{
  "resourceType": "StructureDefinition",
  "id": "clinical-study",
  "url": "https://www.vision-zero-oncology.de/fhir/StructureDefinition/clinical-study",
  "name": "Clinical_Study",
  "title": "Profile Clinical Study",
  "status": "draft",
  "publisher": "VISION ZERO E.V.",
  "contact": [
    {
      "telecom": [
        {
          "system": "url",
          "value": "https://www.vision-zero-oncology.de/"
        }
      ]
    }
  ],
  "description": "Profile to describe a clinical study in which a patient takes part.",
  "fhirVersion": "4.0.1",
  "mapping": [
    {
      "identity": "BRIDG5.1",
      "uri": "https://bridgmodel.nci.nih.gov",
      "name": "BRIDG 5.1 Mapping"
    },
    {
      "identity": "v2",
      "uri": "http://hl7.org/v2",
      "name": "HL7 v2 Mapping"
    },
    {
      "identity": "rim",
      "uri": "http://hl7.org/v3",
      "name": "RIM Mapping"
    },
    {
      "identity": "clinicaltrials-gov",
      "uri": "http://clinicaltrials.gov",
      "name": "ClinicalTrials.gov Mapping"
    },
    {
      "identity": "w5",
      "uri": "http://hl7.org/fhir/fivews",
      "name": "FiveWs Pattern Mapping"
    }
  ],
  "kind": "resource",
  "abstract": false,
  "type": "ResearchStudy",
  "baseDefinition": "http://hl7.org/fhir/StructureDefinition/ResearchStudy",
  "derivation": "constraint",
  "differential": {
    "element": [
      {
        "id": "ResearchStudy.identifier",
        "path": "ResearchStudy.identifier",
        "slicing": {
          "discriminator": [
            {
              "type": "pattern",
              "path": "$this"
            }
          ],
          "rules": "open"
        },
        "mustSupport": true
      },
      {
        "id": "ResearchStudy.identifier:eudraCT",
        "path": "ResearchStudy.identifier",
        "sliceName": "eudraCT",
        "short": "Eudra CT Number",
        "min": 0,
        "max": "1",
        "patternIdentifier": {
          "system": "https://www.clinicaltrialsregister.eu"
        }
      },
      {
        "id": "ResearchStudy.identifier:eudraCT.system",
        "path": "ResearchStudy.identifier.system",
        "min": 1,
        "patternUri": "https://www.clinicaltrialsregister.eu",
        "mustSupport": true
      },
      {
        "id": "ResearchStudy.identifier:eudraCT.value",
        "path": "ResearchStudy.identifier.value",
        "min": 1,
        "mustSupport": true
      },
      {
        "id": "ResearchStudy.identifier:NCT",
        "path": "ResearchStudy.identifier",
        "sliceName": "NCT",
        "short": "NCT number",
        "min": 0,
        "max": "1",
        "patternIdentifier": {
          "system": "http://clinicaltrials.gov"
        }
      },
      {
        "id": "ResearchStudy.identifier:NCT.system",
        "path": "ResearchStudy.identifier.system",
        "min": 1,
        "patternUri": "http://clinicaltrials.gov",
        "mustSupport": true
      },
      {
        "id": "ResearchStudy.identifier:NCT.value",
        "path": "ResearchStudy.identifier.value",
        "min": 1,
        "mustSupport": true
      },
      {
        "id": "ResearchStudy.identifier:PMID",
        "path": "ResearchStudy.identifier",
        "sliceName": "PMID",
        "short": "Pubmed ID",
        "min": 0,
        "max": "1",
        "patternIdentifier": {
          "system": "http://www.ncbi.nlm.nih.gov/pubmed"
        }
      },
      {
        "id": "ResearchStudy.identifier:PMID.system",
        "path": "ResearchStudy.identifier.system",
        "min": 1,
        "patternUri": "http://www.ncbi.nlm.nih.gov/pubmed",
        "mustSupport": true
      },
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        "id": "ResearchStudy.identifier:PMID.value",
        "path": "ResearchStudy.identifier.value",
        "min": 1,
        "mustSupport": true
      },
      {
        "id": "ResearchStudy.identifier:DOI",
        "path": "ResearchStudy.identifier",
        "sliceName": "DOI",
        "short": "Digital Object Identifier",
        "min": 0,
        "max": "1",
        "patternIdentifier": {
          "system": "https://doi.org"
        }
      },
      {
        "id": "ResearchStudy.identifier:DOI.system",
        "path": "ResearchStudy.identifier.system",
        "min": 1,
        "patternUri": "https://doi.org",
        "mustSupport": true
      },
      {
        "id": "ResearchStudy.identifier:DOI.value",
        "path": "ResearchStudy.identifier.value",
        "min": 1,
        "mustSupport": true
      },
      {
        "id": "ResearchStudy.identifier:URI",
        "path": "ResearchStudy.identifier",
        "sliceName": "URI",
        "short": "Uniform Resource Identifier",
        "min": 0,
        "max": "1",
        "patternIdentifier": {
          "system": "urn:ietf:rfc:3986"
        }
      },
      {
        "id": "ResearchStudy.identifier:URI.system",
        "path": "ResearchStudy.identifier.system",
        "min": 1,
        "patternUri": "urn:ietf:rfc:3986",
        "mustSupport": true
      },
      {
        "id": "ResearchStudy.identifier:URI.value",
        "path": "ResearchStudy.identifier.value",
        "min": 1,
        "mustSupport": true
      },
      {
        "id": "ResearchStudy.identifier:DRKS",
        "path": "ResearchStudy.identifier",
        "sliceName": "DRKS",
        "short": "Deusches Register Klinischer Studien",
        "min": 0,
        "max": "1",
        "patternIdentifier": {
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        }
      },
      {
        "id": "ResearchStudy.identifier:DRKS.system",
        "path": "ResearchStudy.identifier.system",
        "min": 1,
        "patternUri": "https://www.drks.de",
        "mustSupport": true
      },
      {
        "id": "ResearchStudy.identifier:DRKS.value",
        "path": "ResearchStudy.identifier.value",
        "min": 1,
        "mustSupport": true
      },
      {
        "id": "ResearchStudy.title",
        "path": "ResearchStudy.title",
        "mustSupport": true
      },
      {
        "id": "ResearchStudy.status",
        "path": "ResearchStudy.status",
        "mustSupport": true
      },
      {
        "id": "ResearchStudy.primaryPurposeType",
        "path": "ResearchStudy.primaryPurposeType",
        "mustSupport": true
      },
      {
        "id": "ResearchStudy.phase",
        "path": "ResearchStudy.phase",
        "min": 1,
        "binding": {
          "strength": "required",
          "valueSet": "http://hl7.org/fhir/ValueSet/research-study-phase"
        }
      },
      {
        "id": "ResearchStudy.category",
        "path": "ResearchStudy.category",
        "slicing": {
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            {
              "type": "pattern",
              "path": "$this"
            }
          ],
          "rules": "open"
        },
        "min": 1,
        "mustSupport": true
      },
      {
        "id": "ResearchStudy.category:studyCategory",
        "path": "ResearchStudy.category",
        "sliceName": "studyCategory",
        "min": 1,
        "max": "1",
        "mustSupport": true,
        "binding": {
          "strength": "required",
          "valueSet": "https://www.vision-zero-oncology.de/fhir/ValueSet/studienkategorien-ncit"
        }
      },
      {
        "id": "ResearchStudy.category:studyDesign",
        "path": "ResearchStudy.category",
        "sliceName": "studyDesign",
        "min": 0,
        "max": "*",
        "mustSupport": true,
        "binding": {
          "strength": "required",
          "valueSet": "https://www.vision-zero-oncology.de/fhir/ValueSet/studiendesign-ncit"
        }
      },
      {
        "id": "ResearchStudy.category:typeOfBlinding",
        "path": "ResearchStudy.category",
        "sliceName": "typeOfBlinding",
        "min": 0,
        "max": "1",
        "mustSupport": true,
        "binding": {
          "strength": "required",
          "valueSet": "https://www.vision-zero-oncology.de/fhir/ValueSet/type-of-blinding-ncit"
        }
      },
      {
        "id": "ResearchStudy.category:typeOfRandomization",
        "path": "ResearchStudy.category",
        "sliceName": "typeOfRandomization",
        "min": 0,
        "max": "1",
        "mustSupport": true,
        "binding": {
          "strength": "required",
          "valueSet": "https://www.vision-zero-oncology.de/fhir/ValueSet/type-of-randomization-ncit"
        }
      },
      {
        "id": "ResearchStudy.focus",
        "path": "ResearchStudy.focus",
        "mustSupport": true,
        "binding": {
          "strength": "extensible",
          "valueSet": "https://www.vision-zero-oncology.de/fhir/ValueSet/study-focus-ncit"
        }
      },
      {
        "id": "ResearchStudy.arm",
        "path": "ResearchStudy.arm",
        "mustSupport": true
      },
      {
        "id": "ResearchStudy.arm.type",
        "path": "ResearchStudy.arm.type",
        "mustSupport": true,
        "binding": {
          "strength": "required",
          "valueSet": "https://www.vision-zero-oncology.de/fhir/ValueSet/type-of-study-arm-ncit"
        }
      }
    ]
  }
}