<StructureDefinition xmlns="http://hl7.org/fhir">
  <id value="HdBe-MedicationUse2" />
  <url value="https://fhir.healthdata.be/StructureDefinition/HdBe-MedicationUse2" />
  <name value="HdBeMedicationUse2" />
  <title value="HdBe MedicationUse2" />
  <status value="draft" />
  <date value="2022-10-17T09:09:13.9562003+00:00" />
  <publisher value="Healthdata.be (Sciensano)" />
  <contact>
    <name value="Service portal – healthdata.be" />
    <telecom>
      <system value="url" />
      <value value="https://sciensano.service-now.com/sp" />
      <use value="work" />
    </telecom>
  </contact>
  <description value="MedicationUse2 is a statement on the historic, current or intended use of a certain medicine." />
  <copyright value="Copyright and related rights waived via CC0, https://creativecommons.org/publicdomain/zero/1.0/. This does not apply to information from third parties, for example a medical terminology system. The implementer alone is responsible for identifying and obtaining any necessary licenses or authorizations to utilize third party IP in connection with the specification or otherwise." />
  <fhirVersion value="4.0.1" />
  <mapping>
    <identity value="zib-medicationuse2-v1.1.1-2020EN" />
    <uri value="https://zibs.nl/wiki/MedicationUse2-v1.1.1(2020EN)" />
    <name value="zib MedicationUse2-v1.1.1(2020EN)" />
  </mapping>
  <mapping>
    <identity value="HdBe-MedicationUse2" />
    <uri value="https://fhir.healthdata.be/StructureDefinition/LogicalModel/HdBe-MedicationUse2" />
    <name value="HdBe logical model MedicationUse2" />
  </mapping>
  <mapping>
    <identity value="HdBe-InstructionsForUse" />
    <uri value="https://fhir.healthdata.be/StructureDefinition/LogicalModel/HdBe-InstructionsForUse" />
    <name value="HdBe logical model InstructionsForUse" />
  </mapping>
  <kind value="resource" />
  <abstract value="false" />
  <type value="MedicationStatement" />
  <baseDefinition value="http://hl7.org/fhir/StructureDefinition/MedicationStatement" />
  <derivation value="constraint" />
  <snapshot>
    <element id="MedicationStatement">
      <path value="MedicationStatement" />
      <short value="MedicationUse" />
      <definition value="A record of a medication that is being consumed by a patient.   A MedicationStatement may indicate that the patient may be taking the medication now, or has taken the medication in the past or will be taking the medication in the future.  The source of this information can be the patient, significant other (such as a family member or spouse), or a clinician.  A common scenario where this information is captured is during the history taking process during a patient visit or stay.   The medication information may come from sources such as the patient's memory, from a prescription bottle,  or from a list of medications the patient, clinician or other party maintains &#xD;&#xD;The primary difference between a medication statement and a medication administration is that the medication administration has complete administration information and is based on actual administration information from the person who administered the medication.  A medication statement is often, if not always, less specific.  There is no required date/time when the medication was administered, in fact we only know that a source has reported the patient is taking this medication, where details such as time, quantity, or rate or even medication product may be incomplete or missing or less precise.  As stated earlier, the medication statement information may come from the patient's memory, from a prescription bottle or from a list of medications the patient, clinician or other party maintains.  Medication administration is more formal and is not missing detailed information." />
      <comment value="When interpreting a medicationStatement, the value of the status and NotTaken needed to be considered:&#xD;MedicationStatement.status + MedicationStatement.wasNotTaken&#xD;* Status=Active + NotTaken=T = Not currently taking&#xD;* Status=Completed + NotTaken=T = Not taken in the past&#xD;* Status=Intended + NotTaken=T = No intention of taking&#xD;* Status=Active + NotTaken=F = Taking, but not as prescribed&#xD;* Status=Active + NotTaken=F = Taking&#xD;* Status=Intended +NotTaken= F = Will be taking (not started)&#xD;* Status=Completed + NotTaken=F = Taken in past&#xD;* Status=In Error + NotTaken=N/A = In Error." />
      <alias value="MedicatieGebruik" />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="MedicationStatement" />
        <min value="0" />
        <max value="*" />
      </base>
      <constraint>
        <key value="dom-2" />
        <severity value="error" />
        <human value="If the resource is contained in another resource, it SHALL NOT contain nested Resources" />
        <expression value="contained.contained.empty()" />
        <xpath value="not(parent::f:contained and f:contained)" />
        <source value="http://hl7.org/fhir/StructureDefinition/DomainResource" />
      </constraint>
      <constraint>
        <key value="dom-1" />
        <severity value="error" />
        <human value="If the resource is contained in another resource, it SHALL NOT contain any narrative" />
        <expression value="contained.text.empty()" />
        <xpath value="not(parent::f:contained and f:text)" />
        <source value="http://hl7.org/fhir/StructureDefinition/DomainResource" />
      </constraint>
      <constraint>
        <key value="dom-4" />
        <severity value="error" />
        <human value="If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated" />
        <expression value="contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()" />
        <xpath value="not(exists(f:contained/*/f:meta/f:versionId)) and not(exists(f:contained/*/f:meta/f:lastUpdated))" />
        <source value="http://hl7.org/fhir/StructureDefinition/DomainResource" />
      </constraint>
      <constraint>
        <key value="dom-3" />
        <severity value="error" />
        <human value="If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource" />
        <expression value="contained.where(('#'+id in %resource.descendants().reference).not()).empty()" />
        <xpath value="not(exists(for $id in f:contained/*/@id return $id[not(ancestor::f:contained/parent::*/descendant::f:reference/@value=concat('#', $id))]))" />
        <source value="http://hl7.org/fhir/StructureDefinition/DomainResource" />
      </constraint>
      <constraint>
        <key value="mst-1" />
        <severity value="error" />
        <human value="Reason not taken is only permitted if Taken is No" />
        <expression value="reasonNotTaken.exists().not() or (taken = 'n')" />
        <xpath value="not(exists(f:reasonNotTaken)) or f:taken/@value='n'" />
        <source value="http://hl7.org/fhir/StructureDefinition/MedicationStatement" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="Entity. Role, or Act" />
      </mapping>
      <mapping>
        <identity value="workflow" />
        <map value="..Event" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="SubstanceAdministration" />
      </mapping>
      <mapping>
        <identity value="w5" />
        <map value="clinical.medication" />
      </mapping>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.21338" />
        <comment value="MedicationUse" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2" />
      </mapping>
    </element>
    <element id="MedicationStatement.id">
      <path value="MedicationStatement.id" />
      <short value="Logical id of this artifact" />
      <definition value="The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes." />
      <comment value="The only time that a resource does not have an id is when it is being submitted to the server using a create operation." />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="Resource.id" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="id" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <isSummary value="true" />
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
    </element>
    <element id="MedicationStatement.meta">
      <path value="MedicationStatement.meta" />
      <short value="Metadata about the resource" />
      <definition value="The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content may not always be associated with version changes to the resource." />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="Resource.meta" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="Meta" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <isSummary value="true" />
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.implicitRules">
      <path value="MedicationStatement.implicitRules" />
      <short value="A set of rules under which this content was created" />
      <definition value="A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content." />
      <comment value="Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. &#xA;&#xA;This element is labelled as a modifier because the implicit rules may provide additional knowledge about the resource that modifies it's meaning or interpretation." />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="Resource.implicitRules" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="uri" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <isModifier value="true" />
      <isSummary value="true" />
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
    </element>
    <element id="MedicationStatement.language">
      <path value="MedicationStatement.language" />
      <short value="Language of the resource content" />
      <definition value="The base language in which the resource is written." />
      <comment value="Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies  to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource  Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute)." />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="Resource.language" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="code" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <binding>
        <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-maxValueSet">
          <valueReference>
            <reference value="http://hl7.org/fhir/ValueSet/all-languages" />
          </valueReference>
        </extension>
        <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="Language" />
        </extension>
        <strength value="extensible" />
        <description value="A human language." />
      </binding>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
    </element>
    <element id="MedicationStatement.text">
      <path value="MedicationStatement.text" />
      <short value="Text summary of the resource, for human interpretation" />
      <definition value="A human-readable narrative that contains a summary of the resource, and may be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it &quot;clinically safe&quot; for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety." />
      <comment value="Contained resources do not have narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied).  This may be necessary for data from legacy systems where information is captured as a &quot;text blob&quot; or where text is additionally entered raw or narrated and encoded in formation is added later." />
      <alias value="narrative" />
      <alias value="html" />
      <alias value="xhtml" />
      <alias value="display" />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="DomainResource.text" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="Narrative" />
      </type>
      <condition value="ele-1" />
      <condition value="dom-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="Act.text?" />
      </mapping>
    </element>
    <element id="MedicationStatement.contained">
      <path value="MedicationStatement.contained" />
      <short value="Contained, inline Resources" />
      <definition value="These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, and nor can they have their own independent transaction scope." />
      <comment value="This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again." />
      <alias value="inline resources" />
      <alias value="anonymous resources" />
      <alias value="contained resources" />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="DomainResource.contained" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Resource" />
      </type>
      <mapping>
        <identity value="rim" />
        <map value="Entity. Role, or Act" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension">
      <path value="MedicationStatement.extension" />
      <slicing>
        <discriminator>
          <type value="value" />
          <path value="url" />
        </discriminator>
        <description value="Extensions are always sliced by (at least) url" />
        <rules value="open" />
      </slicing>
      <short value="Additional Content defined by implementations" />
      <definition value="May be used to represent additional information that is not part of the basic definition of the resource. In order to make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
      <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
      <alias value="extensions" />
      <alias value="user content" />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="DomainResource.extension" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Extension" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ext-1" />
        <severity value="error" />
        <human value="Must have either extensions or value[x], not both" />
        <expression value="extension.exists() != value.exists()" />
        <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension:renderedDosageInstruction">
      <path value="MedicationStatement.extension" />
      <sliceName value="renderedDosageInstruction" />
      <short value="Optional Extensions Element" />
      <definition value="Pre-adopt from FHIR R5 of the `.renderedDosageInstruction` element found in various medication resources." />
      <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
      <alias value="extensions" />
      <alias value="user content" />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="DomainResource.extension" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Extension" />
        <profile value="https://fhir.healthdata.be/StructureDefinition/ext-RenderedDosageInstruction" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ext-1" />
        <severity value="error" />
        <human value="Must have either extensions or value[x], not both" />
        <expression value="extension.exists() != value.exists()" />
        <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension:renderedDosageInstruction.id">
      <path value="MedicationStatement.extension.id" />
      <representation value="xmlAttr" />
      <short value="xml:id (or equivalent in JSON)" />
      <definition value="unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." />
      <comment value="Note that FHIR strings may not exceed 1MB in size" />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="Element.id" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="string" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension:renderedDosageInstruction.extension">
      <path value="MedicationStatement.extension.extension" />
      <slicing>
        <discriminator>
          <type value="value" />
          <path value="url" />
        </discriminator>
        <description value="Extensions are always sliced by (at least) url" />
        <rules value="open" />
      </slicing>
      <short value="Additional Content defined by implementations" />
      <definition value="May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
      <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
      <alias value="extensions" />
      <alias value="user content" />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="Element.extension" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Extension" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ext-1" />
        <severity value="error" />
        <human value="Must have either extensions or value[x], not both" />
        <expression value="extension.exists() != value.exists()" />
        <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension:renderedDosageInstruction.url">
      <path value="MedicationStatement.extension.url" />
      <representation value="xmlAttr" />
      <short value="identifies the meaning of the extension" />
      <definition value="Source of the definition for the extension code - a logical name or a URL." />
      <comment value="The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension." />
      <min value="1" />
      <max value="1" />
      <base>
        <path value="Extension.url" />
        <min value="1" />
        <max value="1" />
      </base>
      <type>
        <code value="uri" />
      </type>
      <fixedUri value="https://fhir.healthdata.be/StructureDefinition/ext-RenderedDosageInstruction" />
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension:renderedDosageInstruction.value[x]">
      <path value="MedicationStatement.extension.value[x]" />
      <short value="Value of extension" />
      <definition value="The full representation of the dose of the medication included in all dosage instructions. To be used when multiple dosage instructions are included to represent complex dosing such as increasing or tapering doses." />
      <comment value="The content of the renderedDosageInstructions must not be different than the dose represented in the dosageInstruction content." />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="Extension.value[x]" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="string" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
      <mapping>
        <identity value="HdBe-InstructionsForUse" />
        <map value="InstructionsForUse.Description" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension:prescriber">
      <path value="MedicationStatement.extension" />
      <sliceName value="prescriber" />
      <short value="Optional Extensions Element" />
      <definition value="Optional Extension Element - found in all resources." />
      <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
      <alias value="extensions" />
      <alias value="user content" />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="DomainResource.extension" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Extension" />
        <profile value="https://fhir.healthdata.be/StructureDefinition/ext-MedicationUse2.Prescriber" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ext-1" />
        <severity value="error" />
        <human value="Must have either extensions or value[x], not both" />
        <expression value="extension.exists() != value.exists()" />
        <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension:prescriber.id">
      <path value="MedicationStatement.extension.id" />
      <representation value="xmlAttr" />
      <short value="xml:id (or equivalent in JSON)" />
      <definition value="unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." />
      <comment value="Note that FHIR strings may not exceed 1MB in size" />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="Element.id" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="string" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension:prescriber.extension">
      <path value="MedicationStatement.extension.extension" />
      <slicing>
        <discriminator>
          <type value="value" />
          <path value="url" />
        </discriminator>
        <description value="Extensions are always sliced by (at least) url" />
        <rules value="open" />
      </slicing>
      <short value="Additional Content defined by implementations" />
      <definition value="May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
      <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
      <alias value="extensions" />
      <alias value="user content" />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="Element.extension" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Extension" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ext-1" />
        <severity value="error" />
        <human value="Must have either extensions or value[x], not both" />
        <expression value="extension.exists() != value.exists()" />
        <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension:prescriber.url">
      <path value="MedicationStatement.extension.url" />
      <representation value="xmlAttr" />
      <short value="identifies the meaning of the extension" />
      <definition value="Source of the definition for the extension code - a logical name or a URL." />
      <comment value="The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension." />
      <min value="1" />
      <max value="1" />
      <base>
        <path value="Extension.url" />
        <min value="1" />
        <max value="1" />
      </base>
      <type>
        <code value="uri" />
      </type>
      <fixedUri value="https://fhir.healthdata.be/StructureDefinition/ext-MedicationUse2.Prescriber" />
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension:prescriber.value[x]">
      <path value="MedicationStatement.extension.value[x]" />
      <short value="Prescriber" />
      <definition value="The health professional that entered the medication agreement with the patient." />
      <comment value="Each occurrence of the CBB HealthProfessional is normally represented by _two_ FHIR resources: a PractitionerRole resource (instance of [HdBe-HealthProfessional-PractitionerRole](https://fhir.healthdata.be/StructureDefinition/HdBe-HealthProfessional-PractitionerRole)) and a Practitioner resource (instance of [HdBe-HealthProfessional-Practitioner](https://fhir.healthdata.be/StructureDefinition/HdBe-HealthProfessional-Practitioner)). The Practitioner resource is referenced from the PractitionerRole instance. For this reason, sending systems should fill the reference to the PractitionerRole instance here, and not the Practitioner resource." />
      <alias value="Voorschrijver" />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="Extension.value[x]" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="Reference" />
        <profile value="https://fhir.healthdata.be/StructureDefinition/pattern-HealthProfessionalReference" />
        <targetProfile value="https://fhir.healthdata.be/StructureDefinition/HdBe-HealthProfessional-PractitionerRole" />
        <targetProfile value="https://fhir.healthdata.be/StructureDefinition/HdBe-HealthProfessional-Practitioner" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ref-1" />
        <severity value="error" />
        <human value="SHALL have a contained resource if a local reference is provided" />
        <expression value="reference.startsWith('#').not() or (reference.substring(1).trace('url') in %resource.contained.id.trace('ids'))" />
        <xpath value="not(starts-with(f:reference/@value, '#')) or exists(ancestor::*[self::f:entry or self::f:parameter]/f:resource/f:*/f:contained/f:*[f:id/@value=substring-after(current()/f:reference/@value, '#')]|/*/f:contained/f:*[f:id/@value=substring-after(current()/f:reference/@value, '#')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Reference" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="The target of a resource reference is a RIM entry point (Act, Role, or Entity)" />
      </mapping>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.23290" />
        <comment value="Prescriber" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.Prescriber" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension:asAgreedIndicator">
      <path value="MedicationStatement.extension" />
      <sliceName value="asAgreedIndicator" />
      <short value="Optional Extensions Element" />
      <definition value="Optional Extension Element - found in all resources." />
      <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
      <alias value="extensions" />
      <alias value="user content" />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="DomainResource.extension" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Extension" />
        <profile value="https://fhir.healthdata.be/StructureDefinition/ext-MedicationUse2.AsAgreedIndicator" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ext-1" />
        <severity value="error" />
        <human value="Must have either extensions or value[x], not both" />
        <expression value="extension.exists() != value.exists()" />
        <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension:asAgreedIndicator.id">
      <path value="MedicationStatement.extension.id" />
      <representation value="xmlAttr" />
      <short value="xml:id (or equivalent in JSON)" />
      <definition value="unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." />
      <comment value="Note that FHIR strings may not exceed 1MB in size" />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="Element.id" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="string" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension:asAgreedIndicator.extension">
      <path value="MedicationStatement.extension.extension" />
      <slicing>
        <discriminator>
          <type value="value" />
          <path value="url" />
        </discriminator>
        <description value="Extensions are always sliced by (at least) url" />
        <rules value="open" />
      </slicing>
      <short value="Additional Content defined by implementations" />
      <definition value="May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
      <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
      <alias value="extensions" />
      <alias value="user content" />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="Element.extension" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Extension" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ext-1" />
        <severity value="error" />
        <human value="Must have either extensions or value[x], not both" />
        <expression value="extension.exists() != value.exists()" />
        <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension:asAgreedIndicator.url">
      <path value="MedicationStatement.extension.url" />
      <representation value="xmlAttr" />
      <short value="identifies the meaning of the extension" />
      <definition value="Source of the definition for the extension code - a logical name or a URL." />
      <comment value="The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension." />
      <min value="1" />
      <max value="1" />
      <base>
        <path value="Extension.url" />
        <min value="1" />
        <max value="1" />
      </base>
      <type>
        <code value="uri" />
      </type>
      <fixedUri value="https://fhir.healthdata.be/StructureDefinition/ext-MedicationUse2.AsAgreedIndicator" />
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension:asAgreedIndicator.value[x]">
      <path value="MedicationStatement.extension.value[x]" />
      <short value="AsAgreedIndicator" />
      <definition value="Is the medicine used as outlined in the medication agreement?" />
      <alias value="VolgensAfspraakIndicator" />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="Extension.value[x]" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="boolean" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.22492" />
        <comment value="AsAgreedIndicator" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.AsAgreedIndicator" />
      </mapping>
    </element>
    <element id="MedicationStatement.modifierExtension">
      <path value="MedicationStatement.modifierExtension" />
      <slicing>
        <discriminator>
          <type value="value" />
          <path value="url" />
        </discriminator>
        <description value="Extensions are always sliced by (at least) url" />
        <rules value="open" />
      </slicing>
      <short value="Extensions that cannot be ignored" />
      <definition value="May be used to represent additional information that is not part of the basic definition of the resource, and that modifies the understanding of the element that contains it. Usually modifier elements provide negation or qualification. In order to make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions." />
      <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
      <alias value="extensions" />
      <alias value="user content" />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="DomainResource.modifierExtension" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Extension" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ext-1" />
        <severity value="error" />
        <human value="Must have either extensions or value[x], not both" />
        <expression value="extension.exists() != value.exists()" />
        <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
      </constraint>
      <isModifier value="true" />
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.modifierExtension:stopType">
      <path value="MedicationStatement.modifierExtension" />
      <sliceName value="stopType" />
      <short value="Optional Extensions Element" />
      <definition value="This StopType ModifierExtension works differently than the `.status` element of resources because it has a different meaning. The `.status` element represents the status of the resource at the moment of exchanging the resource. This means that over the lifetime of a resource, the status may change (and is very much related to use period). That – in itself – makes mapping StopType (which may never change in an instance) to status not suitable.&#xD;&#xA;&#xD;&#xA;For example: suppose you want the patient to stop taking medication definitively three days from today. This is a stop medication agreement with a StopType of _definitive_. However today, tomorrow and the day after tomorrow the `.status` of this medication agreement is _active_ and only after the end date of the usage period the `status` should be _stopped_. Status and StopType are simply not the same thing." />
      <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
      <alias value="extensions" />
      <alias value="user content" />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="DomainResource.modifierExtension" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Extension" />
        <profile value="https://fhir.healthdata.be/StructureDefinition/ext-StopType" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ext-1" />
        <severity value="error" />
        <human value="Must have either extensions or value[x], not both" />
        <expression value="extension.exists() != value.exists()" />
        <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
      </constraint>
      <isModifier value="true" />
      <isModifierReason value="This element is labeled as a modifier because the stoptype contain codes that mark the resource as no longer active." />
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.modifierExtension:stopType.id">
      <path value="MedicationStatement.modifierExtension.id" />
      <representation value="xmlAttr" />
      <short value="xml:id (or equivalent in JSON)" />
      <definition value="unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." />
      <comment value="Note that FHIR strings may not exceed 1MB in size" />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="Element.id" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="string" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
    </element>
    <element id="MedicationStatement.modifierExtension:stopType.extension">
      <path value="MedicationStatement.modifierExtension.extension" />
      <slicing>
        <discriminator>
          <type value="value" />
          <path value="url" />
        </discriminator>
        <description value="Extensions are always sliced by (at least) url" />
        <rules value="open" />
      </slicing>
      <short value="Additional Content defined by implementations" />
      <definition value="May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
      <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
      <alias value="extensions" />
      <alias value="user content" />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="Element.extension" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Extension" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ext-1" />
        <severity value="error" />
        <human value="Must have either extensions or value[x], not both" />
        <expression value="extension.exists() != value.exists()" />
        <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.modifierExtension:stopType.url">
      <path value="MedicationStatement.modifierExtension.url" />
      <representation value="xmlAttr" />
      <short value="identifies the meaning of the extension" />
      <definition value="Source of the definition for the extension code - a logical name or a URL." />
      <comment value="The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension." />
      <min value="1" />
      <max value="1" />
      <base>
        <path value="Extension.url" />
        <min value="1" />
        <max value="1" />
      </base>
      <type>
        <code value="uri" />
      </type>
      <fixedUri value="https://fhir.healthdata.be/StructureDefinition/ext-StopType" />
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.modifierExtension:stopType.value[x]">
      <path value="MedicationStatement.modifierExtension.value[x]" />
      <short value="MedicationUseStopType" />
      <definition value="Stop type, the manner in which this medication is discontinued (temporary or definitive)." />
      <comment value="MedicationAgreementStopType, AdministrationAgreementStopType and MedicationUseStopType all have a bound ValueSet that contain the exact same StopType values. These are represented in the CBB with the same Valueset. This MedicationStopType is used to bind  to this extension and reusing this extension for all three concepts." />
      <alias value="MedicatieGebruikStopType" />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="Extension.value[x]" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="CodeableConcept" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <binding>
        <strength value="required" />
        <description value="StopType values, based on the valueset named MedicatioStopType, which are applicable for StopType in MedicationAgreement, AdministrationAgreement and MedicationUse." />
        <valueSet value="https://fhir.healthdata.be/ValueSet/MedicationStopType" />
      </binding>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.23132" />
        <comment value="MedicationUseStopType" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.MedicationUseStopType" />
      </mapping>
    </element>
    <element id="MedicationStatement.modifierExtension:repeatPeriodCyclicalSchedule">
      <path value="MedicationStatement.modifierExtension" />
      <sliceName value="repeatPeriodCyclicalSchedule" />
      <short value="Optional Extensions Element" />
      <definition value="Optional Extension Element - found in all resources." />
      <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
      <alias value="extensions" />
      <alias value="user content" />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="DomainResource.modifierExtension" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Extension" />
        <profile value="https://fhir.healthdata.be/StructureDefinition/ext-InstructionsForUse.RepeatPeriodCyclicalSchedule" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ext-1" />
        <severity value="error" />
        <human value="Must have either extensions or value[x], not both" />
        <expression value="extension.exists() != value.exists()" />
        <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
      </constraint>
      <isModifier value="true" />
      <isModifierReason value="The dosage instructions are interperted differently if RepeatPeriodCyclicalSchedule is present. Therorefore this extension is labeld a as a modifier extension." />
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.modifierExtension:repeatPeriodCyclicalSchedule.id">
      <path value="MedicationStatement.modifierExtension.id" />
      <representation value="xmlAttr" />
      <short value="xml:id (or equivalent in JSON)" />
      <definition value="unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." />
      <comment value="Note that FHIR strings may not exceed 1MB in size" />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="Element.id" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="string" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
    </element>
    <element id="MedicationStatement.modifierExtension:repeatPeriodCyclicalSchedule.extension">
      <path value="MedicationStatement.modifierExtension.extension" />
      <slicing>
        <discriminator>
          <type value="value" />
          <path value="url" />
        </discriminator>
        <description value="Extensions are always sliced by (at least) url" />
        <rules value="open" />
      </slicing>
      <short value="Additional Content defined by implementations" />
      <definition value="May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
      <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
      <alias value="extensions" />
      <alias value="user content" />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="Element.extension" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Extension" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ext-1" />
        <severity value="error" />
        <human value="Must have either extensions or value[x], not both" />
        <expression value="extension.exists() != value.exists()" />
        <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.modifierExtension:repeatPeriodCyclicalSchedule.url">
      <path value="MedicationStatement.modifierExtension.url" />
      <representation value="xmlAttr" />
      <short value="identifies the meaning of the extension" />
      <definition value="Source of the definition for the extension code - a logical name or a URL." />
      <comment value="The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension." />
      <min value="1" />
      <max value="1" />
      <base>
        <path value="Extension.url" />
        <min value="1" />
        <max value="1" />
      </base>
      <type>
        <code value="uri" />
      </type>
      <fixedUri value="https://fhir.healthdata.be/StructureDefinition/ext-InstructionsForUse.RepeatPeriodCyclicalSchedule" />
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.modifierExtension:repeatPeriodCyclicalSchedule.value[x]">
      <path value="MedicationStatement.modifierExtension.value[x]" />
      <short value="RepeatPeriodCyclicalSchedule" />
      <definition value="The repeated period in a cyclical schedule (of one or more dosing instructions). A cyclic schedule is noted in days, the corresponding dosing duration is also in days.&#xD;&#xA;&#xD;&#xA;Examples of a cyclical schedule:  &#xD;&#xA;contraceptive pill (21 days, 1 pill 1x a day, then skip for 7 days, repeat), repeat period here is 28 days" />
      <alias value="HerhaalperiodeCyclischSchema" />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="Extension.value[x]" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="Duration" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
      <mapping>
        <identity value="zib-instructionsforuse-v1.2.1-2020EN" />
        <map value="NL-CM:9.12.22505" />
        <comment value="RepeatPeriodCyclicalSchedule" />
      </mapping>
      <mapping>
        <identity value="HdBe-InstructionsForUse" />
        <map value="InstructionsForUse.RepeatPeriodCyclicalSchedule" />
      </mapping>
    </element>
    <element id="MedicationStatement.identifier">
      <path value="MedicationStatement.identifier" />
      <short value="External identifier" />
      <definition value="External identifier - FHIR will generate its own internal identifiers (probably URLs) which do not need to be explicitly managed by the resource.  The identifier here is one that would be used by another non-FHIR system - for example an automated medication pump would provide a record each time it operated; an administration while the patient was off the ward might be made with a different system and entered after the event.  Particularly important if these records have to be updated." />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="MedicationStatement.identifier" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Identifier" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <isSummary value="true" />
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="v2" />
        <map value="CX / EI (occasionally, more often EI maps to a resource id or a URL)" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="II - see see identifier pattern at http://wiki.hl7.org/index.php?title=Common_Design_Patterns#Identifier_Pattern for relevant discussion. The Identifier class is a little looser than the v3 type II because it allows URIs as well as registered OIDs or GUIDs.  Also maps to Role[classCode=IDENT]" />
      </mapping>
      <mapping>
        <identity value="servd" />
        <map value="Identifier" />
      </mapping>
      <mapping>
        <identity value="workflow" />
        <map value="…identifer" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".id" />
      </mapping>
      <mapping>
        <identity value="w5" />
        <map value="id" />
      </mapping>
    </element>
    <element id="MedicationStatement.basedOn">
      <path value="MedicationStatement.basedOn" />
      <short value="Fulfils plan, proposal or order" />
      <definition value="A plan, proposal or order that is fulfilled in whole or in part by this event." />
      <comment value="References SHALL be a reference to an actual FHIR resource, and SHALL be resolveable (allowing for access control, temporary unavailability, etc). Resolution can be either by retrieval from the URL, or, where applicable by resource type, by treating an absolute reference as a canonical URL and looking it up in a local registry/repository." />
      <requirements value="Allows tracing of authorization for the event and tracking whether proposals/recommendations were acted upon." />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="MedicationStatement.basedOn" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/MedicationRequest" />
      </type>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/CarePlan" />
      </type>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/ProcedureRequest" />
      </type>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/ReferralRequest" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ref-1" />
        <severity value="error" />
        <human value="SHALL have a contained resource if a local reference is provided" />
        <expression value="reference.startsWith('#').not() or (reference.substring(1).trace('url') in %resource.contained.id.trace('ids'))" />
        <xpath value="not(starts-with(f:reference/@value, '#')) or exists(ancestor::*[self::f:entry or self::f:parameter]/f:resource/f:*/f:contained/f:*[f:id/@value=substring-after(current()/f:reference/@value, '#')]|/*/f:contained/f:*[f:id/@value=substring-after(current()/f:reference/@value, '#')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Reference" />
      </constraint>
      <isSummary value="true" />
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="The target of a resource reference is a RIM entry point (Act, Role, or Entity)" />
      </mapping>
      <mapping>
        <identity value="workflow" />
        <map value="…basedOn" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".outboundRelationship[typeCode=FLFS].target[classCode=SBADM or PROC or PCPR or OBS, moodCode=RQO orPLAN or PRP]" />
      </mapping>
    </element>
    <element id="MedicationStatement.partOf">
      <path value="MedicationStatement.partOf" />
      <short value="Part of referenced event" />
      <definition value="A larger event of which this particular event is a component or step." />
      <comment value="References SHALL be a reference to an actual FHIR resource, and SHALL be resolveable (allowing for access control, temporary unavailability, etc). Resolution can be either by retrieval from the URL, or, where applicable by resource type, by treating an absolute reference as a canonical URL and looking it up in a local registry/repository." />
      <requirements value="This should not be used when indicating which resource a MedicationStatement has been derived from.  If that is the use case, then MedicationStatement.derivedFrom should be used." />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="MedicationStatement.partOf" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/MedicationAdministration" />
      </type>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/MedicationDispense" />
      </type>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/MedicationStatement" />
      </type>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Procedure" />
      </type>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Observation" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ref-1" />
        <severity value="error" />
        <human value="SHALL have a contained resource if a local reference is provided" />
        <expression value="reference.startsWith('#').not() or (reference.substring(1).trace('url') in %resource.contained.id.trace('ids'))" />
        <xpath value="not(starts-with(f:reference/@value, '#')) or exists(ancestor::*[self::f:entry or self::f:parameter]/f:resource/f:*/f:contained/f:*[f:id/@value=substring-after(current()/f:reference/@value, '#')]|/*/f:contained/f:*[f:id/@value=substring-after(current()/f:reference/@value, '#')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Reference" />
      </constraint>
      <isSummary value="true" />
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="The target of a resource reference is a RIM entry point (Act, Role, or Entity)" />
      </mapping>
      <mapping>
        <identity value="workflow" />
        <map value="…part of" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".outboundRelationship[typeCode=COMP]/target[classCode=SPLY or SBADM or PROC or OBS,moodCode=EVN]" />
      </mapping>
    </element>
    <element id="MedicationStatement.context">
      <path value="MedicationStatement.context" />
      <short value="Encounter / Episode associated with MedicationStatement" />
      <definition value="The encounter or episode of care that establishes the context for this MedicationStatement." />
      <comment value="References SHALL be a reference to an actual FHIR resource, and SHALL be resolveable (allowing for access control, temporary unavailability, etc). Resolution can be either by retrieval from the URL, or, where applicable by resource type, by treating an absolute reference as a canonical URL and looking it up in a local registry/repository." />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="MedicationStatement.context" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Encounter" />
      </type>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/EpisodeOfCare" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ref-1" />
        <severity value="error" />
        <human value="SHALL have a contained resource if a local reference is provided" />
        <expression value="reference.startsWith('#').not() or (reference.substring(1).trace('url') in %resource.contained.id.trace('ids'))" />
        <xpath value="not(starts-with(f:reference/@value, '#')) or exists(ancestor::*[self::f:entry or self::f:parameter]/f:resource/f:*/f:contained/f:*[f:id/@value=substring-after(current()/f:reference/@value, '#')]|/*/f:contained/f:*[f:id/@value=substring-after(current()/f:reference/@value, '#')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Reference" />
      </constraint>
      <isSummary value="true" />
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="The target of a resource reference is a RIM entry point (Act, Role, or Entity)" />
      </mapping>
      <mapping>
        <identity value="workflow" />
        <map value="…context" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".inboundRelationship[typeCode=COMP].source[classCode=ENC, moodCode=EVN, code=&quot;type of encounter or episode&quot;]" />
      </mapping>
    </element>
    <element id="MedicationStatement.status">
      <path value="MedicationStatement.status" />
      <short value="UseIndicator / MedicationUseStopType / PeriodOfUse" />
      <definition value="Status may contain information on the stop type, the manner in which this medication is discontinued (temporary or definitive) and if the medicine is used or not." />
      <comment value="This element is mapped to the CBB concept UseIndicator and implicitly to MedicationUseStopType and PeriodOfUse. Unless a more appropriate status is recorded, the following guidance applies:&#xD;&#xA;&#xD;&#xA;* When MedicationUseStopType has no value and UseIndicator is _true_, `.status` will usually be set to _active_.&#xD;&#xA;* When UseIndicator is _false_, `.status` will be set to _not-taken_.&#xD;&#xA;* When MedicationUseStopType is _14803004_, `.status` will usually be set to _on-hold_.&#xD;&#xA;* When MedicationUseStopType is _255545003_, `.status` will usually be set to _stopped_.&#xD;&#xA;* When PeriodOfUse start date is in the past and PeriodOfUse end date is present and in the future, `.status` will usually be set to _active_.&#xD;&#xA;* When PeriodOfUse end date has a value and in the past, `.status` will usually be set to _completed_.&#xD;&#xA;* When PeriodOfUse duration and start date are known, the end date can be deducted and the previous rules apply. &#xD;&#xA;* When a system is unable to infer the status, `.status` will be set to _unknown_. The _unknown_ code is not to be used to convey other statuses. The _unknown_ code should be used when one of the statuses applies, but the authoring system doesn't know the current state of the MedicationStatement." />
      <alias value="MedicatieGebruikStopType" />
      <alias value="GebruikIndicator" />
      <alias value="Gebruiksperiode" />
      <min value="1" />
      <max value="1" />
      <base>
        <path value="MedicationStatement.status" />
        <min value="1" />
        <max value="1" />
      </base>
      <type>
        <code value="code" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <isModifier value="true" />
      <isSummary value="true" />
      <binding>
        <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="MedicationStatementStatus" />
        </extension>
        <strength value="required" />
        <description value="Use ConceptMap 'MedicationStopType-to-MedicationStatementStatus' to translate CBB terminology to profile terminology in ValueSet 'Medication Status Codes'." />
        <valueSet value="http://hl7.org/fhir/ValueSet/medication-statement-status|4.0.1">
          <extension url="http://hl7.org/fhir/StructureDefinition/11179-permitted-value-conceptmap">
            <valueCanonical value="https://fhir.healthdata.be/ConceptMap/MedicationStopType-to-MedicationStatementStatus" />
          </extension>
        </valueSet>
      </binding>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="workflow" />
        <map value="…status" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".statusCode" />
      </mapping>
      <mapping>
        <identity value="w5" />
        <map value="status" />
      </mapping>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.22399" />
        <comment value="UseIndicator" />
      </mapping>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.23132" />
        <comment value="MedicationUseStopType (implicit, main mapping is on the modifier extension ext-StopType)" />
      </mapping>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.22663" />
        <comment value="PeriodOfUse (implicit, main mapping is on `.effective[x]:effectivePeriod` and extension ext-TimeInterval.Duration)" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.UseIndicator" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.MedicationUseStopType" />
        <comment value="implicit, main mapping is on the modifier extension ext-StopType" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.PeriodOfUse" />
        <comment value="implicit, main mapping is on `.effective[x]:effectivePeriod` and extension ext-TimeInterval.Duration" />
      </mapping>
    </element>
    <element id="MedicationStatement.category">
      <path value="MedicationStatement.category" />
      <short value="Type of medication usage" />
      <definition value="Indicates where type of medication statement and where the medication is expected to be consumed or administered." />
      <comment value="Not all terminology uses fit this general pattern. In some cases, models should not use CodeableConcept and use Coding directly and provide their own structure for managing text, codings, translations and the relationship between elements and pre- and post-coordination." />
      <min value="1" />
      <max value="1" />
      <base>
        <path value="MedicationStatement.category" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="CodeableConcept" />
      </type>
      <patternCodeableConcept>
        <coding>
          <system value="http://snomed.info/sct" />
          <code value="422979000" />
        </coding>
      </patternCodeableConcept>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <isSummary value="true" />
      <binding>
        <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="MedicationStatementCategory" />
        </extension>
        <strength value="preferred" />
        <description value="A coded concept identifying where the medication included in the medicationstatement is expected to be consumed or administered" />
      </binding>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="v2" />
        <map value="CE/CNE/CWE" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="CD" />
      </mapping>
      <mapping>
        <identity value="orim" />
        <map value="fhir:CodeableConcept rdfs:subClassOf dt:CD" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".inboundRelationship[typeCode=COMP].source[classCode=OBS, moodCode=EVN, code=&quot;type of medication usage&quot;].value" />
      </mapping>
      <mapping>
        <identity value="w5" />
        <map value="class" />
      </mapping>
    </element>
    <element id="MedicationStatement.medication[x]">
      <path value="MedicationStatement.medication[x]" />
      <slicing>
        <discriminator>
          <type value="type" />
          <path value="$this" />
        </discriminator>
        <rules value="open" />
      </slicing>
      <short value="What medication was taken" />
      <definition value="Identifies the medication being administered. This is either a link to a resource representing the details of the medication or a simple attribute carrying a code that identifies the medication from a known list of medications." />
      <comment value="If only a code is specified, then it needs to be a code for a specific product. If more information is required, then the use of the medication resource is recommended.  For example if you require form or lot number, then you must reference the Medication resource. ." />
      <min value="1" />
      <max value="1" />
      <base>
        <path value="MedicationStatement.medication[x]" />
        <min value="1" />
        <max value="1" />
      </base>
      <type>
        <code value="CodeableConcept" />
      </type>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Medication" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <isSummary value="true" />
      <binding>
        <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="MedicationCode" />
        </extension>
        <strength value="example" />
        <description value="A coded concept identifying the substance or product being taken." />
      </binding>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="workflow" />
        <map value="…code" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".participation[typeCode=CSM].role[classCode=ADMM or MANU]" />
      </mapping>
      <mapping>
        <identity value="w5" />
        <map value="what" />
      </mapping>
    </element>
    <element id="MedicationStatement.medication[x]:medicationReference">
      <path value="MedicationStatement.medication[x]" />
      <sliceName value="medicationReference" />
      <short value="ProductUsed" />
      <definition value="The product used. This is usually medication. Food, blood products, aids and bandages do not strictly fall under the category of medication, but can be recorded as well.&#xD;&#xA;In principle, this will be the prescribed product, but the product used may differ from the prescribed product." />
      <comment value="If only a code is specified, then it needs to be a code for a specific product. If more information is required, then the use of the medication resource is recommended.  For example if you require form or lot number, then you must reference the Medication resource. ." />
      <alias value="Gebruiksproduct" />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="MedicationStatement.medication[x]" />
        <min value="1" />
        <max value="1" />
      </base>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Medication" />
        <targetProfile value="https://fhir.healthdata.be/StructureDefinition/HdBe-PharmaceuticalProduct" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <isSummary value="true" />
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="workflow" />
        <map value="…code" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".participation[typeCode=CSM].role[classCode=ADMM or MANU]" />
      </mapping>
      <mapping>
        <identity value="w5" />
        <map value="what" />
      </mapping>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.21339" />
        <comment value="ProductUsed" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.ProductUsed" />
      </mapping>
    </element>
    <element id="MedicationStatement.effective[x]">
      <path value="MedicationStatement.effective[x]" />
      <short value="The date/time or interval when the medication was taken" />
      <definition value="The interval of time during which it is being asserted that the patient was taking the medication (or was not taking, when the wasNotGiven element is true)." />
      <comment value="This attribute reflects the period over which the patient consumed the medication and is expected to be populated on the majority of Medication Statements. If the medication is still being taken at the time the statement is recorded, the &quot;end&quot; date will be omitted." />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="MedicationStatement.effective[x]" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="dateTime" />
      </type>
      <type>
        <code value="Period" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <isSummary value="true" />
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="workflow" />
        <map value="…occurrence[x]" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".effectiveTime" />
      </mapping>
      <mapping>
        <identity value="w5" />
        <map value="when.done" />
      </mapping>
    </element>
    <element id="MedicationStatement.dateAsserted">
      <path value="MedicationStatement.dateAsserted" />
      <short value="When the statement was asserted?" />
      <definition value="The date when the medication statement was asserted by the information source." />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="MedicationStatement.dateAsserted" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="dateTime" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <isSummary value="true" />
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".participation[typeCode=AUT].time" />
      </mapping>
      <mapping>
        <identity value="w5" />
        <map value="when.recorded" />
      </mapping>
    </element>
    <element id="MedicationStatement.informationSource">
      <path value="MedicationStatement.informationSource" />
      <short value="Person or organization that provided the information about the taking of this medication" />
      <definition value="The person or organization that provided the information about the taking of this medication. Note: Use derivedFrom when a MedicationStatement is derived from other resources, e.g Claim or MedicationRequest." />
      <comment value="References SHALL be a reference to an actual FHIR resource, and SHALL be resolveable (allowing for access control, temporary unavailability, etc). Resolution can be either by retrieval from the URL, or, where applicable by resource type, by treating an absolute reference as a canonical URL and looking it up in a local registry/repository." />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="MedicationStatement.informationSource" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Patient" />
      </type>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Practitioner" />
      </type>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/RelatedPerson" />
      </type>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Organization" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ref-1" />
        <severity value="error" />
        <human value="SHALL have a contained resource if a local reference is provided" />
        <expression value="reference.startsWith('#').not() or (reference.substring(1).trace('url') in %resource.contained.id.trace('ids'))" />
        <xpath value="not(starts-with(f:reference/@value, '#')) or exists(ancestor::*[self::f:entry or self::f:parameter]/f:resource/f:*/f:contained/f:*[f:id/@value=substring-after(current()/f:reference/@value, '#')]|/*/f:contained/f:*[f:id/@value=substring-after(current()/f:reference/@value, '#')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Reference" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="The target of a resource reference is a RIM entry point (Act, Role, or Entity)" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".participation[typeCode=INF].role[classCode=PAT, or codes for Practioner or Related Person (if PAT is the informer, then syntax for self-reported =true)" />
      </mapping>
      <mapping>
        <identity value="w5" />
        <map value="who.source" />
      </mapping>
    </element>
    <element id="MedicationStatement.subject">
      <path value="MedicationStatement.subject" />
      <short value="Who is/was taking  the medication" />
      <definition value="The person, animal or group who is/was taking the medication." />
      <comment value="References SHALL be a reference to an actual FHIR resource, and SHALL be resolveable (allowing for access control, temporary unavailability, etc). Resolution can be either by retrieval from the URL, or, where applicable by resource type, by treating an absolute reference as a canonical URL and looking it up in a local registry/repository." />
      <min value="1" />
      <max value="1" />
      <base>
        <path value="MedicationStatement.subject" />
        <min value="1" />
        <max value="1" />
      </base>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Group" />
        <targetProfile value="https://fhir.healthdata.be/StructureDefinition/HdBe-Patient" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ref-1" />
        <severity value="error" />
        <human value="SHALL have a contained resource if a local reference is provided" />
        <expression value="reference.startsWith('#').not() or (reference.substring(1).trace('url') in %resource.contained.id.trace('ids'))" />
        <xpath value="not(starts-with(f:reference/@value, '#')) or exists(ancestor::*[self::f:entry or self::f:parameter]/f:resource/f:*/f:contained/f:*[f:id/@value=substring-after(current()/f:reference/@value, '#')]|/*/f:contained/f:*[f:id/@value=substring-after(current()/f:reference/@value, '#')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Reference" />
      </constraint>
      <isSummary value="true" />
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="The target of a resource reference is a RIM entry point (Act, Role, or Entity)" />
      </mapping>
      <mapping>
        <identity value="workflow" />
        <map value="…subject" />
      </mapping>
      <mapping>
        <identity value="v2" />
        <map value="PID-3-Patient ID List" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".participation[typeCode=SBJ].role[classCode=PAT]" />
      </mapping>
      <mapping>
        <identity value="w5" />
        <map value="who" />
      </mapping>
    </element>
    <element id="MedicationStatement.derivedFrom">
      <path value="MedicationStatement.derivedFrom" />
      <short value="Additional supporting information" />
      <definition value="Allows linking the MedicationStatement to the underlying MedicationRequest, or to other information that supports or is used to derive the MedicationStatement." />
      <comment value="Likely references would be to MedicationRequest, MedicationDispense, Claim, Observation or QuestionnaireAnswers.  The most common use cases for deriving a MedicationStatement comes from creating a MedicationStatement from a MedicationRequest or from a lab observation or a claim.  it should be noted that the amount of information that is available varies from the type resource that you derive the MedicationStatement from." />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="MedicationStatement.derivedFrom" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Resource" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ref-1" />
        <severity value="error" />
        <human value="SHALL have a contained resource if a local reference is provided" />
        <expression value="reference.startsWith('#').not() or (reference.substring(1).trace('url') in %resource.contained.id.trace('ids'))" />
        <xpath value="not(starts-with(f:reference/@value, '#')) or exists(ancestor::*[self::f:entry or self::f:parameter]/f:resource/f:*/f:contained/f:*[f:id/@value=substring-after(current()/f:reference/@value, '#')]|/*/f:contained/f:*[f:id/@value=substring-after(current()/f:reference/@value, '#')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Reference" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="The target of a resource reference is a RIM entry point (Act, Role, or Entity)" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".outboundRelationship[typeCode=SPRT]/target[classCode=ACT,moodCode=EVN]" />
      </mapping>
    </element>
    <element id="MedicationStatement.taken">
      <path value="MedicationStatement.taken" />
      <short value="y | n | unk | na" />
      <definition value="Indicator of the certainty of whether the medication was taken by the patient." />
      <comment value="This element is labeled as a modifier because it indicates that the medication was not taken." />
      <min value="1" />
      <max value="1" />
      <base>
        <path value="MedicationStatement.taken" />
        <min value="1" />
        <max value="1" />
      </base>
      <type>
        <code value="code" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <isModifier value="true" />
      <isSummary value="true" />
      <binding>
        <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="MedicationStatementTaken" />
        </extension>
        <strength value="required" />
        <description value="A coded concept identifying level of certainty if patient has taken or has not taken the medication" />
      </binding>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="workflow" />
        <map value="…notDone" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".actionNegationInd" />
      </mapping>
    </element>
    <element id="MedicationStatement.reasonNotTaken">
      <path value="MedicationStatement.reasonNotTaken" />
      <short value="True if asserting medication was not given" />
      <definition value="A code indicating why the medication was not taken." />
      <comment value="Not all terminology uses fit this general pattern. In some cases, models should not use CodeableConcept and use Coding directly and provide their own structure for managing text, codings, translations and the relationship between elements and pre- and post-coordination." />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="MedicationStatement.reasonNotTaken" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="CodeableConcept" />
      </type>
      <condition value="ele-1" />
      <condition value="mst-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <binding>
        <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="MedicationStatementNotTakenReason" />
        </extension>
        <strength value="example" />
        <description value="A coded concept indicating the reason why the medication was not taken" />
      </binding>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="v2" />
        <map value="CE/CNE/CWE" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="CD" />
      </mapping>
      <mapping>
        <identity value="orim" />
        <map value="fhir:CodeableConcept rdfs:subClassOf dt:CD" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".outboundRelationship[typeCode=RSON]/target[classCode=OBS,moodCode=EVN, code=&quot;reason not taken&quot;].value" />
      </mapping>
    </element>
    <element id="MedicationStatement.reasonCode">
      <path value="MedicationStatement.reasonCode" />
      <slicing>
        <discriminator>
          <type value="exists" />
          <path value="text" />
        </discriminator>
        <rules value="open" />
      </slicing>
      <short value="Reason for why the medication is being/was taken" />
      <definition value="A reason for why the medication is being/was taken." />
      <comment value="This could be a diagnosis code. If a full condition record exists or additional detail is needed, use reasonForUseReference." />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="MedicationStatement.reasonCode" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="CodeableConcept" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <binding>
        <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="MedicationReason" />
        </extension>
        <strength value="example" />
        <description value="A coded concept identifying why the medication is being taken." />
      </binding>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="v2" />
        <map value="CE/CNE/CWE" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="CD" />
      </mapping>
      <mapping>
        <identity value="orim" />
        <map value="fhir:CodeableConcept rdfs:subClassOf dt:CD" />
      </mapping>
      <mapping>
        <identity value="workflow" />
        <map value="…reasoneCodeableConcept" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".reasonCode" />
      </mapping>
      <mapping>
        <identity value="w5" />
        <map value="why" />
      </mapping>
    </element>
    <element id="MedicationStatement.reasonCode:reasonForUse">
      <path value="MedicationStatement.reasonCode" />
      <sliceName value="reasonForUse" />
      <short value="Reason for why the medication is being/was taken" />
      <definition value="A reason for why the medication is being/was taken." />
      <comment value="This could be a diagnosis code. If a full condition record exists or additional detail is needed, use reasonForUseReference." />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="MedicationStatement.reasonCode" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="CodeableConcept" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <binding>
        <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="MedicationReason" />
        </extension>
        <strength value="example" />
        <description value="A coded concept identifying why the medication is being taken." />
      </binding>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="v2" />
        <map value="CE/CNE/CWE" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="CD" />
      </mapping>
      <mapping>
        <identity value="orim" />
        <map value="fhir:CodeableConcept rdfs:subClassOf dt:CD" />
      </mapping>
      <mapping>
        <identity value="workflow" />
        <map value="…reasoneCodeableConcept" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".reasonCode" />
      </mapping>
      <mapping>
        <identity value="w5" />
        <map value="why" />
      </mapping>
    </element>
    <element id="MedicationStatement.reasonCode:reasonForUse.id">
      <path value="MedicationStatement.reasonCode.id" />
      <representation value="xmlAttr" />
      <short value="xml:id (or equivalent in JSON)" />
      <definition value="unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." />
      <comment value="Note that FHIR strings may not exceed 1MB in size" />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="Element.id" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="string" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
    </element>
    <element id="MedicationStatement.reasonCode:reasonForUse.extension">
      <path value="MedicationStatement.reasonCode.extension" />
      <slicing>
        <discriminator>
          <type value="value" />
          <path value="url" />
        </discriminator>
        <description value="Extensions are always sliced by (at least) url" />
        <rules value="open" />
      </slicing>
      <short value="Additional Content defined by implementations" />
      <definition value="May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
      <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
      <alias value="extensions" />
      <alias value="user content" />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="Element.extension" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Extension" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ext-1" />
        <severity value="error" />
        <human value="Must have either extensions or value[x], not both" />
        <expression value="extension.exists() != value.exists()" />
        <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.reasonCode:reasonForUse.coding">
      <path value="MedicationStatement.reasonCode.coding" />
      <short value="Code defined by a terminology system" />
      <definition value="A reference to a code defined by a terminology system." />
      <comment value="Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information.  Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true." />
      <requirements value="Allows for translations and alternate encodings within a code system.  Also supports communication of the same instance to systems requiring different encodings." />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="CodeableConcept.coding" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Coding" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <isSummary value="true" />
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="v2" />
        <map value="CE/CNE/CWE subset one of the sets of component 1-3 or 4-6" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="CV" />
      </mapping>
      <mapping>
        <identity value="orim" />
        <map value="fhir:Coding rdfs:subClassOf dt:CDCoding" />
      </mapping>
      <mapping>
        <identity value="v2" />
        <map value="C*E.1-8, C*E.10-22" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="union(., ./translation)" />
      </mapping>
      <mapping>
        <identity value="orim" />
        <map value="fhir:CodeableConcept.coding rdfs:subPropertyOf dt:CD.coding" />
      </mapping>
    </element>
    <element id="MedicationStatement.reasonCode:reasonForUse.text">
      <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable">
        <valueBoolean value="true" />
      </extension>
      <path value="MedicationStatement.reasonCode.text" />
      <short value="ReasonForUse" />
      <definition value="The reason for using the medication, particularly in self-care medicine purchased by the patient themselves." />
      <comment value="Very often the text is the same as a displayName of one of the codings." />
      <requirements value="The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source." />
      <alias value="RedenGebruik" />
      <min value="1" />
      <max value="1" />
      <base>
        <path value="CodeableConcept.text" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="string" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <isSummary value="true" />
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="v2" />
        <map value="C*E.9. But note many systems use C*E.2 for this" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="./originalText[mediaType/code=&quot;text/plain&quot;]/data" />
      </mapping>
      <mapping>
        <identity value="orim" />
        <map value="fhir:CodeableConcept.text rdfs:subPropertyOf dt:CD.originalText" />
      </mapping>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.22491" />
        <comment value="ReasonForUse" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.ReasonForUse" />
      </mapping>
    </element>
    <element id="MedicationStatement.reasonReference">
      <path value="MedicationStatement.reasonReference" />
      <short value="Condition or observation that supports why the medication is being/was taken" />
      <definition value="Condition or observation that supports why the medication is being/was taken." />
      <comment value="This is a reference to a condition that is the reason why the medication is being/was taken.  If only a code exists, use reasonForUseCode." />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="MedicationStatement.reasonReference" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Condition" />
      </type>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Observation" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ref-1" />
        <severity value="error" />
        <human value="SHALL have a contained resource if a local reference is provided" />
        <expression value="reference.startsWith('#').not() or (reference.substring(1).trace('url') in %resource.contained.id.trace('ids'))" />
        <xpath value="not(starts-with(f:reference/@value, '#')) or exists(ancestor::*[self::f:entry or self::f:parameter]/f:resource/f:*/f:contained/f:*[f:id/@value=substring-after(current()/f:reference/@value, '#')]|/*/f:contained/f:*[f:id/@value=substring-after(current()/f:reference/@value, '#')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Reference" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="The target of a resource reference is a RIM entry point (Act, Role, or Entity)" />
      </mapping>
      <mapping>
        <identity value="workflow" />
        <map value="…reasonReference" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".outboundRelationship[typeCode=RSON]/target[classCode=OBS,moodCode=EVN, code=&quot;reason for use&quot;].value" />
      </mapping>
      <mapping>
        <identity value="w5" />
        <map value="why" />
      </mapping>
    </element>
    <element id="MedicationStatement.note">
      <path value="MedicationStatement.note" />
      <short value="Further information about the statement" />
      <definition value="Provides extra information about the medication statement that is not conveyed by the other attributes." />
      <comment value="For systems that do not have structured annotations, they can simply communicate a single annotation with no author or time.  This element may need to be included in narrative because of the potential for modifying information.  *Annotations SHOULD NOT* be used to communicate &quot;modifying&quot; information that could be computable. (This is a SHOULD because enforcing user behavior is nearly impossible)." />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="MedicationStatement.note" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Annotation" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="v2" />
        <map value="N/A" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="Act" />
      </mapping>
      <mapping>
        <identity value="workflow" />
        <map value="…note" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".inboundRelationship[typeCode=SUBJ]/source[classCode=OBS,moodCode=EVN,code=&quot;annotation&quot;].value" />
      </mapping>
    </element>
    <element id="MedicationStatement.note.id">
      <path value="MedicationStatement.note.id" />
      <representation value="xmlAttr" />
      <short value="xml:id (or equivalent in JSON)" />
      <definition value="unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." />
      <comment value="Note that FHIR strings may not exceed 1MB in size" />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="Element.id" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="string" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
    </element>
    <element id="MedicationStatement.note.extension">
      <path value="MedicationStatement.note.extension" />
      <slicing>
        <discriminator>
          <type value="value" />
          <path value="url" />
        </discriminator>
        <description value="Extensions are always sliced by (at least) url" />
        <rules value="open" />
      </slicing>
      <short value="Additional Content defined by implementations" />
      <definition value="May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
      <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
      <alias value="extensions" />
      <alias value="user content" />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="Element.extension" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Extension" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="ext-1" />
        <severity value="error" />
        <human value="Must have either extensions or value[x], not both" />
        <expression value="extension.exists() != value.exists()" />
        <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" />
        <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="N/A" />
      </mapping>
    </element>
    <element id="MedicationStatement.note.author[x]">
      <path value="MedicationStatement.note.author[x]" />
      <short value="Individual responsible for the annotation" />
      <definition value="The individual responsible for making the annotation." />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="Annotation.author[x]" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Practitioner" />
      </type>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Patient" />
      </type>
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/RelatedPerson" />
      </type>
      <type>
        <code value="string" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <isSummary value="true" />
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="v2" />
        <map value="N/A" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="Act.participant[typeCode=AUT].role" />
      </mapping>
    </element>
    <element id="MedicationStatement.note.time">
      <path value="MedicationStatement.note.time" />
      <short value="When the annotation was made" />
      <definition value="Indicates when this particular annotation was made." />
      <min value="0" />
      <max value="1" />
      <base>
        <path value="Annotation.time" />
        <min value="0" />
        <max value="1" />
      </base>
      <type>
        <code value="dateTime" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <isSummary value="true" />
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="v2" />
        <map value="N/A" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="Act.effectiveTime" />
      </mapping>
    </element>
    <element id="MedicationStatement.note.text">
      <path value="MedicationStatement.note.text" />
      <short value="Comment" />
      <definition value="Comments on the medication use." />
      <comment value="Note that FHIR strings may not exceed 1MB in size" />
      <alias value="Toelichting" />
      <min value="1" />
      <max value="1" />
      <base>
        <path value="Annotation.text" />
        <min value="1" />
        <max value="1" />
      </base>
      <type>
        <code value="string" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="v2" />
        <map value="N/A" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="Act.text" />
      </mapping>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.21624" />
        <comment value="Comment" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.Comment" />
      </mapping>
    </element>
    <element id="MedicationStatement.dosage">
      <path value="MedicationStatement.dosage" />
      <short value="DosingInstructions / InstructionsForUse" />
      <definition value="Instructions for the use of the medication, e.g. dose and route of administration. In the event of medication use, this is the pattern of use established by the patient or which the patient followed." />
      <comment value="This element _mostly_ represents the DosingInstructions container from CBB InstructionsForUse, but also includes the AdditionalInstructions and RouteOfAdministration concepts, which are normally placed on the same level as this container. As a result, these concepts are **duplicated** in every repetition of this element, even though these concepts should be present just once according to the CBB.&#xD;&#xA;&#xD;&#xA;The RepeatPeriodCyclicalSchedule and Description elements of the CBB are not represented in this profile. When a HdBe profile contains a InstructionsForUse.DosageInstructions datatype, the RepeatPeriodCyclicalSchedule and Description elements are separately added to this profile as well.&#xD;&#xA;&#xD;&#xA;This element does not contain a mapping to the Dosage container from CBB InstructionsForUse. However, the child concepts of Dosage are all mapped. Multiple Dosage instances are represented by another DosingInstructions that contains a similiar SequenceNumber." />
      <alias value="Doseerinstructie" />
      <alias value="Gebruiksinstructie" />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="MedicationStatement.dosage" />
        <min value="0" />
        <max value="*" />
      </base>
      <type>
        <code value="Dosage" />
        <profile value="https://fhir.healthdata.be/StructureDefinition/HdBe-InstructionsForUse.DosageInstructions" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value=".outboundRelationship[typeCode=COMP].target[classCode=SBADM, moodCode=INT]" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="refer dosageInstruction mapping" />
      </mapping>
      <mapping>
        <identity value="zib-instructionsforuse-v1.2.1-2020EN" />
        <map value="NL-CM:9.12.22095" />
        <comment value="DosingInstructions" />
      </mapping>
      <mapping>
        <identity value="HdBe-InstructionsForUse" />
        <map value="InstructionsForUse.DosingInstructions" />
      </mapping>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.22504" />
        <comment value="InstructionsForUse" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.InstructionsForUse" />
      </mapping>
    </element>
    <element id="MedicationStatement.statusReason">
      <path value="MedicationStatement.statusReason" />
      <short value="ReasonForChangeOrDiscontinuationOfUse" />
      <definition value="Reason for changing or discontinuing use of medication." />
      <alias value="RedenWijzigenOfStoppenGebruik" />
      <base>
        <path value="MedicationStatement.statusReason" />
      </base>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.22493" />
        <comment value="ReasonForChangeOrDiscontinuationOfUse" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.ReasonForChangeOrDiscontinuationOfUse" />
      </mapping>
    </element>
    <element id="MedicationStatement.effective[x]">
      <path value="MedicationStatement.effective[x]" />
      <slicing>
        <discriminator>
          <type value="type" />
          <path value="$this" />
        </discriminator>
        <rules value="open" />
      </slicing>
      <base>
        <path value="MedicationStatement.effective[x]" />
      </base>
    </element>
    <element id="MedicationStatement.effective[x]:effectivePeriod">
      <path value="MedicationStatement.effective[x]" />
      <sliceName value="effectivePeriod" />
      <short value="PeriodOfUse" />
      <definition value="Medication use can be recorded for a certain moment or over a certain period. Thus, medication use can be recorded multiple times during the use of medication. The usage period is the period or moment over which the data is recorded.&#xA;**Start date:** This is the time at which the agreement was to take effect (or took effect or will take effect). &#xA;**End date:** The time at which the period of use ends (or ended or will end). To avoid confusion between 'to' and 'up to', the submission of time is always mandatory for the end date." />
      <comment value="This is not a duration - that's a measure of time (a separate type), but a duration that occurs at a fixed value of time. A Period specifies a range of time; the context of use will specify whether the entire range applies (e.g. &quot;the patient was an inpatient of the hospital for this time range&quot;) or one value from the range applies (e.g. &quot;give to the patient between these two times&quot;). If duration is required, specify the type as Interval|Duration." />
      <alias value="Gebruiksperiode" />
      <min value="0" />
      <max value="*" />
      <base>
        <path value="MedicationStatement.effective[x]" />
      </base>
      <type>
        <code value="Period" />
        <profile value="https://fhir.healthdata.be/StructureDefinition/HdBe-TimeInterval" />
      </type>
      <condition value="ele-1" />
      <constraint>
        <key value="ele-1" />
        <severity value="error" />
        <human value="All FHIR elements must have a @value or children" />
        <expression value="hasValue() | (children().count() &gt; id.count())" />
        <xpath value="@value|f:*|h:div" />
        <source value="http://hl7.org/fhir/StructureDefinition/Element" />
      </constraint>
      <constraint>
        <key value="per-1" />
        <severity value="error" />
        <human value="If present, start SHALL have a lower value than end" />
        <expression value="start.empty() or end.empty() or (start &lt;= end)" />
        <xpath value="not(exists(f:start)) or not(exists(f:end)) or (f:start/@value &lt;= f:end/@value)" />
        <source value="http://hl7.org/fhir/StructureDefinition/Period" />
      </constraint>
      <mapping>
        <identity value="rim" />
        <map value="n/a" />
      </mapping>
      <mapping>
        <identity value="v2" />
        <map value="DR" />
      </mapping>
      <mapping>
        <identity value="rim" />
        <map value="IVL&lt;TS&gt;[lowClosed=&quot;true&quot; and highClosed=&quot;true&quot;] or URG&lt;TS&gt;[lowClosed=&quot;true&quot; and highClosed=&quot;true&quot;]" />
      </mapping>
      <mapping>
        <identity value="HdBe-TimeInterval" />
        <map value="TimeInterval" />
      </mapping>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.22663" />
        <comment value="PeriodOfUse" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.PeriodOfUse" />
      </mapping>
    </element>
    <element id="MedicationStatement.dateAsserted">
      <path value="MedicationStatement.dateAsserted" />
      <short value="MedicationUseDateTime" />
      <definition value="Date on which this use is entered." />
      <alias value="MedicatieGebruikDatumTijd" />
      <base>
        <path value="MedicationStatement.dateAsserted" />
      </base>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.22398" />
        <comment value="MedicationUseDateTime" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.MedicationUseDateTime" />
      </mapping>
    </element>
  </snapshot>
  <differential>
    <element id="MedicationStatement">
      <path value="MedicationStatement" />
      <short value="MedicationUse" />
      <comment value="When interpreting a medicationStatement, the value of the status and NotTaken needed to be considered:&#xD;MedicationStatement.status + MedicationStatement.wasNotTaken&#xD;* Status=Active + NotTaken=T = Not currently taking&#xD;* Status=Completed + NotTaken=T = Not taken in the past&#xD;* Status=Intended + NotTaken=T = No intention of taking&#xD;* Status=Active + NotTaken=F = Taking, but not as prescribed&#xD;* Status=Active + NotTaken=F = Taking&#xD;* Status=Intended +NotTaken= F = Will be taking (not started)&#xD;* Status=Completed + NotTaken=F = Taken in past&#xD;* Status=In Error + NotTaken=N/A = In Error." />
      <alias value="MedicatieGebruik" />
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.21338" />
        <comment value="MedicationUse" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension">
      <path value="MedicationStatement.extension" />
      <slicing>
        <discriminator>
          <type value="value" />
          <path value="url" />
        </discriminator>
        <rules value="open" />
      </slicing>
      <min value="0" />
    </element>
    <element id="MedicationStatement.extension:renderedDosageInstruction">
      <path value="MedicationStatement.extension" />
      <sliceName value="renderedDosageInstruction" />
      <min value="0" />
      <type>
        <code value="Extension" />
        <profile value="https://fhir.healthdata.be/StructureDefinition/ext-RenderedDosageInstruction" />
      </type>
    </element>
    <element id="MedicationStatement.extension:renderedDosageInstruction.value[x]">
      <path value="MedicationStatement.extension.value[x]" />
      <mapping>
        <identity value="HdBe-InstructionsForUse" />
        <map value="InstructionsForUse.Description" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension:prescriber">
      <path value="MedicationStatement.extension" />
      <sliceName value="prescriber" />
      <min value="0" />
      <max value="1" />
      <type>
        <code value="Extension" />
        <profile value="https://fhir.healthdata.be/StructureDefinition/ext-MedicationUse2.Prescriber" />
      </type>
    </element>
    <element id="MedicationStatement.extension:prescriber.value[x]">
      <path value="MedicationStatement.extension.value[x]" />
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.Prescriber" />
      </mapping>
    </element>
    <element id="MedicationStatement.extension:asAgreedIndicator">
      <path value="MedicationStatement.extension" />
      <sliceName value="asAgreedIndicator" />
      <min value="0" />
      <max value="1" />
      <type>
        <code value="Extension" />
        <profile value="https://fhir.healthdata.be/StructureDefinition/ext-MedicationUse2.AsAgreedIndicator" />
      </type>
    </element>
    <element id="MedicationStatement.extension:asAgreedIndicator.value[x]">
      <path value="MedicationStatement.extension.value[x]" />
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.AsAgreedIndicator" />
      </mapping>
    </element>
    <element id="MedicationStatement.modifierExtension">
      <path value="MedicationStatement.modifierExtension" />
      <slicing>
        <discriminator>
          <type value="value" />
          <path value="url" />
        </discriminator>
        <rules value="open" />
      </slicing>
      <min value="0" />
    </element>
    <element id="MedicationStatement.modifierExtension:stopType">
      <path value="MedicationStatement.modifierExtension" />
      <sliceName value="stopType" />
      <min value="0" />
      <type>
        <code value="Extension" />
        <profile value="https://fhir.healthdata.be/StructureDefinition/ext-StopType" />
      </type>
    </element>
    <element id="MedicationStatement.modifierExtension:stopType.value[x]">
      <path value="MedicationStatement.modifierExtension.value[x]" />
      <short value="MedicationUseStopType" />
      <alias value="MedicatieGebruikStopType" />
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.23132" />
        <comment value="MedicationUseStopType" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.MedicationUseStopType" />
      </mapping>
    </element>
    <element id="MedicationStatement.modifierExtension:repeatPeriodCyclicalSchedule">
      <path value="MedicationStatement.modifierExtension" />
      <sliceName value="repeatPeriodCyclicalSchedule" />
      <min value="0" />
      <type>
        <code value="Extension" />
        <profile value="https://fhir.healthdata.be/StructureDefinition/ext-InstructionsForUse.RepeatPeriodCyclicalSchedule" />
      </type>
    </element>
    <element id="MedicationStatement.modifierExtension:repeatPeriodCyclicalSchedule.value[x]">
      <path value="MedicationStatement.modifierExtension.value[x]" />
      <mapping>
        <identity value="HdBe-InstructionsForUse" />
        <map value="InstructionsForUse.RepeatPeriodCyclicalSchedule" />
      </mapping>
    </element>
    <element id="MedicationStatement.status">
      <path value="MedicationStatement.status" />
      <short value="UseIndicator / MedicationUseStopType / PeriodOfUse" />
      <definition value="Status may contain information on the stop type, the manner in which this medication is discontinued (temporary or definitive) and if the medicine is used or not." />
      <comment value="This element is mapped to the CBB concept UseIndicator and implicitly to MedicationUseStopType and PeriodOfUse. Unless a more appropriate status is recorded, the following guidance applies:&#xD;&#xA;&#xD;&#xA;* When MedicationUseStopType has no value and UseIndicator is _true_, `.status` will usually be set to _active_.&#xD;&#xA;* When UseIndicator is _false_, `.status` will be set to _not-taken_.&#xD;&#xA;* When MedicationUseStopType is _14803004_, `.status` will usually be set to _on-hold_.&#xD;&#xA;* When MedicationUseStopType is _255545003_, `.status` will usually be set to _stopped_.&#xD;&#xA;* When PeriodOfUse start date is in the past and PeriodOfUse end date is present and in the future, `.status` will usually be set to _active_.&#xD;&#xA;* When PeriodOfUse end date has a value and in the past, `.status` will usually be set to _completed_.&#xD;&#xA;* When PeriodOfUse duration and start date are known, the end date can be deducted and the previous rules apply. &#xD;&#xA;* When a system is unable to infer the status, `.status` will be set to _unknown_. The _unknown_ code is not to be used to convey other statuses. The _unknown_ code should be used when one of the statuses applies, but the authoring system doesn't know the current state of the MedicationStatement." />
      <alias value="MedicatieGebruikStopType" />
      <alias value="GebruikIndicator" />
      <alias value="Gebruiksperiode" />
      <binding>
        <strength value="required" />
        <description value="Use ConceptMap 'MedicationStopType-to-MedicationStatementStatus' to translate CBB terminology to profile terminology in ValueSet 'Medication Status Codes'." />
        <valueSet value="http://hl7.org/fhir/ValueSet/medication-statement-status|4.0.1">
          <extension url="http://hl7.org/fhir/StructureDefinition/11179-permitted-value-conceptmap">
            <valueCanonical value="https://fhir.healthdata.be/ConceptMap/MedicationStopType-to-MedicationStatementStatus" />
          </extension>
        </valueSet>
      </binding>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.22399" />
        <comment value="UseIndicator" />
      </mapping>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.23132" />
        <comment value="MedicationUseStopType (implicit, main mapping is on the modifier extension ext-StopType)" />
      </mapping>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.22663" />
        <comment value="PeriodOfUse (implicit, main mapping is on `.effective[x]:effectivePeriod` and extension ext-TimeInterval.Duration)" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.UseIndicator" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.MedicationUseStopType" />
        <comment value="implicit, main mapping is on the modifier extension ext-StopType" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.PeriodOfUse" />
        <comment value="implicit, main mapping is on `.effective[x]:effectivePeriod` and extension ext-TimeInterval.Duration" />
      </mapping>
    </element>
    <element id="MedicationStatement.statusReason">
      <path value="MedicationStatement.statusReason" />
      <short value="ReasonForChangeOrDiscontinuationOfUse" />
      <definition value="Reason for changing or discontinuing use of medication." />
      <alias value="RedenWijzigenOfStoppenGebruik" />
      <binding>
        <strength value="required" />
        <valueSet value="https://fhir.healthdata.be/ValueSet/MedicationReason" />
      </binding>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.22493" />
        <comment value="ReasonForChangeOrDiscontinuationOfUse" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.ReasonForChangeOrDiscontinuationOfUse" />
      </mapping>
    </element>
    <element id="MedicationStatement.category">
      <path value="MedicationStatement.category" />
      <min value="1" />
      <patternCodeableConcept>
        <coding>
          <system value="http://snomed.info/sct" />
          <code value="422979000" />
        </coding>
      </patternCodeableConcept>
    </element>
    <element id="MedicationStatement.medication[x]">
      <path value="MedicationStatement.medication[x]" />
      <slicing>
        <discriminator>
          <type value="type" />
          <path value="$this" />
        </discriminator>
        <rules value="open" />
      </slicing>
    </element>
    <element id="MedicationStatement.medication[x]:medicationReference">
      <path value="MedicationStatement.medication[x]" />
      <sliceName value="medicationReference" />
      <short value="ProductUsed" />
      <definition value="The product used. This is usually medication. Food, blood products, aids and bandages do not strictly fall under the category of medication, but can be recorded as well.&#xD;&#xA;In principle, this will be the prescribed product, but the product used may differ from the prescribed product." />
      <alias value="Gebruiksproduct" />
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Medication" />
        <targetProfile value="https://fhir.healthdata.be/StructureDefinition/HdBe-PharmaceuticalProduct" />
      </type>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.21339" />
        <comment value="ProductUsed" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.ProductUsed" />
      </mapping>
    </element>
    <element id="MedicationStatement.subject">
      <path value="MedicationStatement.subject" />
      <type>
        <code value="Reference" />
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Group" />
        <targetProfile value="https://fhir.healthdata.be/StructureDefinition/HdBe-Patient" />
      </type>
    </element>
    <element id="MedicationStatement.effective[x]">
      <path value="MedicationStatement.effective[x]" />
      <slicing>
        <discriminator>
          <type value="type" />
          <path value="$this" />
        </discriminator>
        <rules value="open" />
      </slicing>
    </element>
    <element id="MedicationStatement.effective[x]:effectivePeriod">
      <path value="MedicationStatement.effective[x]" />
      <sliceName value="effectivePeriod" />
      <short value="PeriodOfUse" />
      <definition value="Medication use can be recorded for a certain moment or over a certain period. Thus, medication use can be recorded multiple times during the use of medication. The usage period is the period or moment over which the data is recorded.&#xA;**Start date:** This is the time at which the agreement was to take effect (or took effect or will take effect). &#xA;**End date:** The time at which the period of use ends (or ended or will end). To avoid confusion between 'to' and 'up to', the submission of time is always mandatory for the end date." />
      <alias value="Gebruiksperiode" />
      <type>
        <code value="Period" />
        <profile value="https://fhir.healthdata.be/StructureDefinition/HdBe-TimeInterval" />
      </type>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.22663" />
        <comment value="PeriodOfUse" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.PeriodOfUse" />
      </mapping>
    </element>
    <element id="MedicationStatement.dateAsserted">
      <path value="MedicationStatement.dateAsserted" />
      <short value="MedicationUseDateTime" />
      <definition value="Date on which this use is entered." />
      <alias value="MedicatieGebruikDatumTijd" />
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.22398" />
        <comment value="MedicationUseDateTime" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.MedicationUseDateTime" />
      </mapping>
    </element>
    <element id="MedicationStatement.reasonCode">
      <path value="MedicationStatement.reasonCode" />
      <slicing>
        <discriminator>
          <type value="exists" />
          <path value="text" />
        </discriminator>
        <rules value="open" />
      </slicing>
    </element>
    <element id="MedicationStatement.reasonCode:reasonForUse">
      <path value="MedicationStatement.reasonCode" />
      <sliceName value="reasonForUse" />
      <max value="1" />
    </element>
    <element id="MedicationStatement.reasonCode:reasonForUse.text">
      <path value="MedicationStatement.reasonCode.text" />
      <short value="ReasonForUse" />
      <definition value="The reason for using the medication, particularly in self-care medicine purchased by the patient themselves." />
      <alias value="RedenGebruik" />
      <min value="1" />
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.22491" />
        <comment value="ReasonForUse" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.ReasonForUse" />
      </mapping>
    </element>
    <element id="MedicationStatement.note">
      <path value="MedicationStatement.note" />
      <max value="1" />
    </element>
    <element id="MedicationStatement.note.text">
      <path value="MedicationStatement.note.text" />
      <short value="Comment" />
      <definition value="Comments on the medication use." />
      <alias value="Toelichting" />
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.21624" />
        <comment value="Comment" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.Comment" />
      </mapping>
    </element>
    <element id="MedicationStatement.dosage">
      <path value="MedicationStatement.dosage" />
      <short value="DosingInstructions / InstructionsForUse" />
      <definition value="Instructions for the use of the medication, e.g. dose and route of administration. In the event of medication use, this is the pattern of use established by the patient or which the patient followed." />
      <alias value="Gebruiksinstructie" />
      <type>
        <code value="Dosage" />
        <profile value="https://fhir.healthdata.be/StructureDefinition/HdBe-InstructionsForUse.DosageInstructions" />
      </type>
      <mapping>
        <identity value="zib-medicationuse2-v1.1.1-2020EN" />
        <map value="NL-CM:9.11.22504" />
        <comment value="InstructionsForUse" />
      </mapping>
      <mapping>
        <identity value="HdBe-MedicationUse2" />
        <map value="MedicationUse2.InstructionsForUse" />
      </mapping>
    </element>
  </differential>
</StructureDefinition>