StructureDefinition/wirkstoffrelation"
                }
            ],
            "itemCodeableConcept": {
                "coding":  [
                    {
                        "code": "2M83C4R6ZB",
                        "system": "http://fdasis.nlm.nih.gov",
                        "display": "CALCIUM CATION"
                    },
                    {
                        "code": "14127-61-8",
                        "system": "urn:oid:2.16.840.1.113883.6.61",
                        "display": "Calcium cation"
                    },
                    {
                        "code": "5540006",
                        "system": "http://snomed.info/sct",
                        "display": "Calcium (substance)"
                    }
                ]
            },
            "strength": {
                "numerator": {
                    "value": 500.54,
                    "code": "mg",
                    "system": "http://unitsofmeasure.org",
                    "unit": "milligram"
                },
                "denominator": {
                    "value": 1,
                    "code": "10222000",
                    "system": "http://standardterms.edqm.eu",
                    "unit": "Effervescent tablet"
                }
            }
        }
    ]
}