<status value="draft" /> <date value="2022-10-17T09:09:13.9562003+00:00" /> <publisher value="Healthdata.be (Sciensano)" /> <contact> <name value="Service portal – healthdata.be" /> <telecom> <system value="url" /> <value value="https://sciensano.service-now.com/sp" /> <use value="work" /> </telecom> </contact> <description value="Instructions for the use or administration of the medication, e.g. dose and route of administration. In the event of medication use, this is the pattern of use established by the patient or which the patient followed." /> <copyright value="Copyright and related rights waived via CC0, https://creativecommons.org/publicdomain/zero/1.0/. This does not apply to information from third parties, for example a medical terminology system. The implementer alone is responsible for identifying and obtaining any necessary licenses or authorizations to utilize third party IP in connection with the specification or otherwise." /> <fhirVersion value="4.0.1" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <uri value="https://zibs.nl/wiki/InstructionsForUse-v1.2.1(2020EN)" /> <name value="zib InstructionsForUse-v1.2.1(2020EN)" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <uri value="https://zibs.nl/wiki/Range-v1.0.1(2020EN)" /> <name value="zib Range-v1.0.1(2020EN)" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <uri value="https://fhir.healthdata.be/StructureDefinition/LogicalModel/HdBe-InstructionsForUse" /> <name value="HdBe logical model InstructionsForUse" /> </mapping> <mapping> <identity value="HdBe-Range" /> <uri value="https://fhir.healthdata.be/StructureDefinition/LogicalModel/HdBe-Range" /> <name value="HdBe logical model Range" /> </mapping> <kind value="complex-type" /> <abstract value="false" /> <type value="Dosage" /> <baseDefinition value="http://hl7.org/fhir/StructureDefinition/Dosage" /> <derivation value="constraint" /> <snapshot> <element id="Dosage"> <path value="Dosage" /> <short value="DosingInstructions" /> <definition value="Indicates how the medication is/was taken or should be taken by the patient." /> <comment value="This element _mostly_ represents the DosingInstructions container from CBB InstructionsForUse, but also includes the AdditionalInstructions and RouteOfAdministration concepts, which are normally placed on the same level as this container. As a result, these concepts are **duplicated** in every repetition of this element, even though these concepts should be present just once according to the CBB. The RepeatPeriodCyclicalSchedule and Description elements of the CBB are not represented in this profile. When a HdBe profile contains a InstructionsForUse.DosageInstructions datatype, the RepeatPeriodCyclicalSchedule and Description elements are separately added to this profile as well. This element does not contain a mapping to the Dosage container from CBB InstructionsForUse. However, the child concepts of Dosage are all mapped. Multiple Dosage instances are represented by another DosingInstructions that contains a similiar SequenceNumber." /> <alias value="Doseerinstructie" /> <min value="0" /> <max value="*" /> <base> <path value="Dosage" /> <min value="0" /> <max value="*" /> </base> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value=".outboundRelationship[typeCode=COMP].target[classCode=SBADM, moodCode=INT]" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.22095" /> <comment value="DosingInstructions" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions" /> </mapping> </element> <element id="Dosage.id"> <path value="Dosage.id" /> <representation value="xmlAttr" /> <short value="xml:id (or equivalent in JSON)" /> <definition value="unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." /> <comment value="Note that FHIR strings may not exceed 1MB in size" /> <min value="0" /> <max value="1" /> <base> <path value="Element.id" /> <min value="0" /> <max value="1" /> </base> <type> <code value="string" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> </element> <element id="Dosage.extension"> <path value="Dosage.extension" /> <slicing> <discriminator> <type value="value" /> <path value="url" /> </discriminator> <description value="Extensions are always sliced by (at least) url" /> <rules value="open" /> </slicing> <short value="Additional Content defined by implementations" /> <definition value="May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." /> <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." /> <alias value="extensions" /> <alias value="user content" /> <min value="0" /> <max value="*" /> <base> <path value="Element.extension" /> <min value="0" /> <max value="*" /> </base> <type> <code value="Extension" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="ext-1" /> <severity value="error" /> <human value="Must have either extensions or value[x], not both" /> <expression value="extension.exists() != value.exists()" /> <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" /> <source value="http://hl7.org/fhir/StructureDefinition/Extension" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="N/A" /> </mapping> </element> <element id="Dosage.sequence"> <path value="Dosage.sequence" /> <short value="SequenceNumber" /> <definition value="This indicates the sequence of the dosing instructions within the medication agreement." /> <comment value="32 bit number; for values larger than this, use decimal" /> <requirements value="If the sequence number of multiple Dosages is the same, then it is implied that the instructions are to be treated as concurrent. If the sequence number is different, then the Dosages are intended to be sequential." /> <alias value="Volgnummer" /> <min value="0" /> <max value="1" /> <base> <path value="Dosage.sequence" /> <min value="0" /> <max value="1" /> </base> <type> <code value="integer" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value=".text" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.22503" /> <comment value="SequenceNumber" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.SequenceNumber" /> </mapping> </element> <element id="Dosage.text"> <path value="Dosage.text" /> <short value="Free text dosage instructions e.g. SIG" /> <definition value="Free text dosage instructions e.g. SIG." /> <comment value="Note that FHIR strings may not exceed 1MB in size" /> <requirements value="Free text dosage instructions can be used for cases where the instructions are too complex to code. The content of this attribute does not include the name or description of the medication. When coded instructions are present, the free text instructions may still be present for display to humans taking or administering the medication. It is expected that the text instructions will always be populated. If the dosage.timing attribute is also populated, then the dosage.text should reflect the same information as the timing." /> <min value="0" /> <max value="1" /> <base> <path value="Dosage.text" /> <min value="0" /> <max value="1" /> </base> <type> <code value="string" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value=".text" /> </mapping> </element> <element id="Dosage.additionalInstruction"> <path value="Dosage.additionalInstruction" /> <short value="AdditionalInstructions" /> <definition value="The additional instructions contain extra information on the use of the current prescription. This includes all instructions for use. The text can come from the original “paper" medication prescription, but can also be generated from the coded information. This concept may contain more information than what is structurally coded in the information below, but may not conflict with it. The instructions may not conflict with other components of the request for administration. The instructions can also refer to an existing protocol." /> <comment value="Please note that in contrast to the CBB, this AdditionalInstructions concept is grouped under the DosingInstructions concept. This CBB concept should thus be duplicated when there are multiple DosingInstructions." /> <requirements value="Additional instruction such as "Swallow with plenty of water" which may or may not be coded." /> <alias value="AanvullendeInstructie" /> <min value="0" /> <max value="*" /> <base> <path value="Dosage.additionalInstruction" /> <min value="0" /> <max value="*" /> </base> <type> <code value="CodeableConcept" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <binding> <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName"> <valueString value="AdditionalInstruction" /> </extension> <strength value="example" /> <description value="A coded concept identifying additional instructions such as "take with water" or "avoid operating heavy machinery"." /> </binding> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="v2" /> <map value="CE/CNE/CWE" /> </mapping> <mapping> <identity value="rim" /> <map value="CD" /> </mapping> <mapping> <identity value="orim" /> <map value="fhir:CodeableConcept rdfs:subClassOf dt:CD" /> </mapping> <mapping> <identity value="rim" /> <map value=".text" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19944" /> <comment value="AdditionalInstructions" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.AdditionalInstructions" /> </mapping> </element> <element id="Dosage.patientInstruction"> <path value="Dosage.patientInstruction" /> <short value="Patient or consumer oriented instructions" /> <definition value="Instructions in terms that are understood by the patient or consumer." /> <comment value="Note that FHIR strings may not exceed 1MB in size" /> <min value="0" /> <max value="1" /> <base> <path value="Dosage.patientInstruction" /> <min value="0" /> <max value="1" /> </base> <type> <code value="string" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value=".text" /> </mapping> </element> <element id="Dosage.timing"> <path value="Dosage.timing" /> <short value="AdministeringSchedule" /> <definition value="Specifications of the times at which the medication is to be administered. This is indicated as follows: * Time(s) (16:00) or indications (“before meals”) at which the medication is to be taken each day. * A specific number of times the medication is to be taken each day ("3x a day"), indicated with the frequency. * A time interval between consecutive doses (“Every 2 hours”, “every 3 days”), indicated with the word Interval. * Combined periods with an interval and duration (“1 daily for three out of four weeks: the pill schedule”) If a certain medication is not to be taken daily, the aforementioned can be combined with daily indications: * One or more week days on which the medication is to be administered (e.g. “Monday, Wednesday, Friday”) * ”3x a week”, “2x a month”. The specified administration “infinite” is automatically to be repeated until: * The end date and time has been reached * The total administration duration has been reached (14 days) * A specific amount of administrations has been reached (“20 doses”), to be entered in the Frequency concept." /> <comment value="This attribute may not always be populated while the Dosage.text is expected to be populated. If both are populated, then the Dosage.text should reflect the content of the Dosage.timing." /> <requirements value="The timing schedule for giving the medication to the patient. The Schedule data type allows many different expressions. For example: "Every 8 hours"; "Three times a day"; "1/2 an hour before breakfast for 10 days from 23-Dec 2011:"; "15 Oct 2013, 17 Oct 2013 and 1 Nov 2013". Sometimes, a rate can imply duration when expressed as total volume / duration (e.g. 500mL/2 hours implies a duration of 2 hours). However, when rate doesn't imply duration (e.g. 250mL/hour), then the timing.repeat.duration is needed to convey the infuse over time period." /> <alias value="Toedieningsschema" /> <min value="0" /> <max value="1" /> <base> <path value="Dosage.timing" /> <min value="0" /> <max value="1" /> </base> <type> <code value="Timing" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="v2" /> <map value="N/A" /> </mapping> <mapping> <identity value="rim" /> <map value="QSET<TS> (GTS)" /> </mapping> <mapping> <identity value="rim" /> <map value=".effectiveTime" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19948" /> <comment value="AdministeringSchedule" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule" /> </mapping> </element> <element id="Dosage.timing.id"> <path value="Dosage.timing.id" /> <representation value="xmlAttr" /> <short value="xml:id (or equivalent in JSON)" /> <definition value="unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." /> <comment value="Note that FHIR strings may not exceed 1MB in size" /> <min value="0" /> <max value="1" /> <base> <path value="Element.id" /> <min value="0" /> <max value="1" /> </base> <type> <code value="string" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> </element> <element id="Dosage.timing.extension"> <path value="Dosage.timing.extension" /> <slicing> <discriminator> <type value="value" /> <path value="url" /> </discriminator> <description value="Extensions are always sliced by (at least) url" /> <rules value="open" /> </slicing> <short value="Additional Content defined by implementations" /> <definition value="May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." /> <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." /> <alias value="extensions" /> <alias value="user content" /> <min value="0" /> <max value="*" /> <base> <path value="Element.extension" /> <min value="0" /> <max value="*" /> </base> <type> <code value="Extension" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="ext-1" /> <severity value="error" /> <human value="Must have either extensions or value[x], not both" /> <expression value="extension.exists() != value.exists()" /> <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" /> <source value="http://hl7.org/fhir/StructureDefinition/Extension" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="N/A" /> </mapping> </element> <element id="Dosage.timing.event"> <path value="Dosage.timing.event" /> <short value="When the event occurs" /> <definition value="Identifies specific times when the event occurs." /> <requirements value="In an MAR, for instance, you need to take a general specification, and turn it into a precise specification." /> <min value="0" /> <max value="*" /> <base> <path value="Timing.event" /> <min value="0" /> <max value="*" /> </base> <type> <code value="dateTime" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="QLIST<TS>" /> </mapping> </element> <element id="Dosage.timing.repeat"> <path value="Dosage.timing.repeat" /> <short value="When the event is to occur" /> <definition value="A set of rules that describe when the event is scheduled." /> <requirements value="Many timing schedules are determined by regular repetitions." /> <min value="0" /> <max value="1" /> <base> <path value="Timing.repeat" /> <min value="0" /> <max value="1" /> </base> <type> <code value="Element" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="tim-9" /> <severity value="error" /> <human value="If there's an offset, there must be a when (and not C, CM, CD, CV)" /> <expression value="offset.empty() or (when.exists() and ((when in ('C' | 'CM' | 'CD' | 'CV')).not()))" /> <xpath value="not(exists(f:offset)) or exists(f:when)" /> <source value="http://hl7.org/fhir/StructureDefinition/Timing" /> </constraint> <constraint> <key value="tim-5" /> <severity value="error" /> <human value="period SHALL be a non-negative value" /> <expression value="period.exists() implies period >= 0" /> <xpath value="f:period/@value >= 0 or not(f:period/@value)" /> <source value="http://hl7.org/fhir/StructureDefinition/Timing" /> </constraint> <constraint> <key value="tim-6" /> <severity value="error" /> <human value="If there's a periodMax, there must be a period" /> <expression value="periodMax.empty() or period.exists()" /> <xpath value="not(exists(f:periodMax)) or exists(f:period)" /> <source value="http://hl7.org/fhir/StructureDefinition/Timing" /> </constraint> <constraint> <key value="tim-7" /> <severity value="error" /> <human value="If there's a durationMax, there must be a duration" /> <expression value="durationMax.empty() or duration.exists()" /> <xpath value="not(exists(f:durationMax)) or exists(f:duration)" /> <source value="http://hl7.org/fhir/StructureDefinition/Timing" /> </constraint> <constraint> <key value="tim-8" /> <severity value="error" /> <human value="If there's a countMax, there must be a count" /> <expression value="countMax.empty() or count.exists()" /> <xpath value="not(exists(f:countMax)) or exists(f:count)" /> <source value="http://hl7.org/fhir/StructureDefinition/Timing" /> </constraint> <constraint> <key value="tim-1" /> <severity value="error" /> <human value="if there's a duration, there needs to be duration units" /> <expression value="duration.empty() or durationUnit.exists()" /> <xpath value="not(exists(f:duration)) or exists(f:durationUnit)" /> <source value="http://hl7.org/fhir/StructureDefinition/Timing" /> </constraint> <constraint> <key value="tim-10" /> <severity value="error" /> <human value="If there's a timeOfDay, there cannot be be a when, or vice versa" /> <expression value="timeOfDay.empty() or when.empty()" /> <xpath value="not(exists(f:timeOfDay)) or not(exists(f:when))" /> <source value="http://hl7.org/fhir/StructureDefinition/Timing" /> </constraint> <constraint> <key value="tim-2" /> <severity value="error" /> <human value="if there's a period, there needs to be period units" /> <expression value="period.empty() or periodUnit.exists()" /> <xpath value="not(exists(f:period)) or exists(f:periodUnit)" /> <source value="http://hl7.org/fhir/StructureDefinition/Timing" /> </constraint> <constraint> <key value="tim-4" /> <severity value="error" /> <human value="duration SHALL be a non-negative value" /> <expression value="duration.exists() implies duration >= 0" /> <xpath value="f:duration/@value >= 0 or not(f:duration/@value)" /> <source value="http://hl7.org/fhir/StructureDefinition/Timing" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="Implies PIVL or EIVL" /> </mapping> </element> <element id="Dosage.timing.repeat.id"> <path value="Dosage.timing.repeat.id" /> <representation value="xmlAttr" /> <short value="xml:id (or equivalent in JSON)" /> <definition value="unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." /> <comment value="Note that FHIR strings may not exceed 1MB in size" /> <min value="0" /> <max value="1" /> <base> <path value="Element.id" /> <min value="0" /> <max value="1" /> </base> <type> <code value="string" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> </element> <element id="Dosage.timing.repeat.extension"> <path value="Dosage.timing.repeat.extension" /> <slicing> <discriminator> <type value="value" /> <path value="url" /> </discriminator> <description value="Extensions are always sliced by (at least) url" /> <rules value="open" /> </slicing> <short value="Additional Content defined by implementations" /> <definition value="May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." /> <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." /> <alias value="extensions" /> <alias value="user content" /> <min value="0" /> <max value="*" /> <base> <path value="Element.extension" /> <min value="0" /> <max value="*" /> </base> <type> <code value="Extension" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="ext-1" /> <severity value="error" /> <human value="Must have either extensions or value[x], not both" /> <expression value="extension.exists() != value.exists()" /> <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" /> <source value="http://hl7.org/fhir/StructureDefinition/Extension" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="N/A" /> </mapping> </element> <element id="Dosage.timing.repeat.extension:timingExact"> <path value="Dosage.timing.repeat.extension" /> <sliceName value="timingExact" /> <short value="Whether specified times must be followed as closely as possible" /> <definition value="If true, indicates that the specified times, frequencies, periods are expected to be adhered to as precisely as possible. If false, indicates that a typical degree of variability based on institutional and/or patient convenience is acceptable." /> <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." /> <alias value="extensions" /> <alias value="user content" /> <min value="0" /> <max value="1" /> <base> <path value="Element.extension" /> <min value="0" /> <max value="*" /> </base> <type> <code value="Extension" /> <profile value="http://hl7.org/fhir/StructureDefinition/timing-exact" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="ext-1" /> <severity value="error" /> <human value="Must have either extensions or value[x], not both" /> <expression value="extension.exists() != value.exists()" /> <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" /> <source value="http://hl7.org/fhir/StructureDefinition/Extension" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="N/A" /> </mapping> <mapping> <identity value="v2" /> <map value="N/A" /> </mapping> <mapping> <identity value="rim" /> <map value="GTS.IsFlexible" /> </mapping> </element> <element id="Dosage.timing.repeat.extension:timingExact.id"> <path value="Dosage.timing.repeat.extension.id" /> <representation value="xmlAttr" /> <short value="xml:id (or equivalent in JSON)" /> <definition value="unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." /> <comment value="Note that FHIR strings may not exceed 1MB in size" /> <min value="0" /> <max value="1" /> <base> <path value="Element.id" /> <min value="0" /> <max value="1" /> </base> <type> <code value="string" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> </element> <element id="Dosage.timing.repeat.extension:timingExact.extension"> <path value="Dosage.timing.repeat.extension.extension" /> <slicing> <discriminator> <type value="value" /> <path value="url" /> </discriminator> <description value="Extensions are always sliced by (at least) url" /> <rules value="open" /> </slicing> <short value="Additional Content defined by implementations" /> <definition value="May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." /> <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." /> <alias value="extensions" /> <alias value="user content" /> <min value="0" /> <max value="0" /> <base> <path value="Element.extension" /> <min value="0" /> <max value="*" /> </base> <type> <code value="Extension" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="ext-1" /> <severity value="error" /> <human value="Must have either extensions or value[x], not both" /> <expression value="extension.exists() != value.exists()" /> <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" /> <source value="http://hl7.org/fhir/StructureDefinition/Extension" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="N/A" /> </mapping> </element> <element id="Dosage.timing.repeat.extension:timingExact.url"> <path value="Dosage.timing.repeat.extension.url" /> <representation value="xmlAttr" /> <short value="identifies the meaning of the extension" /> <definition value="Source of the definition for the extension code - a logical name or a URL." /> <comment value="The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension." /> <min value="1" /> <max value="1" /> <base> <path value="Extension.url" /> <min value="1" /> <max value="1" /> </base> <type> <code value="uri" /> </type> <fixedUri value="http://hl7.org/fhir/StructureDefinition/timing-exact" /> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="N/A" /> </mapping> </element> <element id="Dosage.timing.repeat.extension:timingExact.value[x]"> <path value="Dosage.timing.repeat.extension.value[x]" /> <slicing> <discriminator> <type value="type" /> <path value="$this" /> </discriminator> <ordered value="false" /> <rules value="open" /> </slicing> <short value="Value of extension" /> <definition value="Indicates that the timing as specified by `.frequency`, `.period` and `.periodUnit` should be strictly interpreted. This is the case when the CBB concept Interval is expressed using these elements (as opposed to the CBB concept Frequency). The times can be chosen freely, but distribution throughout the day is more precise, and the interval between times is important (e.g. in the case of antibiotics) In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics)." /> <comment value="Notes on the CBB concepts Frequency and Interval: 1. An interval (in FHIR) is just a normal frequency with a period of 1 and is represented in FHIR as just another frequency using `.frequency`, `.period` and `.periodUnit`. However, the CBB differentiates between the two concepts in the timing precision (the Interval concept defines precise intervals while the Frequency concept defines approximate intervals). When the interval is precise, this is communicated using the extension in `extension:timingExact`. 2. On the other hand, the CBB Frequency concept might be used to express a single-use, non-repeating series by omitting the time unit. In FHIR, this is _not_ represented as a frequency, but with the `.count` element. 3. Lastly, the Frequency concept may be used to express either a single nominal value or a range. A range is represented by respectively setting the minimum and maximum value to `.frequency` and `.frequencyMax`, or to `.count` and `.countMax` for single-use events. A nominal value is expressed by setting its value to `.frequency` or to `.count` for single-use events, and leaving `.frequencyMax` and `.countMax` unpopulated. In summary: * CBB concept Frequency: * With time unit: * Nominal value: `.frequency`, `.period` and `.periodUnit` * Range: `.frequency`, `.frequencyMax`, `.period` and `.periodUnit` * Without time unit: * Nominal value: `.count` * Range: `.count` and `.countMax` * CBB concept Interval: `.frequency` (set to 1), `.period`, `.periodUnit` and `.extension:timingExact` (set to _true_)" /> <min value="0" /> <max value="1" /> <base> <path value="Extension.value[x]" /> <min value="0" /> <max value="1" /> </base> <type> <code value="base64Binary" /> </type> <type> <code value="boolean" /> </type> <type> <code value="code" /> </type> <type> <code value="date" /> </type> <type> <code value="dateTime" /> </type> <type> <code value="decimal" /> </type> <type> <code value="id" /> </type> <type> <code value="instant" /> </type> <type> <code value="integer" /> </type> <type> <code value="markdown" /> </type> <type> <code value="oid" /> </type> <type> <code value="positiveInt" /> </type> <type> <code value="string" /> </type> <type> <code value="time" /> </type> <type> <code value="unsignedInt" /> </type> <type> <code value="uri" /> </type> <type> <code value="Address" /> </type> <type> <code value="Age" /> </type> <type> <code value="Annotation" /> </type> <type> <code value="Attachment" /> </type> <type> <code value="CodeableConcept" /> </type> <type> <code value="Coding" /> </type> <type> <code value="ContactPoint" /> </type> <type> <code value="Count" /> </type> <type> <code value="Distance" /> </type> <type> <code value="Duration" /> </type> <type> <code value="HumanName" /> </type> <type> <code value="Identifier" /> </type> <type> <code value="Money" /> </type> <type> <code value="Period" /> </type> <type> <code value="Quantity" /> </type> <type> <code value="Range" /> </type> <type> <code value="Ratio" /> </type> <type> <code value="Reference" /> </type> <type> <code value="SampledData" /> </type> <type> <code value="Signature" /> </type> <type> <code value="Timing" /> </type> <type> <code value="Meta" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="N/A" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19950" /> <comment value="Interval (implicit, main mapping is on .frequency, .period and .periodMax)" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Interval" /> <comment value="implicit, main mapping is on .frequency, .period and .periodMax" /> </mapping> </element> <element id="Dosage.timing.repeat.extension:timingExact.value[x]:valueBoolean"> <path value="Dosage.timing.repeat.extension.value[x]" /> <sliceName value="valueBoolean" /> <short value="Value of extension" /> <definition value="Value of extension - may be a resource or one of a constrained set of the data types (see Extensibility in the spec for list)." /> <min value="0" /> <max value="1" /> <base> <path value="Extension.value[x]" /> <min value="0" /> <max value="1" /> </base> <type> <code value="boolean" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="N/A" /> </mapping> </element> <element id="Dosage.timing.repeat.bounds[x]"> <path value="Dosage.timing.repeat.bounds[x]" /> <slicing> <discriminator> <type value="type" /> <path value="$this" /> </discriminator> <rules value="open" /> </slicing> <short value="Length/Range of lengths, or (Start and/or end) limits" /> <definition value="Either a duration for the length of the timing schedule, a range of possible length, or outer bounds for start and/or end limits of the timing schedule." /> <min value="0" /> <max value="1" /> <base> <path value="Timing.repeat.bounds[x]" /> <min value="0" /> <max value="1" /> </base> <type> <code value="Duration" /> </type> <type> <code value="Range" /> </type> <type> <code value="Period" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="IVL(TS) used in a QSI" /> </mapping> </element> <element id="Dosage.timing.repeat.bounds[x]:boundsDuration"> <path value="Dosage.timing.repeat.bounds[x]" /> <sliceName value="boundsDuration" /> <short value="DoseDuration" /> <definition value="The intended time duration for these dosing instructions, e.g. 5 days or 8 weeks. In the case of medication for an indefinite period, the dosing duration is left empty in the last dosing instruction." /> <alias value="Doseerduur" /> <min value="0" /> <max value="1" /> <base> <path value="Timing.repeat.bounds[x]" /> <min value="0" /> <max value="1" /> </base> <type> <code value="Duration" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="IVL(TS) used in a QSI" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.22506" /> <comment value="DoseDuration" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.DoseDuration" /> </mapping> </element> <element id="Dosage.timing.repeat.count"> <path value="Dosage.timing.repeat.count" /> <short value="Frequency / minimumValue / nominalValue" /> <definition value="Usually, frequency comprises both amount and time unit (3 times a day), but it can occur without the time unit (single use). This is represented by this `.count` element and optionally `.countMax` if a range should be represented. A reasonable distribution over the day is expected, but exact times are not given. This is left to the patient. It is the most common manner of extramural prescription. In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics)." /> <comment value="Notes on the CBB concepts Frequency and Interval: 1. An interval (in FHIR) is just a normal frequency with a period of 1 and is represented in FHIR as just another frequency using `.frequency`, `.period` and `.periodUnit`. However, the CBB differentiates between the two concepts in the timing precision (the Interval concept defines precise intervals while the Frequency concept defines approximate intervals). When the interval is precise, this is communicated using the extension in `extension:timingExact`. 2. On the other hand, the CBB Frequency concept might be used to express a single-use, non-repeating series by omitting the time unit. In FHIR, this is _not_ represented as a frequency, but with the `.count` element. 3. Lastly, the Frequency concept may be used to express either a single nominal value or a range. A range is represented by respectively setting the minimum and maximum value to `.frequency` and `.frequencyMax`, or to `.count` and `.countMax` for single-use events. A nominal value is expressed by setting its value to `.frequency` or to `.count` for single-use events, and leaving `.frequencyMax` and `.countMax` unpopulated. In summary: * CBB concept Frequency: * With time unit: * Nominal value: `.frequency`, `.period` and `.periodUnit` * Range: `.frequency`, `.frequencyMax`, `.period` and `.periodUnit` * Without time unit: * Nominal value: `.count` * Range: `.count` and `.countMax` * CBB concept Interval: `.frequency` (set to 1), `.period`, `.periodUnit` and `.extension:timingExact` (set to _true_)" /> <requirements value="Repetitions may be limited by end time or total occurrences." /> <alias value="Frequentie" /> <alias value="nominaleWaarde" /> <alias value="minimumWaarde" /> <min value="0" /> <max value="1" /> <base> <path value="Timing.repeat.count" /> <min value="0" /> <max value="1" /> </base> <type> <code value="integer" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="PIVL.count" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19949" /> <comment value="Frequency (single use only)" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.2" /> <comment value="minimumValue" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.4" /> <comment value="nominalValue" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Frequency" /> <comment value="single use only" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.NominalValue" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.MinimumValue" /> </mapping> </element> <element id="Dosage.timing.repeat.countMax"> <path value="Dosage.timing.repeat.countMax" /> <short value="Frequency / maximumValue" /> <definition value="Usually, frequency comprises both amount and time unit (3 times a day), but it can occur without the time unit (single use). This is represented by the `.count` element and optionally `.countMax` if a range should be represented. A reasonable distribution over the day is expected, but exact times are not given. This is left to the patient. It is the most common manner of extramural prescription. In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics)." /> <comment value="Notes on the CBB concepts Frequency and Interval: 1. An interval (in FHIR) is just a normal frequency with a period of 1 and is represented in FHIR as just another frequency using `.frequency`, `.period` and `.periodUnit`. However, the CBB differentiates between the two concepts in the timing precision (the Interval concept defines precise intervals while the Frequency concept defines approximate intervals). When the interval is precise, this is communicated using the extension in `extension:timingExact`. 2. On the other hand, the CBB Frequency concept might be used to express a single-use, non-repeating series by omitting the time unit. In FHIR, this is _not_ represented as a frequency, but with the `.count` element. 3. Lastly, the Frequency concept may be used to express either a single nominal value or a range. A range is represented by respectively setting the minimum and maximum value to `.frequency` and `.frequencyMax`, or to `.count` and `.countMax` for single-use events. A nominal value is expressed by setting its value to `.frequency` or to `.count` for single-use events, and leaving `.frequencyMax` and `.countMax` unpopulated. In summary: * CBB concept Frequency: * With time unit: * Nominal value: `.frequency`, `.period` and `.periodUnit` * Range: `.frequency`, `.frequencyMax`, `.period` and `.periodUnit` * Without time unit: * Nominal value: `.count` * Range: `.count` and `.countMax` * CBB concept Interval: `.frequency` (set to 1), `.period`, `.periodUnit` and `.extension:timingExact` (set to _true_)" /> <alias value="Frequentie" /> <alias value="maximumWaarde" /> <min value="0" /> <max value="1" /> <base> <path value="Timing.repeat.countMax" /> <min value="0" /> <max value="1" /> </base> <type> <code value="integer" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="PIVL.count" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19949" /> <comment value="Frequency" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.3" /> <comment value="maximumValue" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Frequency" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.MaximumValue" /> </mapping> </element> <element id="Dosage.timing.repeat.duration"> <path value="Dosage.timing.repeat.duration" /> <short value="DurationOfAdministration" /> <definition value="The duration of administration defines the length of time during which the drug is administered and is mainly used in the slow parenteral administration of fluids. The `durationUnit` defines the time unit." /> <comment value="For some events the duration is part of the definition of the event (e.g. IV infusions, where the duration is implicit in the specified quantity and rate). For others, it's part of the timing specification (e.g. exercise)." /> <requirements value="Some activities are not instantaneous and need to be maintained for a period of time." /> <alias value="Toedieningsduur" /> <min value="0" /> <max value="1" /> <base> <path value="Timing.repeat.duration" /> <min value="0" /> <max value="1" /> </base> <type> <code value="decimal" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="PIVL.phase" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.23141" /> <comment value="DurationOfAdministration" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.DurationOfAdministration" /> </mapping> </element> <element id="Dosage.timing.repeat.durationMax"> <path value="Dosage.timing.repeat.durationMax" /> <short value="How long when it happens (Max)" /> <definition value="The upper limit of how long this thing happens for when it happens." /> <comment value="For some events the duration is part of the definition of the event (e.g. IV infusions, where the duration is implicit in the specified quantity and rate). For others, it's part of the timing specification (e.g. exercise)." /> <requirements value="Some activities are not instantaneous and need to be maintained for a period of time." /> <min value="0" /> <max value="1" /> <base> <path value="Timing.repeat.durationMax" /> <min value="0" /> <max value="1" /> </base> <type> <code value="decimal" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="PIVL.phase" /> </mapping> </element> <element id="Dosage.timing.repeat.durationUnit"> <path value="Dosage.timing.repeat.durationUnit" /> <short value="DurationOfAdministration" /> <definition value="The units of time, in UCUM units, for the duration of administration of time during which the drug is administered." /> <comment value="Note that FHIR strings may not exceed 1MB in size" /> <alias value="Toedieningsduur" /> <min value="0" /> <max value="1" /> <base> <path value="Timing.repeat.durationUnit" /> <min value="0" /> <max value="1" /> </base> <type> <code value="code" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <binding> <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName"> <valueString value="UnitsOfTime" /> </extension> <strength value="required" /> <description value="A unit of time (units from UCUM)." /> </binding> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="PIVL.phase.unit" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.23141" /> <comment value="DurationOfAdministration" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.DurationOfAdministration" /> </mapping> </element> <element id="Dosage.timing.repeat.frequency"> <path value="Dosage.timing.repeat.frequency" /> <short value="Frequency / minimumValue / nominalValue / Interval" /> <definition value="The number of times to repeat the action within the specified period. If frequencyMax is present, this element indicates the lower bound of the allowed range of the frequency. If the `extension:timingExact` element is absent or set to _false_, a reasonable distribution over the day is expected, but exact times are not given. This is left to the patient. It is the most common manner of extramural prescription. In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics). If the `extension:timingExact` element is present and set to _true_, the times can be chosen freely, but distribution throughout the day is more precise, and the interval between times is important (e.g. in the case of antibiotics) In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics)." /> <comment value="Notes on the CBB concepts Frequency and Interval: 1. An interval (in FHIR) is just a normal frequency with a period of 1 and is represented in FHIR as just another frequency using `.frequency`, `.period` and `.periodUnit`. However, the CBB differentiates between the two concepts in the timing precision (the Interval concept defines precise intervals while the Frequency concept defines approximate intervals). When the interval is precise, this is communicated using the extension in `extension:timingExact`. 2. On the other hand, the CBB Frequency concept might be used to express a single-use, non-repeating series by omitting the time unit. In FHIR, this is _not_ represented as a frequency, but with the `.count` element. 3. Lastly, the Frequency concept may be used to express either a single nominal value or a range. A range is represented by respectively setting the minimum and maximum value to `.frequency` and `.frequencyMax`, or to `.count` and `.countMax` for single-use events. A nominal value is expressed by setting its value to `.frequency` or to `.count` for single-use events, and leaving `.frequencyMax` and `.countMax` unpopulated. In summary: * CBB concept Frequency: * With time unit: * Nominal value: `.frequency`, `.period` and `.periodUnit` * Range: `.frequency`, `.frequencyMax`, `.period` and `.periodUnit` * Without time unit: * Nominal value: `.count` * Range: `.count` and `.countMax` * CBB concept Interval: `.frequency` (set to 1), `.period`, `.periodUnit` and `.extension:timingExact` (set to _true_)" /> <alias value="Frequentie" /> <alias value="minimumWaarde" /> <alias value="nominaleWaarde" /> <alias value="Interval" /> <min value="0" /> <max value="1" /> <base> <path value="Timing.repeat.frequency" /> <min value="0" /> <max value="1" /> </base> <type> <code value="integer" /> </type> <defaultValueInteger value="1" /> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="PIVL.phase" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19949" /> <comment value="Frequency" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.2" /> <comment value="minimumValue" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.4" /> <comment value="nominalValue" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19950" /> <comment value="Interval" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Frequency" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.MinimumValue" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.NominalValue" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Interval" /> </mapping> </element> <element id="Dosage.timing.repeat.frequencyMax"> <path value="Dosage.timing.repeat.frequencyMax" /> <short value="Frequency / maximumValue" /> <definition value="If present, indicates that the frequency is a range - so to repeat between [frequency] and [frequencyMax] times within the period or period range. If the `extension:timingExact` element is absent or set to _false_, a reasonable distribution over the day is expected, but exact times are not given. This is left to the patient. It is the most common manner of extramural prescription. In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics). If the `extension:timingExact` element is present and set to _true_, the times can be chosen freely, but distribution throughout the day is more precise, and the interval between times is important (e.g. in the case of antibiotics) In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics)." /> <comment value="Notes on the CBB concepts Frequency and Interval: 1. An interval (in FHIR) is just a normal frequency with a period of 1 and is represented in FHIR as just another frequency using `.frequency`, `.period` and `.periodUnit`. However, the CBB differentiates between the two concepts in the timing precision (the Interval concept defines precise intervals while the Frequency concept defines approximate intervals). When the interval is precise, this is communicated using the extension in `extension:timingExact`. 2. On the other hand, the CBB Frequency concept might be used to express a single-use, non-repeating series by omitting the time unit. In FHIR, this is _not_ represented as a frequency, but with the `.count` element. 3. Lastly, the Frequency concept may be used to express either a single nominal value or a range. A range is represented by respectively setting the minimum and maximum value to `.frequency` and `.frequencyMax`, or to `.count` and `.countMax` for single-use events. A nominal value is expressed by setting its value to `.frequency` or to `.count` for single-use events, and leaving `.frequencyMax` and `.countMax` unpopulated. In summary: * CBB concept Frequency: * With time unit: * Nominal value: `.frequency`, `.period` and `.periodUnit` * Range: `.frequency`, `.frequencyMax`, `.period` and `.periodUnit` * Without time unit: * Nominal value: `.count` * Range: `.count` and `.countMax` * CBB concept Interval: `.frequency` (set to 1), `.period`, `.periodUnit` and `.extension:timingExact` (set to _true_)" /> <alias value="maximumWaarde" /> <alias value="Frequentie" /> <min value="0" /> <max value="1" /> <base> <path value="Timing.repeat.frequencyMax" /> <min value="0" /> <max value="1" /> </base> <type> <code value="integer" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="PIVL.phase" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19949" /> <comment value="Frequency" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.3" /> <comment value="maximumValue" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Frequency" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.MaximumValue" /> </mapping> </element> <element id="Dosage.timing.repeat.period"> <path value="Dosage.timing.repeat.period" /> <short value="Frequency / Interval" /> <definition value="Indicates the duration of time over which repetitions are to occur; e.g. to express "3 times per day", 3 would be the frequency and "1 day" would be the period. If periodMax is present, this element indicates the lower bound of the allowed range of the period length. If the `extension:timingExact` element is absent or set to _false_, a reasonable distribution over the day is expected, but exact times are not given. This is left to the patient. It is the most common manner of extramural prescription. In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics). If the `extension:timingExact` element is present and set to _true_, the times can be chosen freely, but distribution throughout the day is more precise, and the interval between times is important (e.g. in the case of antibiotics) In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics)." /> <comment value="Notes on the CBB concepts Frequency and Interval: 1. An interval (in FHIR) is just a normal frequency with a period of 1 and is represented in FHIR as just another frequency using `.frequency`, `.period` and `.periodUnit`. However, the CBB differentiates between the two concepts in the timing precision (the Interval concept defines precise intervals while the Frequency concept defines approximate intervals). When the interval is precise, this is communicated using the extension in `extension:timingExact`. 2. On the other hand, the CBB Frequency concept might be used to express a single-use, non-repeating series by omitting the time unit. In FHIR, this is _not_ represented as a frequency, but with the `.count` element. 3. Lastly, the Frequency concept may be used to express either a single nominal value or a range. A range is represented by respectively setting the minimum and maximum value to `.frequency` and `.frequencyMax`, or to `.count` and `.countMax` for single-use events. A nominal value is expressed by setting its value to `.frequency` or to `.count` for single-use events, and leaving `.frequencyMax` and `.countMax` unpopulated. In summary: * CBB concept Frequency: * With time unit: * Nominal value: `.frequency`, `.period` and `.periodUnit` * Range: `.frequency`, `.frequencyMax`, `.period` and `.periodUnit` * Without time unit: * Nominal value: `.count` * Range: `.count` and `.countMax` * CBB concept Interval: `.frequency` (set to 1), `.period`, `.periodUnit` and `.extension:timingExact` (set to _true_)" /> <alias value="Frequentie" /> <alias value="Interval" /> <min value="0" /> <max value="1" /> <base> <path value="Timing.repeat.period" /> <min value="0" /> <max value="1" /> </base> <type> <code value="decimal" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="PIVL.phase" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19949" /> <comment value="Frequency" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19950" /> <comment value="Interval" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Frequency" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Interval" /> </mapping> </element> <element id="Dosage.timing.repeat.periodMax"> <path value="Dosage.timing.repeat.periodMax" /> <short value="Upper limit of period (3-4 hours)" /> <definition value="If present, indicates that the period is a range from [period] to [periodMax], allowing expressing concepts such as "do this once every 3-5 days." /> <comment value="Do not use a IEEE type floating point type, instead use something that works like a true decimal, with inbuilt precision (e.g. Java BigInteger)" /> <min value="0" /> <max value="1" /> <base> <path value="Timing.repeat.periodMax" /> <min value="0" /> <max value="1" /> </base> <type> <code value="decimal" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="PIVL.phase" /> </mapping> </element> <element id="Dosage.timing.repeat.periodUnit"> <path value="Dosage.timing.repeat.periodUnit" /> <short value="Frequency / Interval" /> <definition value="The units of time for the period in UCUM units for Frequency and Interval. If the `extension:timingExact` element is absent or set to _false_, a reasonable distribution over the day is expected, but exact times are not given. This is left to the patient. It is the most common manner of extramural prescription. In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics). If the `extension:timingExact` element is present and set to _true_, the times can be chosen freely, but distribution throughout the day is more precise, and the interval between times is important (e.g. in the case of antibiotics) In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics)." /> <comment value="Notes on the CBB concepts Frequency and Interval: 1. An interval (in FHIR) is just a normal frequency with a period of 1 and is represented in FHIR as just another frequency using `.frequency`, `.period` and `.periodUnit`. However, the CBB differentiates between the two concepts in the timing precision (the Interval concept defines precise intervals while the Frequency concept defines approximate intervals). When the interval is precise, this is communicated using the extension in `extension:timingExact`. 2. On the other hand, the CBB Frequency concept might be used to express a single-use, non-repeating series by omitting the time unit. In FHIR, this is _not_ represented as a frequency, but with the `.count` element. 3. Lastly, the Frequency concept may be used to express either a single nominal value or a range. A range is represented by respectively setting the minimum and maximum value to `.frequency` and `.frequencyMax`, or to `.count` and `.countMax` for single-use events. A nominal value is expressed by setting its value to `.frequency` or to `.count` for single-use events, and leaving `.frequencyMax` and `.countMax` unpopulated. In summary: * CBB concept Frequency: * With time unit: * Nominal value: `.frequency`, `.period` and `.periodUnit` * Range: `.frequency`, `.frequencyMax`, `.period` and `.periodUnit` * Without time unit: * Nominal value: `.count` * Range: `.count` and `.countMax` * CBB concept Interval: `.frequency` (set to 1), `.period`, `.periodUnit` and `.extension:timingExact` (set to _true_)" /> <alias value="Frequentie" /> <alias value="Interval" /> <min value="0" /> <max value="1" /> <base> <path value="Timing.repeat.periodUnit" /> <min value="0" /> <max value="1" /> </base> <type> <code value="code" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <binding> <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName"> <valueString value="UnitsOfTime" /> </extension> <strength value="required" /> <description value="A unit of time (units from UCUM)." /> </binding> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="PIVL.phase.unit" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19949" /> <comment value="Frequency. When frequency is used, set `extenstion.exact` to false." /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19950" /> <comment value="Interval" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Frequency" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Interval" /> </mapping> </element> <element id="Dosage.timing.repeat.dayOfWeek"> <path value="Dosage.timing.repeat.dayOfWeek" /> <short value="WeekDay" /> <definition value="WeekDay indicates a pattern of doses on fixed week days." /> <comment value="If no days are specified, the action is assumed to happen every day as otherwise specified." /> <alias value="Weekdag" /> <min value="0" /> <max value="*" /> <base> <path value="Timing.repeat.dayOfWeek" /> <min value="0" /> <max value="*" /> </base> <type> <code value="code" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <binding> <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName"> <valueString value="DayOfWeek" /> </extension> <strength value="required" /> <description value="Use ConceptMap 'WeekDay_to_DaysOfWeek' to translate CBB terminology to profile terminology in ValueSet 'DaysOfWeek.'" /> <valueSet value="http://hl7.org/fhir/ValueSet/days-of-week|4.0.1"> <extension url="http://hl7.org/fhir/StructureDefinition/11179-permitted-value-conceptmap"> <valueCanonical value="https://fhir.healthdata.be/ConceptMap/WeekDay-to-DaysOfWeek" /> </extension> </valueSet> </binding> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19952" /> <comment value="WeekDay" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.WeekDay" /> </mapping> </element> <element id="Dosage.timing.repeat.timeOfDay"> <path value="Dosage.timing.repeat.timeOfDay" /> <short value="AdministrationTime" /> <definition value="The time of administration is a specific time of day (on the clock). This time usually isn’t (intended to be) exact. There can be multiple administering times in one day. The ideal time of administration can also be entered as a time of day (morning, afternoon, evening, night-time). The administration time is then to be left empty, and the time of day can be entered in the TimeOfDay concept." /> <comment value="If there's a timeOfDay, there cannot be a when, or vice versa." /> <alias value="Toedientijd" /> <min value="0" /> <max value="*" /> <base> <path value="Timing.repeat.timeOfDay" /> <min value="0" /> <max value="*" /> </base> <type> <code value="time" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19951" /> <comment value="AdministrationTime" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.AdministrationTime" /> </mapping> </element> <element id="Dosage.timing.repeat.when"> <path value="Dosage.timing.repeat.when" /> <short value="TimeOfDay" /> <definition value="Time of day: morning, afternoon, evening, night." /> <comment value="When more than one event is listed, the event is tied to the union of the specified events." /> <requirements value="Timings are frequently determined by occurrences such as waking, eating and sleep." /> <alias value="Dagdeel" /> <min value="0" /> <max value="*" /> <base> <path value="Timing.repeat.when" /> <min value="0" /> <max value="*" /> </base> <type> <code value="code" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <binding> <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName"> <valueString value="EventTiming" /> </extension> <strength value="required" /> <description value="Use ConceptMap 'TimeOfDay_to_EventTiming' to translate CBB terminology to profile terminology in ValueSet 'EventTiming.'" /> <valueSet value="http://hl7.org/fhir/ValueSet/event-timing"> <extension url="http://hl7.org/fhir/StructureDefinition/11179-permitted-value-conceptmap"> <valueCanonical value="https://fhir.healthdata.be/ConceptMap/TimeOfDay-to-EventTiming" /> </extension> </valueSet> </binding> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="EIVL.event" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19953" /> <comment value="TimeOfDay" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.TimeOfDay" /> </mapping> </element> <element id="Dosage.timing.repeat.offset"> <path value="Dosage.timing.repeat.offset" /> <short value="Minutes from event (before or after)" /> <definition value="The number of minutes from the event. If the event code does not indicate whether the minutes is before or after the event, then the offset is assumed to be after the event." /> <comment value="32 bit number; for values larger than this, use decimal" /> <min value="0" /> <max value="1" /> <base> <path value="Timing.repeat.offset" /> <min value="0" /> <max value="1" /> </base> <type> <code value="unsignedInt" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="EIVL.offset" /> </mapping> </element> <element id="Dosage.timing.code"> <path value="Dosage.timing.code" /> <short value="BID | TID | QID | AM | PM | QD | QOD | Q4H | Q6H +" /> <definition value="A code for the timing schedule. Some codes such as BID are ubiquitous, but many institutions define their own additional codes. If a code is provided, the code is understood to be a complete statement of whatever is specified in the structured timing data, and either the code or the data may be used to interpret the Timing, with the exception that .repeat.bounds still applies over the code (and is not contained in the code)." /> <comment value="BID etc are defined as 'at institutionally specified times'. For example, an institution may choose that BID is "always at 7am and 6pm". If it is inappropriate for this choice to be made, the code BID should not be used. Instead, a distinct organization-specific code should be used in place of the HL7-defined BID code and/or the a structured representation should be used (in this case, specifying the two event times)." /> <min value="0" /> <max value="1" /> <base> <path value="Timing.code" /> <min value="0" /> <max value="1" /> </base> <type> <code value="CodeableConcept" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <binding> <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName"> <valueString value="TimingAbbreviation" /> </extension> <strength value="preferred" /> <description value="Code for a known / defined timing pattern." /> </binding> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="v2" /> <map value="CE/CNE/CWE" /> </mapping> <mapping> <identity value="rim" /> <map value="CD" /> </mapping> <mapping> <identity value="orim" /> <map value="fhir:CodeableConcept rdfs:subClassOf dt:CD" /> </mapping> <mapping> <identity value="rim" /> <map value="QSC.code" /> </mapping> </element> <element id="Dosage.asNeeded[x]"> <path value="Dosage.asNeeded[x]" /> <slicing> <discriminator> <type value="type" /> <path value="$this" /> </discriminator> <rules value="open" /> </slicing> <short value="Take "as needed" (for x)" /> <definition value="Indicates whether the Medication is only taken when needed within a specific dosing schedule (Boolean option), or it indicates the precondition for taking the Medication (CodeableConcept)." /> <comment value="Can express "as needed" without a reason by setting the Boolean = True. In this case the CodeableConcept is not populated. Or you can express "as needed" with a reason by including the CodeableConcept. In this case the Boolean is assumed to be True. If you set the Boolean to False, then the dose is given according to the schedule and is not "prn" or "as needed"." /> <min value="0" /> <max value="1" /> <base> <path value="Dosage.asNeeded[x]" /> <min value="0" /> <max value="1" /> </base> <type> <code value="boolean" /> </type> <type> <code value="CodeableConcept" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <binding> <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName"> <valueString value="MedicationAsNeededReason" /> </extension> <strength value="example" /> <description value="A coded concept identifying the precondition that should be met or evaluated prior to consuming or administering a medication dose. For example "pain", "30 minutes prior to sexual intercourse", "on flare-up" etc." /> </binding> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value=".outboundRelationship[typeCode=PRCN].target[classCode=OBS, moodCode=EVN, code="as needed"].value=boolean or codable concept" /> </mapping> </element> <element id="Dosage.asNeeded[x]:asNeededCodeableConcept"> <path value="Dosage.asNeeded[x]" /> <sliceName value="asNeededCodeableConcept" /> <short value="Condition" /> <definition value="The condition for administering medication can be: * a physiological measurement value (plasma glucose concentration, body temperature, blood pressure); * a symptom or other circumstance (in the event of a headache, or itch). Physiological measurement values or other conditions do not need to be coded. These can be expressed in free text in the Description concept." /> <comment value="Can express "as needed" without a reason by setting the Boolean = True. In this case the CodeableConcept is not populated. Or you can express "as needed" with a reason by including the CodeableConcept. In this case the Boolean is assumed to be True. If you set the Boolean to False, then the dose is given according to the schedule and is not "prn" or "as needed"." /> <alias value="Criterium" /> <min value="0" /> <max value="1" /> <base> <path value="Dosage.asNeeded[x]" /> <min value="0" /> <max value="1" /> </base> <type> <code value="CodeableConcept" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <binding> <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName"> <valueString value="MedicationAsNeededReason" /> </extension> <strength value="required" /> <description value="A coded concept identifying the precondition that should be met or evaluated prior to consuming or administering a medication dose. For example "pain", "30 minutes prior to sexual intercourse", "on flare-up" etc." /> <valueSet value="https://fhir.healthdata.be/ValueSet/AsNeededCriterium" /> </binding> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value=".outboundRelationship[typeCode=PRCN].target[classCode=OBS, moodCode=EVN, code="as needed"].value=boolean or codable concept" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19945" /> <comment value="Condition" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AsNeeded.Condition" /> </mapping> </element> <element id="Dosage.site"> <path value="Dosage.site" /> <short value="Body site to administer to" /> <definition value="Body site to administer to." /> <comment value="If the use case requires attributes from the BodySite resource (e.g. to identify and track separately) then use the standard extension [body-site-instance](extension-body-site-instance.html). May be a summary code, or a reference to a very precise definition of the location, or both." /> <requirements value="A coded specification of the anatomic site where the medication first enters the body." /> <min value="0" /> <max value="1" /> <base> <path value="Dosage.site" /> <min value="0" /> <max value="1" /> </base> <type> <code value="CodeableConcept" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <binding> <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName"> <valueString value="MedicationAdministrationSite" /> </extension> <strength value="example" /> <description value="A coded concept describing the site location the medicine enters into or onto the body." /> </binding> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="v2" /> <map value="CE/CNE/CWE" /> </mapping> <mapping> <identity value="rim" /> <map value="CD" /> </mapping> <mapping> <identity value="orim" /> <map value="fhir:CodeableConcept rdfs:subClassOf dt:CD" /> </mapping> <mapping> <identity value="rim" /> <map value=".approachSiteCode" /> </mapping> </element> <element id="Dosage.route"> <path value="Dosage.route" /> <short value="RouteOfAdministration" /> <definition value="The route through which the medication is administered (oral, nasal, intravenous, etc.)." /> <comment value="Please note that in contrast to the CBB, this RouteOfAdministration concept is grouped under the DosingInstructions concept. This CBB concept should thus be duplicated when there are multiple DosingInstructions." /> <requirements value="A code specifying the route or physiological path of administration of a therapeutic agent into or onto a patient's body." /> <alias value="Toedieningsweg" /> <min value="0" /> <max value="1" /> <base> <path value="Dosage.route" /> <min value="0" /> <max value="1" /> </base> <type> <code value="CodeableConcept" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <binding> <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName"> <valueString value="RouteOfAdministration" /> </extension> <strength value="required" /> <description value="A coded concept describing the route or physiological path of administration of a therapeutic agent into or onto the body of a subject." /> <valueSet value="https://fhir.healthdata.be/ValueSet/RouteOfMedicationAdministration" /> </binding> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="v2" /> <map value="CE/CNE/CWE" /> </mapping> <mapping> <identity value="rim" /> <map value="CD" /> </mapping> <mapping> <identity value="orim" /> <map value="fhir:CodeableConcept rdfs:subClassOf dt:CD" /> </mapping> <mapping> <identity value="rim" /> <map value=".routeCode" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19941" /> <comment value="RouteOfAdministration" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.RouteOfAdministration" /> </mapping> </element> <element id="Dosage.method"> <path value="Dosage.method" /> <short value="Technique for administering medication" /> <definition value="Technique for administering medication." /> <comment value="Terminologies used often pre-coordinate this term with the route and or form of administration." /> <requirements value="A coded value indicating the method by which the medication is introduced into or onto the body. Most commonly used for injections. For examples, Slow Push; Deep IV." /> <min value="0" /> <max value="1" /> <base> <path value="Dosage.method" /> <min value="0" /> <max value="1" /> </base> <type> <code value="CodeableConcept" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <binding> <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName"> <valueString value="MedicationAdministrationMethod" /> </extension> <strength value="example" /> <description value="A coded concept describing the technique by which the medicine is administered." /> </binding> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="v2" /> <map value="CE/CNE/CWE" /> </mapping> <mapping> <identity value="rim" /> <map value="CD" /> </mapping> <mapping> <identity value="orim" /> <map value="fhir:CodeableConcept rdfs:subClassOf dt:CD" /> </mapping> <mapping> <identity value="rim" /> <map value=".doseQuantity" /> </mapping> </element> <element id="Dosage.dose[x]"> <path value="Dosage.dose[x]" /> <slicing> <discriminator> <type value="type" /> <path value="$this" /> </discriminator> <ordered value="false" /> <rules value="open" /> </slicing> <short value="Amount of medication per dose" /> <definition value="Amount of medication per dose." /> <comment value="Note that this specifies the quantity of the specified medication, not the quantity for each active ingredient(s). Each ingredient amount can be communicated in the Medication resource. For example, if one wants to communicate that a tablet was 375 mg, where the dose was one tablet, you can use the Medication resource to document that the tablet was comprised of 375 mg of drug XYZ. Alternatively if the dose was 375 mg, then you may only need to use the Medication resource to indicate this was a tablet. If the example were an IV such as dopamine and you wanted to communicate that 400mg of dopamine was mixed in 500 ml of some IV solution, then this would all be communicated in the Medication resource. If the administration is not intended to be instantaneous (rate is present or timing has a duration), this can be specified to convey the total amount to be administered over the period of time as indicated by the schedule e.g. 500 ml in dose, with timing used to convey that this should be done over 4 hours." /> <requirements value="The amount of therapeutic or other substance given at one administration event." /> <min value="0" /> <max value="1" /> <base> <path value="Dosage.dose[x]" /> <min value="0" /> <max value="1" /> </base> <type> <code value="Range" /> </type> <type> <code value="Quantity" /> <profile value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value=".doseQuantity" /> </mapping> </element> <element id="Dosage.dose[x]:doseAndRate"> <path value="Dosage.dose[x]" /> <sliceName value="doseAndRate" /> <short value="Dosage" /> <definition value="Instructions for the administrator to administer the medication (the patient themselves, a nurse or other aid). When taking stock of medication use, the dosage describes the pattern of use established by the patient. Once the dose schedule (distribution of doses over time) and the dose have been determined, then there should be one single instruction for use. Multiple parallel instructions for use can be included in the event of a changing dose within one day and in the event of a variable use frequency. Multiple sequential instructions for use can be included in the event of changing doses within one period and/or in the event of a changing dose schedule." /> <comment value="DurationOfAdministration is not mapped to this element but to `.timing.repeat.duration` and `.timing.repeat.durationUnit`." /> <requirements value="The amount of therapeutic or other substance given at one administration event." /> <alias value="Dosering" /> <min value="0" /> <max value="1" /> <base> <path value="Dosage.dose[x]" /> <min value="0" /> <max value="1" /> </base> <type> <code value="Range" /> </type> <type> <code value="Quantity" /> <profile value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value=".doseQuantity" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19935" /> <comment value="Dosage" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage" /> </mapping> </element> <element id="Dosage.dose[x]:doseAndRate.id"> <path value="Dosage.dose[x].id" /> <representation value="xmlAttr" /> <short value="xml:id (or equivalent in JSON)" /> <definition value="unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." /> <comment value="Note that FHIR strings may not exceed 1MB in size" /> <min value="0" /> <max value="1" /> <base> <path value="Element.id" /> <min value="0" /> <max value="1" /> </base> <type> <code value="string" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> </element> <element id="Dosage.dose[x]:doseAndRate.extension"> <path value="Dosage.dose[x].extension" /> <slicing> <discriminator> <type value="value" /> <path value="url" /> </discriminator> <description value="Extensions are always sliced by (at least) url" /> <rules value="open" /> </slicing> <short value="Additional Content defined by implementations" /> <definition value="May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." /> <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." /> <alias value="extensions" /> <alias value="user content" /> <min value="0" /> <max value="*" /> <base> <path value="Element.extension" /> <min value="0" /> <max value="*" /> </base> <type> <code value="Extension" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="ext-1" /> <severity value="error" /> <human value="Must have either extensions or value[x], not both" /> <expression value="extension.exists() != value.exists()" /> <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" /> <source value="http://hl7.org/fhir/StructureDefinition/Extension" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="N/A" /> </mapping> </element> <element id="Dosage.dose[x]:doseAndRate.dose[x]"> <path value="Dosage.dose[x].dose[x]" /> <slicing> <discriminator> <type value="type" /> <path value="$this" /> </discriminator> <rules value="open" /> </slicing> <short value="Dose" /> <definition value="The dose indicates the amount/unit per administration. The unit can be any unit that can occur with this particular medicine." /> <alias value="Keerdosis" /> <base> <path value="Dosage.doseAndRate.dose[x]" /> </base> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19940" /> <comment value="Dose" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.Dose" /> </mapping> </element> <element id="Dosage.dose[x]:doseAndRate.dose[x]:doseRange"> <path value="Dosage.dose[x].dose[x]" /> <sliceName value="doseRange" /> <short value="Set of values bounded by low and high" /> <definition value="A set of ordered Quantities defined by a low and high limit." /> <comment value="The stated low and high value are assumed to have arbitrarily high precision when it comes to determining which values are in the range. I.e. 1.99 is not in the range 2 -> 3." /> <min value="0" /> <max value="*" /> <base> <path value="Dosage.doseAndRate.dose[x]" /> </base> <type> <code value="Range" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="rng-2" /> <severity value="error" /> <human value="If present, low SHALL have a lower value than high" /> <expression value="low.empty() or high.empty() or (low <= high)" /> <xpath value="not(exists(f:low/f:value/@value)) or not(exists(f:high/f:value/@value)) or (number(f:low/f:value/@value) <= number(f:high/f:value/@value))" /> <source value="http://hl7.org/fhir/StructureDefinition/Range" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="v2" /> <map value="NR and also possibly SN (but see also quantity)" /> </mapping> <mapping> <identity value="rim" /> <map value="IVL<QTY[not(type="TS")]> [lowClosed="true" and highClosed="true"]or URG<QTY[not(type="TS")]>" /> </mapping> </element> <element id="Dosage.dose[x]:doseAndRate.dose[x]:doseRange.id"> <path value="Dosage.dose[x].dose[x].id" /> <representation value="xmlAttr" /> <short value="xml:id (or equivalent in JSON)" /> <definition value="unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." /> <comment value="Note that FHIR strings may not exceed 1MB in size" /> <min value="0" /> <max value="1" /> <base> <path value="Element.id" /> <min value="0" /> <max value="1" /> </base> <type> <code value="string" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> </element> <element id="Dosage.dose[x]:doseAndRate.dose[x]:doseRange.extension"> <path value="Dosage.dose[x].dose[x].extension" /> <slicing> <discriminator> <type value="value" /> <path value="url" /> </discriminator> <description value="Extensions are always sliced by (at least) url" /> <rules value="open" /> </slicing> <short value="Additional Content defined by implementations" /> <definition value="May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." /> <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." /> <alias value="extensions" /> <alias value="user content" /> <min value="0" /> <max value="*" /> <base> <path value="Element.extension" /> <min value="0" /> <max value="*" /> </base> <type> <code value="Extension" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="ext-1" /> <severity value="error" /> <human value="Must have either extensions or value[x], not both" /> <expression value="extension.exists() != value.exists()" /> <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" /> <source value="http://hl7.org/fhir/StructureDefinition/Extension" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="N/A" /> </mapping> </element> <element id="Dosage.dose[x]:doseAndRate.dose[x]:doseRange.low"> <path value="Dosage.dose[x].dose[x].low" /> <short value="minimumValue" /> <definition value="The minimal value of the range. The boundary is inclusive." /> <comment value="If the low element is missing, the low boundary is not known." /> <alias value="minimumWaarde" /> <min value="0" /> <max value="1" /> <base> <path value="Range.low" /> <min value="0" /> <max value="1" /> </base> <type> <code value="Quantity" /> <profile value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity" /> </type> <condition value="ele-1" /> <condition value="rng-2" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="qty-3" /> <severity value="error" /> <human value="If a code for the unit is present, the system SHALL also be present" /> <expression value="code.empty() or system.exists()" /> <xpath value="not(exists(f:code)) or exists(f:system)" /> <source value="http://hl7.org/fhir/StructureDefinition/Quantity" /> </constraint> <constraint> <key value="sqty-1" /> <severity value="error" /> <human value="The comparator is not used on a SimpleQuantity" /> <expression value="comparator.empty()" /> <xpath value="not(exists(f:comparator))" /> <source value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity" /> </constraint> <isModifier value="false" /> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="v2" /> <map value="SN (see also Range) or CQ" /> </mapping> <mapping> <identity value="rim" /> <map value="PQ, IVL<PQ>, MO, CO, depending on the values" /> </mapping> <mapping> <identity value="v2" /> <map value="NR.1" /> </mapping> <mapping> <identity value="rim" /> <map value="./low" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.2" /> <comment value="minimumValue" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.MinimumValue" /> </mapping> </element> <element id="Dosage.dose[x]:doseAndRate.dose[x]:doseRange.high"> <path value="Dosage.dose[x].dose[x].high" /> <short value="maximumValue" /> <definition value="The maximum value of the range. The boundary is inclusive." /> <comment value="If the high element is missing, the high boundary is not known." /> <alias value="maximumWaarde" /> <min value="0" /> <max value="1" /> <base> <path value="Range.high" /> <min value="0" /> <max value="1" /> </base> <type> <code value="Quantity" /> <profile value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity" /> </type> <condition value="ele-1" /> <condition value="rng-2" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="qty-3" /> <severity value="error" /> <human value="If a code for the unit is present, the system SHALL also be present" /> <expression value="code.empty() or system.exists()" /> <xpath value="not(exists(f:code)) or exists(f:system)" /> <source value="http://hl7.org/fhir/StructureDefinition/Quantity" /> </constraint> <constraint> <key value="sqty-1" /> <severity value="error" /> <human value="The comparator is not used on a SimpleQuantity" /> <expression value="comparator.empty()" /> <xpath value="not(exists(f:comparator))" /> <source value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity" /> </constraint> <isModifier value="false" /> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="v2" /> <map value="SN (see also Range) or CQ" /> </mapping> <mapping> <identity value="rim" /> <map value="PQ, IVL<PQ>, MO, CO, depending on the values" /> </mapping> <mapping> <identity value="v2" /> <map value="NR.2" /> </mapping> <mapping> <identity value="rim" /> <map value="./high" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.3" /> <comment value="maximumValue" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.MaximumValue" /> </mapping> </element> <element id="Dosage.dose[x]:doseAndRate.dose[x]:doseQuantity"> <path value="Dosage.dose[x].dose[x]" /> <sliceName value="doseQuantity" /> <short value="nominalValue" /> <definition value="Amount of medication per dose. The nominal value of the quantity." /> <comment value="The context of use may frequently define what kind of quantity this is and therefore what kind of units can be used. The context of use may also restrict the values for the comparator." /> <alias value="nominaleWaarde" /> <min value="0" /> <max value="*" /> <base> <path value="Dosage.doseAndRate.dose[x]" /> </base> <type> <code value="Quantity" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="qty-3" /> <severity value="error" /> <human value="If a code for the unit is present, the system SHALL also be present" /> <expression value="code.empty() or system.exists()" /> <xpath value="not(exists(f:code)) or exists(f:system)" /> <source value="http://hl7.org/fhir/StructureDefinition/Quantity" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="v2" /> <map value="SN (see also Range) or CQ" /> </mapping> <mapping> <identity value="rim" /> <map value="PQ, IVL<PQ>, MO, CO, depending on the values" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.4" /> <comment value="nominalValue" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.NominalValue" /> </mapping> </element> <element id="Dosage.dose[x]:doseAndRate.rate[x]"> <path value="Dosage.dose[x].rate[x]" /> <slicing> <discriminator> <type value="type" /> <path value="$this" /> </discriminator> <rules value="open" /> </slicing> <short value="AdministeringSpeed" /> <definition value="The administering speed is used in slow administration of liquid. In practice, the measuring unit is almost always ml/hour. Entering an interval (such as 0-10 ml/hour) is also a commonly used option. For example, with an administering speed of 10ml/hour: * amount = 10, * dose unit = ml, * time unit = hour" /> <alias value="Toedieningssnelheid" /> <base> <path value="Dosage.doseAndRate.rate[x]" /> </base> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19942" /> <comment value="AdministeringSpeed" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSpeed" /> </mapping> </element> <element id="Dosage.dose[x]:doseAndRate.rate[x]:rateRange"> <path value="Dosage.dose[x].rate[x]" /> <sliceName value="rateRange" /> <short value="Set of values bounded by low and high" /> <definition value="A set of ordered Quantities defined by a low and high limit." /> <comment value="The stated low and high value are assumed to have arbitrarily high precision when it comes to determining which values are in the range. I.e. 1.99 is not in the range 2 -> 3." /> <min value="0" /> <max value="*" /> <base> <path value="Dosage.doseAndRate.rate[x]" /> </base> <type> <code value="Range" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="rng-2" /> <severity value="error" /> <human value="If present, low SHALL have a lower value than high" /> <expression value="low.empty() or high.empty() or (low <= high)" /> <xpath value="not(exists(f:low/f:value/@value)) or not(exists(f:high/f:value/@value)) or (number(f:low/f:value/@value) <= number(f:high/f:value/@value))" /> <source value="http://hl7.org/fhir/StructureDefinition/Range" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="v2" /> <map value="NR and also possibly SN (but see also quantity)" /> </mapping> <mapping> <identity value="rim" /> <map value="IVL<QTY[not(type="TS")]> [lowClosed="true" and highClosed="true"]or URG<QTY[not(type="TS")]>" /> </mapping> </element> <element id="Dosage.dose[x]:doseAndRate.rate[x]:rateRange.id"> <path value="Dosage.dose[x].rate[x].id" /> <representation value="xmlAttr" /> <short value="xml:id (or equivalent in JSON)" /> <definition value="unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." /> <comment value="Note that FHIR strings may not exceed 1MB in size" /> <min value="0" /> <max value="1" /> <base> <path value="Element.id" /> <min value="0" /> <max value="1" /> </base> <type> <code value="string" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> </element> <element id="Dosage.dose[x]:doseAndRate.rate[x]:rateRange.extension"> <path value="Dosage.dose[x].rate[x].extension" /> <slicing> <discriminator> <type value="value" /> <path value="url" /> </discriminator> <description value="Extensions are always sliced by (at least) url" /> <rules value="open" /> </slicing> <short value="Additional Content defined by implementations" /> <definition value="May be used to represent additional information that is not part of the basic definition of the element. In order to make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." /> <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." /> <alias value="extensions" /> <alias value="user content" /> <min value="0" /> <max value="*" /> <base> <path value="Element.extension" /> <min value="0" /> <max value="*" /> </base> <type> <code value="Extension" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="ext-1" /> <severity value="error" /> <human value="Must have either extensions or value[x], not both" /> <expression value="extension.exists() != value.exists()" /> <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" /> <source value="http://hl7.org/fhir/StructureDefinition/Extension" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value="N/A" /> </mapping> </element> <element id="Dosage.dose[x]:doseAndRate.rate[x]:rateRange.low"> <path value="Dosage.dose[x].rate[x].low" /> <short value="minimumValue" /> <definition value="The minimal value of the range. The boundary is inclusive." /> <comment value="If the low element is missing, the low boundary is not known." /> <alias value="minimumWaarde" /> <min value="0" /> <max value="1" /> <base> <path value="Range.low" /> <min value="0" /> <max value="1" /> </base> <type> <code value="Quantity" /> <profile value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity" /> </type> <condition value="ele-1" /> <condition value="rng-2" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="qty-3" /> <severity value="error" /> <human value="If a code for the unit is present, the system SHALL also be present" /> <expression value="code.empty() or system.exists()" /> <xpath value="not(exists(f:code)) or exists(f:system)" /> <source value="http://hl7.org/fhir/StructureDefinition/Quantity" /> </constraint> <constraint> <key value="sqty-1" /> <severity value="error" /> <human value="The comparator is not used on a SimpleQuantity" /> <expression value="comparator.empty()" /> <xpath value="not(exists(f:comparator))" /> <source value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity" /> </constraint> <isModifier value="false" /> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="v2" /> <map value="SN (see also Range) or CQ" /> </mapping> <mapping> <identity value="rim" /> <map value="PQ, IVL<PQ>, MO, CO, depending on the values" /> </mapping> <mapping> <identity value="v2" /> <map value="NR.1" /> </mapping> <mapping> <identity value="rim" /> <map value="./low" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.2" /> <comment value="minimumValue" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.MinimumValue" /> </mapping> </element> <element id="Dosage.dose[x]:doseAndRate.rate[x]:rateRange.high"> <path value="Dosage.dose[x].rate[x].high" /> <short value="maximumValue" /> <definition value="The maximum value of the range. The boundary is inclusive." /> <comment value="If the high element is missing, the high boundary is not known." /> <alias value="maximumWaarde" /> <min value="0" /> <max value="1" /> <base> <path value="Range.high" /> <min value="0" /> <max value="1" /> </base> <type> <code value="Quantity" /> <profile value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity" /> </type> <condition value="ele-1" /> <condition value="rng-2" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="qty-3" /> <severity value="error" /> <human value="If a code for the unit is present, the system SHALL also be present" /> <expression value="code.empty() or system.exists()" /> <xpath value="not(exists(f:code)) or exists(f:system)" /> <source value="http://hl7.org/fhir/StructureDefinition/Quantity" /> </constraint> <constraint> <key value="sqty-1" /> <severity value="error" /> <human value="The comparator is not used on a SimpleQuantity" /> <expression value="comparator.empty()" /> <xpath value="not(exists(f:comparator))" /> <source value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity" /> </constraint> <isModifier value="false" /> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="v2" /> <map value="SN (see also Range) or CQ" /> </mapping> <mapping> <identity value="rim" /> <map value="PQ, IVL<PQ>, MO, CO, depending on the values" /> </mapping> <mapping> <identity value="v2" /> <map value="NR.2" /> </mapping> <mapping> <identity value="rim" /> <map value="./high" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.3" /> <comment value="maximumValue" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.MaximumValue" /> </mapping> </element> <element id="Dosage.dose[x]:doseAndRate.rate[x]:rateQuantity"> <path value="Dosage.dose[x].rate[x]" /> <sliceName value="rateQuantity" /> <short value="nominalValue" /> <definition value="The nominal value of the quantity." /> <comment value="The context of use may frequently define what kind of quantity this is and therefore what kind of units can be used. The context of use may also restrict the values for the comparator." /> <alias value="nominaleWaarde" /> <min value="0" /> <max value="*" /> <base> <path value="Dosage.doseAndRate.rate[x]" /> </base> <type> <code value="Quantity" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="qty-3" /> <severity value="error" /> <human value="If a code for the unit is present, the system SHALL also be present" /> <expression value="code.empty() or system.exists()" /> <xpath value="not(exists(f:code)) or exists(f:system)" /> <source value="http://hl7.org/fhir/StructureDefinition/Quantity" /> </constraint> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="v2" /> <map value="SN (see also Range) or CQ" /> </mapping> <mapping> <identity value="rim" /> <map value="PQ, IVL<PQ>, MO, CO, depending on the values" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.4" /> <comment value="nominalValue" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.NominalValue" /> </mapping> </element> <element id="Dosage.maxDosePerPeriod"> <path value="Dosage.maxDosePerPeriod" /> <short value="MaximumDose" /> <definition value="A maximum dose maximizes (in time) the usage of a drug in an 'as needed' prescription." /> <comment value="This is intended for use as an adjunct to the dosage when there is an upper cap. For example "2 tablets every 4 hours to a maximum of 8/day"." /> <requirements value="The maximum total quantity of a therapeutic substance that may be administered to a subject over the period of time. For example, 1000mg in 24 hours." /> <alias value="MaximaleDosering" /> <min value="0" /> <max value="1" /> <base> <path value="Dosage.maxDosePerPeriod" /> <min value="0" /> <max value="1" /> </base> <type> <code value="Ratio" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="rat-1" /> <severity value="error" /> <human value="Numerator and denominator SHALL both be present, or both are absent. If both are absent, there SHALL be some extension present" /> <expression value="(numerator.empty() xor denominator.exists()) and (numerator.exists() or extension.exists())" /> <xpath value="(count(f:numerator) = count(f:denominator)) and ((count(f:numerator) > 0) or (count(f:extension) > 0))" /> <source value="http://hl7.org/fhir/StructureDefinition/Ratio" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="v2" /> <map value="N/A" /> </mapping> <mapping> <identity value="rim" /> <map value="RTO" /> </mapping> <mapping> <identity value="rim" /> <map value=".maxDoseQuantity" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19946" /> <comment value="MaximumDose" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AsNeeded.MaximumDose" /> </mapping> </element> <element id="Dosage.maxDosePerAdministration"> <path value="Dosage.maxDosePerAdministration" /> <short value="Upper limit on medication per administration" /> <definition value="Upper limit on medication per administration." /> <comment value="This is intended for use as an adjunct to the dosage when there is an upper cap. For example, a body surface area related dose with a maximum amount, such as 1.5 mg/m2 (maximum 2 mg) IV over 5 – 10 minutes would have doseQuantity of 1.5 mg/m2 and maxDosePerAdministration of 2 mg." /> <requirements value="The maximum total quantity of a therapeutic substance that may be administered to a subject per administration." /> <min value="0" /> <max value="1" /> <base> <path value="Dosage.maxDosePerAdministration" /> <min value="0" /> <max value="1" /> </base> <type> <code value="Quantity" /> <profile value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="qty-3" /> <severity value="error" /> <human value="If a code for the unit is present, the system SHALL also be present" /> <expression value="code.empty() or system.exists()" /> <xpath value="not(exists(f:code)) or exists(f:system)" /> <source value="http://hl7.org/fhir/StructureDefinition/Quantity" /> </constraint> <constraint> <key value="sqty-1" /> <severity value="error" /> <human value="The comparator is not used on a SimpleQuantity" /> <expression value="comparator.empty()" /> <xpath value="not(exists(f:comparator))" /> <source value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity" /> </constraint> <isModifier value="false" /> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="v2" /> <map value="SN (see also Range) or CQ" /> </mapping> <mapping> <identity value="rim" /> <map value="PQ, IVL<PQ>, MO, CO, depending on the values" /> </mapping> <mapping> <identity value="rim" /> <map value="not supported" /> </mapping> </element> <element id="Dosage.maxDosePerLifetime"> <path value="Dosage.maxDosePerLifetime" /> <short value="Upper limit on medication per lifetime of the patient" /> <definition value="Upper limit on medication per lifetime of the patient." /> <comment value="The context of use may frequently define what kind of quantity this is and therefore what kind of units can be used. The context of use may also restrict the values for the comparator." /> <requirements value="The maximum total quantity of a therapeutic substance that may be administered per lifetime of the subject." /> <min value="0" /> <max value="1" /> <base> <path value="Dosage.maxDosePerLifetime" /> <min value="0" /> <max value="1" /> </base> <type> <code value="Quantity" /> <profile value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <constraint> <key value="qty-3" /> <severity value="error" /> <human value="If a code for the unit is present, the system SHALL also be present" /> <expression value="code.empty() or system.exists()" /> <xpath value="not(exists(f:code)) or exists(f:system)" /> <source value="http://hl7.org/fhir/StructureDefinition/Quantity" /> </constraint> <constraint> <key value="sqty-1" /> <severity value="error" /> <human value="The comparator is not used on a SimpleQuantity" /> <expression value="comparator.empty()" /> <xpath value="not(exists(f:comparator))" /> <source value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity" /> </constraint> <isModifier value="false" /> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="v2" /> <map value="SN (see also Range) or CQ" /> </mapping> <mapping> <identity value="rim" /> <map value="PQ, IVL<PQ>, MO, CO, depending on the values" /> </mapping> <mapping> <identity value="rim" /> <map value="not supported" /> </mapping> </element> <element id="Dosage.rate[x]"> <path value="Dosage.rate[x]" /> <short value="Amount of medication per unit of time" /> <definition value="Amount of medication per unit of time." /> <comment value="It is possible to supply both a rate and a doseQuantity to provide full details about how the medication is to be administered and supplied. If the rate is intended to change over time, depending on local rules/regulations, each change should be captured as a new version of the MedicationRequest with an updated rate, or captured with a new MedicationRequest with the new rate." /> <requirements value="Identifies the speed with which the medication was or will be introduced into the patient. Typically the rate for an infusion e.g. 100 ml per 1 hour or 100 ml/hr. May also be expressed as a rate per unit of time e.g. 500 ml per 2 hours. Other examples: 200 mcg/min or 200 mcg/1 minute; 1 liter/8 hours. Sometimes, a rate can imply duration when expressed as total volume / duration (e.g. 500mL/2 hours implies a duration of 2 hours). However, when rate doesn't imply duration (e.g. 250mL/hour), then the timing.repeat.duration is needed to convey the infuse over time period." /> <min value="0" /> <max value="1" /> <base> <path value="Dosage.rate[x]" /> <min value="0" /> <max value="1" /> </base> <type> <code value="Ratio" /> </type> <type> <code value="Range" /> </type> <type> <code value="Quantity" /> <profile value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity" /> </type> <condition value="ele-1" /> <constraint> <key value="ele-1" /> <severity value="error" /> <human value="All FHIR elements must have a @value or children" /> <expression value="hasValue() | (children().count() > id.count())" /> <xpath value="@value|f:*|h:div" /> <source value="http://hl7.org/fhir/StructureDefinition/Element" /> </constraint> <isSummary value="true" /> <mapping> <identity value="rim" /> <map value="n/a" /> </mapping> <mapping> <identity value="rim" /> <map value=".rateQuantity" /> </mapping> </element> </snapshot> <differential> <element id="Dosage"> <path value="Dosage" /> <short value="DosingInstructions" /> <comment value="This element _mostly_ represents the DosingInstructions container from CBB InstructionsForUse, but also includes the AdditionalInstructions and RouteOfAdministration concepts, which are normally placed on the same level as this container. As a result, these concepts are **duplicated** in every repetition of this element, even though these concepts should be present just once according to the CBB. The RepeatPeriodCyclicalSchedule and Description elements of the CBB are not represented in this profile. When a HdBe profile contains a InstructionsForUse.DosageInstructions datatype, the RepeatPeriodCyclicalSchedule and Description elements are separately added to this profile as well. This element does not contain a mapping to the Dosage container from CBB InstructionsForUse. However, the child concepts of Dosage are all mapped. Multiple Dosage instances are represented by another DosingInstructions that contains a similiar SequenceNumber." /> <alias value="Doseerinstructie" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.22095" /> <comment value="DosingInstructions" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions" /> </mapping> </element> <element id="Dosage.sequence"> <path value="Dosage.sequence" /> <short value="SequenceNumber" /> <definition value="This indicates the sequence of the dosing instructions within the medication agreement." /> <alias value="Volgnummer" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.22503" /> <comment value="SequenceNumber" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.SequenceNumber" /> </mapping> </element> <element id="Dosage.additionalInstruction"> <path value="Dosage.additionalInstruction" /> <short value="AdditionalInstructions" /> <definition value="The additional instructions contain extra information on the use of the current prescription. This includes all instructions for use. The text can come from the original “paper" medication prescription, but can also be generated from the coded information. This concept may contain more information than what is structurally coded in the information below, but may not conflict with it. The instructions may not conflict with other components of the request for administration. The instructions can also refer to an existing protocol." /> <comment value="Please note that in contrast to the CBB, this AdditionalInstructions concept is grouped under the DosingInstructions concept. This CBB concept should thus be duplicated when there are multiple DosingInstructions." /> <alias value="AanvullendeInstructie" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19944" /> <comment value="AdditionalInstructions" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.AdditionalInstructions" /> </mapping> </element> <element id="Dosage.timing"> <path value="Dosage.timing" /> <short value="AdministeringSchedule" /> <definition value="Specifications of the times at which the medication is to be administered. This is indicated as follows: * Time(s) (16:00) or indications (“before meals”) at which the medication is to be taken each day. * A specific number of times the medication is to be taken each day ("3x a day"), indicated with the frequency. * A time interval between consecutive doses (“Every 2 hours”, “every 3 days”), indicated with the word Interval. * Combined periods with an interval and duration (“1 daily for three out of four weeks: the pill schedule”) If a certain medication is not to be taken daily, the aforementioned can be combined with daily indications: * One or more week days on which the medication is to be administered (e.g. “Monday, Wednesday, Friday”) * ”3x a week”, “2x a month”. The specified administration “infinite” is automatically to be repeated until: * The end date and time has been reached * The total administration duration has been reached (14 days) * A specific amount of administrations has been reached (“20 doses”), to be entered in the Frequency concept." /> <alias value="Toedieningsschema" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19948" /> <comment value="AdministeringSchedule" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule" /> </mapping> </element> <element id="Dosage.timing.repeat.extension"> <path value="Dosage.timing.repeat.extension" /> <slicing> <discriminator> <type value="value" /> <path value="url" /> </discriminator> <rules value="open" /> </slicing> <min value="0" /> </element> <element id="Dosage.timing.repeat.extension:timingExact"> <path value="Dosage.timing.repeat.extension" /> <sliceName value="timingExact" /> <min value="0" /> <type> <code value="Extension" /> <profile value="http://hl7.org/fhir/StructureDefinition/timing-exact" /> </type> </element> <element id="Dosage.timing.repeat.extension:timingExact.value[x]"> <path value="Dosage.timing.repeat.extension.value[x]" /> <definition value="Indicates that the timing as specified by `.frequency`, `.period` and `.periodUnit` should be strictly interpreted. This is the case when the CBB concept Interval is expressed using these elements (as opposed to the CBB concept Frequency). The times can be chosen freely, but distribution throughout the day is more precise, and the interval between times is important (e.g. in the case of antibiotics) In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics)." /> <comment value="Notes on the CBB concepts Frequency and Interval: 1. An interval (in FHIR) is just a normal frequency with a period of 1 and is represented in FHIR as just another frequency using `.frequency`, `.period` and `.periodUnit`. However, the CBB differentiates between the two concepts in the timing precision (the Interval concept defines precise intervals while the Frequency concept defines approximate intervals). When the interval is precise, this is communicated using the extension in `extension:timingExact`. 2. On the other hand, the CBB Frequency concept might be used to express a single-use, non-repeating series by omitting the time unit. In FHIR, this is _not_ represented as a frequency, but with the `.count` element. 3. Lastly, the Frequency concept may be used to express either a single nominal value or a range. A range is represented by respectively setting the minimum and maximum value to `.frequency` and `.frequencyMax`, or to `.count` and `.countMax` for single-use events. A nominal value is expressed by setting its value to `.frequency` or to `.count` for single-use events, and leaving `.frequencyMax` and `.countMax` unpopulated. In summary: * CBB concept Frequency: * With time unit: * Nominal value: `.frequency`, `.period` and `.periodUnit` * Range: `.frequency`, `.frequencyMax`, `.period` and `.periodUnit` * Without time unit: * Nominal value: `.count` * Range: `.count` and `.countMax` * CBB concept Interval: `.frequency` (set to 1), `.period`, `.periodUnit` and `.extension:timingExact` (set to _true_)" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19950" /> <comment value="Interval (implicit, main mapping is on .frequency, .period and .periodMax)" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Interval" /> <comment value="implicit, main mapping is on .frequency, .period and .periodMax" /> </mapping> </element> <element id="Dosage.timing.repeat.bounds[x]"> <path value="Dosage.timing.repeat.bounds[x]" /> <slicing> <discriminator> <type value="type" /> <path value="$this" /> </discriminator> <rules value="open" /> </slicing> </element> <element id="Dosage.timing.repeat.bounds[x]:boundsDuration"> <path value="Dosage.timing.repeat.bounds[x]" /> <sliceName value="boundsDuration" /> <short value="DoseDuration" /> <definition value="The intended time duration for these dosing instructions, e.g. 5 days or 8 weeks. In the case of medication for an indefinite period, the dosing duration is left empty in the last dosing instruction." /> <alias value="Doseerduur" /> <type> <code value="Duration" /> </type> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.22506" /> <comment value="DoseDuration" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.DoseDuration" /> </mapping> </element> <element id="Dosage.timing.repeat.count"> <path value="Dosage.timing.repeat.count" /> <short value="Frequency / minimumValue / nominalValue" /> <definition value="Usually, frequency comprises both amount and time unit (3 times a day), but it can occur without the time unit (single use). This is represented by this `.count` element and optionally `.countMax` if a range should be represented. A reasonable distribution over the day is expected, but exact times are not given. This is left to the patient. It is the most common manner of extramural prescription. In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics)." /> <comment value="Notes on the CBB concepts Frequency and Interval: 1. An interval (in FHIR) is just a normal frequency with a period of 1 and is represented in FHIR as just another frequency using `.frequency`, `.period` and `.periodUnit`. However, the CBB differentiates between the two concepts in the timing precision (the Interval concept defines precise intervals while the Frequency concept defines approximate intervals). When the interval is precise, this is communicated using the extension in `extension:timingExact`. 2. On the other hand, the CBB Frequency concept might be used to express a single-use, non-repeating series by omitting the time unit. In FHIR, this is _not_ represented as a frequency, but with the `.count` element. 3. Lastly, the Frequency concept may be used to express either a single nominal value or a range. A range is represented by respectively setting the minimum and maximum value to `.frequency` and `.frequencyMax`, or to `.count` and `.countMax` for single-use events. A nominal value is expressed by setting its value to `.frequency` or to `.count` for single-use events, and leaving `.frequencyMax` and `.countMax` unpopulated. In summary: * CBB concept Frequency: * With time unit: * Nominal value: `.frequency`, `.period` and `.periodUnit` * Range: `.frequency`, `.frequencyMax`, `.period` and `.periodUnit` * Without time unit: * Nominal value: `.count` * Range: `.count` and `.countMax` * CBB concept Interval: `.frequency` (set to 1), `.period`, `.periodUnit` and `.extension:timingExact` (set to _true_)" /> <alias value="Frequentie" /> <alias value="nominaleWaarde" /> <alias value="minimumWaarde" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19949" /> <comment value="Frequency (single use only)" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.2" /> <comment value="minimumValue" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.4" /> <comment value="nominalValue" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Frequency" /> <comment value="single use only" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.NominalValue" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.MinimumValue" /> </mapping> </element> <element id="Dosage.timing.repeat.countMax"> <path value="Dosage.timing.repeat.countMax" /> <short value="Frequency / maximumValue" /> <definition value="Usually, frequency comprises both amount and time unit (3 times a day), but it can occur without the time unit (single use). This is represented by the `.count` element and optionally `.countMax` if a range should be represented. A reasonable distribution over the day is expected, but exact times are not given. This is left to the patient. It is the most common manner of extramural prescription. In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics)." /> <comment value="Notes on the CBB concepts Frequency and Interval: 1. An interval (in FHIR) is just a normal frequency with a period of 1 and is represented in FHIR as just another frequency using `.frequency`, `.period` and `.periodUnit`. However, the CBB differentiates between the two concepts in the timing precision (the Interval concept defines precise intervals while the Frequency concept defines approximate intervals). When the interval is precise, this is communicated using the extension in `extension:timingExact`. 2. On the other hand, the CBB Frequency concept might be used to express a single-use, non-repeating series by omitting the time unit. In FHIR, this is _not_ represented as a frequency, but with the `.count` element. 3. Lastly, the Frequency concept may be used to express either a single nominal value or a range. A range is represented by respectively setting the minimum and maximum value to `.frequency` and `.frequencyMax`, or to `.count` and `.countMax` for single-use events. A nominal value is expressed by setting its value to `.frequency` or to `.count` for single-use events, and leaving `.frequencyMax` and `.countMax` unpopulated. In summary: * CBB concept Frequency: * With time unit: * Nominal value: `.frequency`, `.period` and `.periodUnit` * Range: `.frequency`, `.frequencyMax`, `.period` and `.periodUnit` * Without time unit: * Nominal value: `.count` * Range: `.count` and `.countMax` * CBB concept Interval: `.frequency` (set to 1), `.period`, `.periodUnit` and `.extension:timingExact` (set to _true_)" /> <alias value="Frequentie" /> <alias value="maximumWaarde" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19949" /> <comment value="Frequency" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.3" /> <comment value="maximumValue" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Frequency" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.MaximumValue" /> </mapping> </element> <element id="Dosage.timing.repeat.duration"> <path value="Dosage.timing.repeat.duration" /> <short value="DurationOfAdministration" /> <definition value="The duration of administration defines the length of time during which the drug is administered and is mainly used in the slow parenteral administration of fluids. The `durationUnit` defines the time unit." /> <alias value="Toedieningsduur" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.23141" /> <comment value="DurationOfAdministration" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.DurationOfAdministration" /> </mapping> </element> <element id="Dosage.timing.repeat.durationUnit"> <path value="Dosage.timing.repeat.durationUnit" /> <short value="DurationOfAdministration" /> <definition value="The units of time, in UCUM units, for the duration of administration of time during which the drug is administered." /> <alias value="Toedieningsduur" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.23141" /> <comment value="DurationOfAdministration" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.DurationOfAdministration" /> </mapping> </element> <element id="Dosage.timing.repeat.frequency"> <path value="Dosage.timing.repeat.frequency" /> <short value="Frequency / minimumValue / nominalValue / Interval" /> <definition value="The number of times to repeat the action within the specified period. If frequencyMax is present, this element indicates the lower bound of the allowed range of the frequency. If the `extension:timingExact` element is absent or set to _false_, a reasonable distribution over the day is expected, but exact times are not given. This is left to the patient. It is the most common manner of extramural prescription. In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics). If the `extension:timingExact` element is present and set to _true_, the times can be chosen freely, but distribution throughout the day is more precise, and the interval between times is important (e.g. in the case of antibiotics) In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics)." /> <comment value="Notes on the CBB concepts Frequency and Interval: 1. An interval (in FHIR) is just a normal frequency with a period of 1 and is represented in FHIR as just another frequency using `.frequency`, `.period` and `.periodUnit`. However, the CBB differentiates between the two concepts in the timing precision (the Interval concept defines precise intervals while the Frequency concept defines approximate intervals). When the interval is precise, this is communicated using the extension in `extension:timingExact`. 2. On the other hand, the CBB Frequency concept might be used to express a single-use, non-repeating series by omitting the time unit. In FHIR, this is _not_ represented as a frequency, but with the `.count` element. 3. Lastly, the Frequency concept may be used to express either a single nominal value or a range. A range is represented by respectively setting the minimum and maximum value to `.frequency` and `.frequencyMax`, or to `.count` and `.countMax` for single-use events. A nominal value is expressed by setting its value to `.frequency` or to `.count` for single-use events, and leaving `.frequencyMax` and `.countMax` unpopulated. In summary: * CBB concept Frequency: * With time unit: * Nominal value: `.frequency`, `.period` and `.periodUnit` * Range: `.frequency`, `.frequencyMax`, `.period` and `.periodUnit` * Without time unit: * Nominal value: `.count` * Range: `.count` and `.countMax` * CBB concept Interval: `.frequency` (set to 1), `.period`, `.periodUnit` and `.extension:timingExact` (set to _true_)" /> <alias value="Frequentie" /> <alias value="minimumWaarde" /> <alias value="nominaleWaarde" /> <alias value="Interval" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19949" /> <comment value="Frequency" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.2" /> <comment value="minimumValue" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.4" /> <comment value="nominalValue" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19950" /> <comment value="Interval" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Frequency" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.MinimumValue" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.NominalValue" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Interval" /> </mapping> </element> <element id="Dosage.timing.repeat.frequencyMax"> <path value="Dosage.timing.repeat.frequencyMax" /> <short value="Frequency / maximumValue" /> <definition value="If present, indicates that the frequency is a range - so to repeat between [frequency] and [frequencyMax] times within the period or period range. If the `extension:timingExact` element is absent or set to _false_, a reasonable distribution over the day is expected, but exact times are not given. This is left to the patient. It is the most common manner of extramural prescription. In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics). If the `extension:timingExact` element is present and set to _true_, the times can be chosen freely, but distribution throughout the day is more precise, and the interval between times is important (e.g. in the case of antibiotics) In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics)." /> <comment value="Notes on the CBB concepts Frequency and Interval: 1. An interval (in FHIR) is just a normal frequency with a period of 1 and is represented in FHIR as just another frequency using `.frequency`, `.period` and `.periodUnit`. However, the CBB differentiates between the two concepts in the timing precision (the Interval concept defines precise intervals while the Frequency concept defines approximate intervals). When the interval is precise, this is communicated using the extension in `extension:timingExact`. 2. On the other hand, the CBB Frequency concept might be used to express a single-use, non-repeating series by omitting the time unit. In FHIR, this is _not_ represented as a frequency, but with the `.count` element. 3. Lastly, the Frequency concept may be used to express either a single nominal value or a range. A range is represented by respectively setting the minimum and maximum value to `.frequency` and `.frequencyMax`, or to `.count` and `.countMax` for single-use events. A nominal value is expressed by setting its value to `.frequency` or to `.count` for single-use events, and leaving `.frequencyMax` and `.countMax` unpopulated. In summary: * CBB concept Frequency: * With time unit: * Nominal value: `.frequency`, `.period` and `.periodUnit` * Range: `.frequency`, `.frequencyMax`, `.period` and `.periodUnit` * Without time unit: * Nominal value: `.count` * Range: `.count` and `.countMax` * CBB concept Interval: `.frequency` (set to 1), `.period`, `.periodUnit` and `.extension:timingExact` (set to _true_)" /> <alias value="maximumWaarde" /> <alias value="Frequentie" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19949" /> <comment value="Frequency" /> </mapping> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.3" /> <comment value="maximumValue" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Frequency" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.MaximumValue" /> </mapping> </element> <element id="Dosage.timing.repeat.period"> <path value="Dosage.timing.repeat.period" /> <short value="Frequency / Interval" /> <definition value="Indicates the duration of time over which repetitions are to occur; e.g. to express "3 times per day", 3 would be the frequency and "1 day" would be the period. If periodMax is present, this element indicates the lower bound of the allowed range of the period length. If the `extension:timingExact` element is absent or set to _false_, a reasonable distribution over the day is expected, but exact times are not given. This is left to the patient. It is the most common manner of extramural prescription. In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics). If the `extension:timingExact` element is present and set to _true_, the times can be chosen freely, but distribution throughout the day is more precise, and the interval between times is important (e.g. in the case of antibiotics) In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics)." /> <comment value="Notes on the CBB concepts Frequency and Interval: 1. An interval (in FHIR) is just a normal frequency with a period of 1 and is represented in FHIR as just another frequency using `.frequency`, `.period` and `.periodUnit`. However, the CBB differentiates between the two concepts in the timing precision (the Interval concept defines precise intervals while the Frequency concept defines approximate intervals). When the interval is precise, this is communicated using the extension in `extension:timingExact`. 2. On the other hand, the CBB Frequency concept might be used to express a single-use, non-repeating series by omitting the time unit. In FHIR, this is _not_ represented as a frequency, but with the `.count` element. 3. Lastly, the Frequency concept may be used to express either a single nominal value or a range. A range is represented by respectively setting the minimum and maximum value to `.frequency` and `.frequencyMax`, or to `.count` and `.countMax` for single-use events. A nominal value is expressed by setting its value to `.frequency` or to `.count` for single-use events, and leaving `.frequencyMax` and `.countMax` unpopulated. In summary: * CBB concept Frequency: * With time unit: * Nominal value: `.frequency`, `.period` and `.periodUnit` * Range: `.frequency`, `.frequencyMax`, `.period` and `.periodUnit` * Without time unit: * Nominal value: `.count` * Range: `.count` and `.countMax` * CBB concept Interval: `.frequency` (set to 1), `.period`, `.periodUnit` and `.extension:timingExact` (set to _true_)" /> <alias value="Frequentie" /> <alias value="Interval" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19949" /> <comment value="Frequency" /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19950" /> <comment value="Interval" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Frequency" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Interval" /> </mapping> </element> <element id="Dosage.timing.repeat.periodUnit"> <path value="Dosage.timing.repeat.periodUnit" /> <short value="Frequency / Interval" /> <definition value="The units of time for the period in UCUM units for Frequency and Interval. If the `extension:timingExact` element is absent or set to _false_, a reasonable distribution over the day is expected, but exact times are not given. This is left to the patient. It is the most common manner of extramural prescription. In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics). If the `extension:timingExact` element is present and set to _true_, the times can be chosen freely, but distribution throughout the day is more precise, and the interval between times is important (e.g. in the case of antibiotics) In the case of Baxter packs and intramural care, such a prescription is used to draw up a (location-specific) outline for distribution times (logistics)." /> <comment value="Notes on the CBB concepts Frequency and Interval: 1. An interval (in FHIR) is just a normal frequency with a period of 1 and is represented in FHIR as just another frequency using `.frequency`, `.period` and `.periodUnit`. However, the CBB differentiates between the two concepts in the timing precision (the Interval concept defines precise intervals while the Frequency concept defines approximate intervals). When the interval is precise, this is communicated using the extension in `extension:timingExact`. 2. On the other hand, the CBB Frequency concept might be used to express a single-use, non-repeating series by omitting the time unit. In FHIR, this is _not_ represented as a frequency, but with the `.count` element. 3. Lastly, the Frequency concept may be used to express either a single nominal value or a range. A range is represented by respectively setting the minimum and maximum value to `.frequency` and `.frequencyMax`, or to `.count` and `.countMax` for single-use events. A nominal value is expressed by setting its value to `.frequency` or to `.count` for single-use events, and leaving `.frequencyMax` and `.countMax` unpopulated. In summary: * CBB concept Frequency: * With time unit: * Nominal value: `.frequency`, `.period` and `.periodUnit` * Range: `.frequency`, `.frequencyMax`, `.period` and `.periodUnit` * Without time unit: * Nominal value: `.count` * Range: `.count` and `.countMax` * CBB concept Interval: `.frequency` (set to 1), `.period`, `.periodUnit` and `.extension:timingExact` (set to _true_)" /> <alias value="Frequentie" /> <alias value="Interval" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19949" /> <comment value="Frequency. When frequency is used, set `extenstion.exact` to false." /> </mapping> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19950" /> <comment value="Interval" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Frequency" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.Interval" /> </mapping> </element> <element id="Dosage.timing.repeat.dayOfWeek"> <path value="Dosage.timing.repeat.dayOfWeek" /> <short value="WeekDay" /> <definition value="WeekDay indicates a pattern of doses on fixed week days." /> <comment value="If no days are specified, the action is assumed to happen every day as otherwise specified." /> <alias value="Weekdag" /> <binding> <strength value="required" /> <description value="Use ConceptMap 'WeekDay_to_DaysOfWeek' to translate CBB terminology to profile terminology in ValueSet 'DaysOfWeek.'" /> <valueSet value="http://hl7.org/fhir/ValueSet/days-of-week|4.0.1"> <extension url="http://hl7.org/fhir/StructureDefinition/11179-permitted-value-conceptmap"> <valueCanonical value="https://fhir.healthdata.be/ConceptMap/WeekDay-to-DaysOfWeek" /> </extension> </valueSet> </binding> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19952" /> <comment value="WeekDay" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.WeekDay" /> </mapping> </element> <element id="Dosage.timing.repeat.timeOfDay"> <path value="Dosage.timing.repeat.timeOfDay" /> <short value="AdministrationTime" /> <definition value="The time of administration is a specific time of day (on the clock). This time usually isn’t (intended to be) exact. There can be multiple administering times in one day. The ideal time of administration can also be entered as a time of day (morning, afternoon, evening, night-time). The administration time is then to be left empty, and the time of day can be entered in the TimeOfDay concept." /> <comment value="If there's a timeOfDay, there cannot be a when, or vice versa." /> <alias value="Toedientijd" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19951" /> <comment value="AdministrationTime" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.AdministrationTime" /> </mapping> </element> <element id="Dosage.timing.repeat.when"> <path value="Dosage.timing.repeat.when" /> <short value="TimeOfDay" /> <definition value="Time of day: morning, afternoon, evening, night." /> <alias value="Dagdeel" /> <binding> <strength value="required" /> <description value="Use ConceptMap 'TimeOfDay_to_EventTiming' to translate CBB terminology to profile terminology in ValueSet 'EventTiming.'" /> <valueSet value="http://hl7.org/fhir/ValueSet/event-timing"> <extension url="http://hl7.org/fhir/StructureDefinition/11179-permitted-value-conceptmap"> <valueCanonical value="https://fhir.healthdata.be/ConceptMap/TimeOfDay-to-EventTiming" /> </extension> </valueSet> </binding> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19953" /> <comment value="TimeOfDay" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSchedule.TimeOfDay" /> </mapping> </element> <element id="Dosage.asNeeded[x]"> <path value="Dosage.asNeeded[x]" /> <slicing> <discriminator> <type value="type" /> <path value="$this" /> </discriminator> <rules value="open" /> </slicing> </element> <element id="Dosage.asNeeded[x]:asNeededCodeableConcept"> <path value="Dosage.asNeeded[x]" /> <sliceName value="asNeededCodeableConcept" /> <short value="Condition" /> <definition value="The condition for administering medication can be: * a physiological measurement value (plasma glucose concentration, body temperature, blood pressure); * a symptom or other circumstance (in the event of a headache, or itch). Physiological measurement values or other conditions do not need to be coded. These can be expressed in free text in the Description concept." /> <alias value="Criterium" /> <type> <code value="CodeableConcept" /> </type> <binding> <strength value="required" /> <valueSet value="https://fhir.healthdata.be/ValueSet/AsNeededCriterium" /> </binding> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19945" /> <comment value="Condition" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AsNeeded.Condition" /> </mapping> </element> <element id="Dosage.route"> <path value="Dosage.route" /> <short value="RouteOfAdministration" /> <definition value="The route through which the medication is administered (oral, nasal, intravenous, etc.)." /> <comment value="Please note that in contrast to the CBB, this RouteOfAdministration concept is grouped under the DosingInstructions concept. This CBB concept should thus be duplicated when there are multiple DosingInstructions." /> <alias value="Toedieningsweg" /> <binding> <strength value="required" /> <valueSet value="https://fhir.healthdata.be/ValueSet/RouteOfMedicationAdministration" /> </binding> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19941" /> <comment value="RouteOfAdministration" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.RouteOfAdministration" /> </mapping> </element> <element id="Dosage.doseAndRate"> <path value="Dosage.doseAndRate" /> <short value="Dosage" /> <definition value="Instructions for the administrator to administer the medication (the patient themselves, a nurse or other aid). When taking stock of medication use, the dosage describes the pattern of use established by the patient. Once the dose schedule (distribution of doses over time) and the dose have been determined, then there should be one single instruction for use. Multiple parallel instructions for use can be included in the event of a changing dose within one day and in the event of a variable use frequency. Multiple sequential instructions for use can be included in the event of changing doses within one period and/or in the event of a changing dose schedule." /> <comment value="DurationOfAdministration is not mapped to this element but to `.timing.repeat.duration` and `.timing.repeat.durationUnit`." /> <alias value="Dosering" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19935" /> <comment value="Dosage" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage" /> </mapping> </element> <element id="Dosage.doseAndRate.dose[x]"> <path value="Dosage.doseAndRate.dose[x]" /> <slicing> <discriminator> <type value="type" /> <path value="$this" /> </discriminator> <rules value="open" /> </slicing> <short value="Dose" /> <definition value="The dose indicates the amount/unit per administration. The unit can be any unit that can occur with this particular medicine." /> <alias value="Keerdosis" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19940" /> <comment value="Dose" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.Dose" /> </mapping> </element> <element id="Dosage.doseAndRate.dose[x]:doseRange"> <path value="Dosage.doseAndRate.dose[x]" /> <sliceName value="doseRange" /> <type> <code value="Range" /> </type> </element> <element id="Dosage.doseAndRate.dose[x]:doseRange.low"> <path value="Dosage.doseAndRate.dose[x].low" /> <short value="minimumValue" /> <definition value="The minimal value of the range. The boundary is inclusive." /> <alias value="minimumWaarde" /> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.2" /> <comment value="minimumValue" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.MinimumValue" /> </mapping> </element> <element id="Dosage.doseAndRate.dose[x]:doseRange.high"> <path value="Dosage.doseAndRate.dose[x].high" /> <short value="maximumValue" /> <definition value="The maximum value of the range. The boundary is inclusive." /> <alias value="maximumWaarde" /> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.3" /> <comment value="maximumValue" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.MaximumValue" /> </mapping> </element> <element id="Dosage.doseAndRate.dose[x]:doseQuantity"> <path value="Dosage.doseAndRate.dose[x]" /> <sliceName value="doseQuantity" /> <short value="nominalValue" /> <definition value="Amount of medication per dose. The nominal value of the quantity." /> <alias value="nominaleWaarde" /> <type> <code value="Quantity" /> </type> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.4" /> <comment value="nominalValue" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.NominalValue" /> </mapping> </element> <element id="Dosage.doseAndRate.rate[x]"> <path value="Dosage.doseAndRate.rate[x]" /> <slicing> <discriminator> <type value="type" /> <path value="$this" /> </discriminator> <rules value="open" /> </slicing> <short value="AdministeringSpeed" /> <definition value="The administering speed is used in slow administration of liquid. In practice, the measuring unit is almost always ml/hour. Entering an interval (such as 0-10 ml/hour) is also a commonly used option. For example, with an administering speed of 10ml/hour: * amount = 10, * dose unit = ml, * time unit = hour" /> <alias value="Toedieningssnelheid" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19942" /> <comment value="AdministeringSpeed" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AdministeringSpeed" /> </mapping> </element> <element id="Dosage.doseAndRate.rate[x]:rateRange"> <path value="Dosage.doseAndRate.rate[x]" /> <sliceName value="rateRange" /> <type> <code value="Range" /> </type> </element> <element id="Dosage.doseAndRate.rate[x]:rateRange.low"> <path value="Dosage.doseAndRate.rate[x].low" /> <short value="minimumValue" /> <definition value="The minimal value of the range. The boundary is inclusive." /> <alias value="minimumWaarde" /> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.2" /> <comment value="minimumValue" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.MinimumValue" /> </mapping> </element> <element id="Dosage.doseAndRate.rate[x]:rateRange.high"> <path value="Dosage.doseAndRate.rate[x].high" /> <short value="maximumValue" /> <definition value="The maximum value of the range. The boundary is inclusive." /> <alias value="maximumWaarde" /> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.3" /> <comment value="maximumValue" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.MaximumValue" /> </mapping> </element> <element id="Dosage.doseAndRate.rate[x]:rateQuantity"> <path value="Dosage.doseAndRate.rate[x]" /> <sliceName value="rateQuantity" /> <short value="nominalValue" /> <definition value="The nominal value of the quantity." /> <alias value="nominaleWaarde" /> <type> <code value="Quantity" /> </type> <mapping> <identity value="zib-range-v1.0.1-2020EN" /> <map value="NL-CM:20.1.4" /> <comment value="nominalValue" /> </mapping> <mapping> <identity value="HdBe-Range" /> <map value="Range.NominalValue" /> </mapping> </element> <element id="Dosage.maxDosePerPeriod"> <path value="Dosage.maxDosePerPeriod" /> <short value="MaximumDose" /> <definition value="A maximum dose maximizes (in time) the usage of a drug in an 'as needed' prescription." /> <alias value="MaximaleDosering" /> <mapping> <identity value="zib-instructionsforuse-v1.2.1-2020EN" /> <map value="NL-CM:9.12.19946" /> <comment value="MaximumDose" /> </mapping> <mapping> <identity value="HdBe-InstructionsForUse" /> <map value="InstructionsForUse.DosingInstructions.Dosage.AsNeeded.MaximumDose" /> </mapping> </element> </differential> </StructureDefinition>